Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer by Zhang X, Liu N, Wei M, Yang C, Lin Y, Zeng Y, Li Y, Zhou L, Li T, Zheng Q, Yu H, Zhang J, Gu Y, Xia N, Li S

“…Xiuli Zhang,1,2,* Nan Liu,1,2,* Mingjing Wei,1,2 Chuanlai Yang,1,2 Yanhua Lin,1,2 Yarong Zeng,1,2 Yufang Li,1,2 Lizhi Zhou,1,2 Tingting Li,1,2 Qingbing Zheng,1,2 Hai Yu,1,2 Jun Zhang,1,2 Ying Gu,1,2 Ningshao Xia,1,2 Shaowei Li1,2 1State Key Laboratory of Vaccines for Infectious Diseases, XiangAn Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People’s Republic of China; 2National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, The Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences, Xiamen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaowei Li, Email shaowei@xmu.edu.cn Ying Gu, Email guying@xmu.edu.cnBackground: Despite therapeutic benefits of anti-Programmed Death-Ligand 1 (PD-L1) therapy in triple-negative breast cancer (TNBC), low response rates and resistance limit its efficacy. …”
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Automated Digital Safety Planning Interventions for Young Adults: Qualitative Study Using Online Co-design Methods by Jonah Meyerhoff, Sarah A Popowski, Tanvi Lakhtakia, Emily Tack, Rachel Kornfield, Kaylee P Kruzan, Charles J Krause, Theresa Nguyen, Kevin Rushton, Anthony R Pisani, Madhu Reddy, Kimberly A Van Orden, David C Mohr

“…Digital suicide prevention interventions have the potential to increase access to suicide prevention care by circumventing attitudinal and structural barriers that prevent access to formal mental health care. …”
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Interference of a phytoconstituent from Nymphaea lotus-derived ligand N-acetyl glucosamine with signaling receptors in diabetes mellitus development: A targeted computational analy... by Sunday Amos Onikanni, Tran Nhat-Phong Dao, Adewale Oluwaseun Fadaka, Halliru Zailani, Oluwafemi Shittu Bakare, Omolola Esther Amos, Ashwil Klein, Valens Munyembaraga, Morenike Grace Ajayi, Adebola Iyabode Akinjokun, Babatunji Emmanuel Oyinloye, Leandro Miranda-Alves

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Communication and relationships: how patients perceive informational and interactional organizational justice can improve patient-centered care, a study with samples from Spain and... by Diana Pérez-Arechaederra, Elena Briones, Luis García-Ortiz

“…This study aims to improve the understanding of patients’ experiences with health care organizations to enable health care service management to enhance patient-centered care quality. Given the structural differences in healthcare systems in Spain and the U.S., we examined both contexts to strengthen our analysis of patient perceptions that are critical for improving patient-centered care across different systems. …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…T-tests and ANOVA assessed socio-demographic differences in ageism, and regression analysis examined DAS’s predictive effects. Structural Equation Modeling (SEM) explored the pathways linking DAS to ageism via mediators.Results: A moderate level of ageism was observed, with significant variations across socio-demographic factors like academic year, physical health, and contact with older adults. …”
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Particularities in differential diagnostics of epileptogenic brain malformations on the low-field MRI-device by V. S. Khalilov, A. A. Kholin, B. R. Bakaeva, M. Yu. Bobylova, Kh. Sh. Gazdieva

“…In 24 patients were revealed structural brain changes that have neuroradiological signs of brain malformations. …”
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Surface molecular engineering to enable processing of sulfide solid electrolytes in humid ambient air by Mengchen Liu, Jessica J. Hong, Elias Sebti, Ke Zhou, Shen Wang, Shijie Feng, Tyler Pennebaker, Zeyu Hui, Qiushi Miao, Ershuang Lu, Nimrod Harpak, Sicen Yu, Jianbin Zhou, Jeong Woo Oh, Min-Sang Song, Jian Luo, Raphaële J. Clément, Ping Liu

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Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men by Nina Le Bert, Wan Ni Chia, Wei Yee Wan, Alvin Kuo Jing Teo, Samuel Zeng-Rong Chong, Nicole Tan, Doreen Soek Chin Tan, Adeline Chia, Iain Beehuat Tan, Kamini Kunasegaran, Qin Xuan Chua, Mohammad Yazid Abdad, Aven Shan Hua Ng, Shawn Vasoo, Julian Xiao-Li Ang, Mao Sheng Lee, Louisa Sun, Jinyan Fang, Feng Zhu, Alex R. Cook, Tar Choon Aw, Jingxiang Huang, Clarence Tam, Fong Sin Lee, Hannah Clapham, Enan Jun-Kang Goh, Monica Socheata Suor Peou, Shiow Pin Tan, Siew Kim Ong, Lin-Fa Wang, Antonio Bertoletti, Li Yang Hsu, Biauw Chi Ong

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Metabolism of tryptophan in non-small lung cancer patients with different effect of PD-1 / PD-L1 inhibitors immunotherapy by E. Yu. Zlatnik, A. B. Sagakyants, I. A. Novikova, A. Yu. Maksimov, O. P. Shatova, S. A. Appolonova, N. E. Moskaleva, S. A. Rumyantsev, A. V. Shestopalov

“…Introduction. In the structure of cancer incidence, lung cancer ranks first among men. …”
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Genetic diversity and phylogenetic relationship through the use of microsatellites in Gossypium hirsutum L. by Syeda Yashfeen Fatima, Tahira Luqman, Shabbir Hussain, Sahar Nadeem, Muhammad Kashif Riaz Khan, Allah Ditta, Muhammad Asif

“…Clustering based on molecular data classified the germplasm into three groups and measuring genetic distance through Euclidean distance while structure analysis revealed three gene-exchanging populations, representing a limited genetic basis in breeding programs. …”
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EPR study of interlayer interaction in Gd₂O₃/Fe nanostructure by A. M. Kasumov, A. I. Dmitriev, Yu. M. Bataiev, M. M. Bataiev, V. M. Karavaeva, K. A. Korotkov, A. I. Ievtushenko

“… In this work, a nanoscale structure consisting of contacting layers of a metal of the iron subgroup and a rare earth metal oxide (REM) is considered. …”
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ARGO: ARctic greenhouse Gas Observation metadata version 1 by J. Vogt, M. M. T. A. Pallandt, L. S. Basso, A. Bolek, K. Ivanova, M. Schlutow, G. Celis, M. Kuhn, M. Mauritz, E. A. G. Schuur, K. Arndt, A.-M. Virkkala, I. Wargowsky, M. Göckede

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Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling by Anni Suominen, Aino Suni, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Minying Cai, Eriika Savontaus, Virpi Talman, Risto Kerkelä, Petteri Rinne

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Blood Biomarker‐Based Predictive Indicator for Liver Metastasis in Alpha‐Fetoprotein‐Producing Gastric Cancer and Multi‐Omics Tumor Microenvironment Insights by Yongfeng Ding, Yiran Chen, Jing Zhang, Qingrui Wang, Songting Zhu, Junjie Jiang, Chao He, Jincheng Wang, Laizhen Tou, Jingwei Zheng, Bicheng Chen, Sizhe Hu, Xiongfei Yu, Haohao Wang, Yimin Lu, Mei Kong, Yanyan Chen, Haiyong Wang, Haibin Zhang, Hongxia Xu, Fei Teng, Xian Shen, Nong Xu, Jian Ruan, Zhan Zhou, Jun Lu, Lisong Teng

“…Single‐cell RNA sequencing and multiplex immunofluorescence identified the potential roles of tumor‐associated neutrophils and tertiary lymphoid structures in shaping the immune microenvironment. These findings are validated in a real‐world cohort receiving anti‐programmed cell death 1 (anti‐PD‐1) therapy, which showed concordant effectiveness. …”
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SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice by Jordan M. Chambers, Dominique Croteau, David R. Pimentel, Adam C. Gower, Marcello Panagia, Tomas Baka, Fuzhong Qin, Ivan Luptak, Wilson S. Colucci

“…Conclusions: The SGLT2 inhibitor ERTU corrected the expression of myocardial gene programs for oxidative phosphorylation and fatty acid metabolism, and was associated with increased production of ATP, decreased release of mitochondrial ROS, and amelioration of the consequences of mitochondrial dysfunction on myocardial structure and function.…”
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Synthesis and transformation in the series of 2-((5-(2,4- and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)acetic acids by D. V. Dovbnia, A. H. Kaplaushenko, Yu. S. Frolova

“…Physical and chemical properties were investigated for the synthesized compounds. The structure of the obtained substances was confirmed by elemental analysis, IR-spectroscopy, 1H NMR-spectrometry, and their individuality were established by thin-layer chromatography. …”
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Delivering a Group-Based Quality of Life Intervention to Young Adult Cancer Survivors via a Web Platform: Feasibility Trial by Rina S Fox, Tara K Torres, Terry A Badger, Emmanuel Katsanis, DerShung Yang, Stacy D Sanford, David E Victorson, Betina Yanez, Frank J Penedo, Michael H Antoni, Laura B Oswald

“…Qualitative feedback identified needed revisions to the aesthetics (eg, images), content (eg, session titles), function (eg, clarity of functionality), and structure (eg, expandable sections), which were implemented. …”
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Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization by Shafinaz Rahman Sarah, Abhishek Garg, Sadiyah Afroz, Shaleen Korch, Arjun Ray, Amita Gupta, Vandana Malhotra

“…Results from molecular dynamics simulations, in vitro binding, and co-expression studies with RelJK proteins indicate that the secondary structure changes associated with Thr77 phosphorylation in RelK toxin compromise its binding to the RelJ antitoxin. …”
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A case study of the development of a valid and pragmatic implementation science measure: the Barriers and Facilitators in Implementation of Task-Sharing Mental Health interventions... by Lawrence H. Yang, Judy K. Bass, PhuongThao D Le, Ritika Singh, Dristy Gurung, Paola R. Velasco, Margaux M. Grivel, Ezra Susser, Charles M. Cleland, Rubén Alvarado, Brandon A. Kohrt, Arvin Bhana

“…Results Continuous stakeholder involvement and concurrent pilot testing resulted in several adaptations of the BeFITS-MH measure’s structure, scaling, and format to enhance contextual relevance and utility. …”
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Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation by Roberta Gagliardini, Andrea Giacomelli, Cristina Mussini, Stephen R. Cole, Jessie K. Edwards, Carmela Pinnetti, Alessandro Raimondi, Spinello Antinori, Silvia Nozza, Valentina Mazzotta, Giulia Carla Marchetti, Sergio Lo Caputo, Alessandro Tavelli, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri

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