Insight into rifampicin resistance behind discordant mutations in RpoB of Mycobacterium tuberculosis: A molecular dynamics simulations study by Muhammad Tahir Khan, Elise Dumont, Jialou Zhu, Kashif Iqbal Sahibzada, Madeeha Shahzad Lodhi, Mehmood Qadir, Dongqing Wei

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Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial by Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

“…Non-synonymous and neoantigen mutation burden were no different between groups, however R-mesotheliomas were infiltrated with activated CD8+ T- and CD19+ B-lymphocytes, organised into tertiary lymphoid structures. B-cell infiltration correlated with pro-inflammatory chemokines including IL24 and CCL19. …”
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Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers

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Dynamics and Trends in the Incidence of Rabies in the Russian Federation and some Adjacent Regions of Eurasia in 2013–2021 by O. N. Zaykova, M. A. Losich, E. V. Rusakova, O. A. Verkhovsky, A. A. Shabeykin, T. V. Grebennikova

“…As a result, the proportion of dogs and cats in the morbidity structure has significantly increased, which, given their proximity to humans, ensures the maintenance of a high level of epidemiological risk. …”
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Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice by A. E. Karateev, Yu. V. Barysheva, Ya. V. Belokon, T. Yu. Bolshakova, Yu. Yu. Grabovetskaya, E. A. Dolzhenkova, L. N. Eliseeva, O. B. Ershova, E. V. Zonova, I. Yu. Chernova, A. O. Isakanova, M. N. Kirpikova, V. T. Komarov, E. V. Kryukova, A. I. Kulikov, D. I. Lakhin, L. A. Levasheva, L. V. Masneva, L. V. Menshikova, Yu. V. Mishina, S. V. Norina, Yu. N. Pashkovsky, A. V. Petrov, A. G. Rusanov, A. V. Sarapulova, K. A. Svodtseva, O. V. Semagina, A. N. Sudakova, S. N. Tkachenko, M. M. Toporkov, S. K. Tutelyan, G. R. Fadienko, O. S. Filonenko, O. P. Fomina, A. S. Chernov

“…A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). …”
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Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

“…In this paper, we report a discovery of seven cluster candidates with massive quiescent galaxies at z  ∼ 2 in the 3.5 deg ^2 area of the XMM Large Scale Structure field, roughly doubling the known cluster sample at this frontier redshift if confirmed. …”
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Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer by Vladimira Zlinska, Zuzana Feketova, Aleksandra Czyrek, Julia Chudzian, Martina Lenarcic Zivkovic, Vlad-Constantin Ursachi, Pooja Dudeja, Bohumil Fafilek, Jan Rynes, Gustavo Rico-Llanos, Adolf Koudelka, Tanaya Roy, Martyna Biadun, Vendula Raskova, Katerina Svozilova, Michaela Stroblova, Mateusz Krzyscik, Kalina Hristova, Daniel Krowarsch, Silvie Foldynova-Trantirkova, Malgorzata Zakrzewska, Lukas Trantirek, Pavel Krejci

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Exploration of the Motivating and Controlling Contexts of Childbearing in Yazd City by Maliheh Alimondegari, Ahmad Kalateh Sadati, Hamideh Shiri Mohammad Abaad, Zahra Falakodin, Forozandeh Kalantari

“…The study involved 25 women from Yazd, with whom semi-structured interviews lasting between 80 and 120 minutes were conducted. …”
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Perbandingan Penggunaan Katalis Alam (Zeolit dan Bentonit) dalam Sintesis Biodiesel dari Minyak Goreng Komersil by Nila Tanyela Berghuis, Mutaqqin Mutaqqin, Farid Imam Hidayat, Sugianto Sugianto, Harbi Pratama, Anggun Kirana, David Aji Rifaldi, Abelia Jesica, Paradigma Maulana, Afif Thufail

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概念為本跨領域課程發展之研究—以國際文憑組織中學階段課程為例 Concept-Based Interdisciplinary Curriculum Development in International Baccalaureate Schools in Taiwan– The International Baccalaureate Middle Years... by 洪麗卿 Li-Ching Hung, 劉美慧 Meihui Liu, 王俐蘋 Li-Ping Wang

“…This demonstrates the school’s pragmatic experiences in integrating the IB program into the national education system. The implications of this study were considered in combination with the practices of the two schools, and a concept-based interdisciplinary curriculum module was summarized to provide a reference for future implementation of such programs. …”
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First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer by Juan Sempere-Valverde, Juan Sempere-Valverde, Eva Aylagas, Vitaly Syomin, Vitaly Syomin, Marcos A. L. Teixeira, Glafira D. Kolbasova, Glafira D. Kolbasova, Sofía Ruiz-Velasco, Sahar Chebaane, Arthur Anker, João Curdia, Ronald Cadiz, Dylan M. Cottrell, Andrea Desiderato, Luiz F. Andrade, Chakkiath Paul Antony, Carolina Bocanegra-Castano, Matilde Marzucchi, Angelo Poliseno, Doaa Baker, Basmah Alabdulaziz, Flor Torres, Ameer A. Eweida, Ameer A. Eweida, Susana Carvalho, Susana Carvalho

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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…Blockchain is essentially a public ledger, where groups of transactions or events are recorded and stored in a chain-like data structure; this approach creates a fast yet secure way to transfer funds. …”
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On Signifiable Computability: Part II: An Axiomatization of Signifiable Computation and Debugger Theorems by Vladimir A. Kulyukin

“…In a previous article, we formalized the signification and reference of real numbers and showed that data structures representable as multidimensional matrices of discretely finite real numbers are signifiable. …”
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Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

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The effect of Plant Growth Promoting Rhizohacteria on activities of antioxidative enzymes, physiological characteristics and root growth of four chickpea (Cicer arietinum L.) culti... by Rahim Naseri, Abbas Soleymani Fard, Amir Mirzaei, Fereshteh Darabi, Amin Fathi

“…Therefore, the decline in growth and productivity due to these stress factors is associated with increased levels of ROS, which cause damage to cellular structures and macromolecules. In order to maintain or increase crop productivity it becomes necessary to evolve efficient low-cost technologies for abiotic stress management. …”
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Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa by Fredros Okumu, Sarah J. Moore, Prashanth Selvaraj, Arnon Houri Yafin, Elijah O. Juma, GloriaSalome G. Shirima, Silas Majambere, Andy Hardy, Bart G. J. Knols, Betwel J. Msugupakulya, Marceline Finda, Najat Kahamba, Edward Thomsen, Ayman Ahmed, Sarah Zohdy, Prosper Chaki, Peter DeChant, Kimberly Fornace, Nicodem Govella, Steven Gowelo, Emmanuel Hakizimana, Busiku Hamainza, Jasper N. Ijumba, William Jany, Hmooda Toto Kafy, Emmanuel W. Kaindoa, Lenson Kariuki, Samson Kiware, Eliningaya J. Kweka, Neil F. Lobo, Dulcisária Marrenjo, Damaris Matoke-Muhia, Charles Mbogo, Robert S. McCann, April Monroe, Bryson Alberto Ndenga, Halfan S. Ngowo, Eric Ochomo, Mercy Opiyo, Richard Reithinger, Chadwick Haadezu Sikaala, Allison Tatarsky, David Takudzwa, Fedra Trujillano, Ellie Sherrard-Smith

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Mannich Base Derived from Lawsone Inhibits PKM2 and Induces Neoplastic Cell Death by Lucas Rubini-Dias, Tácio V. A. Fernandes, Michele P. de Souza, Déborah Hottz, Afonso T. Arruda, Amanda de A. Borges, Gabriel Ouverney, Fernando de C. da Silva, Luana da S. M. Forezi, Gabriel Limaverde-Sousa, Bruno K. Robbs

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Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
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Propuesta metodológica para la enseñanza de la biomedicina orientada a las herramientas de detección y diagnóstico molecular para estudiantes de Medicina by Gabriela Naranjo, Carolina Tituaña-Puente, Camila Maldonado, Daniela Alejandra Velasco-Uquillas, Grecia Victoria Vivas-Colmenares, José Rubén Ramírez-Iglesias

“…Methods: The proposed structure is based on the requirements of basic science subjects that students must complete to understand molecular diagnostics. …”
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