Digital Health Technologies for Coeliac Disease: A Realist Approach by Rosie Cooper, Matthew Kurien, Steve Ariss, Geoff Wong

“…Treatment requires life-long adherence to a gluten-free diet (GFD) which aims to reduce the risk of complications and preserve individuals’ functional status and quality of life (QoL). As a chronic condition, life-long healthcare is recommended for individuals with CD in the form of structured monitoring and follow-up, often resulting in significant health and economic costs to both the individual and wider society. …”
Get full text

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-... by Julie Bruce, Jason Madan, Martin Underwood, Roger Kenyon, Miriam Ratna, Ranjit Lall, Gavin D Perkins, Ella Terblanche, Kerry Raynes, Brenda O'Neill, Mandana Zanganeh, Rowena Williams, Danny McAuley, Paul Dark, Bronwen Connolly, Chen Ji, Judy Martina Bradley, Rachel Clarke, Jill Costley, Nigel D Hart, Penelope Firshman, Katherine Jones, Annette Henderson

“…The intervention is a six week multicomponent, structured, rehabilitation programme, delivered remotely by a trained intervention team. …”
Get full text

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-... by Julie Bruce, Jason Madan, Martin Underwood, Roger Kenyon, Mariam Ratna, Ranjit Lall, Gavin D Perkins, Ella Terblanche, Kerry Raynes, Brenda O'Neill, Mandana Zanganeh, Rowena Williams, Danny McAuley, Paul Dark, Bronwen Connolly, Chen Ji, Judy Martina Bradley, Rachel Clarke, Jill Costley, Nigel D Hart, Penelope Firshman, Katherine Jones, Annette Henderson

“…The intervention is a six week multicomponent, structured, rehabilitation programme, delivered remotely by a trained intervention team. …”
Get full text

The Role of Circulating Biomarkers in Patients with Coronary Microvascular Disease by Rossella Quarta, Giovanni Martino, Letizia Rosa Romano, Giovanni Lopes, Francesco Fabio Greco, Carmen Anna Maria Spaccarotella, Ciro Indolfi, Antonio Curcio, Alberto Polimeni

Get full text

Fractional-Order Modeling of Sediment Transport and Coastal Erosion Mitigation in Shorelines Under Extreme Climate Conditions: A Case Study in Iraq by Ibtisam Aldawish, Rabha W. Ibrahim

“…Numerical simulations reveal that the proposed structures provide moderate sediment retention but degrade over time, leading to diminishing effectiveness. …”
Get full text

A scoping review on exercise prescription in hemophilia: A pathway for enhanced mobility and reduced bleeding risk by Abhishek Sharma, Aksh Chahal, Richa Hirendra Rai, Bartosz Maciej Wójcik, Nidhi Sharma

“…Although evidence supports the benefits of structured exercise, there remains a need for standardized guidelines specific to hemophilia. …”
Get full text

Monitoring the effectiveness of the natural anticoagulant sulodexide in pregnant women with autoimmune hyperthyroidism on the background of hyperhomocysteinemia by A.Yu. Scherbakov, Т. А. Mіelikova

“…Among the factors that affect hemostasis, thyroid hormones occupy a special place, they are able to influence not only the functional activity of platelets, but also adjust the intensity of the plasma and tissue fibrinolysis. …”
Get full text

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice by Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang

“…APPL1 is a signaling protein with multiple functional structural domains and plays an important role in the APN signaling pathway. …”
Get full text

Patient acceptability of intravitreal complement inhibitors in geographic atrophy (GA): protocol for a UK-based cross-sectional study by David P Crabb, Deanna J Taylor, Christiana Dinah, Mandeep Sekhon, Jamie Enoch, Arevik Ghulakhszian

“…The correlation between acceptability and functional and structural biomarkers of GA will be established. …”
Get full text

Predicting depression in healthy young adults: A machine learning approach using longitudinal neuroimaging data by Ailing Zhang, Haobo Zhang

“…This study aimed to develop predictive models for depression in young adults using machine learning (ML) techniques and longitudinal data from the Beck Depression Inventory, structural MRI (sMRI), and resting-state functional MRI (rs-fMRI). …”
Get full text

Physiological Mechanisms Driving Microcirculatory Enhancement: the Impact of Physical Activity by Jianyu Li, Guochun Liu, Dong Zhang, Keying Zhang, Chunmei Cao

“…Physical activity also ameliorates inflammation markers and oxidative stress levels, upregulates the expression of silent information regulator 2 homolog 3, genes for hypoxia-inducible factors under hypoxic conditions, and induces favorable changes in multiple hemodynamic and hemorheological parameters. These structural and functional adaptations optimize myocardial blood flow regulation during exercise and improve both oxygen transport and utilization capacity, which are beneficial for the rehabilitation of chronic disease patients. …”
Get full text

An Unusual Congenital Heart Disease: Giant Left Atrial Appendage by Julio C. Sauza-Sosa, Erika L. De la Cruz-Reyna, Carlos N. Velazquez-Gutierrez

“…Cardiac magnetic resonance corroborated the huge left atrial appendage (Figure 1B). No other structural or functional heart abnormalities were diagnosed. …”
Get full text

RETROSPECTIVE ANALYSIS OF IMPLANT USAGE IN THE TREATMENT OF PATIENTS WITH DENTAL ARCH DEFECTS by V.M. Luchynskyi

“…Prospects for further research include the investigation of the structural and functional condition of the jaws to develop more effective therapeutic approaches to dental implantation. …”
Get full text

Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson’s disease: Innovative therapies and their translation by Shimin Pang, Zhili Ren, Hui Ding, Piu Chan

“…We identify key processes, including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids. Importantly, structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormal α-synuclein expression and gastrointestinal dysmotility, which could serve as an initiating event in Parkinson’s disease. …”
Get full text

The Long-Term Effects of Alcohol on the Central Nervous System: Mechanisms, Cognitive Decline, and Associated Disorders by Marcelina Matuszewska, Monika Brzozowska, Wiktoria Wardal, Natalia Furlepa, Robert Rzenno, Karolina Wojciechowska, Katarzyna Wicha, Natalia Sidz, Magdalena Tomaszewska, Wiktoria Jedlikowska

“…These effects are mediated by mechanisms such as oxidative stress, neuroinflammation, and disruptions in neurotransmission. Structural changes, including gray matter loss and hippocampal atrophy, underlie functional deficits such as memory impairment, cognitive decline, and emotional dysregulation. …”
Get full text

Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization by Xing-wang Wang, Cheng-qiang Ye, Qian Tang, Hong-mei Yu, Jing Wang, Guo-sheng Fu, Ke-feng Ren, Lu Yu, Jian Ji

Get full text

Spatial heterogeneity determines the gastrointestinal microbiome signatures and ecological processes that govern bacterial community assembly in sheep by Yukun Zhang, Jiangbo Cheng, Changchun Lin, Fadi Li, Xiaoxue Zhang, Chong Li, Deyin Zhang, Xiaobin Yang, Dan Xu, Yuan Zhao, Liming Zhao, Xiaolong Li, Huibin Tian, Xiuxiu Weng, Weimin Wang

“…In this study, we collected 338 samples from 10 different regions of the sheep GIT and systematically investigated their microbiome signatures, including community structure, enterotypes, interactions among taxa, and microbial community assembly. …”
Get full text

The impact of maximal oxygen uptake (VO₂max) on athletic performance and health - a review by Julia Charkot, Wojciech Bieńkowski, bartlomiej kusy, Michał Bieńkowski, Mikołaj Charkot, Piotr Kucharczyk, Irmina Jaszczuk, Patrycja Retman

“… Introduction and purpose: Maximal oxygen uptake (VO₂max) is a key indicator of aerobic capacity, widely used in sports science and clinical diagnostics. It reflects the functional efficiency of the cardiovascular, respiratory, and muscular systems. …”
Get full text

Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis by Michael Vincent DiCaro, Brianna Yee, KaChon Lei, Kavita Batra, Buddhadeb Dawn

“…The findings of this systematic review and meta-analysis may shed light on the efficacy of MSC therapy in improving cardiac functional and structural parameters and reducing adverse cardiac events following acute MI. …”
Get full text

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis by Amit U Joshi, Nay L Saw, Hannes Vogel, Anna D Cunnigham, Mehrdad Shamloo, Daria Mochly‐Rosen

“…In both cell models, inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions. Sustained treatment of mice expressing G93A SOD1 mutation with P110, beginning at the onset of disease symptoms at day 90, produced an improvement in motor performance and survival, suggesting that Drp1 hyperactivation may be an attractive target in the treatment of ALS patients.…”
Get full text