DEVELOPMENT OF METHODS OF SIMULATION OF THE INTERACTION OF BIOLOGICALLY ACTIVE SUBSTANCES WITH THE ACTIVE CENTER OF ANGIOTENSIN-CONVERTING ENZYME by A. A. Glushko, A. S. Chiriapkin, V. S. Chiriapkin, A. M. Murtuzalieva, Yu. A. Polkovnikova

“…The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).…”
Get full text

MITOCHONDRIAL DYSFUNCTION AS POSSIBLE CAUSE OF IMPAIRED FOLLICULAR DEVELOPMENT by A. A. Pozdnyakova, M. A. Volodina, S. J. Rshtuni, L. A. Marchenko, M. Yu. Vysokikh

“…Mitochondria play leading role in senescence program realization. One of the early manifestations of this process is loss of reproductive function in female (menopause). …”
Get full text

Genome-wide identification and expression profiling of the bZIP gene family in Chrysanthemum indicum and the functional analysis of CibZIP29 under cadmium stress by Shengyan Chen, Yin Zhang, Kaiyuan Zhang, Shuguang Liu, Yujia Yang, Xingnong Xu

“…Phylogenetic analysis grouped them into 12 subgroups, supported by conserved motifs, gene, and protein structure analyses. Tandem and segmental duplications were found to be key drivers of CibZIP gene family expansion, with Ka/Ks analysis indicating purifying selection of duplicated genes. …”
Get full text

The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells by Jianghong Xiang, Yihan Lai, Zuping He

“…By maintaining the chromatin loop structure, the cohesin complex is involved in DNA repair and gene transcription, which in turn controls the pluripotency, self-renewal, and differentiation of stem cells. …”
Get full text

Cemiplimab-Induced Vogt-Koyanagi-Harada-Like Syndrome in a Patient With Cutaneous Squamous Cell Carcinoma of the Lower Back by Shapoo Nidha MD, Rehman Abdul MD, Mattana Joseph MD, Jen-Chin Wang MD, Gotlieb Vladimir MD

“…Cemiplimab is a programmed death receptor-1 inhibitor that has been approved for the treatment of advanced cutaneous squamous cell carcinoma (CSCC). …”
Get full text

DH-plant production in culture of unpollinated ovules of cucumber (Cucumis sativus L.) by E. A. Domblides, N. A. Shmykova, S. N. Belov, I. B. Korottseva, A. V. Soldatenko

“…Highest number of embryo-like structures in all accessions developed from ovaries 2.1-2.6 cm long. …”
Get full text

Synthesis and transformation in the series of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids by D. V. Dovbnia, A. H. Kaplaushenko, Yu. S. Frolova

“…Physical and chemical properties were investigated for the synthesized compounds. The structure of the obtained substances was confirmed by elemental analysis, IR-spectroscopy, 1H NMR-spectrometry, and their individuality were established by thin-layer chromatography. …”
Get full text

Maternal health education and social support needs across the perinatal continuum of care: a thematic analysis of interviews with postpartum women in Punjab, India by Preetika Sharma, Rashmi Bagga, Maliha Khan, Mona Duggal, Darshan Hosapatna Basavarajappa, Alka Ahuja, Ankita Kankaria, Nadia Diamond-Smith, Vijay Kumar, Manju Kashyap, Pushpendra Singh, Jasmeet Kaur, Alison M. El Ayadi

“…Participant narratives highlighted the crucial role of both formal and informal support structures, with a heavy reliance on advice from community health workers (ASHAs), midwives, and doctors. …”
Get full text

Delivering a Group-Based Quality of Life Intervention to Young Adult Cancer Survivors via a Web Platform: Feasibility Trial by Rina S Fox, Tara K Torres, Terry A Badger, Emmanuel Katsanis, DerShung Yang, Stacy D Sanford, David E Victorson, Betina Yanez, Frank J Penedo, Michael H Antoni, Laura B Oswald

“…Qualitative feedback identified needed revisions to the aesthetics (eg, images), content (eg, session titles), function (eg, clarity of functionality), and structure (eg, expandable sections), which were implemented. …”
Get full text

Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization by Shafinaz Rahman Sarah, Abhishek Garg, Sadiyah Afroz, Shaleen Korch, Arjun Ray, Amita Gupta, Vandana Malhotra

“…Results from molecular dynamics simulations, in vitro binding, and co-expression studies with RelJK proteins indicate that the secondary structure changes associated with Thr77 phosphorylation in RelK toxin compromise its binding to the RelJ antitoxin. …”
Get full text

Identifikasi Komponen Aktif Jahe Merah (Zingiber officinale Roscoe var. Rubrum) sebagai Sumber Antioksidan dengan Pendekatan Metabolomik Berbasis HPLC by Diny Agustini Sandrasari, Nuri Andarwulan, Didah Nur Faridah, Fitriya Nur Annisa Dewi

Get full text

Evaluation of control strategies for airport refueling system by Qing SHEN, Peng LIU, Jing GONG, Xiaoping LI, Yanqing WANG

“…This program was then cross-checked against SPS software results to validate its accuracy. …”
Get full text

Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients by Daniel Y. Chu, Jiancheng Hou, Thomas Hosseini, Veena A. Nair, Nagesh Adluru, Yuri Danilov, Kurt A. Kaczmarek, Mary E. Meyerand, Mitchell Tyler, Mitchell Tyler, Vivek Prabhakaran

“…Recently, translingual neural stimulation (TLNS) has emerged as a potential therapy for mmTBI-related balance and gait deficits by inducing neuroplastic changes in the brain gray matter structure. However, it is still unclear how interactions within and between functional networks in brain are affected by TLNS. …”
Get full text

Pre-breeding in alfalfa germplasm develops highly differentiated populations, as revealed by genome-wide microhaplotype markers by Cesar A. Medina, Dongyan Zhao, Meng Lin, Manoj Sapkota, Alexander M. Sandercock, Craig T. Beil, Moira J. Sheehan, Brian M. Irish, Long-Xi Yu, Hari Poudel, Annie Claessens, Virginia Moore, Jamie Crawford, Julie Hansen, Donald Viands, Michael D. Peel, Neal Tilhou, Heathcliffe Riday, E. Charles Brummer, Zhanyou Xu

“…Principal component analysis and discriminant analysis of principal components revealed significant population structure among the alfalfa populations based on geographical origin, while the check cultivars formed a central cluster. …”
Get full text

Inner Plexiform Layer Substrata Are Discernible with Commercial OCT and Affected by Aging by Victor S.M.C. Correa, MD, Maria Emfietzoglou, MD, Gustavo Sakuno, MD, PhD, Rosanne Naafs, MSc, Joan W. Miller, MD, Alexander Charonis, MD, Demetrios G. Vavvas, MD, PhD

“…Results: The IPL exhibited a multilayered structure with 5 sublayers, 3 hyperreflective and 2 hyporeflective, arranged in an alternating pattern. …”
Get full text

Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
Get full text

Malaria risk factors in northern Namibia: The importance of occupation, age and mobility in characterizing high-risk populations. by Jennifer L Smith, Davis Mumbengegwi, Erastus Haindongo, Carmen Cueto, Kathryn W Roberts, Roly Gosling, Petrina Uusiku, Immo Kleinschmidt, Adam Bennett, Hugh J Sturrock

“…Other actionable risk factors for malaria included housing and behavioral characteristics, including traditional home construction and sleeping in an open structure (versus modern structure: aOR: 2.01 95%CI 1.45-2.79 and aOR: 4.76 95%CI: 2.14-10.57); cross border travel in the prior 30 days (aOR: 10.55 95%CI 2.94-37.84); and outdoor agricultural work at night (aOR: 2.09 95%CI 1.12-3.87). …”
Get full text

Algorithm for analyzing randomness in point patterns by Tony Sampaio, Jorge Rocha, Cláudia M. Viana, Silvana Camboin, Fábio Marcelo Breunig, Edenilson Nascimento, Elaine de Cacia de Lima Frick

Get full text

Gold-coated ZnO nanostructures on no-core optical fiber for ammonia detection in food spoilage applications by Suphavit Thaneerat, Karnpote Roekwibunsi, Gaurika Vasan, Kankan Swargiary, Ratchawi Jammee, Dalawan Limthin, Pannathorn Jitpratak, Charusluk Viphavakit

Get full text

Microstructure examination of the biocorrosion susceptibility of mild steel coated with Zn and Zn-CaCO3 in a biodiesel environment by Vivi A. Fardilah, Ilham Alkian, Yustina M. Pusparizkita, Cristian Aslan, Mohammad Tauviqirrahman, J. Jamari, Athanasius P. Bayuseno

Get full text