Transformation of the WHO Africa Region Secretariat: an exploratory study of the health policy lessons from health governance strengthening interventions for just and sustainable h... by Bernard Hope Taderera

“…Leadership structures and systems were streamlined to strengthen organizational functions for the delivery of desired outcomes to achieve Responsive Strategic Operations. …”
Get full text

A culturally adapted psychologically informed, audiologist-delivered, manualized intervention for chronic tinnitus patients in Malaysia: Protocol for a randomized controlled feasib... by Mohamad Azmeer Sadali, Wan Syafira Ishak, Mahadir Ahmad, Derek J Hoare

“…Assessments occur at baseline, post-intervention (1 month), and at a 3-month follow-up. At follow-up, semi-structured interviews guided by the Theoretical Framework of Acceptability will explore participants' perceptions of the intervention.…”
Get full text

Identifying conducive contexts and working mechanisms of sedentary behaviour interventions in older adults: a realist review protocol as part of the ‘Stand UP Seniors’ project by Sebastien F M Chastin, Greet Cardon, Sofie Compernolle, Delfien Van Dyck, Kenneth Vanhove, Emelien Lauwerier

“…Sedentary behaviour is ubiquitous in older adults and has a strong link with age-related functional declines and chronic health conditions. Although several interventions have been developed aimed at the reduction of sedentary behaviour in older adults, little in-depth information is available on how these complex interventions work in different contexts. …”
Get full text

LEGO^®-Based Therapy in School Settings for Social Behavior Stimulation in Children with Autism Spectrum Disorder: Comparing Peer-Mediated and Expert Intervention by Luciana Oliveira Angelis, Fernanda Tebexreni Orsati, Maria Cristina Triguero Veloz Teixeira

“…Conclusions: The results suggest that a structured intervention combined with peer-mediated stimulation may be an effective method for promoting adaptive and prosocial behaviors in children with ASD.…”
Get full text

A mindfulness-based, cognitive, social, digital relapse-prevention intervention for youth with depression in Australia: study protocol for a randomised controlled trial of Rebound by Mario Alvarez-Jimenez, Sarah Bendall, Peter Koval, Simon Rice, Daniela Cagliarini, Lee Valentine, Penni Russon, Jess Phillips, Reeva Lederman, Cathrine Mihalopoulos, Helen Herrman, Cesar Gonzalez-Blanch, Alexandra Parker, Shaminka N Mangelsdorf, Richard M Ryan, Sarah Hetrick, Yong Yi Lee, Greg Murray, Christopher Davey, Virginia Liu, Simon D'Alfonso, Brendan Pawsey, John Gleeson

“…Introduction Major depressive disorder (MDD) causes significant disease burden and functional impairment during adolescence and young adulthood. …”
Get full text

Comparing effects of wearable robot-assisted gait training on functional changes and neuroplasticity: A preliminary study. by Jungsoo Lee, Kassymzhomart Kunanbayev, Donggon Jang, Dae-Shik Kim

“…The effect sizes of functional and structural neuroplasticity showed "medium" and "very small," respectively. …”
Get full text

Functional Outcome of Extended Curettage and Reconstruction using Sandwich Technique for Giant Cell Tumor around Knee by Kevin Jose, Joe Joseph Cherian, Jerin Jeevo, Anoop Pilar, Rinju Krishnan, Mevin Mathew Nedumparambil

“…The primary objectives of treatment are to entirely eliminate the tumor, rebuild the defect, and restore limb functionality. Numerous surgical treatment options have been proposed, ranging from more drastic interventions, such as en bloc excision, to less invasive techniques such as curettage or curettage combined with bone grafting. …”
Get full text

Neglect and Neurodevelopment: A Narrative Review Understanding the Link Between Child Neglect and Executive Function Deficits by Silvia Herrero-Roldán, Alexandra Martín-Rodríguez

“…Special emphasis is placed on alterations in brain structure and function, dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, and emerging epigenetic evidence. …”
Get full text

Developing an early warning land degradation indicator based on geostatistical analysis of Ecosystem Functional Types dynamics by Cristina Domingo-Marimon, Małgorzata Jenerowicz-Sanikowska, Lluís Pesquer, Marek Ruciński, Michał Krupiński, Edyta Woźniak, Anna Foks-Ryznar, Mohammad Abdul Quader

“…Remote sensing datasets and techniques, particularly land cover maps, provide crucial data for capturing spatial and temporal changes, supporting informed decision-making and targeted interventions. However, these maps often emphasize structural rather than functional attributes and, also due to their thematic and temporal resolution, may not detect early degradation signs. …”
Get full text

Ultrasound Improves Gallbladder Contraction Function: A Non-Invasive Experimental Validation Using Small Animals by Run Guo, Tian Chen, Fan Ding, Li-Ping Liu, Fang Chen, Gang Zhao, Bo Zhang

“…Extended ultrasound exposure produced sustained functional improvements without tissue damage. Conclusions: Ultrasound effectively enhances gallbladder contractile function through mechanisms involving smooth muscle structural modification and calcium signaling modulation. …”
Get full text

The effect of physical activity on resilience of Chinese children: the chain mediating effect of executive function and emotional regulation by Yifan Xu, Kai Qi, Shuqiao Meng, Xiaoxiao Dong, Shimeng Wang, Dandan Chen, Aiguo Chen

“…SPSS 29.0 and AMOS 29.0 were used for data analysis and structural equation model testing. Results The results revealed significant positive correlations between PA and resilience (r = 0.545, p < 0.01) and ER (r = 0.413, p < 0.01), as well as a significant negative correlation with EF (r = -0.341, p < 0.01), where shorter reaction times indicate better EF. …”
Get full text

Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia by Luigi Giuliani, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Edoardo Caporusso, Paola Bucci, Giulia M. Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj

“…The role of working memory impairment in the pathways to functional outcomes in schizophrenia highlights the importance of implementing integrated pharmacological and cognitive remediation interventions targeting neurocognition. …”
Get full text

The association between family function and adolescents’ non-suicidal self-injury behaviors—is Chinese culture involved? by Cheng-jia Yang, Cheng-jia Yang, Rui Zhou, Rui Zhou, Yin-Du Liu, Shi-Bin Wang, Cai-Lan Hou, Cai-Lan Hou, Fu-Jun Jia, Fu-Jun Jia

“…In the Chinese cultural context, where family structure and attitudes toward sexuality are unique, the link between family function and adolescent NSSI remains underexplored.MethodsThis cross-sectional study recruited 157 adolescent psychiatric patients (aged 13–18) from both outpatient and inpatient settings. …”
Get full text

Effects of an integrated social-art intervention on cognitive and psychosocial outcomes among older adults with mild cognitive impairment in nursing homes: a mixed methods study by Chenshan Huang, Yuanjiao Yan, Wilson Wai San Tam, Wenqian Sun, Yu Ye, Nafang Wang, Yanhong Shi, Ziping Zhu, Danting Chen, Lin Chen, Junyu Zhao, Rong Lin, Hong Li

“…Abstract Background The rising prevalence of mild cognitive impairment (MCI) among older adults in nursing homes necessitates effective interventions to slow the progression to dementia. Integrated social-art interventions have shown promise in enhancing cognitive function and reducing social isolation. …”
Get full text

Non-Invasive Diagnosis and Monitoring of Diabetic Nephropathy: Assessment of Renal Function and Fibrosis by Diffusion Kurtosis Imaging by Yuan JL, Hu LA, Wang XY, Shi ZY, Chen T, Huang XZ, Wu Y, Cai QJ, Yang ZX, Chen XY, Yuan L, Zhang Y

“…Among the DKI indicators, MK had the highest AUC (0.922, 95% CI: 0.843– 1.000).Conclusion: The noninvasive monitoring of DN was feasible with DKI, and MK could indicate the renal function and fibrosis of DN patients. Changes in MK may also serve as a biomarker to assess treatment response (eg, microstructural improvement) after therapeutic interventions (eg, drug therapy for diabetic nephropathy, anti-fibrotic therapy).Plain Language Summary: Diabetic nephropathy (DN) is a serious kidney complication of diabetes and the leading cause of end-stage renal disease. …”
Get full text

Prediction of the Functional Result of Surgery for the Full Thickness of the Macular Hole Based on the Analysis of the Safety of Retinal Tissue by E. M. Popov, D. S. Maltsev, A. N. Kulikov

“…The reflectivity of RPE was evaluated within the hole on structural en face projections of RPE slab. Six months postoperatively, correlation between baseline OCT characteristics and visual outcome was evaluated.Results. …”
Get full text

Training protocol characteristics in studies comparing functional versus traditional training: systematic review of controlled trials by Jader Alfredo Beck, Jean Marlon Machado, Amandda de Souza, Cristiano Gomes Sanchotene, Fábio Hech Dominski, Caroline Ruschel

“…Objective: To assess the characteristics of training protocols in studies comparing functional training and traditional training interventions in clinical trials, through a systematic review. …”
Get full text

Mitochondrial Quality Control in Health and Disease by Lin Ye, Xinzhi Fu, Qi Li

“…Mitochondrial quality control (MQC) encompasses a coordinated network of mitochondrial biogenesis, dynamics (fusion and fission), and selective autophagy (mitophagy), which together sustain mitochondrial structure and function. Under physiological conditions, MQC ensures the removal of dysfunctional mitochondria, restricts excessive reactive oxygen species production, and modulates apoptosis, thereby supporting the high energy demands of organs such as the heart and brain. …”
Get full text

The YoungFitT project: Study protocol for a randomized mixed-methods trial of physical exercise and mind-body interventions, with or without virtual reality, in university students... by Samira Rostami, Adrià Bermudo-Gallaguet, Neus Camins-Vila, Blai Ferrer-Uris, Albert Busquets, Mireia Ribera, Laura Coll, Jaime Gallego Vila, Ramon Oliva Martínez, Mel Slater, Gustavo Garcia Diez, Nazareth Perales Castellanos, Mar Larrosa, Jofre Bielsa-Pascual, Pere Torán-Montserrat, Olga Bruna Rabassa, Myriam Guerra-Balic, Kirk I Erickson, Belinda Brown, Maria Mataró Serrat

“…<h4>Discussion</h4>The proposed interventions are expected to produce differential effects on psychological well-being and cognitive function. …”
Get full text

SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function by Sen Duan, Qindong Zhang, Jinqiang Zhu, Jiaming Wang

“…Additionally, SS-31 reduced NOS2 expression by 50%, highlighting its therapeutic potential in age-related bone loss. SS-31 intervention not only normalizes mitochondrial structure and function, reducing ROS levels and enhancing oxygen consumption rates, but also targets the NOS2 gene, a potential drug target, which upon knockdown, leads to a substantial upregulation of osteogenic markers and an improvement in mitochondrial function. …”
Get full text