A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…BackgroundDystrophin is a key protein encoded by the DMD gene, serves as a scaffold linking the cytoskeleton to the extracellular matrix that plays a critical role in muscle contraction, relaxation, and structural integrity. Mutations, particularly single-point amino acid substitutions, can lead to dysfunctional Dystrophin, causing muscular dystrophies, with Duchenne muscular dystrophy (DMD) being the most severe form.ObjectiveThis study aimed to evaluate the effects of 184 single-point amino acid substitutions on the structure and function of Dystrophin using computational approaches.MethodsMany computational tools were used to predict the impact of amino acid substitutions on protein stability, solubility, and function. …”
Get full text

In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases by Jelena Lovrić, Jingjing Yan, XueQing Li, Tony Karlsborn, Mattias Bood, Anders Dahlén, Constanze Hilgendorf, Deepak Kumar Bhatt

Get full text

Potential compensatory mechanism for cognitive impairment in type 2 diabetes and prediabetes: altered structure-function coupling by Weiye Lu, Xuan Huang, Die Shen, Kun Wang, Jiahe Wang, Ziyu Diao, Shijun Qiu, Shijun Qiu

“…BackgroundStructure-function (SC-FC) coupling may be more sensitive to detecting changes in the brain than any single modality. …”
Get full text

Impact of a Structured Social Skills Training Program on Adolescents and Young Adults with Level 1 Autism by Leonardo Zoccante, Sara Sabaini, Erika Rigotti, Sophia Marlene Bonatti, Camilla Lintas, Marco Zaffanello

“…This study aims to evaluate the effectiveness of a structured social skills training programme for adolescents and young adults with level 1 ASD. …”
Get full text

HPV16 genome structure analysis in oropharyngeal cancer PDXs identifies tumors with integrated and episomal genomes by Claire D. James, Raymonde O. Otoa, Aya H. Youssef, Christian T. Fontan, Malay K. Sannigrahi, Brad Windle, Devraj Basu, Iain M. Morgan

“…Here we characterize HPV genome structures in eight HPV16+ OPC patient-derived xenografts (PDXs), and evaluate their responses to standard chemotherapy. …”
Get full text

Pelvic floor structural changes during the first singleton pregnancy and the risk factors of stress urinary incontinence by Chuanqing Sun, Hongyu Yang, Keting Li, Ping He

“…Conclusions Pelvic floor structure begin to change during pregnancy, as the pregnancy advanced, the hiatal area increased gradually.…”
Get full text

The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia by Sagarika Bhattacharjee, P. T. Sivakumar, Ganesan Venkatasubramanian, Kenichi Oishi, Kyrana Tsapkini, S. H. Annabel Chen, Brenda Rapp, John E. Desmond, T. N. Sathyaprabha, Kaviraja Udupa, Rajan Kashyap

“…Since tDCS current distribution depends on brain structure and function, variant-specific montages are essential. …”
Get full text

Development of Deployable Reflector Antenna for the SAR-Satellite, Part 3: Environmental Test of Structural-Thermal Model by Hyun-Guk Kim, Dong-Geon Kim, Ryoon-Ho Do, Min-Ju Kwak, Kyung-Rae Koo, Youngjoon Yu

“…The sinusoidal vibration test was implemented to investigate the fundamental frequency for inplane/normal directions and evaluate the structural stability of reflector antenna. By using experimental data obtained from the thermal-balance test, the well-correlated thermal analysis model was established to execute the orbital thermal analysis. …”
Get full text

Towards Achilles Tendon Injury Prevention in Athletes with Structural MRI Biomarkers: A Machine Learning Approach by Norbert Kapinski, Karol Jaskulski, Justyna Witkowska, Adam Kozlowski, Pawel Adamczyk, Bartosz Wysoczanski, Agnieszka Zdrodowska, Adam Niemaszyk, Beata Ciszkowska-Lyson, Michal Starczewski

“…Aiming to identify relationships between the structured assessment of the Achilles tendon and its function that could support injury prevention. …”
Get full text

Is AI the future of evaluation in medical education?? AI vs. human evaluation in objective structured clinical examination by Murat Tekin, Mustafa Onur Yurdal, Çetin Toraman, Güneş Korkmaz, İbrahim Uysal

“…Abstract Background Objective Structured Clinical Examinations (OSCEs) are widely used in medical education to assess students’ clinical and professional skills. …”
Get full text

Fine Scale Patterns of Population Structure and Connectivity in Scandinavian Flat Oysters in Scandinavia (Ostrea edulis L.) by Chloé Robert, Homère J. Alves Monteiro, Alan Le Moan, Arnaud Tanguy, Ane T. Laugen, Jakob Hemmer‐Hansen, Åsa Strand, Pierre De Wit

“…However, despite recent studies focusing on flat oyster population structure along the European coast, little is known about the population structure of oysters in the Skagerrak marginal sea in Scandinavia, and how it is related to neighbouring regions. …”
Get full text

The Impact of Extracurricular Activities on Pre-Service Teacher Professional Development: A Structural Equation Modeling Study by Funda Uysal

“…Data from 775 pre-service teachers (71.1% female) across multiple disciplines at a Turkish university were analyzed using structural equation modeling (χ²/df = 2.855, RMSEA = 0.049, CFI = 0.93, TLI = 0.92). …”
Get full text

Diabetes care in the pandemic era in the Midwestern USA: a semi-structured interview study of the patient perspective by Shakoora A Sabree, Kimberly Dukes, Carolina Gonzalez Bravo, Morolake J Adeagbo, Sarai Edwards, Kasey Wainwright, Sienna E Schaeffer, Aneli Villa, Aloha D Wilks, Martha L Carvour

“…Objectives To understand patients’ experiences with diabetes care during the COVID-19 pandemic, with an emphasis on rural, medically underserved, and/or minoritised racial and ethnic groups in the Midwestern USA.Design Community-engaged, semi-structured interviews were conducted by medical student researchers trained in qualitative interviewing. …”
Get full text

Temporal trends of blood-based markers in various psychiatric disorders and their cross-sectional brain structure associations by Yu-Jia Wang, Zairen Zhou, Yu-Zhu Li, Ju-Jiao Kang, Jin-Tai Yu, Jian-Feng Feng, Wei Cheng, Guoqing Pan, Jia You, Linbo Wang

“…This study aimed to explore these trends in the decade before and after diagnosis, along with the cross-sectional relationships with brain structures. Methods: Utilizing UK Biobank data, we conducted a nested case-control analysis of individuals aged 40-69 years diagnosed with anxiety (n = 27,216), bipolar disorder (n = 1325), depression (n = 36,570), or schizophrenia (n = 1478) within 10 years of baseline. …”
Get full text

Correlations Between Morpho-structural Properties of the Brain and Cognitive and Motor Deficits in Individuals with Traumatic Brain Injury by Alaleh Alivar, Soha Saleh, Michael Glassen, Easter S. Suviseshamuthu, Vikram Shenoy Handiru, Didier Allexandre, Guang H. Yue

“…This study explores the relationship between neurobehavioral as well as physical function deficits and structural changes in brain white matter (WM) and gray matter (GM) in individuals with TBI by evaluating morphometric magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data. …”
Get full text

Analysing the Functional and Structural Impact of Single Nucleotide Polymorphisms in Matrix Metalloproteinase 3 Gene: An In-silico Approach by Rejitha Ramachandran, Saritha C joseph, kc Sajeevan, Shajee S Nair

“…Aim: To identify pathogenic missense SNPs in the human MMP3 gene and analyse their effects on structure and function. Materials and Methods: This was a record-based cross-sectional study performed using data retrieved from online resources. …”
Get full text

Structural Equation Modeling and Genome-Wide Selection for Multiple Traits to Enhance Arabica Coffee Breeding Programs by Matheus Massariol Suela, Camila Ferreira Azevedo, Ana Carolina Campana Nascimento, Eveline Teixeira Caixeta Moura, Antônio Carlos Baião de Oliveira, Gota Morota, Moysés Nascimento

“…To address these challenges, we conducted a comprehensive analysis involving confirmatory factor analysis (CFA), Bayesian networks (BN), structural equation modeling (SEM), and genome-wide selection (GWS) using data from 195 arabica coffee plants. …”
Get full text

Cortical thickness and structural covariance network alterations in cerebral amyloid angiopathy: A graph theoretical analysis by Yijun Lin, Bin Gao, Yang Du, Mengyao Li, Yanfang Liu, Xingquan Zhao

“…Methods: We employed structural covariance network (SCN) analysis based on cortical thickness data from ultra-high field 7 T MRI to investigate network alterations in CAA patients. …”
Get full text

Cardiac structure and function in anabolic-androgenic steroid users: a 16-year follow-up study by Sigrun Halvorsen, Dan Atar, Anne Rossebø, Tea Sætereng Fyksen, Jørgen Gravning, Paul Vanberg, Ole Jørgen Grøtta

“…Background and aim Long-term data on cardiac changes in anabolic-androgenic steroid (AAS) users are lacking. …”
Get full text

Paclobutrazol and maleic hydrazide-induced growth inhibition in warm season turfgrasses through structural and physiological differences by Muhammad Mubashir Shahzad, Gulzar Akhtar, Muhammad Asif Shehzad, Sami Ullah, Hafiz Nazar Faried, Kashif Razzaq, Fahim Nawaz, Ishtiaq A. Rajwana, Muhammad Amin, Muhammad Ahsan

Get full text