Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies by Pekka Kallunki, Florence Sotty, Katarina Willén, Michal Lubas, Laurent David, Malene Ambjørn, Ann-Louise Bergström, Louise Buur, Ibrahim Malik, Steffen Nyegaard, Thomas Thiilmark Eriksen, Berit O. Krogh, Jeffrey B. Stavenhagen, Kathrine J. Andersen, Lars Ø. Pedersen, Ersoy Cholak, Edward N. van den Brink, Rik Rademaker, Tom Vink, David Satijn, Paul W.H.I. Parren, Søren Christensen, Line R. Olsen, Josefine N. Søderberg, Sandra Vergo, Allan Jensen, Jan Egebjerg, Pernille Gry Wulff-Larsen, Mikkel N. Harndahl, Dina S. M. Damlund, Kaare Bjerregaard-Andersen, Karina Fog

“…The epitope of amlenetug was mapped to amino acids 112-117 and further characterized by crystallographic structure analysis. Based on our data, we hypothesize that targeting α-synuclein will potentially slow further disease progression by inhibiting further pathology development but be without impact on established pathology and symptoms.…”
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Population Genomics, Virulence Traits, and Antimicrobial Resistance of <i>Streptococcus suis</i> Isolated in China by Yuying Li, Bin Ma, Xue Jia, Yanxi Wan, Shiting Ni, Guosheng Chen, Xin Zong, Hui Jin, Jinquan Li, Chen Tan

“…This study contributes to the understanding of the population structure and genetic characteristics of <i>suis</i>, provides a framework and novel partitioning approach for future investigations into its virulence and pathogenicity, and complements the data on antibiotic resistance.…”
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Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition by Morgan E. Walker, Wei Zhu, Janine H. Peterson, Hao Wang, Jon Patteson, Aileen Soriano, Han Zhang, Todd Mayhood, Yan Hou, Samaneh Mesbahi-Vasey, Meigang Gu, John Frost, Jun Lu, Jennifer Johnston, Christopher Hipolito, Songnian Lin, Ronald E. Painter, Daniel Klein, Abbas Walji, Adam Weinglass, Terri M. Kelly, Adrian Saldanha, Jeffrey Schubert, Harris D. Bernstein, Scott S. Walker

“…The central BAM subunit (BamA) is an attractive antibacterial target because its structure and cell surface localization are conserved, it catalyzes an essential reaction, and potent bactericidal compounds that inhibit its activity have been described. …”
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Development and psychometric evaluation of the 12-item Polish version of the Pain Vigilance and Awareness Questionnaire by Joanna Kłosowska, Aleksandra Budzisz, Daryna Rubanets, Izabela Anna Łaska, Helena Bieniek, Justyna Brączyk, Karolina Wiercioch-Kuzianik, Elżbieta Anita Bajcar, Magdalena Żegleń, Magdalena Niedbał, Julia Badzińska, Anna Przeklasa-Muszyńska, Lance M. McCracken, Przemysław Bąbel

“…None of the previously proposed models describing the factor structure of the PVAQ scale adequately fit the data. …”
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Changes in subarctic Pacific phytoplankton communities over the last two decades by Marta Konik, Marta Konik, Marta Konik, Brian P. V. Hunt, M. Angelica Peña, Toru Hirawake, Christian Marchese, Christian Marchese, Christian Marchese, Perumthuruthil Suseelan Vishnu, Perumthuruthil Suseelan Vishnu, Astrid Bracher, Astrid Bracher, Hongyan Xi, Maycira Costa

“…Time series of remotely sensed data are now of sufficient length to begin to assess change in the ocean at large spatial and temporal scales. …”
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Experimental investigation on thermal storage performance of double U-tube phase change thermal storage tank by Liu Lu, Gang Liu, Qihui Wang, Yuan Xie, Xiaohu Yang, Hailong Li

“…These findings provide valuable experimental data for optimizing the structure and operating parameters of large-scale PCTSTs.…”
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Seasonality Has Greater Influence on Amphibian Cutaneous Mycobiome than Host Species by Han Zhang, Kunyang Zhang, Hongying Ma, Jie Deng, Cheng Fang, Hu Zhao, Xiaoran An, Jianlu Zhang, Qijun Wang, Wei Jiang, Fei Kong

“…The results showed that seasonal variation exerted a significantly stronger influence than host species on the fungal community structure (alpha diversity, beta diversity, species composition, abundance, and biomarkers). …”
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Genome-Wide Association Study and Genomic Prediction of Essential Agronomic Traits in Diversity Panel of Soybean Varieties by Qianli Dong, Yuting Cheng, Yiyang Li, Yan Tong, Dazhuang Liu, Jiaxin Yu, Na Zhao, Bao Liu, Xiaoyang Ding, Chunming Xu

“…We assessed 15 agronomic traits under three distinct environments, noting substantial phenotypic variations in the panel and stable correlations among traits. The population structure analysis, based on genotyping-by-sequencing (GBS) data, revealed seven subpopulations within the panel and significant gene flows among these subpopulations. …”
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EAM Integrated Widely Tunable DBR Lasers Based on InGaAlAs&#x002F;InP MQWs by Mengyang Zhong, Huan Li, Daibing Zhou, Kun Yang, Fei Guo, Dan Lu, Lingjuan Zhao, Song Liang

“…At 25&#x00B0;, the electro-absorption modulator (EAM) of the device has a small signal modulation bandwidth exceeding 27 GHz, which is notably higher than the bandwidth for a TEML device having the same structure but InGaAsP MQW active material. At 25 Gb&#x002F;s NRZ data modulation, to achieve 10E-10 bit error rate (BER), the power penalty after 5 and 10 km fiber transmission are 1 and 3 dB, respectively. …”
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Temporal variability on Seagrass Cover and Species Composition in a Tourism Hotspot: A case study in Derawan Island by Kusumaningtyas Mariska Astrid, Zulfikar Andi, Rustam Agustin, Salim Hadiwijaya L., Rahayu Yusmiana P., Daulat August, Suryono Devi Dwiyanti, Ati Restu Nur Afi, Sudirman Nasir, Khairunnisa Khairunnisa, Hidayat Wahyu

“…This study aims to assess the resilience of the seagrass ecosystem on Derawan Island by examining temporal variability in seagrass cover and community structure. Permanent plots were established to monitor changes in seagrass cover and community composition. …”
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An innovative thermal simulation study of microstructure improvement by delay forging during solidification by Jiongshen Chen, Li Rong, Chenxi Ma, Wu Wei, Shengping Wen, Kunyuan Gao, Hui Huang, Zuoren Nie

“…Temperature and force data were collected using the Gleeble system for analysis. …”
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Wheat dwarf virus and its impact on the 2020 harvest in some regions of Ukraine by L. Mishchenko, A. Dunich, I. Mishchenko, A. Dashchenko, O. Boyko, O. Skufinskyi, A. Kyrychenko, N. Kozub, T. Mukha

“…Visual diagnostics, enzyme-linked immunosorbent assay in double sandwich modification (DAS-ELISA), polymerase chain reaction, biometric, determination of yield and its structure, statistical data processing. Results. …”
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Magnetic Bifunctional Ru-Enzyme Catalyst Allows for Sustainable Conversion of Cellulose Derivative to D-Sorbitol by Boris B. Tikhonov, Daniil R. Lisichkin, Alexandrina M. Sulman, Alexander I. Sidorov, Alexey V. Bykov, Yury V. Lugovoy, Alexey Y. Karpenkov, Lyudmila M. Bronstein, Valentina G. Matveeva

“…To optimize the nanobiocatalyst structure and composition, we first synthesized the biocatalyst, MNA-CSP-Cel (CSP stands for the CS layer cross-linked by TPP), as well as the nanocatalyst, MNA-CSP-Ru, and studied them in the one-step reactions of hydrolysis and hydrogenation, respectively. …”
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Characterization and kinetic analysis of Vc1509, a NAD+ dependent deacetylase from Vibrio cholerae by Arindam Jana, Pragyan Mishra, Ritu Ghosh, Ajit Kumar Dhal, Shibangini Beura, Amrita Mishra, Rahul Modak

“…Vc1509 is a monomeric protein and harbours conserved secondary structure features of CobB. Our data show that Vc1509 is an active NAD+ dependent lysine de-acylase capable of targeting a broad range of acylated substrates, providing new insights into the enzymatic properties and substrate specificity of CobB bacterial deacetylases.…”
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Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations by Bingzheng Zhou, Ruichen Sui, Luxian Yu, Delin Qi, Shengyun Fu, Ying Luo, Hongfang Qi, Xiaohuan Li, Kai Zhao, Sijia Liu, Fei Tian

“…In the kidney, the tight junction formed dense structure in the renal tubules under lake water condition compared with the loose structure in freshwater. …”
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Investigation of genomic and pathogenicity characteristics of Streptococcus suis ST1 human strains from Guangxi Zhuang Autonomous Region (GX) between 2005 and 2020 in China by Weiming Kang, Mingliu Wang, Xueli Yi, Jianping Wang, Xiyan Zhang, Zongfu Wu, Yan Wang, Hui Sun, Marcelo Gottschalk, Han Zheng, Jianguo Xu

“…To enhance our understanding of S. suis ST1 population characteristics, we conducted an investigation into the phylogenetic structure, genomic features, and virulence levels of 73 S. suis ST1 human strains from GX between 2005 and 2020. …”
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Non-Parker Spiral Interplanetary Magnetic Field Configurations Observed in Near-Earth Space: Statistical Features of Their Occurrence and Solar Wind Conditions by Jong-Sun Park, Quanqi Shi, Jungjoon Seough, Hui Zhang, Tao Tang, Ruilong Guo, Kyung-Suk Cho, Dong-Hun Lee, Khan-Hyuk Kim

“…Moreover, our results suggest that spacecraft missions to various areas in interplanetary space are needed to better understand spatiotemporal evolutions of the solar-originated magnetic field structure in the heliosphere.…”
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The Relatıonship Between Functional Movement And Body Stability With Service Speed On Veteran Tennis Players by İpek Eroğlu Kolayiş, Hüseyin Günay

“…A healthy psychical structure with a wide range of mobility can contribute to the performance of a variety of sport branches including tennis. …”
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Computational Adaptive Optics for HAR Hybrid Trench Array Topography Measurement by Utilizing Coherence Scanning Interferometry by Wenyou Qiao, Zhishan Gao, Qun Yuan, Lu Chen, Zhenyan Guo, Xiao Huo, Qian Wang

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Young family as the basis of forming family potential in perspective by H. H. Mamadalieva

“…The family represents an association of people based on marriage or consanguinity, who have a common life and mutual responsibility, and is an essential component of the social structure of the society. It is the most important life value in many countries. …”
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