Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities by Xin Lai, Caizhi Li, Xinglinzi Tang, Xinyi Luo, Feiyan Wu, Yuhong Liang, Bihui Huang, Hang Li, Hang Li

“…Super-enhancers (SEs) are dynamic chromatin structures that function as epigenetic hubs, orchestrating cell-type-specific transcriptional programs crucial for immune cell differentiation, functional specialization, and adaptive responses. …”
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Assessment of Flood Mitigation Strategies: A Case Study of the Aït Athmane Center in the Errachidia Region by Kadiri Abdelhakim, Essafraoui Badre, Messaoudi Badre, Aït Lahssaine Ismail, Ait Said Brahim, El Ouali Mohamed, Kabiri Lahcen

“…These primarily involve simple mechanical adjustments such as constructing gabion weirs, raising retaining walls along the Wadi's banks, and creating crossing structures.…”
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An overview of biopesticide regulatory frameworks in selected countries in Southern Africa by Kahsay Tadesse Mawcha, Kahsay Tadesse Mawcha, Dorothy Kyampaire, Chrian Marciale, Stella Simiyu-Wafukho, Stella Simiyu-Wafukho, Chifundo Chinyama, Olubukola Oluranti Babalola, Grace Kinyanjui, Grace Kinyanjui, Dennis Ndolo

“…The study details the stages of bill passage, from initial drafting and introduction to presidential assent, highlighting variations in parliamentary structures, public participation, and the role of subsidiary legislation. …”
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HTS analysis of resistance induction against PPV by four hairpin constructs in Nicotiana benthamiana Domin by Maryam Ghaderi Sohi, Kahraman Gürcan, Saffet Teber, Mikail Akbulut, Yazgan Tunç, Mehmet Yaman, Ali Khadivi, Azam Nikbakht-Dehkordi, Harun Karcı, Burak Özgören, Vahid Roumi

“…The potential of hairpin structures in the production of siRNAs and miRNAs in both wild-type and transgenic plants was compared by small RNA high-throughput sequencing. …”
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Environmental risk factors associated with community diarrheal disease in Ethiopia by Devin LaPolt, Sage Smith, Lina Gazu, Silvia Alonso, Amete Mihret Teshale, Binyam Moges Azmeraye, Galana Mamo Ayana, Dessie Abebaw Angaw, Desalegne Degefaw, Ariel V. Garsow, Aaron Beczkiewicz, Getnet Yimer, Michala J. Krakowski, Robert Scharff, Eyasu T. Seyoum, Barbara Kowalcyk

“…REDCAP mobile app was used to collect data during face-to-face interviews using a structured, pretested questionnaire. Descriptive statistics characterized household environmental exposures. …”
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Implementation and maintenance of breast cancer screening among Chinese rural women: a mixed-methods evaluation based on RE-AIM framework by Huijiao Yan, Qiankun Wang, Le Dang, Xianzhi Duan, Zhirong Bai, Yinhui Feng, Linlin Zhang, Suyala Qimuge, Haiying Gao, Xinchun Wang, Min Sun, Shuxia Ma, Cailing Yan, Fanghui Zhao, Youlin Qiao

“…The qualitative study, conducted in 2024, collected data through semi-structured interviews with nine health workers and analyzed the transcripts using thematic analysis. …”
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Discriminant analysis of occupational performance characteristics in patients with major depressive disorders and healthy individuals by Tomonari Hayasaka, Izumi Nagashima, Miku Hoshino, Koji Teruya, Yasuyuki Matumoto, Masami Murao, Taku Maruki, Masako Watanabe, Takeshi Katagiri, Yayoi Imamura, Mariko Kurihara, Yuki Oe, Yoshikazu Takaesu, Takashi Tsuboi, Koichiro Watanabe, Hitoshi Sakurai

“…Abstract Aim Assessing symptoms and daily functioning in patients with major depressive disorder (MDD) can be challenging, as their limited self‐monitoring abilities may result in behavior observed during structured interviews not accurately reflecting their daily lives. …”
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The second victim phenomenon among German emergency medical technicians: a cross-sectional study based on the SeViD questionnaire (SeViD-VIII) by Hartwig Marung, Victoria Klemm, Reinhard Strametz, Thomas Neusius, Matthias Raspe, Hannah Roesner, Harald Karutz, Klaus Runggaldier, Rainer Petzina, Luis Teichmann, Stefan Bushuven

“…The implementation of structured peer support programs may help mitigate the impact of SVP.…”
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Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management—a review by Jhan Sebastian Saavedra Torres, Francisco Javier Tamayo-Giraldo, Alejandro Bejarano-Zuleta, Alejandro Bejarano-Zuleta, H. A. Nati-Castillo, Diego A. Quintero, M. J. Ospina-Mejía, Camila Salazar-Santoliva, Isaac Suárez-Sangucho, Esteban Ortiz-Prado, Juan S. Izquierdo-Condoy

“…Timely and targeted interventions, including antimicrobial therapy, cytokine modulation, immune restoration, metabolic support, and structured rehabilitation strategies, are pivotal for improving outcomes. …”
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Artificial intelligence conversational agents in mental health: Patients see potential, but prefer humans in the loop by Hyein S. Lee, Hyein S. Lee, Colton Wright, Julia Ferranto, Jessica Buttimer, Clare E. Palmer, Andrew Welchman, Kathleen M. Mazor, Kimberly A. Fisher, David Smelson, Laurel O’Connor, Laurel O’Connor, Nisha Fahey, Nisha Fahey, Apurv Soni, Apurv Soni, Apurv Soni

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SYNTHESIS OF NEW N-HYDROXYPHENYL AND TOLYL DERIVATIVES OF PYRIMIDINE-4(1H) –ONE WITH ANTI-INFLAMMATORY ACTIVITY by I. P. Kodonidi, O. O. Novikov, S. A. Kuleshova, Ju. I. Rjabukhin, S. S. Shatokhin, A. V. Ivchenko, M. I. Kodonidi, O. M. Zhilina

“…The research was carried out using the logical-structural approach and information technologies. The computer analysis of biological activity was carried out by the PASS program. …”
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Development of a reliable method for human triple-negative breast cancer organotypic culture: Improving imaging and genomic studies in 3D cultures by Mercedes Olvera-Valencia, Verónica Garcia-Castillo, Rosalío Ramos-Payan, Maribel Aguilar-Medina, Samuel Trujano-Camacho, Alejandro López-Saavedra, Laurence A. Marchat, Cesar López-Camarillo, Ronen Sumagin, Eloy Pérez-Yepez, Carlos Pérez-Plasencia

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Factors associated with utilization of skilled birth attendance among women of reproductive age in North Horr Sub-County, Northern Kenya, 2021 by Qabale Anna Duba, Elvis Omondi Oyugi, Paul Nyongesa, Joseph Obiero Ogutu

“…We interviewed the women using structured questionnaires and performed descriptive statistics. …”
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Thematic Analysis of Factors Influencing Helmet Non-Use among Motorcyclists in Gorgan by Vajihe Jalaeian Bakhshande, Seyes Rasoul Davoodi

“…Data were collected through semi-structured interviews with 15 motorcyclists in Gorgan City. …”
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Silymarin as a potent polyphenol against metabolic disease pathways: A computational insight and ADMET/MM-PBSA analysis by Fatemeh Mahmoudi Lamooki, Fatemeh Alami, Farzad Mirab Toupchi, Parham Jalali, Armita Banimahdidehkordi, Payam Baziyar, Shamim Ghiabi, Ehsan Heidari-Soureshjani, Seyedeh Atefeh Mirahmadi

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A Comparative Study of the Perspectives of Long‐Stay Immigrants, Nurses and Cultural Mediators on Intercultural Communication: A Secondary Qualitative Analysis by Francesc Ramos‐Roure, Maria Feijoo‐Cid, Josep Maria Manresa‐Dominguez, Jordi Segura‐Bernal, Rosa García‐Sierra, Maria Isabel Fernández‐Cano, Antonia Arreciado Marañón, Eduard Moreno‐Gabriel, Clara Flamarich Gol, Pere Toran‐Monserrat

“…Results The results are structured under the core category “Agreements and discrepancies in intercultural communication,” split into two subcategories: (1) Communication and the role of culture; (2) (Non) equitable and culturally (in)sensitive care. …”
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Case Report: Lasting complete response to pembrolizumab in mismatch repair-deficient cardiac sarcoma: a genomic characterization by Daniela A. Ferraro, Bettina Bisig, Bettina Bisig, David C. Rotzinger, Fresia Pareja, Edoardo Missiaglia, Edoardo Missiaglia, Ioannis Voutsadakis, Ioannis Voutsadakis, Krisztian Homicsko, Krisztian Homicsko, Antonia Digklia, Antonia Digklia

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Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…Herein, we present a comprehensive and structured assessment of this emerging interdisciplinary field. …”
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Effect of Enhanced Recovery After Surgery (ERAS) Implementation on Postoperative Atrial Fibrillation in Cardiac Surgery by Romain Niessen, Valentina Rancati, Mario Verdugo-Marchese, Ziyad Gunga, Anna Nowacka, Valentine Melly, Christophe Abellan, Karima Alouazen, Tamila Abdurashidova, Caroline Botteau, Matthias Kirsch, Zied Ltaief

“…<b>Conclusions</b>: The implementation of a structured ERAS protocol significantly reduced POAF incidence, improved compliance with preventive strategies, and enhanced key aspects of postoperative recovery.…”
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Knowledge, perception, and attitude toward COVID-19 vaccines in the Ho township, Volta region by Vivian Tackie, Christiana Asiedu, Ewoenam Darkey, Beatrice Hammond, Linda Jailer, Janet Osei Konadu, Samuel Otieku Cyril, Williams Marie Noel, Isaac Aidoo Erzuah

“…The response rate was 99.5% (441). A structured questionnaire was used to collect the data. …”
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