RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis by Samantha Wong, Yu Xuan Tan, Abigail Yi Ting Loh, Kiat Yi Tan, Hane Lee, Zainab Aziz, Stanley F Nelson, Engin Özkan, Hülya Kayserili, Nathalie Escande‐Beillard, Bruno Reversade

“…In a consanguineous family, we uncovered a homozygous p.Thr543Met variant segregating with a neonatal lethal syndrome with cutaneous, craniofacial, cardiac, and limb anomalies. Structure‐based prediction and functional tests using human knock‐in cells showed that threonine 543 is essential to: (i) ensure RAF1's stability and phosphorylation, (ii) maintain its kinase activity toward substrates of the MAPK pathway, and (iii) protect from stress‐induced apoptosis mediated by ASK1. …”
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Fault location method of wind turbine transmission chain system based on lumped parameter thermal network model by Shiyu Lin, Hongshan Zhao, Chengyan Sun, Weixin Yang, Xibei Li

“…Firstly, we analyzed the main heat generation forms and heat transfer paths based on the structure of transmission chain system. Secondly, the LPTN of transmission chain system is established. …”
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Use of Asset Administration Shell for Monitoring and Control of Industrial Processes in Legacy Systems by Enrik Ramos Lima, Miguel Angel Orellana Postigo, Joao Victor Reis De Oliveira de Sicco, Raimundo Claudio Souza Gomes, Fabio De Sousa Cardoso, Israel Gondres Torne

“…The Reference Architectural Model for Industry 4.0 (RAMI 4.0) was adopted to structure the system architecture. Virtualization was carried out using three AASs: two passive ones, responsible for data acquisition, and one reactive one, in charge of temperature and level control. …”
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Revisiting the temperature evolution law of the CMB with Gaussian processes by Felipe Avila, Alexander Bonilla Rivera, Rafael C. Nunes, R.F.L. Holanda, Armando Bernui

“…We also explore possible phenomenological implications of our findings, including interpretations associated with possible variations in fundamental constants, such as the fine-structure constant α, which could provide a physical explanation for the observed deviations at low redshift.…”
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Pseudo-MS3 Approach Using Electrospray Mass Spectrometry (ESI-MS/MS) to Characterize Certain (2E)-2-[3-(1H-Imidazol-1-yl)-1-phenylpropylidene]hydrazinecarboxamide Derivatives by Ali S. Abdelhameed, Adnan A. Kadi, Mohamed I. Attia, Rihab F. Angawi, Mohamed W. Attwa, Hany W. Darwish

“…It is advantageous for structure elucidation of unknown compounds. We investigate the possibility of using in-source fragmentation with the diverse novel chemical entities encompassing different substituents. …”
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In Vitro Anti-Hepatitis B Virus Activity of Hydroxytyrosol from <i>Lindernia ruellioides</i> by Tong-Shi-Yao Zhao, Kang-Zhi Li, He-Ling Su, Bin Liang, Cheng-Qin Liang, Jin-Tao Gao, Xian-Li Zhou

“…In this study, we isolated and extracted hydroxytyrosol from <i>Lindernia ruellioides</i> with anti-hepatitis B virus (HBV) activity. The structure of hydroxytyrosol was identified by the nuclear magnetic resonance technique. …”
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Artificial Intelligence and Dentomaxillofacial Radiology Education: Innovations and Perspectives by Daniel Negrete, Sérgio Lúcio Pereira de Castro Lopes, Matheus Dantas de Araújo Barretto, Nicole Berton de Moura, Ana Carla Raphaelli Nahás, Andre Luiz Ferreira Costa

“…Although primarily narrative in structure, this review synthesizes the current literature on dentomaxillofacial radiology education, supported by selected insights from medical radiology, to provide a comprehensive and up-to-date perspective on the educational applications of AI. …”
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Real-Time Resonance Detection and Active Damping in Energy Recovery Railways Applications by Giovanni Marini, Alessandro Lidozzi, Marco di Benedetto, M. Moranchel Perez, Luca Solero

“…Thanks to the HIL, the complete catenary system has been modeled according to the real data provided by the train operator. The control algorithm and the related control board have the same structure as the architecture used in the field. …”
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The Lunar Regolith Thickness and Stratigraphy of the Chang’E-6 Landing Site by Jin Li, Chengxiang Yin, Siyue Chi, Wenshuo Mao, Xiaohui Fu, Jiang Zhang

“…One of its scientific objectives is to investigate the subsurface structure and regolith thickness at the landing site. …”
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Optimal Convolutional Networks for Staging and Detecting of Diabetic Retinopathy by Minyar Sassi Hidri, Adel Hidri, Suleiman Ali Alsaif, Muteeb Alahmari, Eman AlShehri

“…Fundus photography and optical coherence tomography (OCT) are used by ophthalmologists to assess retinal thickness and structure, as well as detect edema, hemorrhage, and scarring. …”
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Comment on: “Atom‐Modified gDNA Enhances Cleavage Activity of TtAgo Enabling Ultrasensitive Nucleic Acid Testing” by Yue Tang, Xiao‐han Wang, Xu Xu, Lu‐sheng Xin, Xiu‐dan Wang, Xin‐min Li

“…The data suggest that several details need to be addressed to improve the robustness of 2′F‐gDNA/TtAgo cleavage.…”
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Biomembrane Systems for Convergent Biomimetic Technologies by Boris N. Fedorenko, Аnton V. Lesnichiy, Vladimir F. Sterin, Mikhail А. Latyshev, Aleksey V. Мachnev, Alexander Е. Yablokov, Alexey О. Yakushev

“…The scientific and technical data made it possible to identify the main features of biomembrane systems and classify them. …”
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Developmental remodelling of Drosophila flight muscle sarcomeres: a scaled myofilament lattice model based on multiscale morphometrics by Péter Görög, Tibor Novák, Tamás F. Polgár, Péter Bíró, Adél Gutheil, Csaba Kozma, Tamás Gajdos, Krisztina Tóth, Alexandra Tóth, Miklós Erdélyi, József Mihály, Szilárd Szikora

“…The indirect flight muscle is a widely used model for studying sarcomere structure and muscle development due to its extremely regular architecture. …”
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Hydrogen evolution reaction mechanism on pristine and defective nickel phosphate surfaces by Dyah Puspasari Wijayanti, Muhammad Arkan Nuruzzahran, Dzaki Ahmad Syaifullah, Damar Rastri Adhika, Hamad AlMohamadi, Nadhratun Naiim Mobarak, Ni Luh Wulan Septiani, Adhitya Gandaryus Saputro

“…Additionally, our findings successfully reproduce experimental trends observed for NiPO, platinum, and nickel catalysts. The data suggests that optimizing the surface structure, particularly by enriching the (100) facet with oxygen vacancies, could further enhance the HER performance of NiPO materials.…”
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Regional variability of male and female mortality from three types of coronary artery disease: comparison of two periods 2017-2019 and 2020-2022 by I. V. Samorodskaya, I. V. Klyuchnikov, R. N. Shepel, E. P. Kakorina, O. M. Drapkina

“…The proportion of chronic CAD in the structure of all CAD types is higher in women (80,1±11,9 and 82,9±10,3%) than in men (75,5±14 and 77,6±13%). …”
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Antipatterns in Database Design by S. M. Shcherbakov, K. K. Kalugyan, A. V. Abramova, V. Y. Grechkina

“…The students who completed the training improved their understanding of the principles and practices of database structure design. Conclusion. The use of the proposed catalog of antipatterns in the educational process of the university makes it possible to accelerate the training of young specialists in the techniques of designing the structure of relational databases, avoid common mistakes when creating information systems, and improve the overall design culture.…”
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Diagnostic Accuracy of Golgi Protein 73 (GP73) for Liver Fibrosis Staging in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Scoping Review and Cohort Study by Valentina Pecoraro, Fabio Nascimbeni, Michela Cuccorese, Filippo Gabrielli, Tommaso Fasano, Tommaso Trenti

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The Gorongosa elephants through war and recovery by Joyce Poole, Petter Granli

“…Using individual registration, this study aimed to collect baseline data to estimate the population size, reproductive parameters and growth and to document its composition, including age and sex structure, tusk configuration, family and clan membership. …”
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Sedimentary characteristics and influencing factors of steep slope platform-margin reefs: A case study of Changxing Formation in Kaijiang-Liangping Trough in northeastern Sichuan B... by HUANG Yuxuan, CHEN Xu, WU Saijun, WEI Junhong, WANG Jingyuan

“…Based on seismic， logging， and drilling data， the internal structure， external profile， and planar distribution characteristics of the steep slope platform-margin reefs of the Changxing Formation were systematically compared. …”
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Tibiofemoral Joint Contact Force Estimation Based on OpenSim Musculoskeletal Modeling by WANG Xiaoling, JIAN Jiawei, XIE Qiurong, LIAN Zhanghui, GUO Chunming, GUO Jiemei, LI Yurong

“…ObjectiveTo develop a full-body musculoskeletal model based on OpenSim, which has a knee joint structure with double contact points and three degrees of freedom, and to estimate the knee joint load, so as to provide a reliable basis for precise diagnosis of the patients with knee osteoarthritis and formulation of customized rehabilitation plan in clinic.MethodsAuthorized public dataset from Stanford University, published by the Shiley Center for Orthopaedic Research &amp; Education at Scripps Clinic in La Jolla, California was used, and four subjects who had undergone total knee arthroplasty and implanted the pressure testing instruments were included. …”
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