UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin. by Natalie Saini, Camille K Giacobone, Leszek J Klimczak, Brian N Papas, Adam B Burkholder, Jian-Liang Li, David C Fargo, Re Bai, Kevin Gerrish, Cynthia L Innes, Shepherd H Schurman, Dmitry A Gordenin

“…Finally, we show that DNA replication stalling at common fragile sites are potent sources of gross chromosomal rearrangements in human cells. …”
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Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms by Laura Ryder, Frederic Schrøder Arendrup, José Francisco Martínez, Goda Snieckute, Chiara Pecorari, Riyaz Ahmad Shah, Anders H. Lund, Melanie Blasius, Simon Bekker-Jensen

“…In addition, NO production is associated with ZNF598-mediated ubiquitination of the ribosomal protein RPS10 and GCN2-mediated activation of the integrated stress response, which are well-described responses to the collision of ribosomes. In sum, our work implicates a novel role of NO as an inducer of ribosome collision and activation of ribosomal surveillance mechanisms in human cells.…”
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Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function by Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen

“…Acute small molecule perturbations of SWI/SNF altered the amount of both SWI/SNF and cohesin on chromatin, particularly affecting cohesin binding to CTCF sites. Conclusions This work represents the most comprehensive investigation of cohesin-interacting proteins to date. …”
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CardioGenAI: a machine learning-based framework for re-engineering drugs for reduced hERG liability by Gregory W. Kyro, Matthew T. Martin, Eric D. Watt, Victor S. Batista

“…Scientific contribution This work introduces CardioGenAI, an open-source machine learning-based framework designed to re-engineer drugs for reduced hERG liability while preserving their pharmacological activity. …”
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