TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion by Xuhao Zhang, Yu Gao, Huiping Liao, Wenyan Wang, Zaili Yang, Weian Cao, Ge Li, Jing Wen, Gencheng Han, Yang-Xin Fu

“…Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss driving exhaustion of TILs. …”
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Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium by Rong-San Jiang, Chiang-Wen Lee, Yu-Hsuan Lin, Jing-Jie Wang, Jia-Bin Liao, Kuo-Ti Peng, Yao-Chang chiang, Pei-Ling Chi

“…Conclusions These findings highlight the importance of selecting the appropriate ONS source for therapeutic applications, with DNS-ONS showing greater promise for olfactory epithelium repair and olfactory function restoration.…”
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Routing algorithm for heterogeneous computing force requests based on computing first network by ZHANG Gang, LI Xi

“…By constructing a solution matrix and utilizing evaluation functions, random selection of feasible solutions, and the principle of low demand priority avoidance, a set of feasible solution sets was ultimately found. …”
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The TRPA1 cation channel is upregulated by cigarette smoke in mouse and human macrophages modulating lung inflammation by Anita Steib, Katalin Rozmer, Éva Szőke, József Kun, Nelli Farkas, Diána Feller, Judit Pongrácz, Krisztina Pohóczky, Zsuzsanna Helyes

“…The transient receptor potential ankyrin 1 (TRPA1), a smoking-responsive, non-selective cation channel, is expressed by both capsaicin-sensitive peptidergic sensory nerves and non-neuronal cells of the lung, but there are few and controversial data on its expression and function on macrophages. …”
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Application of artificial intelligence in echocardiography from 2009 to 2024: a bibliometric analysis by Yangli Liu, Lei Zhao, Bin Tu, Jie Wang, Yaqun He, Rufang Jiang, Xiaofeng Wu, Wen Wen, Jian Liu

“…The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2024 through bibliometric analysis and to forecast future developmental trajectories.MethodsWe selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source and conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2024 and used the online analysis platform of bibliometrics, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.ResultsBetween 2009 and 2024, a total of 3,411 publications on AI applications in echocardiography were identified, including 3,000 articles (87.9%) and 411 reviews (12.1%), contributed by researchers from 100 countries/regions. …”
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The evolution and competitive strategies of Akkermansia muciniphila in gut by Ji-Sun Kim, Se Won Kang, Ju Huck Lee, Seung-Hwan Park, Jung-Sook Lee

“…In addition, WapA and anSME, which function in competition and post-translational modification of sulfatase, respectively, have been a particularly important selective pressure in the evolution of group A. …”
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Influence of suturing material on wound healing: Experimental study in dogs by Gazivoda Dragan, Pelemiš Dejan, Vujašković Goran, Đurđević Slaviša

“…When using resorbable materials it is of great importance to determine whether its absorbability and tensile strength help wound healing in function of time. Sutures themselves can become a source of inflammation, that may reduce or compromise the potential of reparation and regeneration. …”
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Enhancing the socio-cultural valuation of ecosystem services in Mountain animal production: a case study from piedmont’s alpine valley (North-west Italy) by Chiara Costamagna, Valentina Maria Merlino, Danielle Borra, Lorenzo Baima, Paolo Cornale, Luca Maria Battaglini

“…The new principal components were employed to cluster the sample in the function of individuals’ perceptions of ecosystem services. …”
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Efficacy of Anti-VEGF/VEGFR Agents on Animal Models of Endometriosis: A Systematic Review and Meta-Analysis. by Shuangge Liu, Xiaoyan Xin, Teng Hua, Rui Shi, Shuqi Chi, Zhishan Jin, Hongbo Wang

“…Subgroup analyses were performed to determine the source of heterogeneity in endometriosis scores and follicle numbers.…”
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A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity. by Andrew P Holmes, Ting Y Yu, Samantha Tull, Fahima Syeda, Stefan M Kuhlmann, Sian-Marie O'Brien, Pushpa Patel, Keith L Brain, Davor Pavlovic, Nigel A Brown, Larissa Fabritz, Paulus Kirchhof

“…<h4>Methods</h4>We used high-resolution optical mapping and sharp microelectrode recordings to quantify regional differences in electrical activation and repolarisation within the intact, superfused murine left atrium and quantified regional ion channel mRNA expression by Taqman Low Density Array. We also performed selected cellular electrophysiology experiments to validate regional differences in ion channel function.…”
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Solar‐Powered Hierarchical Microenvironments with Authigenic Multi‐Field Synergies for Simultaneous Extraction of Freshwater and Cesium by Liuyan Zhu, Lin Zhu, Ting Shi, Ke Zhao, Wenwen He, Lu Han, Zeying Jin, Jialin Kang, Shanfu Sun, Ningning Cao, Zhen Yu

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The MinDag app for symptom monitoring and feedback to patients and clinicians during the initial treatment of bipolar disorder – a feasibility study by Margrethe Collier Høegh, Stine Holmstul Glastad, Siv Hege Lyngstad, Magnus Johan Engen, Sofie Ragnhild Aminoff, Ingrid Melle, Thomas Bjella, Trine Vik Lagerberg

“…Development of digital tools to support the treatment of bipolar disorder and other mental health conditions is resource demanding, and there is a need to clarify criteria to establish proof of concept to guide the selection of tools for upscaling and implementation.…”
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Exome analysis reveals species divergence in TYR and identifies species genetic markers in five endemic Macaca species on Sulawesi Island by Xiaochan Yan, Nami Arakawa, Kanthi Arum Widayati, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Bambang Suryobroto, Yohey Terai, Hiroo Imai

“…Additionally, it explores how these genetic differences influence biological functions, and identifies species-specific genetic markers for species identification and conservation. …”
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A system for generating chatbots to support learning in the field of exact sciences using generative artificial intelligence models by Oleksandr Prokhorov, Dmytro Shymko, Olena Kuzminska, Andrey Chukhray, Oleksii Shatalov, Oleksandr Kholodniak

“…The objectives include: analyzing the challenges and peculiarities of creating chatbots and preparing high-quality datasets; developing the structure and describing the functionality of the chatbot generation system; providing examples of creating various types of chatbots; conducting experiments to determine the effectiveness and cost of chatbot generation. …”
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Integration of single cell and bulk transcriptomes identifies T cell stress subtypes in LUAD by Shengping Min, Linfeng Pan, Xinyu Zhang, Huili Chen, Lixuan Qiu, Xinyu Wang, Yiluo Xie, Kai Zhang, Qiang Zhang, Chaoqun Lian, Jing Zhang

“…The exploration delved into the bio-function of CREG2 in the progression of LUAD.…”
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Seeing Beyond Noise: Improving Cryptocurrency Forecasting with Linear Bias Correction by Sibtain Syed, Syed Muhammad Talha, Arshad Iqbal, Naveed Ahmad, Mohammed Ali Alshara

“…The proposed methodology includes collecting cryptocurrency data and precious metal data from Coindesk and BullionVault, respectively, and then finding the optimal model input combination for each cryptocurrency by lag adjustment and correlating feature selection. Hyperparameter tuning was performed by trial-and-error technique, and an early stopping function was applied to minimize time and space complexity. …”
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Relationship between ecological spatial network and vegetation carbon use efficiency in the Yellow River Basin, China by Chenglong Xu, Xiang Chen, Qiang Yu, Buyanbaatar Avirmed, Jikai Zhao, Wei Liu, Weijie Sun

“…Vegetation, as a crucial carbon sink, is facing extensive degradation under the mounting pressures of urbanization and excessive resource exploitation, exacerbating the imbalance between carbon sources and sinks. …”
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Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing by Zehua Wang, Zhongxiao Zhang

“…Support vector machine-recursive feature elimination (SVM-RFE) and Least Absolute Shrinkage and Selection Operator (LASSO) regression, implemented via the caret and glmnet packages in R, were used to select biomarkers. …”
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An evaluation of the Africa-CORDEX regional climate model's performance in simulating air temperatures and precipitation in the Melka-Wakena catchment, southeast Ethiopia by Tadele Sh Gerasu, Tolera Abdissa Feyissa, Beekan Gurmessa Gudeta, Keneni Demissie, Mulatu Tesfahun

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TECHNOLOGY FOR EFFICIENT USAGE OF HYDROCARBON-CONTAINING WASTE IN PRODUCTION OF MULTI-COMPONENT SOLID FUEL by B. M. Khroustalev, A. N. Pekhota

“…The paper considers modern approaches to usage of hydrocarbon-containing waste as energy resources and presents description of investigations, statistic materials, analysis results on formation of hydrocarbon-containing waste in the Republic of Belarus. …”
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