Economic damage associated with excess salt intake of Russian people in 2016 by Yu. A. Balanova, A. V. Kontsevaya, A. O. Myrzamatova, D. K. Mukaneeva, M. B. Khudyakov

“…The largest contribution of excess salt intake is in the damage associated with CVD (122,8 billion rubles), where half (68,1 billion rubles) is attributable to the ED associated with stroke. In the structure of the ED of each nosology, excess salt intake cause from 4,5% (CVD in general) to 17% (for T2D) and 16,1% (stroke) of the entire damage.Conclusion. …”
Get full text

Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons by Liu J, Ge P, Luo Y, Sun Z, Luo X, Li H, Pei B, Xun L, Zhang X, Jiang Y, Wen H, Liu J, Yang Q, Ma S, Chen H

“…Furthermore, we cover recent advances in treating human diseases by regulating gut microbiota structure and enzyme activity to influence TMAO metabolism and reduce TMAO levels, including the use of probiotics, prebiotics, antibiotics, anti-inflammatory drugs, antiplatelet drugs, hypoglycemic drugs, lipid-lowering drugs, and natural products.Keywords: trimethylamine N-oxide, gut-organ axis, cell death, biomarker, therapeutic strategies…”
Get full text

Development of an Online Scenario-Based Tool to Enable Research Participation and Public Engagement in Cystic Fibrosis Newborn Screening: Mixed Methods Study by Louise Moody, Samantha Clarke, Matt Compton, Rachael Hughson-Gill, Felicity Boardman, Corinna Clark, Pru Holder, James R Bonham, Jane Chudleigh

“…As technology advances, there is the potential to expand the newborn screening program following evaluation of the likely benefits and drawbacks. …”
Get full text

Synthesis of novel 3-(2-bromophenyl)-4-substituted-1H-1,2,4-triazole-5(4H)-thiones derivatives by A. A. Safonov, A. V. Nevmyvaka

“…It was synthesized new 3-(2-bromophenyl)-4-substituted-1H-1,2,4-triazole-5(4H)-thionesand there derivatives, the structure of compounds was confirmed using Elemental analysis (CHNS), 1HNMR and Chromatographic mass spectral analysis. …”
Get full text

Response of community distribution and biodiversity of grassland plants to environmental factors based on a “3-circles” paradigm by WANG Xing, SONG Naiping, YANG Xinguo

“…The average coverage of plant showed a good restoration effect in comparison with that before enclosure and grazing prohibition, but the community structure did not change significantly, and psammophytic species were still the dominant species. …”
Get full text

Analysis of Reference Range Values of Lipid Profile and Lipid Ratio in Healthy Young Adult Population in Makassar, Indonesia by Syamsir syamsir, Liong Boy Kurniawan, Yuyun Widaningsih, Burhanuddin Bahar, Tenri Esa, Andi Ariyandy

Get full text

Land Use and is Impact on Agricultural Productivity in Mutara Sub-County Mitooma District. by Tusingwire, Pamellah

“…The findings revealed that sustainable land management practices, such as crop rotation, cover cropping, and reduced tillage, can improve soil structure, fertility, and water retention capacity as revealed by 62% who strongly agreed, 28% who agreed, 27% disagreed and 11% strongly disagreed. …”
Get full text

Pre-clinical safety studies of intranasal virus-like particles based vaccine for prevention of COVID-19 by Yana Y. Chernoryzh, Valeria M. Kondratieva, Аnastasia P. Malkova, Tatyana E. Savochkina, Olesya V. Eliseeva, Oleg E. Latyshev, Dmitriy Y. Yakunin, Olga N. Zaykova, Ekaterina S. Sludnyakova, Tatyana V. Grebennikova

“…In the subchronic toxicity study on rats, no changes in the general condition, behavior, or death of animals were noted. The structure of internal organs, blood and urine tests, hemostasis did not differ significantly between the groups. …”
Get full text

Development and Application of a 40 K Liquid Capture Chip for Beef Cattle by Qing Liu, Liangyu Shi, Pu Zhang, Bo Yu, Chenhui Liu, Min Xiang, Shuilian Li, Lei Liu, Lei Cheng, Hongbo Chen

“…The SNP chip panel was further used to examine the population structure of a beef cattle population with 205 individuals and demonstrated the ability to differentiate between foreign and indigenous cattle breeds. …”
Get full text

Surface molecular engineering to enable processing of sulfide solid electrolytes in humid ambient air by Mengchen Liu, Jessica J. Hong, Elias Sebti, Ke Zhou, Shen Wang, Shijie Feng, Tyler Pennebaker, Zeyu Hui, Qiushi Miao, Ershuang Lu, Nimrod Harpak, Sicen Yu, Jianbin Zhou, Jeong Woo Oh, Min-Sang Song, Jian Luo, Raphaële J. Clément, Ping Liu

Get full text

Water, Health, and Social Technologies: One Million Cisterns Programme Case Study by José Firmino de Sousa Filho, Walisson Angélico de Araújo, Mariana Sebastião, Adalton Fonseca, Raíza Tourinho, Denise Pimenta, Gervásio Santos, Lucas Emanuel, Roberto F. S. Andrade, Gustavo Casais, Gisele Paixão, Andrea Ferreira, Rachel Coelho, Maria Yuri Ichihara, Júlia Pescarini, Joanna M. N. Guimarães, Paulo Victor da Costa, Ismael Silveira, Rafael Silva, Rita Ribeiro, Maurício L. Barreto, On behalf of the SEDHI team

“…The DPSEEA framework evaluates the structural connections between climate change and human health. …”
Get full text

SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice by Jordan M. Chambers, Dominique Croteau, David R. Pimentel, Adam C. Gower, Marcello Panagia, Tomas Baka, Fuzhong Qin, Ivan Luptak, Wilson S. Colucci

“…Conclusions: The SGLT2 inhibitor ERTU corrected the expression of myocardial gene programs for oxidative phosphorylation and fatty acid metabolism, and was associated with increased production of ATP, decreased release of mitochondrial ROS, and amelioration of the consequences of mitochondrial dysfunction on myocardial structure and function.…”
Get full text

Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity by Siavash Raeisi Dehkordi, Ivy Tsz-Lo Wong, Jing Ni, Jens Luebeck, Kaiyuan Zhu, Gino Prasad, Lena Krockenberger, Guanghui Xu, Biswanath Chowdhury, Utkrisht Rajkumar, Ann Caplin, Daniel Muliaditan, Aditi Gnanasekar, Ceyda Coruh, Qiushi Jin, Kristen Turner, Shu Xian Teo, Andy Wing Chun Pang, Ludmil B. Alexandrov, Christelle En Lin Chua, Frank B. Furnari, John Maciejowski, Thomas G. Paulson, Julie A. Law, Howard Y. Chang, Feng Yue, Ramanuj DasGupta, Jean Zhao, Paul S. Mischel, Vineet Bafna

Get full text

The sustainability of health interventions implemented in Africa: an updated systematic review on evidence and future research perspectives by Ucheoma Nwaozuru, Patrick Murphy, Ashley Richard, Chisom Obiezu-Umeh, Thembekile Shato, Ifeoma Obionu, Titilola Gbajabiamila, David Oladele, Stacey Mason, Bryce P. Takenaka, Lateef Akeem Blessing, Alexis Engelhart, Susan Nkengasong, Innocent David Chinaemerem, Onyekachukwu Anikamadu, Ebenezer Adeoti, Pranali Patel, Temitope Ojo, Olufunto Olusanya, Donna Shelley, Collins Airhihenbuwa, Gbenga Ogedegbe, Oliver Ezechi, Juliet Iwelunmor

“…In contrast, salient barriers were related to structural-level factors (e.g., limited financial resources). …”
Get full text

SUPERCRITICAL FLUID TREATMENT OF THREE-DIMENSIONAL HYDROGEL MATRICES, COMPOSED OF CHITOSAN DERIVATIVES by P. S. Timashev, K. N. Bardakova, S. N. Churbanov, L. I. Krotova, A. M. Grigoriev, M. M. Novikov, S. G. Lakeev, V. I. Sevastianov, V. N. Bagratashvili

“…The kinetic swelling curves were constructed for structures in the base and salt forms of chitosan using gravimetric method and the contact angles were measured using droplet spreading. …”
Get full text

Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation by Roberta Gagliardini, Andrea Giacomelli, Cristina Mussini, Stephen R. Cole, Jessie K. Edwards, Carmela Pinnetti, Alessandro Raimondi, Spinello Antinori, Silvia Nozza, Valentina Mazzotta, Giulia Carla Marchetti, Sergio Lo Caputo, Alessandro Tavelli, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri

Get full text

The research equity and diversity initiative (READI): Changing the face of clinical research through community outreach and engagement by Sally Taylor, Stephanie Freel, Lynn Sutton, Kenisha Bethea, Leatrice Martin, Julie McKeel, Matthew Ray, Perusi B. Muhigaba, Stella Quenstedt, Amanda McMillan, Taryn Cavanaugh Faulk, Jenifer Allen, Kiah Gaskin, Richard Sloane, Salimah El-Amin, Annie Tsui, Cindy Canty-Dumas, Denise C. Snyder, Joseph McClernon, Michelle Lyn, Keisha L. Bentley-Edwards, Mina Silberberg, Steven C. Grambow, Jessica Sperling, Howard Eisenson, Holly Biola, Wanda Boone, Rachel Galanter, Tracie Locklear, Sharleen Traynor, Seronda Robinson, William Pilkington, L. Ebony Boulware, Nadine J. Barrett, Susanna Naggie

“…Current evidence underscores a need to transform how we do clinical research, shifting from academic-driven priorities to co-led community partnership focused programs, accessible and relevant career pathway programs that expand opportunities for career development, and design of trainings and practices to develop cultural competence among research teams. …”
Get full text

Revealing the Diversity of Introduced Coffea canephora Germplasm in Ecuador: Towards a National Strategy to Improve Robusta by Rey Gastón Loor Solórzano, Fabien De Bellis, Thierry Leroy, Luis Plaza, Hilton Guerrero, Cristian Subia, Darío Calderón, Fabián Fernández, Iván Garzón, Diana Lopez, Danilo Vera

“…However, little is known about the diversity and genetic structure of introduced germplasm. This paper provides an overview of the genetic and phenotypic diversity of C. canephora in Ecuador and some proposals for implementing a breeding program. …”
Get full text

Inbreeding patterns and genetic diversity under selection in Teha sheep by Shunzhe Wang, Long Liang, Dilinigeer Ziyayiding, Wenjing Jiao, Hailati Kasimu, Sangang He, Mingjun Liu

“…Teha sheep, a crossbred line between Texel and Kazakh sheep, are an important meat-producing breed in China, yet their genetic structure and inbreeding status remain underexplored. …”
Get full text

Cytological Characterization of <i>vrnp 1</i>, a Pollen-Free Male Sterile Mutant in Mung Bean (<i>Vigna radiata</i>) by Yuxin Cheng, Tianjiao Lan, Kunpeng Deng, Minghai Wang, Shuying Bao, Dan Han, Yapeng Xu, Han Wang, Ning Xu, Zhongxiao Guo

“…Mung bean (<i>Vigna radiata</i>) plays a significant role in agricultural trade, food processing and utilization, and cropping structure adjustment due to its abundant nutritional components, medicine-food homology, capacity for nitrogen fixation, and soil improvement. …”
Get full text