Birth prevalence and associated factors of congenital anomalies among neonates born at a public hospital in Awi Zone, Northwestern Ethiopia: institutional based cross-sectional stu... by Tsegaye Mehare, Yewbmirt Sharew

“…Abstract Background Congenital Anomalies, also known as birth defects, are structural, functional, or metabolic abnormalities present at birth or later in life that can result in physical or developmental impairments. …”
Get full text

Effects of Shenyankang on expression of CTGF and FN in adriamycin-induced nephrosis rats by XIE Yi-feng, LI Yan-fang, ZHAO Xian-feng, LU Zhu-guang, JIANG Yao-ping

“…Results(1) Shenyankang intervention treatment could significantly reduce urinary protein level in nephrotic rats(P<0.05).(2) Shenyankang could significantly reduce serum creatinine, urea and uric acid levels(P<0.05).(3) Shenyankang could significantly improve the renal pathological structure of nephrotic rats, and inhibit the level of renal fibrosis(P<0.05);(4) Shenyankang could significantly reduce glomerular sclerosis index in rats with nephropathy(P<0.05);(5) Immunohistochemical results showed that Shenyankang could significantly inhibit the expression of CTGF and FN proteins in renal tissues of nephrotic rats(P<0.05).(6) The results of qPCR showed that Shenyankang could significantly inhibit the expression of CTGF and FN mRNA in renal tissues of nephrotic rats(P<0.05).(7) For nephrotic rats, the overall improvement level of Shenyankang was weaker than that of prednisone, but the therapeutic effect was still obvious. …”
Get full text

Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature O... by Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y

“…The expression changes of PTEN, Nrf2, and GPX4, which are associated with ferroptosis, were analyzed using immunofluorescence, Western blot, and quantitative reverse-transcription polymerase chain reaction.Results: hUCMSC-Exo intervention can significantly repair the ovarian tissue structure and functional abnormalities in the model rats, especially ferroptosis. …”
Get full text

Advantages of long-term combination pharmacotherapy with a beta-blocker and eplerenone in patients with ST-segment elevation acute coronary syndrome by O. A. Osipova, V. P. Mikhin, A. I. Golovin, O. N. Belousova, D. N. Perutsky, P. K. Alferov, S. L. Konstantinov

“…To conduct a comparative analysis of the effect of long-term pharmacotherapy (12 months) using a β-blocker (nebivolol) and its combination with eplerenone in patients after ST-segment elevation acute coronary syndrome (STE-ACS) with heart failure with mildly reduced ejection fraction (EF) (HFmrEF) on the structural and functional cardiac parameters.Material and methods. …”
Get full text

Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy by Zhibo Hu, Yu Zhou, Cailing Gao, Junfen Liu, Congqing Pan, Jun Guo

“…Results In vitro, AS-IV led to a significant reduction in blood urea nitrogen (BUN), urine albumen-to-creatinine ratio (UACR), serum creatinine (CREA), and hyperglycemia in db/db mice and lessen the pathological alterations in the kidney. Moreover, pyrin structural domain of the NLR family pyrin domain containing 3 (NLRP3), cleaved-caspase-1, gasdermin D (GSDMD), IL-18, and IL-1β were down-expressed and podocyte markers podocin and nphs1 were up-regulated following AS-IV intervention. …”
Get full text

Effects of Electroacupuncture on Syt3 and GluA2 in Rats With Limb Spasms After Intracerebral Hemorrhage by Xudong Lu, Huiling Ren, Hequn Chen, Guosheng Shi, Xuanbo Luo, Kai Liu, Qinglin Zhao, Dawei Zhao, Changfa Li, Wei Bu

“…Muscle tone, neurological deficits, and motor function were assessed. After 3 and 7 days of intervention, the motor cortex was dissected for Western blot analysis of SYT‐3, GLUA2, and P‐GLUA2‐Ser880 expression. …”
Get full text

Predictors of Cognitive Defects and Its Prevention Capabilities in Premature Infants by Irina A. Belyaeva, Alexander A. Baranov, Leyla S. Namazova-Baranova, Kamilla E. Efendieva, Polina S. Arimova, Alexey I. Molodchenkov, Elena P. Bombardirova, Georgiy A. Karkashadze, Tatiana V. Turti, Elena A. Vishnyova

“…The data of longitudinal researches of the premature infants’ development until reaching their adulthood is presented. The structure of cognitive defects in this population is studied. …”
Get full text

Neural Correlates of Motor Recovery after Robot-Assisted Training in Chronic Stroke: A Multimodal Neuroimaging Study by Cheng Chen, Kai Yuan, Xin Wang, Ahsan Khan, Winnie Chiu-wing Chu, Raymond Kai-yu Tong

“…We adopted EEG-informed fMRI technique to understand the functional regions sensitive to training intervention. …”
Get full text

Bringing a Systems Approach to Living Donor Kidney Transplantation by Anna Horton, Katya Loban, Peter Nugus, Marie-Chantal Fortin, Lakshman Gunaratnam, Greg Knoll, Istvan Mucsi, Prosanto Chaudhury, David Landsberg, Michel R. Pâquet, Marcelo Cantarovich, Shaifali Sandal

“…Conclusion: Our findings suggest that interventions that account for full-system function, particularly macro-level coordination between governing organizations can improve LDKT delivery. …”
Get full text

A rare case of adult ovarian inguinal hernia with an associated pelvic ectopic kidney by Komal Mishra, Pratapsingh Parihar, Rakshanda Agrawal

“…Accurate diagnosis relies heavily on imaging modalities, which guide the surgical approach and help rule out complications like torsion. Early surgical intervention is imperative to prevent potential morbidity and preserve ovarian function. …”
Get full text

Establishment and applications of specific nursing models for patients undergoing orthognathic surgery by LIU Fan, BAI Yuanyan

“…The model is divided into three main phases: prehospital early referral care, in-hospital intensive care, and posthospital extended care, and contains five modules: case management, psychological intervention, nutritional guidance, management of complications, and functional recovery. …”
Get full text

The use of dual mobility endoprostheses in patients with unsatisfactory outcomes of trochanteric fractures fixed with a sliding hip screw system (SHS) by A. N. Tsed, N. E. Mushtin, A. K. Dulaev, A. V. Schmeljev

“…The second group included 29 (48.4 %) patients who were implanted with cement-retained dual mobility endoprostheses. We assessed the functional state using the Oxford Hip Score, the level of pain on the visual analogue scale, the degree of disability, the duration of the operation, blood loss, the nature and structure of complications, the frequency of revision interventions.RESULTS. …”
Get full text

Early corticospinal tract sub-pathway lesion load and integrity predict post-stroke motor outcomes by Xin Wen, Wentao Zeng, Chiyin Li, Yue Qin, Yanqiang Qiao, Tao Lu, Wanghuan Dun, Ming Zhang, Junya Mu

“…These findings highlight the pivotal role of non-M1 tracts in post-stroke motor function, particularly the PMd tracts, as a potential intervention target to enhance motor recovery.…”
Get full text

Tropical infections and the gut microbiome: dysbiosis, recovery, and clinical implications by Biruk Demisse Ayalew, Muhammad Umar, Muhammad Saeed, Ahtisham Ali, Kaleb Assefa Berhane, Temesgen Mamo Sharew, Yonatan Abbawa Zewdie, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Abate Bane Shewaye

“…Therapeutic interventions, including probiotics and fecal microbiota transplantation (FMT), show promise in aiding microbiome restoration. …”
Get full text

Quercetin‐Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling by Jiaqi Liu, Youhua Liu, Chaoqun Huang, Chuan He, Tongyudan Yang, Ruiti Ren, Zimeng Xin, Xinxia Wang

“…Here in this study, it is demonstrated that quercetin intervention significantly reverses obesity‐related phenotypes through reshaping the overall structure of microbiota, especially boosting colonization of the beneficial gut commensal Akkermansia muciniphila (A. muciniphila). …”
Get full text

Advances in cardiac organoid research: implications for cardiovascular disease treatment by Ziteng Huang, Keran Jia, Yadan Tan, Yang Yu, Wudian Xiao, Xiangyu Zhou, Jingyan Yi, Chunxiang Zhang

“…Consequently, the development of accurate models that simulate cardiac function holds significant scientific and clinical value for both disease research and therapeutic interventions. …”
Get full text

Augmented Reality and Computational Simulations for the Preprocedural Planning of Transcatheter Aortic Valve Replacement After Previous Transcatheter Mitral Valve Replacement by Roberta Scuoppo, Chiara Catalano, Eleonora Costagliola, Stefano Cannata, Salvatore Pasta, Caterina Gandolfo

“…The use of AR in the operating room enhanced the understanding of device positioning, offering a new dimension of precision of the complex cardiovascular intervention. This study concludes that integrating AR, 3D printing, and computational simulations into preprocedural planning for high-risk structural intervention can significantly improve procedural outcomes by enhancing accuracy, safety, and operator confidence.…”
Get full text

Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder by Shi Tang, Bei Huang, Yanlin Wang, Yaping Liu, Jing Wang, Li Zhou, Siyi Gong, Yuhua Yang, Joey WY Chan, Steven WH Chau, Winnie CW Chu, Jill Abrigo, Jean-François Gagnon, Yun Kwok Wing

Get full text

From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases by Kaixuan Chen, Longjun Chen, Yizhong Ma, Siqi Chen, Jinze Liu, Hangyu Zhou, Yuzhu Chen, Guanyi Liu

“…The skeletal system is an important support structure in the human body, and its homeostatic state is highly relevant to the development of a wide range of orthopaedic diseases. …”
Get full text

Unraveling a novel FBN1 variant in Marfan syndrome with dilated aortic root manifestation by Amirreza Sabahizadeh, Amir Askarinejad, Saranaz Seyed AliAkbar, Mahdieh Soveizi, Golnaz Houshmand, Hojjat Mortezaeian, Amin Elahifar, Majid Maleki, Samira Kalayinia

“…In silico analysis suggested a deleterious impact on protein structure and function, supporting their pathogenic classification. …”
Get full text