Weighted Hybrid Random Forest Model for Significant Feature prediction in Alzheimer’s Disease Stages by M. Rohini, D. Surendran

“…As a consequence of this challenge discussed, whether all the mild cognitively impaired people change to AD cohorts or remain in normal cognition and identification of the structural and functional features remains underexplored. …”
Get full text

Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies by Ji-Hung Wang, Yu-Li Lin, Bang-Gee Hsu

“…In the kidney, endothelial cells maintain vascular integrity and function, contribute to filtration, and support other renal structures. …”
Get full text

Issues of Interpretation and Application of the Notion of “International Legal Legitimation” by A. M. Korzhenyak

“…On the basis of integrative (multidimensional) approach to scientific legal research, taking into account such principles of scientific cognition as theoretical novelty and scientific relevance, the study was guided, in particular, by hermeneutic, formal-legal, formallogical, structural-functional and systematic methods, as well as methods of analysis and synthesis, legal modelling, legal construction and strategic planning.RESEARCH RESULTS. …”
Get full text

Expert Consensus on Full-Cycle Rehabilitation for Elderly Patients with Chronic Heart Failure by HE Jing, JIA Jie, CHEN Xin, DONG Anqin, DING Yipeng, LIAO Weijing, ZHENG Jiejiao, YU Binbing, CHEN Zuobing, FANG Yuan, YAO Liqing, ZHU Yiping, JIANG Zewu, LI Lei, ZHANG Xiu, REN Ling

“…It outlines a full-cycle rehabilitation work model, encompassing management processes, assessment of functional impairments, rehabilitation evaluations and therapeutic interventions. …”
Get full text

Long-term senolytic therapy with Dasatinib and Quercetin alleviates lipofuscin-dependent retinal degeneration in mice by Bo Yang, Kunhuan Yang, Ruitong Xi, Shiying Li, Jingmeng Chen, Yalin Wu

“…Currently, there are no effective interventions for dry AMD. Although there is already evidence suggesting a link between cellular senescence and age-related diseases, it is still unclear whether long-term senolytic therapy with Dasatinib and Quercetin (D + Q) can slow the progression of dry AMD and ultimately prevent retinal structural damage and function loss. …”
Get full text

Lingual and Maxillary Labial Frenuloplasty with Myofunctional Therapy as a Treatment for Mouth Breathing and Snoring by Chirag Govardhan, Janine Murdock, Leyli Norouz-Knutsen, Sanda Valcu-Pinkerton, Soroush Zaghi

“…Mouth breathing is a multifactorial problem that can be attributed to structural, functional, and neurological etiologies, which are not all mutually exclusive. …”
Get full text

Family support and its determinants among older patients with chronic diseases in Guangzhou communities: a mixed-methods study by Yingxian Yu, Lulin Yan, Mi Yao, Guoqiang Sun, Lin Xu, Hao Tang

“…Of the older patients with chronic diseases, 83.7% had good family function, as indicated by an APGAR score of 9 (interquartile range 7–10) or higher. …”
Get full text

Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging by Sarah E. Webster, Sydney M. Les, Nico Deleon, Daken M. Heck, Naomi L. Tsuj, Michael J. Clemente, Prentiss Jones, Nichol E. Holodick

“…By increasing our understanding of ocular aging, these results show that there is a broader role for the immune system in retinal function and integrity in advanced age, opening new areas for the exploration of immune-related interventions in age-associated retinal conditions.…”
Get full text

Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota by Xingduo Liu, Chaoqun Sun, Yuqiong Dai, Feifei Duan, Tianzhen He, Menglu Zhen, Enxi Liang, Shuting Zhang, Yun Xia, Nianchun Hu, Ruoting Zhan, Ruoting Zhan, Dong Deng, Sijun Liu

“…Beta diversity revealed structural divergence between treatment and model groups. …”
Get full text

Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives by Zitong Zhang, Jiahua Meng, Jiaqi Tian, Ning Li, Zhen Chen, Xiang Yun, Dandan Song, Fei Li, Shuyin Duan, Lin Zhang

“…In females, MNPs affect ovarian tissue structure and function, interfere with hormone secretion, and impact the endometrium and embryo implantation. …”
Get full text

Research progress on NAT10-mediated acetylation in normal development and disease by Da Qin, Qing Liu, Xiaochao Ma, Rui Wang, Tianyu Lu, Yue Yang, Ze Tang, Yanbo Zhu

“…This review summarizes the structural and functional roles of NAT10-mediated acetylation in physiological contexts, including cell division, differentiation, inflammation, aging, and viral infection, as well as its emerging roles in cancer. …”
Get full text

Advanced Agrivoltaics in Italy: Innovation, Sustainability, and Regulation for the Future of Rural Energy by Tedioli Francesco

“…Distinct from conventional ground-mounted photovoltaics, these systems support the simultaneous performance of agricultural and energy-producing functions. The study examines recent regulatory interventions – most notably the Unified Renewable Energy Act and the NRRP incentive programme – while addressing persistent implementation challenges. …”
Get full text

Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights by Chen-Ying Zhu, Pei-Han Yu, Qi Sun, De-Fei Hong, Chang Yang, Hua Naranmandura

“…Additionally, future investigations employing integrated multi-omics approaches, advanced structural biology techniques, and AI-driven analyses will further unravel their precise regulatory mechanisms, paving the way for personalized therapeutic interventions, while critically evaluating their translational potential and clinical applications.…”
Get full text

Decellularized Adipose Matrix Rejuvenates Photoaged Skin through Immune Microenvironment Modulation by Jialiang Zhou, Shengjie Jiang, Liyun Wang, Kaili Lin, Jianyong Wu, Haijun Gui, Zhen Gao

“…Current clinical interventions primarily target structural defects, while immune modulation remains underexplored. …”
Get full text

Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT... by Johan Jakobsson, Chris Burtin, Mattias Hedlund, Carl-Johan Boraxbekk, Jonas Westman, Nina Karalija, Per Stål, Thomas Sandström, David Ruttens, Harry R. Gosker, Jana De Brandt, André Nyberg

“…Key secondary outcomes include change from baseline exercise tolerance, brain structure, and function measured by MRI, neuroinflammation measured by PET/CT, systemic inflammation, and intramuscular adaptations. …”
Get full text

Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives by Zilv Ye, Zilv Ye, Sutong Wang, Zhengdong Wan, Birun Huang, Jiawei Guo, Jiawei Guo

“…Diabetic cardiomyopathy (DCM) is a major complication of diabetes mellitus, characterized by microvascular dysfunction and progressive structural and functional deterioration of the heart. …”
Get full text

Molecular constraints of sarcopenia in the ageing muscle by S. Damanti, S. Damanti, E. Senini, R. De Lorenzo, A. Merolla, S. Santoro, C. Festorazzi, M. Messina, G. Vitali, C. Sciorati, A. A. Manfredi, P. Rovere-Querini, P. Rovere-Querini

“…Skeletal muscle comprises multinucleated fibers supported by satellite cells—muscle stem cells essential for repair and regeneration. With age, both the structure and function of these components deteriorate: myonuclei become disorganized, gene expression skews toward catabolic, inflammatory, and fibrotic pathways, and satellite cell numbers and activity decline. …”
Get full text

Radiation Retinopathy: Microangiopathy-Inflammation-Neurodegeneration by Anja-Maria Davids, Inga-Marie Pompös, Norbert Kociok, Jens Heufelder, Sergej Skosyrski, Nadine Reichhart, Antonia M. Joussen, Susanne A. Wolf

“…Methods: We performed a proton beam irradiation of 5–15 Cobalt-Gray-Equivalent (CGE) of the eyes of female C57Bl6/J (Cx3cr1^+/+), Cx3cr1^gfp/+ and Cx3cr1^gfp/gfp mice mimicking the clinical situation and evaluated the structure, function and cellular composition of the retina up to 24 weeks after irradiation. …”
Get full text

The modern aspects of patients’ nutritional support during rehabilitation by A. V. Shvets, О. М. Ivanko, Yu. M. Deputat, O. V. Gorishna, O. V. Rychka

“…So at least one from six servicemen with battle wounds and injuries required various type of rehabilitation interventions. It was calculated that in modern war, the share of combined injures (injures of body multiple parts) in structure of sanitary losses is increasing (till 36.8 % based on MMC CRC data). …”
Get full text

The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review by Filippo Migliorini, Federico Cocconi, Tommaso Bardazzi, Virginia Masoni, Virginia Gardino, Gennaro Pipino, Nicola Maffulli

“…Indeed, a better understanding of the function of the LT and its implications for clinical outcomes in the presence of a torn LT is required. …”
Get full text