Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER status. by Qiyuan Li, Aron C Eklund, Nicolai Juul, Benjamin Haibe-Kains, Christopher T Workman, Andrea L Richardson, Zoltan Szallasi, Charles Swanton

“…In routine oncological practice ER status is determined by semi-quantitative methods such as immunohistochemistry (IHC) or other immunoassays in which the ER expression level is compared to an empirical threshold. …”
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Exploring the role of Peanut (Arachis hypogaea L.) root architecture in enhancing adaptation to climate change for sustainable agriculture and resilient crop production: A review by Yohannes Gelaye, Jihua Li, Huaiyong Luo

“…Biotechnological tools, including quantitative trait loci (QTL) mapping and CRISPR/Cas-based genome editing, are being harnessed to manipulate root traits at the molecular level. …”
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Synergistic CO2 capture using PANI-polymerized UiO-66 embedded in PEBAX mixed matrix membranes by Tayyaba Ishaq, Rahma Tamime, Sadia Bano, Faheem Hassan Akhtar, Asim Laeeq Khan

“…The integration of UiO-66 and PANI with PEBAX offers a promising pathway for developing efficient and effective gas separation technologies, aligning with the industrial requirements for environmental sustainability and energy efficiency.…”
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Investigating the e-learning choice under the learners’ perspective using demand driven learning model: insights from Vietnam by Phong Thanh Nguyen, Quyen Le Hoang Thuy To Nguyen, Luan Thanh Nguyen, Vy Dang Bich Huynh

“…This study investigates the drivers of e-learning choice within the framework of the demand-driven learning model (DDLM), with a primary focus on three core factors: quality content, delivery, and service. Employing a quantitative approach and the PLS-SEM technique, this research uncovers significant findings. …”
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An automated network-based tool to search for metabolic vulnerabilities in cancer by Luis V. Valcárcel, Edurne San José-Enériz, Raquel Ordoñez, Iñigo Apaolaza, Danel Olaverri-Mendizabal, Naroa Barrena, Ana Valcárcel, Leire Garate, Jesús San Miguel, Antonio Pineda-Lucena, Xabier Agirre, Felipe Prósper, Francisco J. Planes

“…Here, we present gmctool, a freely accessible online tool that allows us to accomplish this task in a simple, efficient and intuitive environment. gmctool exploits the concept of genetic Minimal Cut Sets (gMCSs), a theoretical approach to synthetic lethality based on genome-scale metabolic networks, including a unique database of synthetic lethals computed from Human1, the most recent metabolic reconstruction of human cells. gmctool introduces qualitative and quantitative improvements over our previously developed algorithms to predict, visualize and analyze metabolic vulnerabilities in cancer, demonstrating a superior performance than competing algorithms. …”
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Overview of Radar-Based Gait Parameter Estimation Techniques for Fall Risk Assessment by Sevgi Z. Gurbuz, Mohammad Mahbubur Rahman, Zahra Bassiri, Dario Martelli

“…Current methods for fall risk assessment rely on Quantitative Gait Analysis (QGA) using costly optical tracking systems, which are often only available at specialized laboratories that may not be easily accessible to rural communities. …”
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From Voxels to Viruses: Using Deep Learning and Crowdsourcing to Understand a Virus Factory by Avery Pennington, Oliver N. F. King, Win Min Tun, Mark Boyce, Geoff Sutton, David I. Stuart, Mark Basham, Michele C. Darrow

“…The application of citizen science–driven crowdsourcing to the generation of instance segmentations of volumetric bioimages is a step towards developing annotation-efficient segmentation workflows for bioimaging data. …”
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Establishing an Immune System Conferring DNA and RNA Virus Resistance in Plants Using CRISPR/Cas12a Multiplex Gene Editing by Lili Luo, Liqing Miao, Xuhui Ma, Jinjin Hu, Suzhen Li, Wenzhu Yang, Shuai Ma, Rumei Chen, Xiaoqing Liu

“…Our study provides an innovative strategy—an mRNA–gRNA nucleic acid complex—which has proven to be highly effective in the gene‐editing system and offers an efficient antiviral approach for generating virus‐resistant plants.…”
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Diagnostic Accuracy of Presepsin versus Procalcitonin in Early-Onset Neonatal Septicaemia: A Prospective Cohort Study by Prasidutt Sharma, Khurshed Alam Choudhury, Shubhi Agarwal

“…It has a promising future as an efficient sepsis detector and a positive indicator to avoid unnecessary NICU admissions and limit antibiotic therapy due to its high Negative Predictive Value (NPV).…”
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Research on the Instability Mechanism and Control Technology of Gob-Side Entry in Deep Mines with Soft Rock by Lu Ma, Luyi Xing, Chang Liu, Tongyuan Cui, Xi Qiao, Wang Miao, Peng Kong

“…This complexity leads to challenges in roadway stability control which greatly affects the coal mine production succession and safe and efficient mining. This paper takes the gob-side entry in Liuzhuang Coal Mine as the background. …”
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An Explainable Multi-Model Stacked Classifier Approach for Predicting Hepatitis C Drug Candidates by Teuku Rizky Noviandy, Aga Maulana, Ghifari Maulana Idroes, Rivansyah Suhendra, Razief Perucha Fauzie Afidh, Rinaldi Idroes

“…Traditional high-throughput screening (HTS) methods are costly, time-consuming, and prone to false positives, underscoring the necessity for more efficient alternatives. Machine learning (ML), particularly quantitative structure–activity relationship (QSAR) modeling, offers a promising solution by predicting compounds’ biological activity based on chemical structures. …”
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Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway by Wen Zhang, Ruiqian Sun, Yongjun Zhang, Rong Hu, Qian Li, Weili Wu, Xinyu Cao, Jiajian Zhou, Jianfeng Pei, Ping Yuan

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Unstable Slope Identification and Monitoring Using Polarization-Enhanced DS-InSAR: A Case Study in the Bailong River Basin by Yahui Qiu, Yuanjian Wang, Ximin Cui, Debao Yuan, Peixian Li

“…In this study, we propose a distributed scatterer InSAR (DS-InSAR) method centered on efficient polarization channel optimization and the construction of DS target covariance matrices to improve surface deformation monitoring in mountainous regions. …”
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Towards 3D Reconstruction of Multi-Shaped Tunnels Utilizing Mobile Laser Scanning Data by Xuan Ding, Shen Chen, Mu Duan, Jinchang Shan, Chao Liu, Chuli Hu

“…The superiority of this method was further confirmed through qualitative and quantitative comparisons with related approaches. By automatically and efficiently constructing a high-precision 3D tunnel model, the proposed method offers an important model foundation for digital twin engineering and a valuable reference for future tunnel model construction projects.…”
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Study of Complex Impedance Dispersion Model for Two-Phase Laminar Flow by CHENG Linfeng, KE Shizhen, SHI Hongwei, ZHANG Yuhang, LUO Hu, TAO Jie

“…Therefore, it is imperative to identify a more cost-effective and efficient measurement method. Complex impedance spectrum (CIS) detection technology emerges as a promising solution, offering advantages such as low cost, easy implementation, environmental friendliness, and safety. …”
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CRISPRa-Mediated Triple-Gene Activation of <i>ARO10</i>, <i>ARO80,</i> and <i>ADH2</i> for Enhancing 2-Phenylethanol Biosynthesis via the Ehrlich Pathway in <i>Saccharomyces cerevi... by Zijing Zhu, Shuaihu Fang, Pingping Huang, Dianqiang Luo, Xiaobao Qi

“…This study aimed to develop a CRISPR activation (CRISPRa)-mediated <i>S. cerevisiae</i> engineered strain for efficient 2-PE biosynthesis by activating Ehrlich pathway key genes <i>ARO10</i>, <i>ARO80</i>, and <i>ADH2.…”
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A New Evaluation Model for the Readiness and Maturity Level of Intelligent and Sustainable Supply Chain Management Based on Geometric Mean by Sercan Demir, Mehmet Akif Gündüz, Turan Paksoy

“…Real-time information sharing among supply chain players and the effective coordination of each step of the chain are critical for efficient supply chain management. This is made possible by the transition from the traditional supply chain to the digital supply chain. …”
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Targeting ocular tissues with intravenously administered aptamers selected by in vivo SELEX by Sonja Korhonen, Katja Stenberg, Umair Seemab, Piia Bartos, Katariina Mäkiniemi, Jørgen Kjems, Daniel Miotto Dupont, Astrid Subrizi

“…Drugs and carrier molecules that penetrate ocular tissues after intravenous administration are needed for more efficient and patient-friendly treatment of ocular diseases. …”
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Establishment of a TaqMan qPCR method with MGB probe for the specific detection of BVDV field strains circulating in China by Lele An, Lele An, Xiaoting Ren, Yetao Zhang, Shubin Zhang, Yongqing Zhao, Yongqing Zhao

“…In this study, a TaqMan real-time quantitative PCR (qPCR) assay utilizing a minor groove binder (MGB) probe was developed for the detection of BVDV, with a focus on strains currently circulating in China. …”
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Lost in transition: from medical student to clinical supervisor - a mixed-methods study by Capucine Delorme, Terese Stenfors, Anders Sondén

“…Reflexive thematic analysis was used to generate themes. Quantitative data was collected through a survey related to affections, challenges, and organizational aspects of supervision. …”
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