Bioinformatics and network pharmacology-based study to elucidate the multi-target pharmacological mechanism of the indigenous plants of Medina valley in treating HCV-related hepato... by Mubarak A. Alamri

“…But the findings were not validated in actual patients, so further investigation is needed to confirm the potential use of selected medicinal plants towards HCV-related HC.…”
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A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. by Dobril K Ivanov, Gerrit Bostelmann, Benoit Lan-Leung, Julie Williams, Linda Partridge, Valentina Escott-Price, Janet M Thornton

“…We utilised available microarray gene-expression data for two phenotypes (starvation-sensitive and sterile) in Drosophila. …”
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Decrease in pneumococcal co-colonization following vaccination with the seven-valent pneumococcal conjugate vaccine. by Carina Valente, Jason Hinds, Francisco Pinto, Silvio D Brugger, Katherine Gould, Kathrin Mühlemann, Hermínia de Lencastre, Raquel Sá-Leão

“…Microarray analysis confirmed the plyNCR-RFLP results. …”
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Investigating Single-Molecule Molecular Inversion Probes for Medium-Scale Targeted DNA Methylation Analysis by Roy B. Simons, Hieab H. H. Adams, Manfred Kayser, Athina Vidaki

“…However, we still lack a cost-effective, sensitive, medium-scale method for the analysis of hundreds to thousands of user-defined CpGs suitable for minute DNA input amounts (<10 ng). …”
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Amogel: a multi-omics classification framework using associative graph neural networks with prior knowledge for biomarker identification by Chia Yan Tan, Huey Fang Ong, Chern Hong Lim, Mei Sze Tan, Ean Hin Ooi, KokSheik Wong

“…Abstract The advent of high-throughput sequencing technologies, such as DNA microarray and DNA sequencing, has enabled effective analysis of cancer subtypes and targeted treatment. …”
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Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology by Shasha Wu, Shasha Wu, Qing Jiang, Jinhui Wang, Jinhui Wang, Daming Wu, Yan Ren

“…Subsequently, gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Cytoscape plugin CluGO, and Gene Set Enrichment Analysis (GSEA) were utilized to identify immune-related genes. The final selection of immune-related hub genes was determined through the least absolute shrinkage and selection operator (Lasso) regression analysis and PPI analysis. …”
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Mutation Spectrum of the ABCA4 Gene in a Greek Cohort with Stargardt Disease: Identification of Novel Mutations and Evidence of Three Prevalent Mutated Alleles by Kamakari Smaragda, Kokkinou Vassiliki, Koutsodontis George, Stamatiou Polixeni, Giatzakis Christoforos, Anastasakis Anastasios, Aslanides Ioannis Minas, Koukoula Stavrenia, Panagiotoglou Theoni, Datseris Ioannis, Tsilimbaris K. Miltiadis

“…A total of 59 patients were analyzed for ABCA4 mutations using the ABCR400 microarray and PCR-based sequencing of all coding exons and flanking intronic regions. …”
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Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker. by Aileen Marshall, Margus Lukk, Claudia Kutter, Susan Davies, Graeme Alexander, Duncan T Odom

“…Six genes identified by microarray as highly expressed in HH-HCC were confirmed by RT qPCR. …”
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Differentially expressed miR-3680-5p is associated with parathyroid hormone regulation in peritoneal dialysis patients. by Sohyun Jeong, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

“…Total RNA from 15 patients (7 and 8 patients in the low and high iPTH groups, respectively) underwent miRNA microarray analysis, and three differentially upregulated (>2-fold change) miRNAs previously associated with human disease were selected for real-time quantitative PCR (qPCR) analysis. …”
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Two stable variants of Burkholderia pseudomallei strain MSHR5848 express broadly divergent in vitro phenotypes associated with their virulence differences. by A A Shea, R C Bernhards, C K Cote, C J Chase, J W Koehler, C P Klimko, J T Ladner, D A Rozak, M J Wolcott, D P Fetterer, S J Kern, G I Koroleva, S P Lovett, G F Palacios, R G Toothman, J A Bozue, P L Worsham, S L Welkos

“…Microscopic and colony morphology differences on six differential media were observed and only the Rough variant metabolized sugars in selective agar. Antimicrobial susceptibilities and lipopolysaccharide (LPS) features were characterized and phenotype microarray profiles revealed distinct metabolic and susceptibility disparities between the variants. …”
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Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells by Tomokazu Fujimoto, Toshihiro Inoue, Saori Ohira, Nanako Awai-Kasaoka, Takanori Kameda, Miyuki Inoue-Mochita, Hidenobu Tanihara

“…Purpose. To investigate the effect of rho kinase inhibitors on oxidative stress in trabecular meshwork (TM) cells. …”
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TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2 by Jiahao Zhang, Yuning Chen, Gaosong Wang, Hui Huang, Yuankun Liu, Jin Huang, Junfei Shao, Jiantong Jiao, Chao Cheng

“…A TRIM22-overexpressing ubiquitination microarray identified TRIM22 as a potential activator of Bcl-2. …”
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Predictive and prognostic significance of loss of heterozygosity in ABC transporter genes in breast cancer by M. M. Tsyganov, M. K. Ibragimova, E. Yu. Garbukov, O. D. Bragina, E. A. Zdereva, E. A. Usynin, N. V. Litviakov

“…Material and methods. a total of 130 breast cancer patients were included in the study. microarray analysis was performed on Affymetrix Cytoscantm HD Array high-density DNA chips to assess LOH status. …”
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FAM111B knockdown attenuates tumorigenesis of ovarian cancer via the downregulation of MYC by Guoyu Yu, Fang Wei, Wanying Li, Qiuyun Guo, Lihong Zhang

“…Immunohistochemical analyses conducted on tissue-microarray samples obtained from patients with serous ovarian cancer indicated that elevated levels of FAM111B expression were associated with unfavorable prognostic outcomes. …”
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The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis by Kai Zhao, Xiaolong Li, Qingmiao Zhu, Mengyu Zhu, Jinge Huang, Ting Zhao

“…Random forest (RF) and Least Absolute Shrinkage and Selection Operator (Lasso) regression were employed to identify key hub genes. …”
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Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA seq... by Yuqing Li, Jiandong Zhang, Xuemeng Qiu, Yifei Zhang, Jiyue Wu, Qing Bi, Zejia Sun, Wei Wang

“…A 9-gene signature, termed RCD risk score (RCDI), was constructed using the least absolute shrinkage and selection operator and multivariate Cox regression algorithms. …”
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Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis by Chao Wu, Hui Feng, Meng Tian, Baorui Chu, Xianyang Liu, Shuhao Zeng, Yakun Wang, Hong Wang, Shengping Hou, Qingfeng Liang

“…We investigated insomnia-associated genes that may contribute to AU pathogenesis and sought to identify potential biomarkers for insomnia-associated AU.MethodsMicroarray data related to insomnia and AU were downloaded from the Gene Expression Omnibus (GEO) database and analyzed. …”
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Global challenges and solutions to achieving and sustaining measles and rubella elimination by Natasha S. Crowcroft, Anna A. Minta, Sebastien Antoni, Lee Lee Ho, William Perea, Mick N. Mulders, Anindya Sekhar Bose, Aaron Wallace, Diana Chang Blanc, Patrick M. O’Connor

“…Progress will be supported through technological innovations such as microarray patch vaccines. Whether this holistic approach will be more effective than vertical initiatives at achieving measles and rubella elimination remains to be seen. …”
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Investigation on the Electron Emission Regularity of Sputtered Boron Nitride Thin Films and Microstructured Array Surfaces by Yuqing Gu, Juannan Li, Dan Wang

“…The results of laser etching on the BN bulk surface to form microarray structures show that the EEC of BN bulk decreases significantly with the increase of the average aspect ratio of the microstructures. …”
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Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities by Kuo-Shiang Liao, Mu-Rong Kao, Tzu-Hsuan Ma, Mei-Hua Hsu, Tzu-Yin Chen, Balázs Imre, Philip J. Harris, Jiun-Jie Shie, Cheng-Hsun Chiu, Chung-Yi Wu, Yves S. Y. Hsieh

“…Glycan microarray analysis shows that dPNAG glycans with DP8 and DP12 are optimal, with corresponding protein conjugates eliciting the highest IgG titers. …”
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