Concomitant use of sivelestat sodium hydrate and antithrombotic drugs worsens the treatment outcome of patients with acute respiratory distress syndrome and suppression of fibrinol... by Takahiro Kato, Tomohiro Mizuno, Takenao Koseki, Kazuo Takahashi, Shigeki Yamada, Kazuyoshi Imaizumi, Naotake Tsuboi, Naozumi Hashimoto

“…Objectives: Sivelestat sodium hydrate (SSH) may be effective in the early stage of acute respiratory distress syndrome (ARDS) before the neutrophil extracellular trap scaffold structure is complete. Therefore, patients with suppression of fibrinolysis (SF) before the secondary fibrinolytic process might benefit from SSH administration. …”
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Ethical considerations in prevention and management of non-communicable diseases: a narrative review by Elnaz Shahmohamadi, Aryan Ayati, Yasaman Sharifi, Pouya Ebrahimi, Ehsan Shamsi Gooshki, Shirin Djalalinia, Mahbube Ebrahimpur, Moloud Payab, Bagher Larijani

“…For instance general policies, equity in care, interventional programs, and clinical/research data protection. A comprehensive, holistic approach considering all the involved parties can accommodate the wide spectrum of needs and continuum of management for NCDs.Creating an ethical procedure structure in public health systems can provide insight into managing the challenges posed by NCDs to health systems and assist in systematically confronting ethical problems in the management of NCDs. …”
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A Deep Alteration and Oxidation Profile in a Shallow Clay Aquitard: Example of the Tégulines Clay, East Paris Basin, France by Catherine Lerouge, Jean-Charles Robinet, Mathieu Debure, Christophe Tournassat, Alain Bouchet, Ana María Fernández, Christine Flehoc, Catherine Guerrot, Myriam Kars, France Lagroix, Philippe Landrein, Benoit Madé, Philippe Negrel, Guillaume Wille, Francis Claret

“…Mineralogical, geochemical, and petrophysical data showed evidences of gradual oxidation taking place down to a depth of 20 m. …”
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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics by Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine Price, Anand Mayasundari, Lei Yang, Anastasia H. Bednarz, Sophie Machata, Tobias Graef, Denis Bartoschek, Vadim Demichev, Uli Ohmayer, Jun Yang, Henrik Daub, Zoran Rankovic

“…Subsequent hit validation and structure-degradation relationship analyses guided by global proteomics reveal highly selective and potent phenyl glutarimide-based degraders targeting previously uncharacterized neosubstrates such as KDM4B, G3BP2 and VCL; none of which contain the classical CRBN β-hairpin degron. …”
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CLINICAL AND MORPHOLOGICAL DIAGNOSTIC INTRAHEPATIC BILE DUCTS PAUCITY by O. E. Iryshkin, I. M. Iljinsky, O. M. Tsirulnikova, S. V. Gautier

“…Ductopenia was the more frequent indication of syndromatic form of paucity of intrahepatic bile ducts (p = 0,01), while ductular proliferations, which form «ductular structure», were discovered more often in nonsyndromatic paucity of intrahepaticbile ducts (p = 0,03). …”
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Thermal Characteristics of a Double Intra-Cavity Contact VCSEL for Cryogenic Optical Links by Behzad Namvar, Patrik Rajala, Mircea Guina, Teemu Hakkarainen, Heikki Virtanen, Topi Uusitalo, Jukka Viheriala

“…Cryogenic computing systems, including quantum computers, cryo-CMOS and superconducting processors, necessitate efficient optical data links capable of operation at temperatures as low as 4 K. …”
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High-Speed Directly Modulated Laser Integrated with SOA by Jia Chen, Dechao Ban, Ya Jin, Jinhua Bai, Keqi Cao, Xinyan Zhang, Hang Yu, Wei Lin, Xiaonan Chen, Ming Li, Ninghua Zhu, Yu Liu

“…The results reveal that the transmitter and dispersion eye closure (TDEC) of the fabricated DML is lower than that of a conventional laser when the SOA area current reaches a specific threshold, demonstrating the enhanced signal transmission capabilities of our design. This laser structure offers a fresh strategy for the development of high-power, high-speed DMLs.…”
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Detection of Semidetached Eclipsing Binaries from TESS by Xu Ding, KaiFan Ji, QiYuan Cheng, ZhiMing Song, JinLiang Wang, XueFen Tian, ChuanJun Wang

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Comparative effectiveness of small bowel decompression methods in patients with benign small bowel obstruction: results of a multicenter non-randomized controlled retrospective stu... by B. V. Sigua, A. E. Demko, S. V. Petrov, V. А. Samarcev, A. A. Zavrazhnov, P. A. Kotkov, I. A. Solov’ev, E. V. Nishnevich, I. V. Mikhin, I. Ia. Bondarevskiy, A. V. Glebova, M. P. Kuznetsova, A. A. Kurkov, V. P. Zemlyanoy

“…No effect of nasointestinal intubation on the frequency and structure of non-lethal complications was found, which couldn’t be said about postoperative mortality, which was the highest in the group of patients with long intestinal tubes. …”
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Enhanced analysis of the genomic diversity of Mycobacterium bovis in Great Britain to aid control of bovine tuberculosis by Prizam Sandhu, Javier Nunez-Garcia, Stefan Berg, Jo Wheeler, James Dale, Paul Upton, Jane Gibbens, R. Glyn Hewinson, Sara H. Downs, Richard J. Ellis, Eleftheria Palkopoulou

“…Based on the observed phylogenetic structure, we present a SNP-based classification system that replaces the genotype scheme that had been used until recently in GB. …”
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Nonlinear forecasting of stream flows using a chaotic approach and artificial neural networks by Hakan Tongal

“…However, as a result from the kNN model structure, the model failed in the prediction of peak values. …”
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Effects of Elevated Temperature and CO2 Enrichment on Stability of Soil Organic Carbon Storage in Mollisols by Xue Haiqing, Yue Ya, Feng Qian, Long Jieqi, Miao Huan, Miao Shujie, Qiao Yunfa

“…[Objective] The effects of climate change on the stability of organic carbon were revealed from the perspective of the molecular structure of organic carbon in order to provide a theoretical basis for clarifying the impact of future climate change on organic carbon stability and soil fertility in mollisols. …”
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MEDULLARY CARCINOMA OF THE BREAST: ROENTGENOLOGIC AND ULTRASOUND SEMIOTICS by A. B. Abduraimov, K. A. Lesko, V. Yu. Pletneva, I. A. Blokhin

“…Along with the most common type of BC – ductal carcinoma, there are a lot of histological types, distinguished by structure features, which lead to a variable clinical and instrumental semiotics.These histological types of BC in the group marked out special types of BC, including medullary carcinoma. …”
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Seismic Performance of Steel Column Base of Disc-spring Self-centering Energy-consuming Damper by SUN Jiateng, LIU Jianming, ZHU Guangzhi

“…ObjectiveThe rapid restoration of the column base connection's functionality after an earthquake is crucial to the seismic performance of the structure. Currently, the existing self-centering column base connections have the drawbacks of complex construction, inability to integrate energy dissipation, self-resetting and replaceability. …”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…Among them, hammerhead is the smallest and best characterized ribozyme. However, the structure and biochemical data of ribozymes have been disagreed on, making the understanding of its catalysis mechanism a longstanding issue. …”
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Global characterization of mouse testis O-glycoproteome landscape during spermatogenesis by Qiannan Liu, Xiaoyan Lu, Yao Deng, Han Zhang, Rumeng Wei, Hongrui Li, Ying Feng, Juan Wei, Fang Ma, Yan Zhang, Xia Zou

“…Interestingly, we found dynamic changes with an increase Tn and a decrease T structure from early to mature developmental stages. …”
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New Insights into the Phylogeographic History of <i>Dirofilaria immitis</i> in the Canary Islands, Spain by Rodrigo Morchón, Alfonso Balmori-de la Puente, Manuel Collado-Cuadrado, Iván Rodríguez-Escolar, Noelia Costa-Rodríguez, Elena Infante González-Mohino, Elena Carretón, José Alberto Montoya-Alonso

“…To obtain a more complete understanding of its evolutionary history, structure and genomic diversity, comparative studies using next-generation sequencing data from endemic areas are needed, which will help in the long term to implement monitoring and control measures in a given area and to better understand its global phylogeographic history.…”
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Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties by Nilufer P. Seth, Rui Xu, Matthew DuPrie, Amit Choudhury, Samuel Sihapong, Steven Tyler, James Meador, William Avery, Edward Cochran, Thomas Daly, Julia Brown, Laura Rutitzky, Lynn Markowitz, Sujatha Kumar, Traymon Beavers, Sayak Bhattacharya, Hsin Chen, Viraj Parge, Karen Price, Yang Wang, Siddharth Sukumaran, Yvonne Pao, Katie Abouzahr, Fiona Elwood, Jay Duffner, Sucharita Roy, Pushpa Narayanaswami, Jonathan J. Hubbard, Leona E. Ling

“…Here, we present the molecular, cellular, and nonclinical characteristics of nipocalimab that support the reported clinical pharmacology and potential clinical application in IgG-driven, autoantibody- and alloantibody-mediated diseases. The crystal structure of the nipocalimab antigen binding fragment (Fab)/FcRn complex reveals its binding to a unique epitope on the IgG binding site of FcRn that supports the observed pH-independent high-binding affinity to FcRn. …”
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Cu‐Co Dual Sites Tandem Synergistic Effect Boosting Neutral Low Concentration Nitrate Electroreduction to Ammonia by Wenhao Yang, Ziwei Chang, Xu Yu, Ping Wu, Ruxiang Shen, Lianzhou Wang, Xiangzhi Cui, Jianlin Shi

“…The designed Cu‐CoP catalyst exhibits an ammonia yield of 7.65 mg h−1 cm−2 and a Faraday efficiency of 85.1% at −1.0 V under neutral low‐concentration nitrate (10 m M), which is the highest ammonia yield in the reported data. In situ characterization and theoretical calculations confirm the tandem synergistic effect, in which the Cu site favors the adsorption and activation of NO3− to form NO2−, and concurrently modulates the electronic structure of the Co site with optimized Hads adsorption resulting in the significantly enhanced NO3−RR at neutral low concentration nitrate.…”
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Microwave-Assisted pyrolysis of waste plastics: A comprehensive review on process parameters, catalysts, and future prospects by K. M. Oajedul Islam, Nabeel Ahmad, Aniz Chennampilly Ummer, Usama Ahmed, Mohammad Nahid Siddiqui, Marcos Millan, Abdul Gani Abdul Jameel

“…Special emphasis is placed on co-feeding strategies, hydrogen production, and the influence of catalyst structure on aromatic yield. Key challenges—such as hot spot formation, catalyst deactivation, and scale-up limitations—are identified. …”
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