Investigation of Tongqiao Huashuan Granules’ effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmacology and... by Xiaoqu Jiang, Shuyao Yu, Shuaifeng Yao, Sikai Wang, Jing Cai, Zhongsheng Tang, Shijie Zhu

“…Morphological and structural changes in neuronal cells within the CA1 region of the rat hippocampus were examined using hematoxylin and eosin (HE) staining. …”
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Experiences of support to return to work after stroke: longitudinal case studies from RETAKE trial by Diane Trusson, Katie Powers, Kathryn Radford, Audrey Bowen, Kristelle Craven, Jain Holmes, Rebecca Lindley, Christopher McKevitt, Julie Phillips, Ellen Thompson, Caroline Watkins, David J Clarke

“…Objectives This article aims to understand participants’ experiences of being supported to return to work and explores the social and structural factors which support, or act as barriers to, implementation of the Early Stroke Specialist Vocational Rehabilitation intervention. …”
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A patient-centered qualitative evaluation of meaningful change on the NSAA and PUL in Duchenne Muscular Dystrophy by Aviva Gillman, Teofil Ciobanu, Louise Barrett, Evan W. Davies, Alexander P. Murphy, Alex Johnson, Jessica Mills, Phoebe Heinrich, Krystian Przydzial, Bethany Ewens, Gerrit Vandenberg, Stefan Cano, Anna Mayhew

“…The aim of this study is to understand meaningful change in functional abilities as measured by the NSAA and PUL at different ability levels from the perspective of individuals with DMD, caregivers of individuals with DMD, and clinicians.MethodsThe study utilized a non-interventional, descriptive, cross-sectional qualitative design consisting of 69 semi-structured interviews, including individuals with DMD (n = 18), caregivers of individuals with DMD (n = 51), and neuromuscular physiotherapists (n = 2) to understand meaningful change on the NSAA and PUL.ResultsThe results for both instruments indicated that: (i) items that are meaningful differ based on ability level; (ii) maintaining function in lower and upper limbs is the ultimate goal; (iii) meaningful change is often reported in relation to gain or loss of specific function, as opposed to number of total points on the scale; and (iv) losing one scale point corresponds to either a partial or full loss in function and activity, which has differing impacts on daily life.ConclusionThe perception of meaningful change in DMD as measured by the NSAA is influenced by ability levels and ambulatory function, with participants describing their need to maximize certain abilities, maintain function, and retain independence. …”
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The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo by Meng Wang, Xiaoshan Liang, Keqing Jin, Yinyue Liu, Suhui Luo, Qiang Zhang, Xuan Wang, Zhiping Dong, Xumei zhang

“…Moreover, synaptic structural impairment was observed within the hippocampal. …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. …”
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Potential hepatoprotective role of Amphora coffeaeformis algae against diazinon-induced hepatotoxicity in adult Sprague–Dawley rats by Hager Ali Fathy, Sahar Hassan Orabi, Ahmed Farag Elkirdasy, Eman Mohamed Abd El Fattah, Reda M. S. Korany, Hanem Kamal Khalifa, Mohamed Mohamed Ahmed

“…The hepatoprotective effects were assessed through serum liver and kidney function biomarkers, hepatic oxidative stress markers, and histopathological and immunohistochemical analyses of liver tissue. …”
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Alterations in ganglion cell and nerve fiber layer in Leber hereditary optic neuropathy across clinical stages by Michael Oeverhaus, Mareile Knetsch, Ying Chen, Leyla Jabbarli, Carmen Nolden, Anja Eckstein, Nikolaos E. Bechrakis, Philipp Rating

“…As the condition progresses, there is a decline in visual function, accompanied by noticeable structural alterations. …”
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Selenium and Coenzyme Q₁₀ Supplementation and Sex Differences in Cardiovascular Mortality Results from a Prospective Randomized Double-Blind Placebo-Controlled Trial in... by Urban Alehagen, Jan Olav Aaseth, Lutz Schomburg, Trine B. Opstad, Anders Larsson, Jan Alexander

“…The higher prevalence of structural CVD and smoking in males may have contributed to the observed greater supplementation benefits in females. …”
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Lactobacillus Supplementation Modulates Rumen Microbiota and Metabolism in Yaks Under Fattening Feeding Conditions: A Comprehensive Multi-Omics Analysis by Jianlei Jia, Pengjia Bao, Ning Li, Siyuan Kong, Min Chu, Qian Chen, Ping Yan

“…However, the biological mechanisms by which rumen microbiota and its metabolites enable Lactobacillus to modulate rumen structure and maintain functional homeostasis under fattening feeding conditions remain poorly understood. …”
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Effect of acupuncture on episodic memory for amnestic mild cognitive impairment based on hippocampal subregion: study protocol of a randomized, controlled trial by Xinbei Li, Xingying Lu, Juan Ou, Hanqing Lyu, Yongfeng Liu, Jinhuan Zhang

“…BackgroundThe hippocampus is a key brain region for episodic memory, and impairment of episodic memory is the earliest feature of amnestic mild cognitive impairment (aMCI). Preserving the structure and function of the hippocampus plays a key role in preventing progression to Alzheimer’s disease (AD). …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…Consequently, prioritizing the advancement of their planning, design, and functional optimization is imperative. Finally, rigorous evaluation of the effectiveness of sleep quality improvement interventions is essential. …”
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A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical studies by Xiao-Min Lv, Na Li, Lin-Wei Chen, Cheng Sun

“…These mechanisms resulted in enhanced amplitude of A/B waves, improved retinal thickness and visual function.ConclusionResveratrol has neuroprotective, anti-inflammatory and antioxidant effects through multiple mechanisms, thereby reducing retinal damage and maintaining the structure and function of the retina. …”
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Lactiplantibacillus plantarum IOB602 Postbiotic Ameliorates Depression-like Behaviors by Regulating Neuroendocrine Factors and Gut Microbiota in Mice by JING Zhaoxuan, LIANG Peixin, HAN Xuemei, ZHANG Yihua, DENG Langni, JIA Longgang, WANG Yanping, GENG Weitao

“…Analysis of the gut microbiota revealed that postbiotic intervention modulated the structure and composition of the gut microbiota in mice under CUMS, notably increasing the relative abundance of Erysipelotrichaceae and Dubosiella and reducing the relative abundance of Firmicutes and Staphylococcaceae. …”
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Analysis of Echocardiography Indicators Depending on the Type of Surgical Correction of the Mitral Valve in Patients with Ischemic Heart Disease by Volodymyr S. Moroz, Vasyl V. Lazoryshynets

“…As a result of the study, echocardiographic differences in the structure of the mitral valve were established, which influenced the selection of the intervention volume. …”
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Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency by Xiaoxian Zhang, Li Huang, Cheng Li, Jinjuan Yang, Fuyu Duan, Qiang Su, Yuelin Zhang, Meng Kou, Xiaoya Zhou, Liyan Guo, Shaoxiang Chen, Yongxia Niu, Ziyue Li, Sihua Ou, Min Zhang, Kenneth King-Yip Cheng, Jianlong Wu, Xiang Xu, Qizhou Lian

“…Additionally, AAV9-hNdufs6 gene therapy initiated at an early stage increased Ndufs6 expression in cardiac tissue, preserved mitochondrial structure and function, prevented cardiomyocyte fibrosis through modulation of the AMPK/Drp1 signaling pathway. …”
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Zwitterionic chitosan-modified amorphous ZnCuAl-LDH eye drops for efficient treatment of bacterial keratitis by Tingting Hu, Dandan Chu, Haohao Cui, Shibo Wang, Mengke Wang, Ruizheng Liang, Jingguo Li, Zhanrong Li

“…In response, inorganic nanomaterial-based antibacterial eye drops have been developed for bacterial keratitis leveraging their structural controllability, composition diversity and ease of functionalization, However, they typically exert antibacterial effects with the assistance of laser, ultrasound, or X-ray irradiation that may cause irritation or damage to the human eye, or involve intricate structural modifications for antibacterial activation. …”
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Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

“…To further assess the functionality of succinate dehydrogenase, structure-based studies were conducted. …”
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Differential directional effects between insomnia symptoms and suicidal ideation across trait depression levels: a cross-lagged network analysis among Chinese medical undergraduate... by Jingxuan Zhang, Xiaolin Zhang, Xiaolin Zhang, Xiaolin Zhang, Feng Hu, Kuiliang Li, Mengjie Luo, Mengjie Luo, Yang Yu, Yang Yu, Zhengzhi Feng, Zhengzhi Feng

“…High/low TDY networks exhibited structural congruence but significant differences in bridge centrality rankings.ConclusionInsomnia symptoms exacerbate SI by impairing daytime functioning and emotional regulation, with trait anhedonia serving as a critical node. …”
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Bringing a health systems modelling approach to complex evaluations: multicountry applications in HIV, TB and malaria by Adama Faye, Stephen S Lim, Bernardo Hernandez Prado, Herbert Duber, David E Phillips, Guillermo Ambrosio, Audrey Batzel, Carmen Cerezo, Ibrahima Gaye, Bethany Huntley, Edgar Kestler, Constant Kingongo, Emily Linebarger, Jorge Matute, Godefroid Mpanya, Salva Mulongo, Caitlin O'Brien-Carelli, Erin Palmisano, Francisco Rios Casas, Roger Tine, Daniel Whitaker, Jennifer M Ross

“…Introduction Understanding how to deliver interventions more effectively is a growing emphasis in Global Health. …”
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Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure by Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter

“…Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin‐2 (PHB2) at the mitochondrial inner membrane. …”
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