The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders by Daniel Alcolea, Jordi Clarimón, María Carmona‐Iragui, Ignacio Illán‐Gala, Estrella Morenas‐Rodríguez, Isabel Barroeta, Roser Ribosa‐Nogué, Isabel Sala, M. Belén Sánchez‐Saudinós, Laura Videla, Andrea Subirana, Bessy Benejam, Sílvia Valldeneu, Susana Fernández, Teresa Estellés, Miren Altuna, Miguel Santos‐Santos, Lídia García‐Losada, Alexandre Bejanin, Jordi Pegueroles, Víctor Montal, Eduard Vilaplana, Olivia Belbin, Oriol Dols‐Icardo, Sònia Sirisi, Marta Querol‐Vilaseca, Laura Cervera‐Carles, Laia Muñoz, Raúl Núñez, Soraya Torres, M. Valle Camacho, Ignasi Carrió, Sandra Giménez, Constance Delaby, Ricard Rojas‐Garcia, Janina Turon‐Sans, Javier Pagonabarraga, Amanda Jiménez, Rafael Blesa, Juan Fortea, Alberto Lleó

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The Effect of Overcoming the Digital Divide on Middle Frontal Gyrus Atrophy in Aging Adults: Large-Scale Retrospective Magnetic Resonance Imaging Cohort Study by Yumeng Li, Xinyue Zhang, Jiaqing Sun, Junying Zhang, Aiqin Zhu, Xin Li, Zhanjun Zhang

“…ResultsThe DD group showed significant deficits in executive function (tPdtPdPtPP ConclusionsOlder adults who overcome the DD demonstrate preserved gray matter structure and slower cognitive decline, particularly in frontotemporal regions critical for executive function. …”
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Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease by Chika Onochie, Keturah Evi, Cristian O’Flaherty

“…Reversible oxidative modifications regulate enzymatic activity, signaling cascades, and structural stability, supporting normal sperm function, whereas irreversible oxidative damage impairs motility, acrosome reaction, and DNA integrity, contributing to male infertility. …”
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Reinitiating lung development: a novel approach in the management of bronchopulmonary dysplasia by Xuewei Cui, Jianhua Fu

“…Current management of BPD relies heavily on pharmacotherapies and alterations in ventilatory strategies. However, these interventions only mitigate BPD symptoms without addressing underlying alveolar, vascular, structural, and functional deficiencies. …”
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Causal AI Recommendation System for Digital Mental Health: Bayesian Decision-Theoretic Analysis by Mathew Varidel, Victor An, Ian B Hickie, Sally Cripps, Roman Marchant, Jan Scott, Jacob J Crouse, Adam Poulsen, Bridianne O'Dea, Sarah McKenna, Frank Iorfino

“…ResultsThe causal AI recommendation system recommends intervention targets as a function of a user’s baseline presentation, the causal effects of the intervention on itself and other domains, and the utility function. …”
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The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise by Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim

“…Frailty syndrome, a condition marked by increased vulnerability due to age‐related physiological decline, exerts a profound impact on skeletal muscle structure and function. Despite its widespread prevalence, the underlying mechanisms contributing to frailty‐associated muscle deterioration remain poorly elucidated. …”
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Cerebral Palsy Link to Sensorimotor System, Cognition, Emotion and Nociplastic Pain by Wolfgang Laube, Mathilde Sengoelge

“…This damage results in a functional developmental disorder that also affects the structure and function of the neuromatrix in a graded manner due to chronic deconditioning. …”
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DeSPPNet: A Multiscale Deep Learning Model for Cardiac Segmentation by Elizar Elizar, Rusdha Muharar, Mohd Asyraf Zulkifley

“…Background: Cardiac magnetic resonance imaging (MRI) plays a crucial role in monitoring disease progression and evaluating the effectiveness of treatment interventions. Cardiac MRI allows medical practitioners to assess cardiac function accurately by providing comprehensive and quantitative information about the structure and function, hence making it an indispensable tool for monitoring the disease and treatment response. …”
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Relationship between social activities and cognitive impairment in Chinese older adults: the mediating effect of depressive symptoms by Qianke Yang, Shichong Lin, Zhuyun Zhang, Shuhao Du, Dan Zhou

“…BackgroundThe differential impacts of various social activities on dementia prevention and the mediating role of depression in this relationship remain unclear.ObjectivesThis study aimed to identify the effects of different social activities on cognitive function, examine the mediating role of depression, and provide evidence for targeted interventions to prevent cognitive decline.MethodsUsing data from CHARLS, we employed RCS analysis and Structural Equation Modeling to examine the relationships between social activities, depression, and cognitive function in older adults.ResultsSocial activity participation is non-linearly inversely related to both cognitive impairment and depression risk. …”
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Sex-dependent impact of parental verbal abuse on brain lateralization of language by Xingzhen Wang, Jiaojian Wang, Zhenglong Lin, Yang Yang, Min Xu

“…Parental verbal abuse (PVA) is a pervasive yet often overlooked form of child maltreatment linked to significant changes in brain structures crucial for language. This study investigated the impact of PVA on behavior, brain structure, and function related to language, examining how these effects may differ between females and males. …”
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Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration by Yifei Zheng, Jiahui Yang, Xuanyao Li, Linjie Qi, Zhuo Zheng, Jiming Kong, Guohui Zhang, Ying Guo

“…Neuronal senescence, characterized by a progressive decline in structural integrity and function, is a hallmark of neurodegenerative diseases. …”
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Optical Coherence Tomography in the Diagnosis of Open-angle Glaucoma by Yu. N. Yusef, E. E. Kazaryan

“…Future prospects for OCT-A in glaucoma diagnostics using artificial intelligence to predict structural and functional features based on early vascular changes will provide opportunities for early identification of patients at high risk for developing and rapidly progressing glaucoma. …”
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The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review by Jitske Vandersmissen, Ilse Dewachter, Koen Cuypers, Dominique Hansen

“…Abstract Background Type 2 diabetes (T2DM) affects brain structure and function, and is associated with an increased risk of dementia and mild cognitive impairment. …”
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Description of the Human Penile Urethra Epithelium by Matisse Duval, David Brownell, Stéphane Chabaud, Alexis Laungani, Eric Philippe, Stéphane Bolduc

“…<i>Background and Objectives</i>: The male urethra is a complex structure that plays a critical role in genitourinary health and function. …”
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Prevention and Treatment of Peritoneal Dialysis-Associated Fibrosis with Intraperitoneal Anti-Fibrotic Therapy in Experimental Peritoneal Fibrosis by Chiao-Yin Sun, Yu-Ting Hsieh, Shang-Chieh Lu, Chi-Ying F. Huang

“…The key outcomes included changes in the peritoneal structure, inflammatory markers, and transcriptional regulation. …”
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Modulating ion channels with nanobodies by Sher Ali, Ashley Suris, Yun Huang, Yubin Zhou

“…Gaining a deeper understanding of their structural and functional properties has significant implications for developing therapeutic interventions. …”
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Gut microbiota and atrial cardiomyopathy by Tingting Sun, Beibei Song, Bo Li

“…Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria and is closely associated with atrial fibrillation and its complications. …”
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Research Progress on the Mechanism of Acupuncture Treatment of Ischemic Stroke Based on the Space Construction of Nerve-vascular Unit by LI Mengxing, WNAG Yu, LI Zhen, LIU Fang, SHI Kejian

“…It is mainly discussed on acupuncture research from the structural function of NVU to the spatial structure changes in IS, with neurons as the one-dimensional target, neurons, brain microvascular endothelial cells (BMEC) as the two-dimensional target, and with neurons, BMEC and glial cells as the multi-dimensional target.ResultsMost of the previous studies on acupuncture treatment of IS only stayed at a single level of neuron or angiogenesis regulation, and rarely involved the research on the overall NVU and the interaction among its components. …”
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The oily nucleus– role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm by Zobia Umair, Zahid Nawaz, Sumaiya Hasnain, Wolfgang Fischle

“…Nonetheless, in recent years, the impact of nuclear phospholipids on the structure and function of the genome has been found to be more multifaceted and complex. …”
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Mitochondrial metabolism and cancer therapeutic innovation by Hongxiang Du, Tianhan Xu, Sihui Yu, Sufang Wu, Jiawen Zhang

“…Although targeting mitochondrial function represents a promising therapeutic strategy, mitochondrial heterogeneity and adaptive resistance mechanisms complicate interventional approaches. …”
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