Systematic phenotype and genotype characterization of Moebius syndrome by Bryn D. Webb, Julie A. Jurgens, Narisu Narisu, Zhongyang Zhang, Brenda J. Barry, Carol Van Ryzin, Lori L. Bonnycastle, Wai-Man Chan, Tingfen Yan, Silvio Alessandro Di Gioia, Amy J. Swift, Sarah E. MacKinnon, Darren T. Oystreck, Janet C. Rucker, Tamiesha Frempong, Mary C. Whitman, Edmond J. FitzGibbon, Janice S. Lee, Ke Hao, Caroline Andrews, Monica Erazo, Flavia M. Facio, Sherin Shaaban, Thomas P. Naidich, Peter S. Chines, Tanya J. Lehky, Camilo Toro, Andrea L. Gropman, John A. Butman, Christopher K. Zalewski, Carmen C. Brewer, Audrey Thurm, Joseph Snow, Scott M. Paul, Brian P. Brooks, Carlo Pierpaoli, Caroline D. Robson, David G. Hunter, Francis S. Collins, Ethylin Wang Jabs, Elizabeth C. Engle, Irini Manoli

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Assessment of psychosocial aspects in adults in post-COVID-19 condition: the EURONET-SOMA recommendations on core outcome domains for clinical and research use by Stefan Salzmann, Lars de Vroege, Petra Engelmann, Per Fink, Susanne Fischer, Stephan Frisch, Lise Kirstine Gormsen, Katharina Hüfner, Willem J. Kop, Ferenc Köteles, Nadine Lehnen, Bernd Löwe, Christoph Pieh, Victor Pitron, Charlotte Ulrikka Rask, Markku Sainio, Rainer Schaefert, Meike Shedden-Mora, Anne Toussaint, Roland von Känel, Ursula Werneke, Winfried Rief, on behalf of the EURONET-SOMA Group

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Membrane Associated RNA‐Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice by Zhongqiu Zhou, Ying Bai, Xiaochun Gu, Hui Ren, Wen Xi, Yu Wang, Liang Bian, Xue Liu, Ling Shen, Xianyuan Xiang, Wenhui Huang, Zhuojuan Luo, Bing Han, Honghong Yao

“…Abstract Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision‐tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. …”
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Conservative or surgical treatment? Optimizing management strategies in medial hypertensive intracerebral hemorrhages by M.Ye. Polishchuk, A.A. Kaminskyi, A.A. Oblyvach, D.V. Shchehlov, O.M. Honcharuk, A.V. Muravskyi

“…From a prognostic perspective, surgical treatment of medial hematomas increases the likelihood of fatal outcomes and does not enhance functional neurological recovery. Therefore, even in cases of large hemorrhages involving medial (subcortical) brain structures, surgical intervention appears to be unwarranted.…”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…In situ hydrogels were prepared by mixing the HP/ alginate solution, and the n-MO solution containing Ca2+. The structure, physicochemical and mechanical properties of MO-HPA were evaluated. …”
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Implementing an online-delivered exercise program for childhood cancer survivors: A hybrid effectiveness-implementation protocol for the MERRIER studyKey points by David Mizrahi, Alexandra Martiniuk, Laurence Hibbert, Dinisha Govender, Tora Sibbald, Richard Mitchell, Natalia Millard, Lauren Ha, Damian Ragusa, Kylie Brown, Ben Smith

“…The RE-AIM framework will assess reach (e.g. recruitment rate), effectiveness (e.g. physical activity levels), adoption (e.g. qualitative interviews), implementation (e.g. exercise adherence), and maintenance (e.g. self-efficacy at follow-up). Physical function and patient-reported outcomes will be assessed at baseline (T0), post-intervention (T1; week 12) and follow-up (T2, week 24). …”
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Integrating an exercise program into opioid agonist therapy: a pilot study on feasibility, fitness improvements, and participation challenges by Einar Furulund, Siv-Elin Leirvåg Carlsen, Silvia Eiken Alpers, Jørn Henrik Vold, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars Thore Fadnes

“…Changes in aerobic fitness (4-minut step test), psychological distress (10-item Hopkins Symptom Checklist, SCL-10), fatigue (3-items Fatigue Severity Scale, FSS-3), lung function (spirometry), and respiratory symptoms (modified Medical Research Council Dyspnea Scale, mMRC) were assessed, while qualitative interviews provided insights into intervention feasibility. …”
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Measurement of purpose in life among Arabic-speaking adolescents: psychometric properties of an Arabic-language version of the Claremont purpose scale (CPS) by Amir Noureddine, Souheil Hallit, Souheil Hallit, Souheil Hallit, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Tylor Cosgrove, Sahar Obeid, Feten Fekih-Romdhane, Feten Fekih-Romdhane, Ahmed A. Moustafa, Ahmed A. Moustafa

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THE IMMUNOCOMPETENCE OF THE LYMPHOCYTIC POOL OF PERIPHERAL BLOOD IN ACUTE PURULENT LYMPHADENITIS IN CHILDREN by P.I. Tkachenko, S.O. Bilokon, N.M. Lokhmatova, O.B. Dolenko, K.Yu. Rezvina, Yu.V. Popelo

“… The substantial prevalence of different nosological forms of lymphadenitis in children is due to morpho-functional immaturity and age-related features of the structural components of the lymph node. …”
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A study on the relationship between depression, treatment side effects, and marital quality in cervical cancer patients undergoing radiotherapy and chemotherapy (宫颈癌放化疗患者抑郁与治疗副反应和婚... by LI Yuhuan (李玉环), ZENG Ya (曾娅), XING Yuzhen (邢育珍)

“…Objective To explore the relationship between depression and treatment side effects and marital quality in patients undergoing radiotherapy and or chemotherapy for cervical cancer, as well as the moderating role of neurotic personality and quality of life in this relationship, in order to provide a theoretical basis for the prevention of and intervention in patients' depression. Methods The Patient-Reported Outcome Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), the Functional Assessment of Cervical Cancer Therapy Scale (FACT-Cx), the 9-entry Patient Health Questionnaire (PHQ-9), the Big Five personality neuroticism subscale (NEO-FFIN), and the short version of the Marital Adjustment and Prediction Scale (Locke-Wallace) were used to conduct a cross-sectional survey of 1053 cervical cancer patients. …”
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Reversing cardiac hypertrophy and heart failure using a cardiac targeting peptide linked to miRNA106a by Ming Lu, Siqi Cai, Kyle Korolowicz, Claire Deng, Kaan Taskintuna, Gerard Ahern, Raymond B. Yurko, Kazi R. Islam, Bryn Schoonover, Jack B. Lopuszynski, Hongkun Wang, Maliha Zahid, G. Ian Gallicano

“…., hypertension, diabetes mellitus, coronary artery disease, etc.) lead to structural and functional changes in cardiomyocytes, resulting in HF. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…Planting methods also hold significant importance in enhancing the carbon sequestration of urban parks, such as multi-layered vegetation structures that enhance carbon sink capacity but require careful adjustments to avoid excessive shading and competition, thereby achieving more efficient carbon sequestration. …”
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Development and Characterization of CD44-Targeted X-Aptamers with Enhanced Binding Affinity for Cancer Therapeutics by Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G. Gorenstein

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Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial by Ville-Markus Konola, Jari Parkkari, Juhani Multanen, Riku Nikander, Timo Rantalainen, Johanna Vesanto, Satu Pekkala, Merja Kalaja, Johanna K. Ihalainen, Benjamin Waller, Matti Munukka, Harri Sievänen, Mika Nevalainen, Hannu Kautiainen, Victor Casula, Juha Paloneva, Tommi Vasankari, Arttu Peuna, Simo Saarakkala, Miika T. Nieminen, Ari Heinonen

“…Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance. …”
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Research on knowledge, attitude and practice (KAP) regarding dengue infection: a community-based study in rural Cox's Bazar by Saima Bibi

“…Face-to-face interviews were performed using a pretested and semi-structured questionnaire. Problem: DI poses a serious threat to public health, especially in tropical and subtropical areas where the dengue virus vector, the Aedes aegypti mosquito, is abundant.1,2 Bangladesh experienced its major dengue outbreak in 2019, with 100,000 cases and 120 deaths, followed by the second-largest outbreak in 2022, with 60,078 cases and 266 deaths.3,4 Assessment of problem and analysis of its causes: Bangladesh is severely affected by DI, largely due to factors including tropical climate, a dense population, unplanned urbanisation, inadequate vector control and low-literacy rates.5,6DI can cause mild fever to severe conditions, such as haemorrhagic fever, dengue shock syndrome, respiratory symptoms, gastrointestinal disturbance, low platelet count and deranged liver function tests. …”
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A network analysis study of anxiety, depression and loneliness among middle-aged and elderly people in Xining area by Bixuan Dong, Bin Li, Xiaowei Fan, Hongru Chen, Zhancui Dang, Ze Li

“…Additionally, the study conducted a comparative analysis of the network structures to explore gender differences.The objective of this study was to provide theoretical intervention strategies and practical guidelines for the mental health of middle-aged and older individuals in high-altitude regions. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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255 The impact of a personal cancer diagnosis on adolescent and young adult cancer survivors’ social connectedness: A qualitative analysis by Pooja Rao, Joel E Segel, Kristin Bingen, Katie A Devine, Allison M Scott, Laura M Koehly, Ashton M Verdery, Courtney L Rumbaugh, Emily Wasserman, Heather J Costigan, Smita Dandekar, Kevin Rakszawski, Natthapol Songdej, George F Blackall, Monali Vasekar, Seema Naik, Eugene J. Lengerich, Lauren J Van Scoy

“…Objectives/Goals: This study’s objective was to explore how a personal cancer diagnosis impacts the social connectedness (i.e., quality, structure, and functions of social relationships) of adolescent/young adult cancer survivors (AYACS, patients diagnosed with cancer between 15 and 39 years old), to inform intervention development fostering social health. …”
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Exploring Early Mobilization Practices in Adult Intensive Care Units in Jordan: A Cross-Sectional Survey by Wshah A, Obaidat S, Shallan AI, Muhsen A, Bin Sheeha B, Alkasassbeh A, Wshah S, Al Hadidi ARB, Altaim TA, Sawafta B, Alqallab S

“…Adnan Wshah,1 Sakher Obaidat,1 Amjad I Shallan,1 Ahmad Muhsen,1 Bodor Bin Sheeha,2 Asmaa Alkasassbeh,3 Shadi Wshah,4 Abdel Razzaq Bassam Al Hadidi,5 Thamer A Altaim,1 Batul Sawafta,1 Salsabeel Alqallab6 1Department of Physical Therapy, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan; 2Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 3Physiotherapy Department, Faculty of Allied Medical Sciences, Isra University, Amman, Jordan; 4Physical Therapy Department, Jordanian Royal Medical Services, Amman, Jordan; 5Department of Physical Therapy, School of Rehabilitation Sciences, The University of Jordan, Amman, Jordan; 6Al Patrawi Physiotherapy Center, Zarqa, JordanCorrespondence: Adnan Wshah, Department of Physical Therapy, Faculty of Applied Medical Sciences, The Hashemite University, P.O box 330127, Zarqa, 13133, Jordan, Email adnan.wshah@hu.edu.joBackground: Prolonged immobilization in critically ill patients in the intensive care unit (ICU) is associated with adverse health outcomes, such as ICU-acquired weakness (ICU-AW), pressure ulcers, and decreased cardiopulmonary function. Early mobilization has been shown to be an important intervention to mitigate these effects; however, there is limited information regarding its implementation in ICUs in Jordan. …”
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Development of the Psychosocial Rehabilitation Web Application (Psychosocial Rehab App) by Fagner Alfredo Ardisson Cirino Campos, José Carlos Sánches García, Gabriel Lamarca Galdino da Silva, João Antônio Lemos Araújo, Ines Farfán Ulloa, Edilson Carlos Caritá, Fabio Biasotto Feitosa, Marciana Fernandes Moll, Tomás Daniel Menendez Rodriguez, Carla Aparecida Arena Ventura

“…<b>Results:</b> The web app “Psychosocial Rehabilitation Application” displays a home screen for registration and other screens structured into the stages of the psychosocial rehabilitation project (assessment, diagnosis, goals, intervention, agreements, and re-assessment). …”
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