Near telomere-to-telomere genome assembly of the blackspot tuskfish (Choerodon schoenleinii) by Zhongdian Dong, Jiahao Gao, Yanfei Zhao, Jin Gao, Yusong Guo, Zhongduo Wang, Ning Zhang

“…Notably, telomeres were identified at both ends of 23 chromosomes, with 14 being completely gapless and only 12 gaps detected across the remaining nine. A total of 24,524 protein-coding genes were annotated, with 96.25% assigned functional annotations. …”
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Explainable artificial intelligence of DNA methylation-based brain tumor diagnostics by Salvatore Benfatto, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling, David Capper, Volker Hovestadt

“…Here, we describe an interpretable framework to explain the classifier’s decisions. We show that functional genomic regions of various sizes are predominantly employed to distinguish between different tumor classes, ranging from enhancers and CpG islands to large-scale heterochromatic domains. …”
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Discovery of a new subgroup of sulfur dioxygenases and characterization of sulfur dioxygenases in the sulfur metabolic network of Acidithiobacillus caldus. by Wei Wu, Xin Pang, Jianqiang Lin, Xiangmei Liu, Rui Wang, Jianqun Lin, Linxu Chen

“…We cloned and expressed these genes, and detected the SDO activity of recombinant protein A5904_0421 by a GSH-dependent in vitro assay. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Secondary outcomes included: unplanned 60- and 90-day hospital re-admissions; quality of transition; health-related quality of life (EuroQol-5 Dimensions, five-level version); and self-reported healthcare resource use. Data sources National Health Service Secondary Use Services data and Hospital Episodes data for work package 2 and routinely recorded National Health Service acute trust hospital data on re-admissions for work packages 5 and 6. …”
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Bovine PMN responses to extracellular vesicles released by Besnoitia besnoiti tachyzoites and B. besnoiti-infected host cells by Gabriel Espinosa, Constanza Salinas-Varas, Lisbeth Rojas-Barón, Christian Preußer, Elke Pogge von Strandmann, Ulrich Gärtner, Iván Conejeros, Carlos Hermosilla, Anja Taubert

“…Therefore, we tested whether exposure of bovine PMN to EVs from different cellular sources affects classical PMN effector functions and cytokine/chemokine secretion. …”
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Remote work – the new normal needs more research by Annina Ropponen

“…Different Methods to Detect Stress in Knowledge Workers: A Pilot Study for Long-term Monitoring. …”
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Morpho-Molecular and Genomic Characterization of <i>Penicillium mexicanum</i> Isolates Retrieved from a Forsaken Gold Mine by João Trovão, Fabiana Soares, Diana Sofia Paiva, António Portugal

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Carbon-Based Nanoadsorbents for the Removal of Emerging Pollutants by M. Venkata Ratnam, P. Akilamudhan, K. Senthil Kumar, S. Narasimha Reddy, K. Nagamalleswara Rao, Feroz Shaik, D. M. Reddy Prasad

“…Emerging contaminants (ECs) are substances that have been detected in water but have not been thoroughly tested or regulated. …”
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An Affordable AI-Driven and 3D-Printed Personalized Myoelectric Prosthesis: Design, Development, and Assessment by Enzo Romero, Jose G. Garcia, Magno Parra, Sebastian Caballa, Alejandro M. Saldarriaga, Edson F. Luque, Dante J. Rodriguez, Victoria E. Abarca, Dante A. Elias

“…Conventional myoelectric prostheses, while offering functional restoration, have limited adaptability and high cost. …”
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The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord by Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhang

“…Glial cells play crucial roles in regulating physiological and pathological functions, including sensation, the response to infection and acute injury, and chronic neurodegenerative disorders. …”
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Multimodal Therapeutic Effects of Neural Precursor Cells Derived from Human-Induced Pluripotent Stem Cells through Episomal Plasmid-Based Reprogramming in a Rodent Model of Ischemi... by Seung-Hun Oh, Yong-Woo Jeong, Wankyu Choi, Jeong-Eun Noh, Suji Lee, Hyun-Sook Kim, Jihwan Song

“…Stem cell therapy is a promising option for treating functional deficits in the stroke-damaged brain. Induced pluripotent stem cells (iPSCs) are attractive sources for cell therapy as they can be efficiently differentiated into neural lineages. …”
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Characterization of all life stages of Tenebrio molitor: Envisioning innovative applications for this edible insect by Nuno Muñoz-Seijas, Helena Fernandes, José Eugenio López-Periago, David Outeiriño, María Guadalupe Morán-Aguilar, José Manuel Domínguez, José Manuel Salgado

“…The human food security is unavoidably dependent on exploring novel nutritional sources, such as edible insects. However, insects farming needs to improve their rearing practices, such as extracting value from all growing stages, from larvae until adults. …”
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A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
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The Role of Circulating Biomarkers in Patients with Coronary Microvascular Disease by Rossella Quarta, Giovanni Martino, Letizia Rosa Romano, Giovanni Lopes, Francesco Fabio Greco, Carmen Anna Maria Spaccarotella, Ciro Indolfi, Antonio Curcio, Alberto Polimeni

“…Coronary microvascular disease (CMD) comprises a spectrum of conditions characterized by the functional and structural abnormalities of coronary microcirculation, affecting vessels typically smaller than 500 μm. …”
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Artificial intelligence and radiomics applications in adrenal lesions: a systematic review by Matteo Ferro, Octavian Sabin Tataru, Giuseppe Carrieri, Gian Maria Busetto, Ugo Giovanni Falagario, Martina Maggi, Felice Crocetto, Biagio Barone, Francesco Del Giudice, Michele Marchioni, Daniela Terracciano, Giuseppe Lucarelli, Pasquale Ditonno, Raul Gherasim, Ciprian Todea-Moga, Giuseppe Fallara, Marco Tozzi, Antonio Cioffi, Roberto Bianchi, Alessio Digiacomo, Alessandro Veccia, Alessandro Antonelli, Maria Chiara Sighinolfi, Luigi Schips, Bernardo Rocco

“…Background: Adrenal lesions, often incidentally detected, present diagnostic challenges in distinguishing benign from malignant or hormonally active lesions. …”
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Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy. by Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw

“…Sixty percent of the piglets were transgenic, with mutant GUCY2D mRNA detected in the retina of all animals tested. Functional impairment of vision was observed among the transgenic pigs at 3 months of age, with a follow-up at 1 year indicating a subsequent slower progression of phenotype. …”
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New Insights on Quality, Safety, Nutritional, and Nutraceutical Properties of Honeydew Honeys from Italy by Andrea Mara, Federica Mainente, Vasiliki Soursou, Yolanda Picó, Iratxe Perales, Asma Ghorab, Gavino Sanna, Isabel Borrás-Linares, Gianni Zoccatelli, Marco Ciulu

“…This contribution aims to provide a comprehensive characterization of the physico-chemical, palynological, functional, and food safety properties of a large sampling of honeydew honeys collected throughout Italy. …”
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Bird response to intercropping switchgrass within a loblolly pine plantation by Craig Marshall, Samuel K. Riffell, Darren A. Miller, JoVonn G. Hill, Kristine O. Evans, Scott A. Rush

“…However, minimal knowledge currently exists regarding the influence of intercropping switchgrass on ecosystem functions and services and biological diversity of loblolly pine plantations. …”
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Preliminary Investigation of GC–MS Profiling and Antibacterial Activities of Different Solvent Extracts From Litchi chinensis Sonn. Seed by Samia Sharmin, Ali Ahsan Muzahid, Md. Mohibul Islam, Mst. Sarmina Yeasmin, Amit Kumar Dey, Md. Jasim Uddin, G. M. Masud Rana, Jaytirmoy Barmon, Safaet Alam, Md. Nurul Huda Bhuiyan, Nazim Uddin Ahmed

“…Eventually, comprehending the potential biological functions of the detected compounds is explored. GC–MS analysis revealed a diverse array of chemical compounds, with 34, 35, and 25 compounds identified in the n-hexane, n-hexane–chloroform (2:1), and methanol extracts, respectively. …”
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