Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

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Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile by Claudia Carrera-Bravo, Claudia Carrera-Bravo, Tianchi Zhou, Tianchi Zhou, Trang Chu, Jing Wen Hang, Harshvardhan Modh, Chenyuan Huang, Chenyuan Huang, Sitong Zhang, Sitong Zhang, Haining Hao, Haining Hao, Haining Hao, María José Cabada-García, Benoit Malleret, Benoit Malleret, Matthias G. Wacker, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Laurent Rénia, Kevin S. W. Tan

“…Notably, the outward budding and blebbing of the iRBC plasma membrane led to the formation of EVs, which are complex structures with unique functional properties. Proteomic characterization of EVs from CQ-treated iRBCs revealed a high enrichment of proteasome and ribosome protein clusters. …”
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An spike-accum® bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity by Jean Pierre Bikorimana, Nathanael A. Caveney, Nehme EL-Hachem, Gabrielle A. Mandl, John A. Capobianco, Daniela Stanga, Jamilah Abusarah, Mark A. Hancock, Roudy Farah, Marina P. Gonçalves, Darryl Falzarano, Mingmin Liao, Glenn Hamonic, Qiang Liu, Simon Beaudoin, Sebastien Talbot, Moutih Rafei

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Specialty preferences among Nigerian medical students: a cross sectional study by Tobi Olajide, Chioma Ezebialu, Christabel Uche-Orji, Ridwanullah Abdullateef, Chisom Okoye, Esther Olaoye, Jolly Thomas, Joy Adeniyi, Angel Ogiemudia, Simon Aina, Oluwatimilehin Oladapo, Emmanuel Ibitunde, Olumide Bankole, Chukwuebuka Asogwa, Mafusat Ojewumi, Precious Wagwula, Ayomide Fatola, Oluwadabira Adewara, Kenneth Christian, Oghenemaro Jerry-Ogeme, Lawrence Rejoice, Chisom Obah, Nouh Sanusi, Joshua Alabi, Elizabeth Ayegboyin, Atoyebi Olaadura, Isaac Adejumo, Promise Enyesiobi, Peace Alemede, David Uzoechi, Abdulaziz Ahmad, Chimdalu Ezeani, Brian Uche-Orji, Oluwatobi Joshua, Ihunanyachi Agha-Okoro, Godson Omumuawuike, Jessica Gambo, Peace Gbenle, Evan Adetoye, Olamide Odusola, Muhammed Ya’u, Muhammad Karaye, Rufus Akinyemi

“…The study revealed the need for structured career counseling and increased exposure to underrepresented specialties to address the uneven distribution of specialists in Nigeria. …”
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PATHOMORPHOLOGICAL AND COMPUTERIZED TOMOGRAPHY STUDY OF IBUPROFEN AND COMBINATION WITH 2-PHENYL-3-CARBETHOXY-4-DIMETHYLAMINOMETHYL-5-OKSIBENZOFURAN HYDROCHLORIDE (VINBORON) INFLUEN... by F. V. Hladkykh, V. O. Student, N. H. Stepaniuk, S. V. Vernyhorodskyi

“…The use of vinboron in combination with ibuprofen leads to a more pronounced pathogenetic anti-inflammatory structural-modifying effect of this antiphlogistics.…”
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The beneficial effect of spiritual social support on depression and quality of life in chronic renal failure patients undergoing haemodialysis by Susanti, Bistara Difran Nobel, Arif Helmi Setiawan, Ikwan Mochamad, Umamah Faridah, Zahroh Chilyatiz, Sham Fatimah Binti, Nordin Roswati Binti, Cherry Mustamu Alva

“…Methods: The current investigation utilised a quasi-experimental approach with a preand post-test control group structure. Ninety-two patients from Rumah Sakit Islam Surabaya were separated into two groups: intervention (n = 46) versus control (n = 46). …”
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Transcriptomic and proteomic studies of body size and carcass traits and the longest dorsal muscle in Tibetan sheep by Dehui Liu, Xue Li, Lei Wang, Quanbang Pei, Jincai Zhao, De Sun, Qianben Ren, Buying Han, Hanjing Jiang, Wenkui Zhang, Rong Li, Guoxiang Bao, Song Wang, Fei Tian, Sijia Liu, Kai Zhao, Dehong Tian

“…Result The body size traits, carcass traits, and muscle fiber structure of plateau-type Tibetan and Zhashijia sheep were compared. …”
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“Vaccinating a child is upon the woman”: implications for improving uptake for the recently introduced second dose of measles-containing vaccine based on a rapid community assessme... by Adelline Twimukye, Nessa Ryan, Flavia Vivian Najjuma, Yvette Wibabara, Judith Nanyondo, Shillah Nakato, Maria Sarah Nabaggala, Ciara Sugerman, Daniel Kadobera, Rita Atugonza, John Kamulegeya, Joseph Magoola, Racheal Beyagira, Mohammed Lamorde, Alex Riolexus Ario, Alfred Driwale, Shibani Kulkarni

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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
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Deciphering genetic characteristics of South China and North China indigenous pigs through selection signatures by Yahui Gao, Xueyan Feng, Shuqi Diao, Yuqiang Liu, Zhanming Zhong, Xiaotian Cai, Guangzhen Li, Jinyan Teng, Xiaohong Liu, Jiaqi Li, Zhe Zhang

“…After data filtering, we retained 31,521,978 high-quality SNPs. Population structure analysis using PCA revealed distinct genetic clustering among these populations. …”
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Results of modern radiation-hygienic surveys of settlements of Bryansk Oblast of the Russian Federation bordering the Republic of Belarus. Part 1: Characteristics of the settlement... by I. K. Romanovich, A. B. Bazyukin, A. N. Barkovsk, A. M. Biblin, A. A. Bratilova, G. Ya. Bruk, K. V. Varfolomeev, A. V. Gromov, E. A. Drozdova, T. V. Zhesko, S. A. Ivanov, M. V. Kaduka, T. A. Kormanovskaya, O. S. Kravtsova, V. A. Nekrasov, V. P. Ramzaev, K. A. Saprykin, N. V. Titov, O. A. Isakov, E. I. Zlotnikova, A. G. Sosnitskiy, V. I. Filin, A. V. Kudryashov, A. A. Ladik, V. A. Lalayan

“…The modern demographic composition of the population is considered; the structure of private subsidiary plots is investigated. …”
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Cloning and identification of human colipase-like 3 and its homologous cDNAs by LU Yan, XUE Yong-chang, YU Peng, WANG Ping-zhang

“…CL PSL3 was widely expressed and highly conserved in mammalian animals, such as Pan troglodytes, Equus caballus, Cavia porcellus, Loxodonta africana, Mus musculus and Rattus norvegicus, and showed very similar gene structures. Moreover, the CLPSL3 contained 18 highly conserved cysteines in all species, suggesting that it might relate to the disulfide bond formation.Colipase is a co-factor needed by pancreatic lipase for efficient dietary lipid hydrolysis. …”
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Protocol: Value Stream Maping in Healthcare. A systematic literature review by Juan A. Marin-Garcia, Pilar I. Vidal-Carreras, Julio J. Garcia Sabater, Javier Escribano-Martinez

“…We will not include the pharmaceutical industry or the operation of governmental or nongovernmental public health structures (e.g. ministries, the Red Cross or similar). …”
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Good Governance and Seigniorage in a Selected OPEC Countries and Iran by ALI Rashid Shamkhal, Kambiz Paykarjou, beitollah Akbari Moghaddam

“…Establishing good governance based on appropriate economic, political, cultural, and social structures is feasible, but the decision and willingness of rulers to implement it undoubtedly remain among the most influential factors in this endeavor. …”
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The FinnBrain multimodal neonatal template and atlas collection by Jetro J. Tuulari, Aylin Rosberg, Elmo P. Pulli, Niloofar Hashempour, Elena Ukharova, Kristian Lidauer, Ashmeet Jolly, Silja Luotonen, Hilyatushalihah K. Audah, Elena Vartiainen, Wajiha Bano, Ilkka Suuronen, Isabella L. C. Mariani Wigley, Vladimir S. Fonov, D. Louis Collins, Harri Merisaari, Linnea Karlsson, Hasse Karlsson, John D. Lewis

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Association Analysis of <i>SLC11A1</i> Polymorphisms with Somatic Cell Score in Chinese Holstein Cows by Kai Liu, Yufang Liu, Tuo Li, Qiuling Li, Jinyu Wang, Yongfu An, Yuze Yang, Kaiyang Li, Mingxing Chu

“…The bioinformatic analysis showed that these mutations affected the secondary and tertiary structure of <i>SLC11A1</i> mRNA, suggesting that they may affect gene expression or protein translation and function. …”
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Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…Deep learning (DL) offers a promising alternative for capturing nonlinear genetic relationships due to its ability to identify complex patterns without prior assumptions about the data structure. We proposed a novel hybrid model that that combines both DL and GBLUP (DLGBLUP), which uses the output of the traditional GBLUP, and enhances its predicted genetic values (PGV) by accounting for nonlinear genetic relationships between traits using DL. …”
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The effects of Transcendental Meditation on emotional intelligence, stress, fatigue, and sleep quality among Ayurvedic medical students in India by Carol Paredes, Sandy Nidich, Gunvant Yeola, Asmita Wele, Santosh Kamble, Kamalakar Tehre, Robert Keith Wallace, Maxwell Rainforth

“…An autoregressive [AR(1)] covariance structure was specified to account for repeated measures. …”
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Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates by Glorismer Pena-Amelunxen, Mohadeseh Asghari, Kriti Khatri, Jill Glesner, Serge A. Versteeg, Serge A. Versteeg, Ronald van Ree, Ronald van Ree, Martin D. Chapman, Scott A. Smith, Maksymilian Chruszcz, Anna Pomés, Lorenz Aglas, Lorenz Aglas, Lorenz Aglas

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