Clinical and Immunological Analysis of Retinal Pigment Epithelium Transplantation Derived from Induced Pluripotent Stem Cells under Pharmacological Immunosuppression in Rabbits by N. V. Neroeva, N. V. Balatskaya, A. G. Brilliantova, L. A. Katargina, A. E. Kharitonov, M. A. Lagarkova, A. N. Bogomazova

“…When testing biomedical cellular products, special requirements are placed on the animal model, which should simulate pathological changes, such as in humans, and have sufficient immunological tolerance to xenogenic human cells, enabling them to function fully. For this purpose, lines of immuno-modified or immunodeficiency animals are used, usually small rodents (rats and mice), but the small size and structure of their eyes do not allow manipulation in vitreoretinal interventions in humans. …”
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Relationships between different components of intolerance of uncertainty and symptoms of obsessive–compulsive disorder: a network analysis by XiaoBin Ding, Ze Zhao, Jie Wang, Chen Chen, ShuChan Ding, JingYi Gao, Jun Deng, Dan Liu

“…No significant gender differences were found in the network structure. Conclusions This study revealed specific component–symptom patterns between different facets of intolerance of uncertainty (IU) and various obsessive-compulsive symptoms. …”
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Daily time series of 12 human thermal stress indices in Greece, aggregated at commune level (1998–2022)Zenodo by Georgios Charvalis, Michalis Koureas, Chloe Brimicombe, Chara Bogogiannidou, Fani Kalala, Varbara Mouchtouri, Christos Hadjichristodoulou

“…Additionally, it can be used as a basis of a system to inform and devise targeted interventions and policies aimed at mitigating the effects of extreme heat events. …”
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Surgical ICU Admission Criteria: A Scoping Review by Kenneth L. Abbott, MD, Philip Hong, MD, Matthew M. Ruppert, MS, Purvi P. Patel, MD, MHPE, FACS, Philip A. Efron, MD, FACS, FCCM, Natasha Keric, MD, MBA, FACS, Lewis J. Kaplan, MD, FACS, FCCP, FSIS, MCCM, Niels D. Martin, MD, FACS, FCCM, Tyler J. Loftus, MD, PhD, FACS

“…Abstracted data addressed SICU structure, function, findings, and potential future directions. …”
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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosisResearch in context by Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong, Ruize Yu, Rong Jiang, Haotian Dai, Jingyuan Zhang, Xiaohua Gu, Yongle Xu, Chunwei Li, Shan Shan, Feng Xu, Yue Hong, Tao Ren

“…Summary: Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. Recently, the structural and functional defects of small airways have received attention in the early pathogenesis of IPF. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. …”
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Elucidating ATP’s role as solubilizer of biomolecular aggregate by Susmita Sarkar, Saurabh Gupta, Chiranjit Mahato, Dibyendu Das, Jagannath Mondal

“…Computer simulation links ATP’s solubilizing role to its ability to modulate protein’s structural plasticity by unwinding protein conformation. …”
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Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses by Susu Zhang, Susu Zhang, Keli Zong, Jiajun Ruan, Xiaojing Liu, Xu Zhao, Youzhi Zhang, Chun Hu, Xingzhou Li

“…Human rhinovirus 14 (HRV-14) is a leading cause of the common cold, with its 3C protease (3Cpro) playing a crucial role in viral replication by cleaving polyproteins into functional proteins and enzymes. This makes 3Cpro a promising target for therapeutic intervention. …”
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Review: Enhancing the Bioavailability and Stability of Anthocyanins for the Prevention and Treatment of Central Nervous System-Related Diseases by Lan Zhang, Yan Wang, Yalong Cao, Fangxu Wang, Fang Li

“…Future research will focus on the innovative design of nano-delivery systems and structural modification based on artificial intelligence. …”
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Sleep problems from age two to five years and neurological outcome in children born extremely preterm: a cross-sectional study by Kristine Marie Stangenes, Kristine Marie Stangenes, Mari Hysing, Maria Vollsæter, Irene Bircow Elgen, Trond Markestad, Bjørn Bjorvatn, Bjørn Bjorvatn

“…Children with Full scale IQ < 85 were at increased risk of general sleep problems (adjusted odds ratio - aOR 1.8), as well as nighttime awakenings (aOR 2.8), and early morning awakenings (OR 2.9), but not for difficulty falling asleep compared to those with higher IQ levels.EPT children with moderate to severe NDD (NDD 2 and 3) showed a higher prevalence of general sleep problems [adjusted odds ratio (aOR) 3.9], nighttime awakenings (aOR 4.8), and early morning awakenings (OR 7.9) compared to those with no NDD (NDD 0).ConclusionGeneral and specific sleep problems were associated with low cognitive function and moderate to severe NDD. Our findings underscore the importance of addressing sleep within a comprehensive care framework for EPT children and highlight the need for addressing and target interventions for sleep problems.…”
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Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review by Xinming Yang, Xinming Yang, Bo Li, Bo Li, Bo Li, Linna Wu, Ying Cui, Ying Cui

“…A comprehensive search of databases, including PubMed, Web of Science, MEDLINE, and Embase, was conducted, including 79 studies on acupuncture interventions for VCI. Acupoints and their underlying anatomical structures related to peripheral nerves were summarized, and the potential pathways of acupuncture effects via different peripheral nerves were explored.ResultsThe results showed that acupuncture, by stimulating specific acupoints on the head, face, torso, and limbs, significantly affects peripheral nerve networks, including the cervical, lumbar, and sacral plexuses, thoracic nerves, vagus nerve, trigeminal nerve and its branches. …”
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Salt, Aldosterone, and Parathyroid Hormone: What Is the Relevance for Organ Damage? by Cristiana Catena, Gian Luca Colussi, Gabriele Brosolo, Nicole Bertin, Marileda Novello, Andrea Palomba, Leonardo A. Sechi

“…Structured interventions on lifestyle have been suggested as a cost-effective strategy for prevention of cardiovascular disease. …”
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The Role of Local Governments in the Transformation of Public Spaces: The Case of Atakum City Square by Deniz YILDIZ USLU, Tuğçe ŞANLI KATI

“…The main findings show that the power dynamics of local governments affect the functional structure of the square and lead to a narrowing of the diversity of activities. …”
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Determination of the processes driving the acquisition of immunity to malaria using a mathematical transmission model. by João A N Filipe, Eleanor M Riley, Christopher J Drakeley, Colin J Sutherland, Azra C Ghani

“…We have developed an age-structured mathematical model of malaria transmission in which acquired immunity can act in three ways ("immunity functions"): reducing the probability of clinical disease, speeding the clearance of parasites, and increasing tolerance to subpatent infections. …”
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A new approach to cultural scripts of trauma sequelae assessment: The sample case of Switzerland. by Rahel Bachem, Amelie Mazza, David J Eberle, Andreas Maercker

“…<h4>Method</h4>Five semi-structured focus groups were conducted with psychotraumatologists (n = 8) and Swiss trauma survivors (n = 7). …”
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Moderate exercise improves semen quality by enhancing antioxidant and micronutrient levels in obese men by Alaa Sajid Shukur, Nihad Nejres Hilal

“…Semen parameters, including volume, count, motility, and morphology, were also evaluated after 12 weeks of structured moderate-intensity physical activity. Results Biochemical profiling revealed significant elevations in serum CoQ10 (p = 0.04), GSH (p = 0.006), and vitamin D (p = 0.009) following exercise intervention. …”
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Decannulation ahead: a comprehensive diagnostic and therapeutic framework for tracheotomized neurological patients by Rainer Dziewas, Tobias Warnecke, Bendix Labeit, Volker Schulte, Inga Claus, Paul Muhle, Anna Brake, Lena Hollah, Anne Jung, Jonas von Itter, Sonja Suntrup-Krüger

“…Main body Key diagnostic strategies for assessing decannulation readiness focus on airway protection, airway patency, bronchial secretion management, and cough function. These are collectively introduced as the A2BC criteria in this review. …”
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Narrative production abilities of children with autism by Tal Naman, Sveta Fichman, Carmit Altman, Nufar Sukenik

“…Macrostructure analysis examined the organization and structure of the narratives while microstructure analysis focused on linguistic elements such as syntax and word use. …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…Additionally, their impact on protein stability was examined by I-mutant 3.0, MUpro, Consurf, and Netsurf 2.0, combined with conservation and solvent accessibility analyses. Structural analysis with normal and mutant residues of the protein harboring these disease-associated functional SNPs was conducted using TM-align and SWIS MODEL, with visualization aided by PyMOL and the BIOVINA Discovery Studio Visualizer. …”
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Leverage, entrenched managers, and moderating effect of main shareholder’s influence by Bruno José Canassa, Lucas Allan Diniz Schwarz, Maurício Ribeiro do Valle

“…ABSTRACT This study associated the leverage of Brazilian listed companies with their managers’ search for protection against the risk of main shareholder’s intervention. Although the literature has pointed out that managers might increase leverage in order to protect themselves against takeovers, it had not yet investigated the use of debt as a defense against the risk of intervention by the company’s main shareholder. …”
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