Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes by Ivan Borrello, Amy Thomas, Luca Biavati, Robert Leone, Elizabeth M Zawidzka, Claudio Zanettini, Luigi Marchionni

“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
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Gene expansion in the hawkmoth Manduca sexta drives evolution of food-associated odorant receptors by Megha Treesa Tom, Philipp Brand, Sascha Bucks, Jin Zhang, Mario Ernesto Escobar Huezo, Bill S. Hansson, Sonja Bisch-Knaden

“…Our results suggest a link between the studied OR expansion and enhanced detection of odors emitted by valuable nectar sources in M. sexta.…”
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Real-time monitoring of tea volatiles using soft ionization by chemical reaction in transfer with an online sampling interface by Tiange Gu, Jingyi Sun, Saiting Wang, Xiaokun Duan, Hongli Li, Charles Liu, David Da Yong Chen

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Unraveling the mitochondrial genome of the medicinal Chinese motherwort (Leonurus japonicus, Lamiaceae): structural dynamics, organelle-to-nuclear gene transfer, and evolutionary i... by Xinyu Bai, Xinyu Bai, Tingting Zhu, Huiru Chen, Xiaoqun Wang, Jing Liu, Yuqing Feng, Yuqing Feng, Yanbo Huang, Joongku Lee, Goro Kokubugata, Zhechen Qi, Xiaoling Yan

“…Extensive RNA editing underscores post-transcriptional regulation in mitochondrial function. These findings enrich genomic resources for Leonurus, support phylogenetic and evolutionary studies in Lamiaceae, and lay groundwork for molecular breeding and conservation strategies targeting mitochondrial traits. …”
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Combining dopamine and glucose sensings on paper devices for the metabolic study of neurosecretion by Rémi F. Dutheil, Dabeaurard Tho, Iman Pitroipa, Raphaël Trouillon

“…Glucose, the main source of energy of the human body, and dopamine, a major neurotransmitter, are two analytes widely investigated in the study of the brain. …”
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A novel approach to field data augmentation with remote sensing and machine learning in rangelands by Hailey E. Schmidt, Javier Osorio Leyton, Efrain Noa Yarasca, Sorin C. Popescu, Justinn J. Jones, Justin P. Wied, Xinyuan Wu

“…However, these ecosystems are increasingly threatened by woody plant encroachment (WPE), which impacts forage availability, habitat quality, and other ecosystem functions. Despite advances in remote sensing and machine learning (ML) for monitoring and managing WPE, a significant gap persists in providing effective, scalable, and high-quality training data to support early detection efforts. …”
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Conditions for the emergence of circumnutations in plant roots. by Ilya Loshchilov, Emanuela Del Dottore, Barbara Mazzolai, Dario Floreano

“…Here we describe a model capable of replicating root growth behaviors, which we used to analyze the role of circumnuntations, revealing their emergence I) under gravitropic stress, as a combination of signal propagation and sensitivity to the signal carriers; II) as a result of the interplay between gravitropic and thigmotropic responses; and III) as a behavioral strategy to detect and react to resource gradients. The latter function requires the presence of a hypothetical internal oscillator whose parameters are regulated by the perception of environmental resources.…”
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Computer vision based automatic evaluation method of Y2O3 steel coating performance with SEM image by Jianhong Zhao, Huamin Yang, Yi Sui

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Mineral identification in thin sections using a lightweight and attention mechanism by Xin Zhang, Wei Dang, Jun Liu, Zijuan Yin, Guichao Du, Yawen He, Yankai Xue

“…Mineral identification is foundational to geological survey research, mineral resource exploration, and mining engineering. Considering the diversity of mineral types and the challenge of achieving high recognition accuracy for similar features, this study introduces a mineral detection method based on YOLOv8-SBI. …”
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The anti-cancerous mechanism of licochalcone A on human hepatoma cell HepG2 based on the miRNA omics by Jun Wang, Xiuxiu Zhang, Zhijing Ni, Elnur Elam, Kiran Thakur, Kexin Li, Chuyan Wang, Jianguo Zhang, Zhaojun Wei

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Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin by F. Mansouri

“…MBP-brazzein system permits large-scale functional expression and purification of recombinant soluble proteins, providing a basis for the future study of structure and function of brazzein.…”
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Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing by Zahra Ghanem, Feras Alasali, Naser El-Naily, Hassen Loukil, Haytham Y. Mustafa, Saad M. Saad, Abdelaziz Salah Saidi, William Holderbaum

“…Secondly, the study demonstrates the use of Configurable Function Blocks (CFCs) in digital relays to dynamically adjust relay settings based on zero sequence current detection. …”
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An openEHR based infection control system to support monitoring of nosocomial bacterial clusters and contacts by Pascal Biermann, Claas Baier, Ann Christin Vietor, Benedikt Zacher, Tom Baumgartl, Tatiana von Landesberger, Michael Behnke, Michael Storck, Markus Petzold, Martin Kaase, HiGHmed lnfection Control Study Group, Dirk Schlüter, Michael Marschollek, Simone Scheithauer, Antje Wulff

“…Digital, routine data-driven solutions are promising, but often proprietary, non-interoperable, or limited in functional scope. The open-source Smart Infection Control System (SmICS) offers automatic calculations and interactive views on patients' movement and lab data, epidemic curves, contact networks, complemented by temporal-spatial visualizations. …”
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Expression and structural analysis of taste receptor genes in Iberian and Duroc pigs by Cristina Óvilo, Rita Benítez, Yolanda Núñez, Ramón Peiró-Pastor, Fabian García, Eduardo De Mercado, Emilio Gómez-Izquierdo, Juan García-Casco, Clemente López-Bote, María Muñoz

“…The objectives of this work were to deepen the understanding of the regulation of the function of taste receptor genes in the circumvallate papillae of obese Iberian pigs in comparison to Duroc pigs, and to characterize their genetic variation and associations with relevant production traits. …”
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Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model by Samuel Martinez-Meza, Thomas A. Premeaux, Stefano M. Cirigliano, Courtney M. Friday, Stephanie Michael, Sonia Mediouni, Susana T. Valente, Lishomwa C. Ndhlovu, Howard A. Fine, Robert L. Furler O’Brien, Douglas F. Nixon

“…Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. …”
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A Neural Device Inspired by Neuronal Oscillatory Activity with Intrinsic Perception and Decision‐Making by Congtian Gu, Guoliang Ma, Mengze Zhang, Hu Shen, Liaoyuan Pu, Yanhe Song, Shilong Yan, Dakai Wang, Kaixian Ba, Bin Yu, Zhiwu Han, Luquan Ren

“…The device utilizes alternating signals generated by coupling the human body with the power‐frequency electromagnetic field as both a signal source and energy source, mimicking neuronal oscillatory activity. …”
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SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 1; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…Such a process is often resource-intensive and may not be consistent across users and sensors. …”
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MaPep1 and MbPep1, as plant elicitor peptides in banana, confer resistance to banana blood disease caused by Ralstonia syzygii subsp. celebesensis by Praphat Kawicha, Ladawan Rattanapolsan, Ratri Boonruangrod, Yube Yamaguchi, Kusavadee Sangdee, Aphidech Sangdee, Thanwanit Thanyasiriwat

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Identification and characterization of gene networks and key genes related to the high-yield production of milk in high-yield cows using meta-analysis of microarray data by Mahdi Rahmatzadeh, Reza Shokri-Gharelo, Morteza Derakhti-Dizaji, Asghar Bazzaz, Bizhan Mahmoudi

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On the usage of artificial intelligence in leprosy care: A systematic literature review. by Hilson Gomes Vilar de Andrade, Elisson da Silva Rocha, Kayo H de Carvalho Monteiro, Cleber Matos de Morais, Danielle Christine Moura Dos Santos, Dimas Cassimiro Nascimento, Raphael A Dourado, Theo Lynn, Patricia Takako Endo

“…The persistent stigma and social exclusion associated with leprosy complicate eradication efforts exacerbate the wider challenges faced by NTDs in sourcing the necessary resources and attention for control and elimination. …”
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