Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling by Huarui Qiao, Fangzheng Hu, Yiang Wang, Lu Wang, Siyu Zhou, Shaojue Guo, Yiwen Xu, Jianfeng Xu, Qianqian Cui, Qilun Yang, H. Eric Xu, Jianwei Zhu, Yong Geng

“…Furthermore, we developed a high-affinity nanobody that blocks both Norrin and RSPO binding to LGR4, providing a potential tool for therapeutic intervention. These findings elucidate the structural basis of LGR4’s dual signaling roles and lay the groundwork for therapeutic strategies targeting Wnt-related diseases.…”
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Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies? by Chen-Chao Chu, Ya-Hui Hu, Gui-Zhou Li, Jiang Chen, Ning-Ning Zhang, Yi-Xue Gu, Shi-Yu Wu, Hai-Feng Zhang, Yang-Yang Xu, Hong-Li Guo, Xin Tian, Feng Chen

“…As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of various human disorders, there is growing evidence that reveals new opportunities for therapeutic interventions. In this review, we examine the fundamental structure and primary functions of AKAP79/150, emphasizing its pathophysiological mechanisms in different nervous system disorders, particularly inflammatory pain, epilepsy, depression, and Alzheimer's disease. …”
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Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension by Dongxu Hua, Wanlin Huang, Qiyang Xie, Wenna Xu, Lu Tang, Mingwei Liu, Xiaoguang Wu, Qiaodong Zhang, Xu Cao, Peng Li, Yanhui Sheng

“…We identified the potential ligand of GPR39 using structure-based high throughput virtual screening (HTVS) and validated its antihypertensive function in vitro and in vivo. …”
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Bifurcation in the healing or fibrotic response in a network model of fibrosis: role of the initial injury structure by Ethan Israel, Joseph K. Hall, Yuqing Deng, Jason H. T. Bates, Béla Suki

“…Furthermore, we show that selectively modifying the stiffness of pivotal network regions at the time of injury can shift the network’s trajectory from fibrosis to healing, highlighting potential intervention targets. These findings suggest that the network structure of tissue injury may serve as a predictive marker for fibrosis susceptibility and provide a mechanistic basis for understanding the nonlinear progression of PF.…”
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Translation, Cultural Adaptation and Content Validity of the Persian Version of the Structured Cognitive Training Program “NEUROvitalis” by Milad Karimi, Amin Modarres Zadeh, Payam Kabiri, Hasan Ashayeri, Ahmad Rreza Khatoonabadi, Elke Kalbe

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The Dynamical Asymmetry in SARS-CoV2 Protease Reveals the Exchange Between Catalytic Activity and Stability in Homodimers by Velia Minicozzi, Alessandro Giuliani, Giampiero Mei, Leonardo Domenichelli, Mauro Parise, Almerinda Di Venere, Luisa Di Paola

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Functional neuroplasticity in chronic post-stroke aphasia following a singing intervention in a cross-over randomised trial by Noelia Martínez-Molina, Anni Pitkäniemi, Sini-Tuuli Siponkoski, Nella Moisseinen, Linda Kuusela, Sari Laitinen, Essi-Reetta Särkämö, Johanna Pekkola, Susanna Melkas, Gottfried Schlaug, Boris Kleber, Aleksi J. Sihvonen, Teppo Särkämö

“…However, the functional neuroplasticity changes induced by such interventions remain unknown. …”
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Oral microbiome dysbiosis in women with a history of pregnancy loss: a metagenomic cross-sectional study by Ling Liu, Li Wei, Fang Xiang Mou, Wei Zhang, Rui Fang Wang, Qi Wang, Fang Wang

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Angiotensin Receptor–Neprilysin Inhibition (Sacubitril/Valsartan) Reduces Structural Arterial Stiffness in Middle‐Aged Mice by Isabel N. Schellinger, Angelika Dannert, Annet Hoffmann, Giriprakash Chodisetti, Karin Mattern, Anne Petzold, Nora Klöting, Andreas Schuster, Markus U. Wagenhäuser, Fabian Emrich, Michael Stumvoll, Gerd Hasenfuß, Uwe Raaz

“…Arterial stiffening leads to fundamental alterations in central hemodynamics with widespread detrimental implications for organ function resulting in significant morbidity and death, and specific therapies to address the underlying age‐related structural arterial remodeling remain elusive. …”
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The Ellipsoid Zone Is a Structural Biomarker for Visual Outcomes in Diabetic Macular Edema and Macular Hole Management by Shivani Chaturvedi, Amisha Paul, Samya Singh, Levent Akduman, Sandeep Saxena

“…Objectives: The goal was to study the ellipsoid zone (EZ) as a structural biomarker for final visual outcomes after pharmacological intervention in center-involving diabetic macular edema (DME) and surgical intervention for full-thickness macular holes (FTMHs). …”
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Insights into the Structural and Nutritional Variations in Soluble Dietary Fibers in Fruits and Vegetables Influenced by Food Processing Techniques by Wenjie Sui, Shuiqing Wang, Yue Chen, Xiaoxuan Li, Xin Zhuang, Xinhuan Yan, Ye Song

“…This paper not only provides a theoretical basis for the precise application of SDFs in functional foods but also reveals the potential mechanisms involved in regulating the structure of SDFs through processing technology to achieve nutritional intervention in metabolic diseases, which is an important guiding value for the development of food ingredients with specific health effects.…”
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Brain Structural Correlates of EEG Network Hyperexcitability, Symptom Severity, Attention, and Memory in Borderline Personality Disorder by Andrea Schlump, Bernd Feige, Swantje Matthies, Katharina von Zedtwitz, Isabelle Matteit, Thomas Lange, Kathrin Nickel, Katharina Domschke, Marco Reisert, Alexander Rau, Markus Heinrichs, Dominique Endres, Ludger Tebartz van Elst, Simon Maier

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Factor Structure of the Brief Coping Orientation to Problems Experienced Inventory (Brief-COPE) in Chinese Nursing Students by Cheng Cheng, Qingling Wang, Jie Bai

“…This study aimed to explore the factor structure of the Brief Coping Orientation to Problems Experienced Inventory (Brief-COPE) in Chinese nursing students. …”
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The Structure of Stress Experiences in Patients in the Lumbar Spine Pain Syndrome during the COVID-19 Epidemic in Poland by Anna Mazur, Karolina Adamek, Elżbieta Przychodzka, Danuta Zarzycka, Elżbieta Bartoń

“…However, apart from the necessity to protect somatic health, it turned out in a relatively short time that the pandemic also posed a serious threat to the mental functioning of many people. Aim. The aim of the study is assessing the structure of stressful experiences of women and men in the pain syndrome of the lumbar spine during the COVID-19 epidemic in Poland. …”
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Genomic insights into the population structure, antimicrobial resistance, and virulence of Brachyspira hyodysenteriae from diverse geographical regions by Maria Hakimi, Fangshu Ye, Anugrah Saxena, Xiao Hu, Huigang Shen, Paarthiphan Elankumaran, Chloe C. Stinman, Nubia Macedo, Orhan Sahin, Eric R. Burrough, Ganwu Li

“…The identification of nine distinct phylogenetic lineages and associated sublineages highlights the pathogen’s complex population structure and regional variation. Importantly, the study detects AMR genes, including tva(A) and lnu(C), linked to tiamulin and lincomycin resistance, that may pose significant challenges to disease management. …”
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Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…Furthermore, the detailed structural insights and inhibitory mechanisms elucidated through molecular dynamics simulations provide valuable knowledge for rational drug design. …”
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Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies by Leela Shah, Leela Shah, Christy D. Yoon, Alessandra M. LaJeunesse, Lilly G. Schirmer, Emma W. Rapallini, Elizabeth M. Planalp, Douglas C. Dean, Douglas C. Dean, Douglas C. Dean

“…In this review, we summarize findings from 25 peer-reviewed studies that leverage structural, functional, and diffusion MRI to examine the effects of prenatal exposure to alcohol, opioids, methamphetamines, cocaine, nicotine, or cannabis. …”
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Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample by Yoichi Sawada, Toru Satoh, Hideaki Saba, Yoshiki Kato, Tomoko Kuwada, Sayoko Shima, Kana Murakami, Megumi Sasaki, Yudai Abe, Kaori Harano

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Strengthening Family Bonds: A Systematic Review of Factors and Interventions That Enhance Family Cohesion by Nicolette V. Roman, Tolulope V. Balogun, Letitia Butler-Kruger, Solomon D. Danga, Janine Therese de Lange, Anja Human-Hendricks, Fundiswa Thelma Khaile, Kezia R. October, Olaniyi J. Olabiyi

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Impact of AI-Powered Adaptive Learning Platforms on English Reading Proficiency: Evidence From Structural Equation Modeling by Jin Wu, Yiyun Wang, Fang Chen, Xueqi Yin, Yun He

“…This study examines the impact and mediating mechanisms of AI-powered adaptive learning platforms on enhancing English reading proficiency. Using structural equation modeling (SEM) on data collected from 118 undergraduate students, this study validates a chained mediation model in which learner engagement mediates the relationship between satisfaction with platform functionalities and perceived learning outcomes. …”
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