Synthesis, physical-chemical properties, antimicrobial and antifungal activity of some 2-(2-((5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-yl)thio)acetyl)-N-R1–hydrazine-carbothioamide... by V. M. Odyntsova, A. M. Kamyshny, N. N. Polischuk

“…They select natural heterocyclic molecules that exhibit various types of pharmacological activity as basic structures. Adamantane derivatives, as well as a number of other framework compounds, in the vast majority are biologically active substances. …”
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Modeling of chronic ovary inflammation by N. А. Volkova, M. S. Yuhta, Т. А. Yurchuk, L. V. Stepanuk, E. D. Ivanova, E. V. Pavlovich

“…For statistical study ANOVA and t-Student tests were used with application of Microsoft Excel Program. Results. In the group of control animals the form and histological structure of ovaries were regular for mature mice without signs of inflammatory changes. …”
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Degradation of low-density polyethylene by a novel strain of bacteria isolated from the plastisphere of marine ecosystems by F.A. Febria, A. Syafrita, A. Putra, H. Hidayat, C. Febrion

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Aortic Aneurysm Inflammatory Cell Detection with Deep Learning methods by Kristóf-Gergö Nagy, Csaba Szferle, Attila Fintha

“…INTRODUCTION: In digital pathology, neural networks such as the Multilayer Perceptron (MLP) and Residual Neural Network (ResNet) are becoming increasingly prevalent for the analysis of tissue structure. However, their application remains constrained. …”
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Equitable access to COVID-19 vaccines in Botswana: a scoping review by John T. Tlhakanelo, John T. Tlhakanelo, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, Vincent Pagiwa, Nankie Ramabu, Khutsafalo Kadimo, Dintle Molosiwa, Grace Njeri Muriithi, Daniel Malik Achala, Elizabeth Naa Adukwei Adote, Chinyere Ojiugo Mbachu, Senait Alemayehu Beshah, Senait Alemayehu Beshah, Nyasha Masuka, Chijioke Osinachi Nwosu, James Akazili, James Akazili, Chikezie Ifeanyi

“…COVID-19 vaccine delivery relied on existing Expanded Program on Immunization (EPI) structures and therefore experienced to existing EPI challenges including, lack of transport, shortage of human resources, and vaccine stock-outs.ConclusionsUnder-performance of immunization programs at the district level, characterized by declining immunization coverage and inadequate outreach services, exacerbates disparities in vaccine access. …”
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Genomics and morphometry of herbarium specimens elucidate the origin of the Cape Verde date palm (Phoenix atlantica A.Chev.) and highlight its agronomic potential by Jerónimo Cid‐Vian, Oscar A. Pérez‐Escobar, William J. Baker, Vincent Bonhomme, Sylvie Ferrand, Sarah Ivorra, Thomas Kaczmarek, Clémence Pagnoux, Jean‐Frédéric Terral, Nathan Wales, Michael D. Purugganan, Simon Creer, Alexander S. T. Papadopulos, Sidonie Bellot, Muriel Gros‐Balthazard

“…Specifically, we investigate the phylogenetic placement, genetic structure, and seed morphology of P. atlantica by generating extensive genomic and seed morphology datasets from expert‐verified historical and modern specimens of Phoenix, including the type specimen of P. atlantica. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…Abstract Background Despite the recognized therapeutic potential of programmed cell death protein 1/programmed death‐ligand 1 (PD‐1/PD‐L1) inhibitors in advanced esophageal squamous cell carcinoma (ESCC), their role in neoadjuvant therapy and reliable efficacy biomarkers remain elusive. …”
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Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain by Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang, Long Zhao, Yang Yang, Yijian Zhang, Lei Xu, Yangyang Lei, Jie Du, Hu Chen, Lian Duan, Mingyi He, Lintao Shi, Lei Liu, Quanjun Wang, Liangding Hu, Bin Zhang

“…Our attempt to devise a novel CAR structure capable of recognizing both tumor antigens and PDL1 encountered challenges since direct targeting of PDL1 resulted in systemic adverse effects. …”
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Genomic Prediction in a Self-Fertilized Progenies of <i>Eucalyptus</i> spp. by Guilherme Ferreira Melchert, Filipe Manoel Ferreira, Fabiana Rezende Muniz, Jose Wilacildo de Matos, Thiago Romanos Benatti, Itaraju Junior Baracuhy Brum, Leandro de Siqueira, Evandro Vagner Tambarussi

“…However, its efficiency may be compromised due to the complex structures of breeding populations, which arise from the use of multiple parents from different species. …”
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Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma by Lei Yang, Qing Zhou, Bo Zhang, Yi-Long Wu, Zhi-Hong Chen, Wen-zhao Zhong, Fen Wang, Yun-Ting He, Song Dong, Xue-Wu Wei, Wei-Dong Chen, Xiao-Rong Yang, Xue-Meng Shang

“…Backgrounds Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the underlying mechanism. …”
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Modulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides by Simone Renwick, Annalee Furst, Mikael Knip, on behalf of the DIABIMMUNE Study Group, Lars Bode, Jayne S. Danska, Emma Allen-Vercoe

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Green synthesis of ZnO nanoparticles using Cosmos caudatus: Effects of calcination temperature and precursor type on photocatalytic and antimicrobial activities by Indah Riwayati, Sugeng Winardi, Suci Madhania, Manabu Shimada, Kusdianto

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BioPipeline Creator—a user-friendly Java-based GUI for managing and customizing biological data pipelines by Cléo Maia Cordeiro, Gislenne da Silva Moia, Mônica Silva de Oliveira, Lucas da Silva e Silva, Maria Paula Cruz Schneider, Sávio S. Costa, Rafael Azevedo Baraúna, Diego Assis das Graças, Artur Silva, Adonney Allan de Oliveira Veras

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Preparation and characterization of polyvinyl alcohol thin films: Rheological, physicochemical and functional properties by Morteza Abazari, Safa Momeni Badeleh, Soroush Barkhordari, Shahen Salih Mohammed, Mohammed Mahmood Ahmed, Muath Sheet Mohammed Ameen, Hossein Abdollahi

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An Overview of Starch-Based Materials for Sustainable Food Packaging: Recent Advances, Limitations, and Perspectives by Tarsila Rodrigues Arruda, Gabriela de Oliveira Machado, Clara Suprani Marques, Amanda Lelis de Souza, Franciele Maria Pelissari, Taíla Veloso de Oliveira, Rafael Resende Assis Silva

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S100A12 in Digestive Diseases and Health: A Scoping Review by Alexandre Carvalho, Jacky Lu, Jamisha D. Francis, Rebecca E. Moore, Kathryn P. Haley, Ryan S. Doster, Steven D. Townsend, Jeremiah G. Johnson, Steven M. Damo, Jennifer A. Gaddy

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Classification of beekeeping provinces in Türkiye using data mining methods and research into production trends. Technical note by Hakan Serin, Alperen Varalan

“…As a result of the K–Means clustering method, a structure with three clusters, comprising 4, 11, and 66 provinces, was obtained. …”
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Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications by Chih Hung Lo, Lenny Yi Tong Cheong, Jialiu Zeng

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TECHNOLOGY OF EDUCATIONAL EVENTS DESIGNING by N. V. Volkova

“…The characteristics of an educational event are emphasized by means of an empirical way: opening (what a person opens for himself); generation (a result of a personal action); and participation in creation of something "new" (new communications, relations and experience). The structure of technology of educational events design including work with concepts (an educational event), substantial and procedural components is presented. …”
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Identification of potential small molecule allosteric modulator sites on IL-1R1 ectodomain using accelerated conformational sampling method. by Chao-Yie Yang

“…Based on the significant conformational change of IL-1R type 1 (IL-1R1) ectodomain upon binding to different ligands observed in crystal structures, we hypothesized that transient small molecule binding sites may exist when IL-1R1 undergoes conformational transition and thus suitable for inhibitor development. …”
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