Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious Diseases by Nidhi Varshney, Rajan Kumar Pandey, Amit Mishra, Sunil Kumar, Hem Chandra Jha

“…This review explores AURKA’s structural and functional roles, emphasizing its involvement in cell cycle progression. …”
Get full text

A multi-graph convolutional network method for Alzheimer’s disease diagnosis based on multi-frequency EEG data with dual-mode connectivity by Qingjie Xu, Qingjie Xu, Libing An, Haiqiang Yang, Haiqiang Yang, Keum-Shik Hong, Keum-Shik Hong

“…This method integrates both functional and structural connectivity to more thoroughly capture the relationships among brain regions. …”
Get full text

Metformin carbon dots enhance neurogenesis and neuroprotection in Alzheimer's disease: A potential nanomedicine approach by Jing Zhang, Xuehan Yang, Sushan Wang, Jianhua Dong, Meishuang Zhang, Ming Zhang, Li Chen

“…We also examined neuronal structure by assessing Map2/NF-H/PSD95/SYN expression in the hippocampus, finding that CMCDs robustly strengthened neuronal structure. …”
Get full text

Rejuvenating aged osteoprogenitors for bone repair by Joshua Reeves, Pierre Tournier, Pierre Becquart, Robert Carton, Yin Tang, Alessandra Vigilante, Dong Fang, Shukry J Habib

“…We demonstrate that aging negatively impacts the calvarial bone structure and its osteogenic tissues, diminishing osteoprogenitor number and function and severely impairing bone formation. …”
Get full text

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South... by Angelique Hölzemer, Christina F Thobakgale, Camilo A Jimenez Cruz, Wilfredo F Garcia-Beltran, Jonathan M Carlson, Nienke H van Teijlingen, Jaclyn K Mann, Manjeetha Jaggernath, Seung-gu Kang, Christian Körner, Amy W Chung, Jamie L Schafer, David T Evans, Galit Alter, Bruce D Walker, Philip J Goulder, Mary Carrington, Pia Hartmann, Thomas Pertel, Ruhong Zhou, Thumbi Ndung'u, Marcus Altfeld

“…Better understanding of the mechanisms by which HIV-1 evades NK-cell-mediated immune pressure and the functional validation of a structural modeling approach will facilitate the development of novel targeted immune interventions to harness the antiviral activities of NK cells.…”
Get full text

Designing hydrogel for application in spinal surgery by Rongpeng Dong, Shuang Zheng, Xueliang Cheng

“…Hydrogels can act as structural supports for transplanted cells to improve cell survival, proliferation, and differentiation, as well as integration into adjacent host tissues. …”
Get full text

Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS) by Hesed Virto-Farfan, Gustavo E. Tafet

“…Dysfunctions in these circuits contribute to heightened impulsivity, impaired decision-making, and emotional dysregulation in individuals with suicidal behavior. Structural and functional abnormalities in the DLPFC, coupled with altered neurotransmitter systems and inflammatory markers, have been consistently linked to suicidality. …”
Get full text

Complexities in diagnosis and treatment of medullary thyroid cancer. Clinical observation by E. V. Frolova, N. N. Naumova, E. V. Salautin, E. A. Volodina

“…To date, the number of referrals from patients with minimal structural and functional changes in the thyroid gland is small, which indicates that the disease is often diagnosed at a later date. …”
Get full text

Forest Succession and Maternity Day Roost Selection by Myotis septentrionalis in a Mesophytic Hardwood Forest by Alexander Silvis, W. Mark Ford, Eric R. Britzke, Nathan R. Beane, Joshua B. Johnson

“…For northern bats, we suggest that day-roost selection is not a function of differences between individual tree species per se, but rather of forest successional patterns, stand and tree structure. …”
Get full text

Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk by Liquan Zhou, Jiani Li, Chen Ding, Yimiao Zhou, Zuowei Xiao

“…Natural polysaccharides (NPs), as a class of bioactive macromolecules with multitarget synergistic regulatory potential, exhibit significant advantages in diabetes intervention. This review systematically summarizes the core hypoglycemic mechanisms of NPs, covering structure–activity relationships, integration of the gut microbiota–metabolism–immunity axis, and regulation of key signaling pathways. …”
Get full text

Decreased gut microbiome-derived indole-3-propionic acid mediates the exacerbation of myocardial ischemia/reperfusion injury following depression via the brain-gut-heart axis by Xingdou Mu, Lele Feng, Qiang Wang, Hong Li, Haitao Zhou, Wei Yi, Yang Sun

“…Our findings provide new insights into the role of the gut microbiota and IPA in depression and CVD, forming the basis of intervention strategies aimed at mitigating the deterioration of cardiac function following MI/R in patients experiencing depression.…”
Get full text

BAT-TR: Turkish Adaptation of Burnout Assessment Tool (BAT) by Ömer Erdem Koçak, Oğuz Gençay, Wilmar B. Schaufeli

“…Like many other European countries, Turkey has a high rate of employee burnout which negatively affects employees’ cognitive, emotional, and physiological functions. In this regard, accurate measurement of burnout and the development of interventions in Turkey are critical. …”
Get full text

Epidemiology and hospitalization costs of chronic kidney disease in Romania by Ildiko Aliz Bradacs, László-István Bába, László Lorenzovici, Andreea Mihaela Precup, Szabolcs Farkas- Ráduly, Gyongyi Tar, Vasile Nastase, Lucia Georgeta Daina, Raul Bozu, Gyula Jozsef Nagy, Dimitrie Cristian Siriopol, Dorel Sandesc, Ovidiu Horea Bedreag, Florin Buicu, Gabriel Mircescu, Gener Ismail

“…Abstract Background Chronic kidney disease or chronic renal failure is a progressive condition defined as abnormalities of kidney structure or function, present for longer than 3 months. …”
Get full text

The Mediating Role of Self-Efficacy in the Relationship Between Locus of Control and Resilience in Primary School Students by Asimenia Papoulidi, Katerina Maniadaki

“…Participants completed a questionnaire including measures assessing resilience, locus of control, and self-efficacy. Structural equation modeling using AMOS 26.0 was used to analyze the data. …”
Get full text

Symptom network analysis of pregnancy stress, depressive symptoms and quality of life: a cross-sectional study of pregnant women in Xinjiang, China, 2023–2024 by Sufeila Shalayiding, Weicui Meng, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Therefore, the aim of this study was to reveal the specific symptom network relationships and core symptoms of pregnant women's pregnancy stress, depressive symptoms and quality of life by themselves and among the three, using a network analysis methodology that integrates the early, middle and late stages of pregnancy, in order to deepen the understanding and to guide precise health interventions. Methods From February 2023 to January 2024, a convenience sampling method was used to conduct a cross-sectional study of 1,349 pregnant women in a tertiary hospital in the Xinjiang Uygur Autonomous Region of China using the Patient Health Questionnaire Depressive Symptom Cluster and the Stress in Pregnancy and Health-Related Quality of Life Scale, to construct a network to perform network estimation, and to determine core nodes of the network structure based on the centrality indexes. …”
Get full text

Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies by Yuhan Wang, Tingting Zhou, Jiajing Zhao, Hongjun Zhu, Xiaodong Tan, Jiahao Chen, Zhuojun Zhang, Lijuan Shen, Shu Lu

“…This review aims to systematically analyze how structural and functional remodeling of Ca2+-handling proteins drives DCM progression and to evaluate therapeutic strategies targeting these pathways. …”
Get full text

ACO-NM hybrid optimization calculation method for transit time of oxygen activation logging in CO2 injection profile by WANG Zhengyan, CHEN Meng, YANG Guofeng, LIU Guoquan, PEI Yang, CHEN Qiang

“…Compared with the traditional methods involving manual peak boundary determination combined with weighted average or Gaussian function fitting methods, this approach offered higher fitting efficiency, reduced human intervention, and lower calculation error.Through a comparative analysis of pulse neutron oxygen activation data processing and interpretation in well X (CO2 injection well) of the M oilfield, the established ACO-NM optimization model could effectively realize the bimodal separation of overlapping peaks in tubing and casing spaces. …”
Get full text

Research progress on the mechanism of succinylation in tumorigenesis and development by Su Xiayi, Bai Jie, Zhang Baihong, Liu Yong

“…Succinylation is a post-translational modification process that plays a crucial role in regulating protein structure and function and is implicated in the pathogenesis of various diseases. …”
Get full text

Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease by Weitao Geng, Dehua Wang, Jiangye He, Xinyuan Li, Longgang Jia, Yanping Wang

“…Chronic kidney disease (CKD) is one kind of illness with abnormal renal structure and function caused by many factors. Probiotics can be used to regulate intestinal microflora and enhance intestinal mucosal barrier, thus, intervention with probiotics may be regarded as one of the potential ways to protect against CKD. …”
Get full text

Connecting the Dots: Linking Centrality Measures to Peer Perceptions in Elementary School Friendship Networks by Prochnow Tyler, Keightley Samuel, Patterson Megan S., Lease Michele

“…This study highlights the complex interplay between structural positions in social networks and peer perceptions of social functioning. …”
Get full text