Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses by Abhishek Cukkemane, Nina Becker, Tatsiana Kupreichyk, Henrike Heise, Dieter Willbold, Oliver H. Weiergräber

“…Disrupted in schizophrenia 1 (DISC1) is a pleiotropic scaffold protein that is postulated to comprise large disordered regions and four distinct structured segments with a high proportion of helical or coiled-coil fold. …”
Get full text

Development and distribution characteristics of geohazards based on sedimentary-structural evolution in Xide County, southwest Sichuan by Xiaohui XIONG, Yongjian BAI, Yongbo TIE, Yanchao GAO, Hua GE, Wei XU, Lingfeng GONG, Jiazhu WANG, Kai TIAN, Menglong HE, Zhihua ZHU

“…The wide and gentle fold structures in red beds are the disaster-prone environment for landslide. …”
Get full text

Comparative Whole-Genome Analysis of Production Traits and Genetic Structure in Baiyu and Chuanzhong Black Goats by Jing Luo, Qi Min, Xueliang Sun, Xinyu Guo, Meijun Song, Xuehui Zeng, Jiazhong Guo, Hongping Zhang, Yanguo Han, Li Li

“…Furthermore, we conducted a comprehensive analysis of genetic diversity, population structure, and selection signatures using whole-genome resequencing data. …”
Get full text

Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture by Rajendra A. Morey, Yuanchao Zheng, Henry Bayly, Delin Sun, Melanie E. Garrett, Marianna Gasperi, Adam X. Maihofer, C. Lexi Baird, Katrina L. Grasby, Ashley A. Huggins, Courtney C. Haswell, Paul M. Thompson, Sarah Medland, Daniel E. Gustavson, Matthew S. Panizzon, William S. Kremen, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue

“…Even though we observed model instability in our application of genomic SEM to high-dimensional data, jointly modeling the genetic architecture of complex traits and investigating multivariate genetic links across neuroimaging phenotypes offers new insights into the genetics of cortical structure and relationships to psychopathology.…”
Get full text

Presence of Pain Shows Greater Effect than Tendon Structural Alignment During Landing Dynamics by Silvia Ortega-Cebrián, Diogo C. F. Silva, Daniela F. Carneiro, Victor Zárate, Leonel A. T. Alves, Diana C. Guedes, Carlos A. Zárate-Tejero, Aïda Cadellans-Arróniz, António Mesquita Montes

“…Kinetics varied significantly by sex and jump type, while pain and tendon structure revealed limited differences.…”
Get full text

Calibration on MEPDG Low Temperature Cracking Model and Recommendation on Asphalt Pavement Structures in Seasonal Frozen Region of China by Hongyan Ma, Dongsheng Wang, Changjun Zhou, Decheng Feng

“…Additionally, multiple factor sensitivity analyses were carried out as well, based on which pavement structures with sound thermal cracking resistance were recommended for seasonal frozen regions in China. …”
Get full text

Structural placental changes in women with intra-pregnancy novel coronavirus infection COVID-19 (review) by A. V. Yakimova, S. Yu. Borovaya, V. R. Mukhamedshina, N. S. Datsenko, S. G. Kucherenko, I. M. Pozdnyakov, E. V. Nikitenko

“…In those that were excluded from the review, information about the clinical course of pregnancy and its outcome during novel coronavirus infection prevailed, or isolated cases of studying insignificant placental structural changes were discussed. Studies with a small number of observations were selected only in the case of the uniqueness of the published data, the absence of scientific papers where similar studies would have been conducted in larger sample.Results. …”
Get full text

Impact of the fishing ban on fish diversity and population structure in the middle reaches of the Yangtze River, China by Juan Du, Juan Du, Huiwu Tian, Zhiyuan Xiang, Kangshun Zhao, Kangshun Zhao, Lixiong Yu, Xinbin Duan, Daqing Chen, Jun Xu, Jun Xu, Mingdian Liu

“…Fish monitoring data collected from 2017–2019 (pre-ban) and 2021–2023 (post-ban) were analyzed to evaluate changes in fish body size, species diversity, and community structure. …”
Get full text

A Deep Learning Inversion Method for 3D Temperature Structures in the South China Sea with Physical Constraints by Dongcan Xu, Yahao Liu, Yuan Kong

“…This study develops a Convolutional Long Short-Term Memory (ConvLSTM) neural network, integrating multi-source satellite remote sensing data, to reconstruct the Ocean Subsurface Temperature Structure (OSTS). …”
Get full text

Investigation of the Relationship between Character Structures and Mental Toughness of High School and University Students Doing Fencing Sports by Ozer Yıldız, İbrahim Bacak

“…The aim of the research is to examine the relationship between character structures and mental toughness of high school and university students doing fencing sports. …”
Get full text

Experimental study of the deformed state of metal structures of load trolleys of overhead cranes with a multipurpose layout drawing by Denisov I.A.

“…The article reflects information about the methodology of experimental research, describes the features of the physical models of metal structures used in the course of the experiment. The data on the vertical displacements of the control points of metal structures when using various loading schemes are given. …”
Get full text

ANALYSIS OF THREE-DIMENSIONAL SPATIAL STRUCTURES IN ARCHAEOASTRONOMY: 3D MODEL OF THE ROCK-CUT MONUMENT “BELINTASH“, BULGARIA by Ognyan OGNYANOV, Penka MAGLOVA, Alexey STOEV

“…The analysis of spatial structures allows significantly more accessible and authentic extraction of archaeoastronomical data and their interpretation.…”
Get full text

Investigation of Shallow Structures as The Pathway of Oil Seep in The Alue Punoe Village, Bireuen District, Aceh Province, Indonesia by . Asrillah, Muhammad Syukri, . Marwan, Fuad Akbar

“…Measurement of magnetic data has been done in the area of oil seeps in the village of the Alue Punoe, with 121 measurement points as a grid within 500 m x 500 m area where each grid is approximately in 250 m2. …”
Get full text

The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis by Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang

“…Consequently, it is important to utilize relevant coordinate data for a comprehensive meta-analysis to identify the shared patterns of structural, functional, and multimodal alternations in TUD.MethodThe present study conducted a systematic retrieval of studies published on PubMed, Web of Science, and Scopus from January 1, 2010, to December 12, 2023, to identify studies on voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) for TUD. …”
Get full text

Local Scour Around Marine Structures: A Comprehensive Review of Influencing Factors, Prediction Methods, and Future Directions by Bingchuan Duan, Duoyin Wang, Chenxi Qin, Lunliang Duan

“…Local scour is a phenomenon of sediment erosion and transport caused by the dynamic interaction between water flow and seabed sediment, posing a serious threat to the safety of marine engineering structures such as cross-sea bridges and offshore wind turbines. …”
Get full text

Safety Protection of Under-passing Existing Rail Transit Structures Based on Midas GTS Finite Element Software by GU Zhangchuan

“…On-site measured data indicate that the maximum horizontal displacement of the existing rail transit main structure is 0.50 mm, and the maximum vertical displacement is 1.60 mm. …”
Get full text

AI-Driven Detection of Alkali-Silica Reaction in Concrete Structures Using Feature-Enhanced Deep Learning Models by Yujie Wu, Mengze Wu, Tianyi Cui, Jiani Lin, Qingke Liao, Jinqiu Shu

Get full text

A Newly Developed Compressed Air Cannon Test Bench Designed for Multi-Impact Analysis of Composite Structures by Ayoub Soufri, Ameur Chettah, Benoît Piezel, Christophe Bouvet

“…Understanding the response and damage evolution of structures subjected to multiple impact events is essential for designing resilient structures capable of withstanding complex loading scenarios, such as impacts from hail, gravel or foreign object debris. …”
Get full text

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer by Ailith Ewing, Alison Meynert, Ryan Silk, Stuart Aitken, Devin P. Bendixsen, Michael Churchman, Stuart L. Brown, Alhafidz Hamdan, Joanne Mattocks, Graeme R. Grimes, Tracy Ballinger, Robert L. Hollis, C. Simon Herrington, John P. Thomson, Kitty Sherwood, Thomas Parry, Edward Esiri-Bloom, Clare Bartos, Ian Croy, Michelle Ferguson, Mairi Lennie, Trevor McGoldrick, Neil McPhail, Nadeem Siddiqui, Rosalind Glasspool, Melanie Mackean, Fiona Nussey, Brian McDade, Darren Ennis, The Scottish Genomes Partnership, Lynn McMahon, Athena Matakidou, Brian Dougherty, Ruth March, J. Carl Barrett, Iain A. McNeish, Andrew V. Biankin, Patricia Roxburgh, Charlie Gourley, Colin A. Semple

Get full text

Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…Biacore-based binding data indicate that both vibostolimab and tiragolumab bind on TIGIT with comparable binding affinity (KD), but different binding kinetics characterized by faster on and off rates, which may contribute to enhanced T-cell activation with vibostolimab, as evidenced by greater IL-2 production in an in vitro cell-based assay. …”
Get full text