Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Given its central involvement in cell division and proliferation, katanin represents a promising target for therapeutic intervention, particularly in cancer treatment. Inhibiting katanin’s function could potentially hinder the uncontrolled growth of cancerous cells, making it an attractive target for novel anti-cancer therapies. …”
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Valve-in-valve transcatheter aortic valve replacement on a self-expandable nitinol frame due to degeneration of primary bioprosthetic valve cusps. Clinical case of a high-risk surg... by L. S. Kokov, V. V. Sokolov, M. V. Parkhomenko, R. Sh. Muslimov, M. V. Bulanova, N. M. Bikbova

“…We present the clinical observation of a 72-year-old female patient with high surgical risk and structural degeneration of a bioprosthetic aortic valve (AV) cusps in the form of stenosis, accompanied by severe dysfunction. …”
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CXCR3 inhibitors for therapeutic interventions: current status and perspectives by Rongrong Huo, Yu Jiang, Li Zhang, Shufang Du, Dan Zhou

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Effectiveness and cost-effectiveness of a structured integrated post-pulmonary embolism follow-up care model (Attend-PE): a rationale and protocol for a multicentre clinical pre-po... by Thomas Kümler, Søren Paaske Johnsen, Anette Arbjerg Højen, Erik Lerkevang Grove, Frederikus A Klok, Bettina Wulff Risør, Stavros Konstantinides, Jan Brink Valentin, Nanna Rolving, Stine Foged Lindegaard

“…Introduction Patients with pulmonary embolism (PE) experience impaired functional ability and reduced quality of life long after discharge from the hospital. …”
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Multidisciplinary interventions in ectodermal dysplasia: A clinical case report by Andres Chaponan-Lavalle, Luis Guillermo Azanedo Garcia, Karla Hernandez Randich, Yolanda Chaponan-Lavalle, Karina Ordaya-Gonzales, Jose Arriola-Montenegro

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Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing by Jie Yang, Qingyu Han, Liping Li, Ruiping Zhang

“…Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. …”
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Clinical experience of cone-beam computed tomography in interventional neuroradiology by D.V. Shchehlov, S.V. Chebanyuk, O.E. Svyrydiuk, S.V. Konotopchyk, O.F. Sydorenko, V.R. Pankiv, M.B. Vyval

“…Objective ‒ to analyze the experience of using cone-beam computed tomography (CBCT) angiography during diagnostic and interventional procedures in the SO «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine». …”
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A Telephone-based Physiotherapy Intervention for Patients with Osteoarthritis of the Knee by Adesola C Odole, Oluwatobi D. Ojo

“…<p>This study assessed the effects of a 6-week telephone based intervention on the pain intensity and physical function of patients with knee osteoarthritis (OA), and compared the results to physiotherapy conducted in the clinic. …”
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Diagnosis and interventional pain management options for sacroiliac joint pain by Ching-Wei Chuang, Sheng-Kai Hung, Po-Ting Pan, Ming-Chang Kao

“…The complex anatomic structures, nerve innervation, and functional biomechanisms of the SI region make it challenging to diagnose and treat the SI joint as a pain source. …”
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FACTORS OF FOREIGN MILITARY INTERVENTION RISK ASSESSMENT IN THE MODERN WORLD by A. A. Ivanov

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Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis by Seda Sevilay Koldaş, Osman Uğur Sezerman, Emel Timuçin

“…Modern clinical research increasingly utilizes long follow-up periods, leading to complex data structures, particularly in metagenomic studies. To address this limitation, we introduce a novel mediation framework based on structural equation modeling that leverages linear mixed-effects models using penalized quasi-likelihood estimation with a debiased lasso. …”
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Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies by Xinyi Zhang, Xinyi Zhang, Zhongge Zhu, Peijie Zhai, Peijie Zhai, Peng Lv, You Yang, Chuanhang Cheng, Busen Wang, Ting Fang, Guanying Zhang, Xiangyang Chi, Jianmin Li, Wei Chen, Yunzhu Dong

“…Subsequently, we predicted key functional residues through structural modeling of antigen-antibody complexes and validated their roles via mutagenesis studies. …”
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Mechanistic Insights on Skin ageing and Dermatologic Interventions to Slow Ageing Process by Rajashree Sriram, V Gopal

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Study on intervention effect of Wearable Cyborg HAL through narrative analysis by Shiori Ikemoto, Shiori Ikemoto, Yoshiyuki Sankai, Yoshiyuki Sankai, Yoshiyuki Sankai, Takeru Sakurai, Takeru Sakurai

“…As the social implementation of HAL progresses, it is important to capture how the physical intervention by HAL affects not only the physical function but also the mental state and social activities of individual users. …”
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Strength training intervention for adult individuals with knee osteoarthritis: Establishing fidelity by Hamza Küçük, Niloufar Ghadamyari, Fatma Neşe Şahin, Güner Çiçek, Tülay Ceylan, Özkan Güler, Onur Mutlu Yaşar, Cüneyt Şensoy, Cansel Arslanoğlu, Erol Doğan, Erkal Arslanoğlu

“…These findings highlight the importance of intervention fidelity in strength training programs for adult individuals with KOA, emphasizing its role in optimizing health outcomes.ConclusionThis study contributes to the growing evidence supporting structured strength training as a viable strategy for managing KOA-related symptoms and enhancing physical function in ageing populations.…”
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Application of Magnetic Resonance Imaging Technology in Pediatric Exercise Intervention Research by CHEN Qun, YANG Zijian, CHENG Xinyi, JIA Siyi, DU Xiaoxia, WANG Mengxing

“…Exercise intervention has become increasingly recognized as an effective method in aiding the rehabilitation of pediatric diseases and promoting structural and functional improvements of the pediatric brain. …”
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Assessment and Optimization of Hydrological Connectivity for Effective Management of Water Resources in the Samian Watershed by Zeinab Hazbavi, Nazila Alaei

“…Accordingly, increasing attention has been given to the structural and functional connectivity of river networks as the primary source of surface water supply, while this can be a potential watershed-scale management solution. …”
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Targeting childhood loneliness in china: in silico interventions and moderated network analysis by Xinle Yu, Xuanzhi Zhang, Kusheng Wu, Zhenqiang Xu, Zhiya Liang, Wanyi Wen, Dinghui Wang, Yanhong Huang

“…Prior research often overlooks symptom-level interactions, limiting the precision of targeted interventions. This study applied network-based methodologies to clarify the structure of loneliness, identify intervention targets, and examine the roles of psychological factors and family socioeconomic status (SES). …”
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Post-Concussion Syndrome and Functional Neurological Disorder: Diagnostic Interfaces, Risk Mechanisms, and the Functional Overlay Model by Ioannis Mavroudis, Foivos Petridis, Eleni Karantali, Alin Ciobica, Sotirios Papagiannopoulos, Dimitrios Kazis

“…Early recognition of functional overlays and stratified psychological interventions may improve outcomes for patients with persistent, medically unexplained symptoms after head trauma. …”
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Brain Reorganization following Intervention in Children with Congenital Hemiplegia: A Systematic Review by E. Inguaggiato, G. Sgandurra, S. Perazza, A. Guzzetta, G. Cioni

“…Our purpose is to review current evidence on the effects of noninvasive intervention strategies on brain structure or function, in children with unilateral cerebral palsy. …”
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