Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma by Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong

“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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Much More Than the Malady: The Promise of a Web-Based Digital Platform Incorporating Self-Report for Research and Clinical Care in Mild Cognitive Impairment by Andrew McGarry, MD, Oliver Roesler, PhD, Jackson Liscombe, PhD, Michael Neumann, PhD, Hardik Kothare, PhD, Abhishek Hosamath, MBM, Lakshmi Arbatti, MS, Anusha Badathala, MD, Stephen Ruhmel, BS, MPH, Bryan J. Hansen, PhD, Madeline Quall, BA, Sandrine Istas, MBio, Arthur Wallace, MD, PhD, David Suendermann-Oeft, PhD, Vikram Ramanarayanan, PhD, Ira Shoulson, MD

“…Traditional clinical trials in neurodegenerative disorders have utilized combinations of examination-based outcomes, global assessments by investigators and participants, and scales aimed at function, some of which are patient-reported outcomes. …”
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First De Novo genome assembly and characterization of Gaultheria prostrata by Yan-Jun Lin, Xiao-Ya Ding, Yi-Wei Huang, Yi-Wei Huang, Lu Lu

“…(Ericaceae), a type of evergreen shrub, known as a natural source of methyl salicylate, possesses rich germplasm resources, strong habitat adaptability, significant ornamental value, and noteworthy pharmacological activities. …”
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Analysis and Optimization of Operating Modes of Mini-CHP on Local Fuels in Conditions of Surplus Electric Power Capacities in the Unified Energy System of Belarus. Part 1 by R. S. Ignatovich, V. A. Sednin, Ye. S. Zuyeva

“…Due to the fact that the ORC installation under study is a component of  the energy source with a high installed peak thermal power, in the current state there is no direct correlation between the outside air temperature and the generation power of the ORC installation. …”
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Integrated Analysis of Single‐Cell and Bulk RNA‐Sequencing Defines N7‐Methylguanosine (m7G)‐Mediated Modifications' Role in Prognosis and the Tumor Immune Microenvironment in Hepat... by Jiahua Liang, Mingjian Ma, Borui Xu, Cheng Zhong, Guangyan Zeng, Huijiao Lu, Jiaming Lai, Jiancong Chen

“…Method Single‐cell RNA sequencing (scRNA‐seq) data was sourced from the GEO repository. Transcriptomic datasets were procured from TCGA, GEO, and ICGC databases. …”
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Identifying Disinformation on the Extended Impacts of COVID-19: Methodological Investigation Using a Fuzzy Ranking Ensemble of Natural Language Processing Models by Jian-An Chen, Wu-Chun Chung, Che-Lun Hung, Chun-Ying Wu

“…MethodsA comprehensive dataset comprising 566 genuine and 2361 fake samples was curated from reliable open sources and processed using advanced techniques. The dataset was randomly split using the scikit-learn package to facilitate both training and evaluation. …”
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Identification of microbial exopolymer producers in sandy and muddy intertidal sediments by compound-specific isotope analysis by Hubas, Cédric, Gaubert-Boussarie, Julie, D’Hondt, An-Sofie, Jesus, Bruno, Lamy, Dominique, Meleder, Vona, Prins, Antoine, Rosa, Philippe, Stock, Willem, Sabbe, Koen

“…The main difference observed was in how epipelic and epipsammic diatoms affected the chemistry of EPS, which had significant implications for the growth of bacteria specialized in utilizing EPS. These differences were likely linked to variations in the functioning of epipelic and epipsammic communities, specifically in how EPS was used either for motility or for cell attachment. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Pose measurement method for coal mine drilling robot based on deep learning by Jiangnan LUO, Jianping LI, Hongxiang JIANG, Deyi ZHANG

“…Then, the measured point cloud is registered using the Fast Point Feature Histogram (FPFH) and Iterative Closest Point (ICP) algorithms to obtain the transformation matrix from the measured point cloud to the source point cloud. Finally, the drilling position and direction vectors were determined, thereby defining the drilling position. …”
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DMYTRО DONTSOV’S TEXTS IN THE ASPECT OF CORPUS LINGUISTICS AND LEXICOGRAPHY by Oksana R. Mykytyuk, Liliia V. Kharchuk

“…Through the use of large-scale empirical data and advanced computer technologies to reach objective insights into language function, linguistic corpora have quickly become invaluable resources. …”
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Acoustic Features for Identifying Suicide Risk in Crisis Hotline Callers: Machine Learning Approach by Zhengyuan Su, Huadong Jiang, Ying Yang, Xiangqing Hou, Yanli Su, Li Yang

“…Basic acoustic features (eg, Mel Frequency Cepstral Coefficients, formant frequencies, jitter, shimmer) and high-level statistical function (HSF) features (using OpenSMILE [Open-Source Speech and Music Interpretation by Large-Space Extraction] with the ComParE 2016 configuration) were extracted. …”
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A multi-omics Mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma by Jia Wang, MD, Jinxin Hu, MS, Dan Qin, MD, Dan Han, MD, Jiapeng Hu, MD

“…Employing Summary Data-based Mendelian Randomization (SMR) and Two-Sample Mendelian Randomization (TSMR), we pinpointed asthma causal genes, causal DNA methylation sites, and methylation sites affecting gene expression, cross validated with at least 2 large-scale GWAS from each source. We utilized colocalization for genetic associations, meta-analysis for data integration, two-step MR for methylation-gene-asthma mediation mechanism. …”
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How does soil carbon sequestration affect greenhouse gas emissions from a sheep farming system? Results of an life cycle assessment case study by Pasquale Arca, Enrico Vagnoni, Pierpaolo Duce, Antonello Franca

“… • Extensification of dairy sheep systems determines lower environmental impact per hectare of utilized agricultural area. • Enteric methane emissions are the main source of GHG emissions of the sheep milk life cycle…”
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Spatial complex correlation characteristics of carbon emissions and carbon transboundary transfer: Assessment of the carbon footprint in four mega-urban agglomerations in China by Chengxue Yu, Haimeng Lei, Hongbo Zheng, Tong Xu, Zhanfeng Dong

“…This study investigates these issues from the dual perspectives of ''carbon sources'' and ''carbon sinks,'' utilizing a modified gravity model to construct a spatial correlation matrix of carbon footprint pressure. …”
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The osteoinductive and osseointegration properties of decellularized extracellular matrix bone derived from different sites by Weihua Huang, Lijing Hao, Xiayu Cai, Chujie Xiao, Huinan Yin, Weikang Xu

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Sensitivity of Firms' Investment to Uncertainty and Cash Flow by Taher Porkavosh, Ezatollah Abbasian, Vahid Mahmoudi

“…The purpose of investment decisions is to obtain a higher return, and to obtain a suitable return through investment, accurate knowledge of the effective factors is essential, because fluctuations in investment can come from various sources. According to real option theory, uncertainty plays a crucial role in shaping investment decisions for companies. …”
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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcguire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…However, these models have faced challenges associated with their poorly scalable creation, sourcing suitable cells, and the extraction of reliable, quantifiable metrics. …”
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An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…Recent observations have increasingly challenged the conventional understanding of atmospheric NH₃ and its potential sources in remote environments. Laboratory studies suggest that the microdroplet redox generation of NH₃ could offer an alternative explanation. …”
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Microwave-assisted extraction of essential oils from basil leaves (Ocimum basilicum L.) and coriander seeds (Coriandrum sativum L.): A comparative study on chemical composition, an... by G.M. Masud Rana, Subarna Sandhani Dey, Bijoy Chandra Ghos, Md. Jasim Uddin, Tahmina Akter Chowdhury, Md. Tariqul Islam, Toufikur Rahman, Md. Jobayear Hossain, Jaytirmoy Barmon, Mst. Sarmina Yeasmin

“…Essential oils (EOs), known for their aromatic and bioactive properties, are widely utilized in the cosmetic and food industries. Microwave-assisted extraction (MAE) has emerged as a green, efficient and rapid technique for extracting EOs from plant sources. …”
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Nanomaterials-assisted photothermal therapy for breast cancer: State-of-the-art advances and future perspectives by Sagnik Nag, Oishi Mitra, Garima Tripathi, Israrahmed Adur, Sourav Mohanto, Muskan Nama, Souvik Samanta, B.H. Jaswanth Gowda, Vetriselvan Subramaniyan, Vino Sundararajan, Vinoth Kumarasamy

“…Due to its spatial specificity and nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down the lane. PTT utilizes a near-infrared (NIR) light source to irradiate the tumor target intravenously or non-invasively, which is converted into heat energy over an optical fibre. …”
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