Vaccination as a solution of the issue of resistance S. pneumoniae by H. P. Ruban, S. V. Struch

“…Composition and resistance profile of the lower respiratory tract microflora isolated from sputum pneumococcal strains in children in 2016–2018, demonstrated up to 72.4% resistance to macrolides, 31.3% resistance to cefotaxime and 8.3% – to ceftriaxone. Spn serotypes structure in under 5 years of age children with meningitis was characterized by relatively high uniformity. …”
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Neural models in diagnostics of the financial result of housing and utility enterprises by I. P. Kurochkina, I. I. Kalinin, L. A. Mamatova, E. B. Shuvalova

“…Innovations  have increased the  usability  of  the  program.  New   interface  allowed  to  analyze data  monthly.  …”
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Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma by Lei Yang, Qing Zhou, Bo Zhang, Yi-Long Wu, Zhi-Hong Chen, Wen-zhao Zhong, Fen Wang, Yun-Ting He, Song Dong, Xue-Wu Wei, Wei-Dong Chen, Xiao-Rong Yang, Xue-Meng Shang

“…EGFR-mutant LUAD lacked CD8+ tissue-resident memory (TRM) cells, which could promote tertiary lymphoid structure generation by secreting CXCL13. In addition, other cell types, including tumor-associated macrophages and cancer-associated fibroblasts, which are capable of recruiting, retaining, and expanding CD8+ TRM cells in the TME, were also deficient in EGFR-mutant LUAD. …”
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Gut microbiota regulates exercise-induced hormetic modulation of cognitive functionResearch in context by Elisa Cintado, Pablo Muela, Lucía Martín-Rodríguez, Ignacio Alcaide, Patricia Tezanos, Klara Vlckova, Benjamín Valderrama, Thomaz F.S. Bastiaanssen, María Rodríguez-Muñoz, María L. de Ceballos, María R. Aburto, John F. Cryan, José Luis Trejo

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CHARACTERISTICS OF PSYCHOLOGICAL MATURITY AS A SOFT-SKILL OF A MODERN PERSONALIT by Mitchenko Kateryna

“…The aim of the article is to substantiate the essence and component structure of psychological maturity, and the set of soft skills as an integral part of an individual’s psychological maturity. …”
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Prevalence of chronic HCV infection in patients with type 2 diabetes mellitus in Russia by P. A. Beliy, K. R. Dudina, O. O. Znoyko, T. N. Markova, I. A. Morozova, N. P. Blokhina, E. A. Nurmukhametova, N. D. Yushchuk

“…The proportion of patients with type 2 diabetes with markers of viral hepatitis (VH) in the Russian Federation is not known, which does not allow us to estimate the burden for the state of this medical problem.OBJECTIVE: Assessment of the prevalence of concomitant pathology, HCV infection and type 2 diabetes, as well as the proportion of severe liver damage in its structure, according to the analysis of the primary medical records of four Moscow hospitals.MATERIALS AND METHODS: A retrospective analysis of the medical records of patients with HCV infection and diabetes mellitus, who admitted at different periods to four hospitals in Moscow, was carried out, as well as a total examination for the presence of anti-HCV in the blood of all patients with diabetes who were admitted within a certain period to the endocrinology department of a multidisciplinary hospital. …”
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DUAL EDUCATION AS A MEAN OF ENSURING PROPER QUALITY OF PROFESSIONAL TRAINING OF MATHEMATICS TEACHERS IN MODERN UKRAINE by Микола Працьовитий, Оксана Требенко, Олександр Школьний, Яніна Гончаренко

“…Solving the problem is envisaged through the implementation of a set of measures to modernize the structure, content, technologies and methods of training mathematics teachers, including the development and implementation of mutually beneficial partnership models between higher education institutions, employers and students, aimed at increasing the effectiveness of practical training of future teachers for the practical application of acquired knowledge and skills, their social and professional adaptation in the conditions of real professional activity. …”
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Symptom network analysis of pregnancy stress, depressive symptoms and quality of life: a cross-sectional study of pregnant women in Xinjiang, China, 2023–2024 by Sufeila Shalayiding, Weicui Meng, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Methods From February 2023 to January 2024, a convenience sampling method was used to conduct a cross-sectional study of 1,349 pregnant women in a tertiary hospital in the Xinjiang Uygur Autonomous Region of China using the Patient Health Questionnaire Depressive Symptom Cluster and the Stress in Pregnancy and Health-Related Quality of Life Scale, to construct a network to perform network estimation, and to determine core nodes of the network structure based on the centrality indexes. Results Maternal pregnancy stress score (1.71 ± 0.55), depressive symptoms (15.36 ± 4.70), and quality of life had the highest social functioning score (74.45 ± 12.63) and the lowest physical functioning score (65.18 ± 26.75). …”
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Study on the Impact of Exclosures on the Physicochemical Properties of Rangeland Soil (Case Study: Northern Golestan Province, Sufikam Rangelands) by Rasool Khatibi, Mohsen Farahi

“…Among the remedial methods for degraded soils, increasing rangeland fertility and striving to improve soil structure stability, reducing livestock trampling through grazing restrictions, are highlighted. …”
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Orientaciones para crear patios activos en los centros escolares (Orientations to create active playgrounds in schools) by Mª Isabel Salas Sánchez, Josep Vidal-Conti

“…The interest of this study consists primarily in specifying the main aspects that should be considered when carrying out changes in the organization and/or structure of school playground areas. The objectives which this article pursues are mainly three.  1) to show evidence from different studies of the importance of recess time in schools.  2) to establish a "road map" to carry out transformations which would help to create active and dynamic spaces contributing, above all, to the improvement of students' health and therefore allowing the teaching staff to carry out the project or program of change (given the particularities and singularities of each one of the centers) and 3) to define some transversal proposals which can be introduced within this space and time. …”
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Productivity and ecological functions of naturally regrown pine forests of the Ukrainian Polissia by Petro Lakyda, Volodymyr Blyshchyk

“…Based on the indicators of basic wood density (341 kg·(m3)-1), the studied stands have a slightly lower density compared to other pine forests of the Ukrainian Polissia zone, which are characterized by high moisture content in wood at a young age, soil conditions (structure, mechanical composition, fertility), which has a significant impact on the formation of late wood, and, consequently, on its density. …”
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Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context by Stephen Joza, Aline Delva, Christina Tremblay, Andrew Vo, Marie Filiatrault, Max Tweedale, Jean-François Gagnon, Ronald B. Postuma, Alain Dagher, Johannes Klein, Michele Hu, Petr Dusek, Stanislav Marecek, Zsoka Varga, John-Paul Taylor, John T. O'Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Stéphane Lehéricy, Marie Vidailhet, Jean-Christophe Corvol, ICEBERG Study Group, Richard Camicioli, Howard Chertkow, Simon Lewis, Elie Matar, Kaylena A. Ehgoetz Martens, Lachlan Churchill, Michael Sommerauer, Sinah Röttgen, Per Borghammer, Karoline Knudsen, Allan K. Hansen, Dario Arnaldi, Beatrice Orso, Pietro Mattioli, Luca Roccatagliata, Oury Monchi, Shady Rahayel, Isabelle Arnulf, Samir Bekadar, Eve Benchetrit, Alexis Brice, Vanessa Brochard, Alizé Chalançon, Benoit Colsch, Florence Cormier-Dequaire, Jean-Christophe Corvol, Virginie Czernecki, Bertrand Degos, Cécile Delorme, Pauline Dodet, Carole Dongmo-Kenfack, Marie-Odile Habert, Farid Ichou, Jonas Ihle, Cécile Galléa, Rahul Gaurav, Marie-Alexandrine Glachant, Manon Gomes, David Grabli, Elodie Hainque, Laetitia Jeancolas, Christelle Laganot, Stéphane Lehéricy, Suzanne Lesage, Smaranda Leu-Semenescu, Richard Levy, Valentine Maheo, Graziella Mangone, Louise Laure Mariani, Aurelie Méneret, Poornima Menon, Fanny Mochel, Vincent Perlbarg, Dijana Petrovska, Fanny Pineau, Nadya Pyatigorskaya, Sophie Rivaud-Pechoux, Emmanuel Roze, Sara Sambin, Julie Socha, Arthur Tenenhaus, Romain Valabregue, Marie Vidailhet, Lydia Yahia-Cherif

“…Findings: SuStaIn identified two distinct subtypes of brain atrophy progression: 1) a “cortical-first” subtype, with atrophy beginning in the frontal lobes and involving the subcortical structures at later stages; and 2) a “subcortical-first” subtype, with atrophy beginning in the limbic areas and involving cortical structures at later stages. …”
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A Systematic Review of the Microfinance Literature: An ADO-TCM Framework Approach by Bahman Khodapanah, Mohammad Bashokouh Ajirlou, Fariba Mesri

“…This framework provides an in-depth analysis of the structure of relevant studies, encompassing predecessors, research decisions, research outcomes (ADO), utilized theories, study contexts, and research methods (TCM). …”
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Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
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Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial by Ville-Markus Konola, Jari Parkkari, Juhani Multanen, Riku Nikander, Timo Rantalainen, Johanna Vesanto, Satu Pekkala, Merja Kalaja, Johanna K. Ihalainen, Benjamin Waller, Matti Munukka, Harri Sievänen, Mika Nevalainen, Hannu Kautiainen, Victor Casula, Juha Paloneva, Tommi Vasankari, Arttu Peuna, Simo Saarakkala, Miika T. Nieminen, Ari Heinonen

“…The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. …”
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Gomphrenin-Based Decarboxylated and Acylated Pigments from Basella alba L. Fruit Extracts Impair Survival of Colorectal Cancer Cells but Not Normal Cells – In Vitro Study by Katarzyna Sutor-Świeży, Łukasz Kozioł, Mateusz Knap, Ewa Dziedzic, Monika Bieniasz, Przemysław Mielczarek, Monika Baj-Krzyworzeka, Rafał Szatanek, Sylwia Bobis-Wozowicz, Łukasz Popenda, Sławomir Wybraniec, Malgorzata Tyszka-Czochara

“…Hence, decarboxylated derivatives with potential health-promoting properties were generated by controlled thermal modifications of gomphrenin structure. Bioactivity experiments were performed on gomphrenin acylated (malabarin and globosin) and decarboxylated derivatives (17-decarboxy-gomphrenin, 2-decarboxy-gomphrenin, and 2,17-bidecarboxy-gomphrenin) derived from the fruit extracts using preparative HPLC. …”
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Elucidating biogeographical patterns in Australian native canids using genome wide SNPs. by Kylie M Cairns, Laura M Shannon, Janice Koler-Matznick, J William O Ballard, Adam R Boyko

“…Mitochondrial and Y chromosome DNA studies show evidence of population structure within the dingo. Here, we present the data from Illumina HD canine chip genotyping for 23 dingoes from five regional populations, and five New Guinea Singing Dogs to further explore patterns of biogeography using genome-wide data. …”
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Vaccine Hesitancy and Immunization Patterns in Central and Eastern Europe: Sociocultural, Economic, Political, and Digital Influences Across Seven Countries by Kurpas D, Stefanicka–Wojtas D, Soll–Morka A, Lomper K, Uchmanowicz B, Blahova B, Bredelytė A, Dumitra GG, Hudáčková V, Javorska K, Juhász Z, Manulik S, Mohos A, Skarbalius E, Tkachenko VI, Uchmanowicz I

“…Differences were influenced by healthcare system structure, public trust, exposure to misinformation, and digital communication strategies.Conclusion: Addressing vaccine hesitancy requires targeted, context-sensitive communication and digital literacy programs. …”
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Strategi Prospektif Pengembangan Dalam Ekowisata Waduk Cirata Yang Berkelanjutan by Purna Hindayani, Armandha Redo Pratama, Zuzzy Anna

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Electrochemical and quantum chemical investigation on the adsorption behavior of a schiff base and its metal complex for corrosion protection of mild steel in 15 wt% HCl solution by Badr El-Haitout, Ratnaningsih Eko Sardjono, Bouchra Es-Sounni, Maryam Chafiq, Rachid Salghi, Mohamed Bakhouch, Aisha H. Al-Moubaraki, Jamilah M. Al-Ahmari, Azza A. Al-Ghamdi, Mohammed Fahim, Belkheir Hammouti, Abdelkarim Chaouiki, Young Gun Ko

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