A quantitative study to evaluate the controls and accountability measures in place to alleviate the leadership and governance challenges impacting the realization of the National H... by Samuel Vuyo Mokoena, Panjasaram Naidoo

“…Abstract Objectives Governance and leadership are regarded as the most crucial aspects in delivering quality health care, and yet they are arguably the most complex functions of any health system. The objective of the study was to investigate the structural problems affecting the implementation of the National Health Insurance (NHI) and address the challenges affecting the NHI building blocks. …”
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Visible Light Active Natural Rutile Photocatalyst Obtained via Nano Milling by Kata Saszet, Enikő Eszter Almási, Ádám Rácz, Katalin Bohács, Milica Todea, Klára Hernádi, Zsolt Pap, Lucian Baia

“…Samples with different mean primary particle size values were obtained by wet stirred media milling, their compositional and structural properties were investigated, and their photocatalytic properties were evaluated under both visible- and UV-light illumination for the degradation of phenol and ibuprofen. …”
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Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection? by Yajun Qiao, Ruiying Cheng, Xiaohui Li, Huimin Zheng, Juan Guo, Lixin Wei, Tingting Gao, Hongtao Bi

“…These factors induce structural and functional alterations in the gut microbiota, disrupting gut-brain axis homeostasis and contributing to the higher prevalence of depression in plateau regions relative to flatland areas. …”
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Urban Land Use Classification Model Fusing Multimodal Deep Features by Yougui Ren, Zhiwei Xie, Shuaizhi Zhai

“…Subsequently, VGG-16 (Visual Geometry Group 16) is used to extract the image convolutional features of the block units, obtaining the raster structure deep features. Finally, the transformer is used to fuse both topological and raster structure deep features, and land use classification is completed using the softmax function. …”
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Personalized EEG-guided brain stimulation targeting in major depression via network controllability and multi-objective optimization by Aihua Wang, Jingnan Sun

“…Spectral graph embedding and structural controllability theory were applied to identify candidate stimulation targets. …”
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Metabolomics-driven exploration of sphingosine 1-phosphate mechanisms in refractory epilepsy by Xinyu Ben, Chang Li, Jiaqi Liu, Ting Liu, Jingyi Tong, Qifu Li

“…Additional omics analyses were conducted using cellular and animal models to explore the specific functions of S1P and related metabolic pathways. Our findings demonstrated that ACER3/SphK1/S1P play protective roles in maintaining mitochondrial structure and function. …”
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The Effects of Endoscopic Third Ventriculostomy Versus Ventriculoperitoneal Shunt on Neuropsychological and Motor Performance in Patients with Idiopathic Normal Pressure Hydrocepha... by Gianluca Scalia, Nicola Alberio, Pietro Trombatore, Mariangela Panebianco, Grazia Razza, Gianluca Galvano, Giovanni Federico Nicoletti, Francesca Graziano

“…However, comparative evidence regarding their impact on cognitive, motor, and structural outcomes remains limited. This study, titled ENVENTOR-iNPH (endoscopic ventriculostomy versus shunt on neuropsychological and motor performance in patients with iNPH), aims to address this gap through a rigorously designed comparative protocol. …”
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Reduction in Brain Parenchymal Volume Correlates with Depression and Cognitive Decline in HIV-Positive Males by Radmila Perić, Duško Kozić, Snežana Brkić, Dajana Lendak, Jelena Ostojić, Vojislava Bugarski Ignjatović, Jasmina Boban

“…These findings highlight the dual impact of HIV on cognitive and emotional health, with structural vulnerabilities in key brain regions playing a central role. …”
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Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study by Joanne Gourgouvelis, Paul Yielder, Bernadette Murphy

“…Exercise as an ad-on treatment for MDD is a promising therapeutic strategy shown to improve mood, cognitive function, and neural structure and function. To advance our understanding of how exercise impacts neural function in MDD, we must also understand how exercise impacts healthy individuals without MDD. …”
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Osteocalcin and metabolic syndrome by Consolim-Colombo Fernanda M., Lopes Heno Ferreira

“…We explore osteocalcin's dual functions: its canonical role in bone mineralisation and structural integrity and its emerging significance as an endocrine regulator of energy homeostasis. …”
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Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases by Tian Tian, Monan Liu, Peter J. Little, Hans Strijdom, Jianping Weng, Suowen Xu

“…The GFRAL receptor is central to its function, mediating the anorexigenic and metabolic effects of GDF15. …”
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Risk factors associated with poor pain outcomes following primary knee replacement surgery: Analysis of data from the clinical practice research datalink, hospital episode statisti... by Hasan Raza Mohammad, Rachael Gooberman-Hill, Antonella Delmestri, John Broomfield, Rita Patel, Joerg Huber, Cesar Garriga, Christopher Eccleston, Rafael Pinedo-Villanueva, Tamer T Malak, Nigel Arden, Andrew Price, Vikki Wylde, Tim J Peters, Ashley W Blom, Andrew Judge

“…Results are presented as relative risk ratios and adjusted risk differences (ARD) by fitting a generalized linear model with a binomial error structure and log link function.<h4>Results</h4>Information was available for 4,750 patients from 2009 to 2016, with a mean age of 69, of whom 56.1% were female. 10.4% of patients had poor pain outcomes. …”
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Autological bone marrow concentrate for the treatment of early stages of femoral head avascular necrosis (literature review) by M. A. Panin, N. V. Zagorodnii, A. V. Boiko, A. S. Petrosyan

“…According to the overwhelming number of authors, the core decompression using autologous bone marrow cells is highly effective, significantly reducing the intensity of pain syndrome and improving the function of the hip joint. The results will be more encouraging with the further development of regenerative medicine, which will provide new samples of cellular preparations for bone tissue structure restoration.…”
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Codesign with citizens to prevent cardiometabolic diseases in disadvantaged neighbourhoods: an interview study on needs and priorities among stakeholders in Sweden by Meena Daivadanam, Helle Mølsted Alvesson, Mats Martinell, Hedda Ottesen, Laran Matta, Jonas Idevall Hagren, Pia McAleenan

“…Additionally, the persistence of a siloed system structure of organisations and the risks associated with accessing target populations through local intermediaries added to the challenges.Conclusion This study highlights the lack of integration of organisational values and functions within and across organisations, hindering cross-sector collaboration and citizen engagement in prevention and health promotion activities. …”
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NAMICA Encapsulation Technology in an Animal Model: MICROscale vs. NANOscale Hyaluronic Acid Particles in Skin Remodeling (Part 2) by Pavel Burko, George Sulamanidze, Dmitriy Nikishin

“…Hyaluronic acid (HA), an integral non-sulfated glycosaminoglycan, plays a pivotal role in numerous biological functions within the extracellular matrix, crucially influencing tissue hydration and cellular activities. …”
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Grief, bereavement and prolonged grief disorder: scoping and mapping the evidence by Gary Raine, Claire Khouja, Meena Khatwa, Helen Fulbright, Katy Sutcliffe, Amanda J. Sowden

“…Conclusions We identified a large number of reviews, but key evidence gaps exist, particularly in relation to intervention cost-effectiveness and social, organisational or structural-level interventions that are needed for addressing inequities and other modifiable factors that can impair grieving and potentially increase the risk of PGD. …”
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Ruminative and mood associations for age differences in social and directive reasons to think and talk about life experiences. by Jorge J Ricarte, Laura Ros, Jose M Latorre, Tom J Barry

“…These reminiscence processes were also differentially associated with depression symptoms between age groups when tested in structural equation models. In older participants, but not young participants, the directive function was negatively associated with depression severity; in young participants, but not old participants, the social function was negatively associated with depression severity. …”
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Soil-transmitted helminth infection, loss of education and cognitive impairment in school-aged children: A systematic review and meta-analysis. by Noel Pabalan, Eloisa Singian, Lani Tabangay, Hamdi Jarjanazi, Michael J Boivin, Amara E Ezeamama

“…The benefit of deworming will be enhanced by strategically employing, integrated interventions. Thus, multi-pronged inter-sectoral strategies that holistically address the environmental and structural roots of child cognitive impairment and educational loss in the developing world may be needed to fully realize the benefit of mass deworming programs.…”
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Constructs across a hierarchical, dimensional model of psychopathology show differential associations with social and general cognitive ability. by Scott D Blain, Jerillyn S Kent, Timothy A Allen, Carly A Lasagna, Chloe A Peyromaure de Bord, Aisha L Udochi, Scott R Sponheim, Colin G DeYoung, Ivy F Tso

“…Data were analyzed using bi-factor exploratory structural equation modeling. Detachment-a psychopathology dimension conceptually linked to social functioning-was associated with worse social cognition, independent of general cognitive ability. …”
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Effect of cognitive-only and cognitive-motor training on preventing falls in community-dwelling older people: protocol for the smart±step randomised controlled trial by Catherine Sherrington, Barbara Toson, Jessica Turner, Jacqueline Close, Daina L Sturnieks, Jasmine Menant, Michael Valenzuela, Kim Delbaere, Robert D Herbert, Amit Lampit, Kathryn Broadhouse, Daniel Schoene, Stephen R Lord, Daina Sturnieks, Stephen Lord, Rob Herbert, Cameron Hicks, Mayna Ratanapongleka, Natassia Smith, Carly Chaplin, Bethany Halmy, Angeliki Stivactas, Ashley Woodbury, Dinaz Parekh, Matthew Hand, Isabella Hoi Kei leung, Polly Barr, Jennifer Davis

“…Secondary outcomes include the proportion of fallers, physical and cognitive performance in 300 participants, and brain structure and function in 105 participants who will undertake MRI scans at baseline and 6 months. …”
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