Global, regional, and national burden of genitourinary cancers in 204 countries and territories, 1990–2021: a systematic analysis for the global burden of disease study 2021 by Zhiyong Zhang, Yingwei Xie, Lei Liu, Yongtao Wang, Shuang Li, Li Chen, Xiangbo Zeng, Yuanchao Zhu, Yishan Zhang, Yongyuan Xiao, Fengjin Zhao, Bihong Xu, Xiaocen Liu, Wenbin Guo, Ganping Wang, Wenlian Xie, Wanlong Tan, Hao Ping, Zaosong Zheng

“…Our study aimed to provide a comprehensive understanding of the global distribution and progression of genitourinary cancers through analyses of the recently updated 2021 Global Burden of Disease (GBD) database. …”
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Development of a Novel Intraperitoneal Icodextrin/Dextrose Solution for Enhanced Sodium Removal by Jennifer L. Asher, Juan B. Ivey-Miranda, Christopher Maulion, Zachary L. Cox, Julian A. Borges-Vela, Genaro H. Mendoza-Zavala, Jose A. Cigarroa-Lopez, Rogelio I. Silva-Rueda, Cristina Revilla-Monsalve, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Oliver Goedje, Ian Crosbie, Christopher McIntyre, Fredrick Finkelstein, Jeffrey M. Turner, Jeffrey M. Testani, Veena S. Rao

“…Results: In rats, increasing concentrations of icodextrin and dextrose IP solutions, up to 30% icodextrin and 10% dextrose, produced progressively greater UF (P < 0.001). In sheep treated with 30% icodextrin and 10% dextrose, the mean UF was ∼3.5-fold greater (1.77 ± 0.22 L vs 0.47 ± 0.34 L; P = 0.005) and the mean sodium removal was ∼4-fold greater (7.07 ± 0.72 g vs 1.78 ± 1.27 g; P = 0.003) compared with commercially available 7.5% icodextrin PD solution. …”
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Hypoxia-inducible factor 2α mediates nonesterified fatty acids and hypoxia-induced lipid accumulation in bovine hepatocytes by Fanrong Kong, Lin Lei, Lin Cai, Jinxia Li, Chenchen Zhao, Menglin Liu, Dandan Qi, Jie Gao, Enzhu Li, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li

“…Overall, these data suggest that NEFA-induced hepatic hypoxia significantly contributes to the progression of hepatic steatosis which in turn, intensifies hypoxia and leads to a self-perpetuating cycle of reciprocal causation, further exacerbating hepatic lipid deposition. …”
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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s dis... by Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L. Hamilton-Nelson, Nicholas R. Wheeler, Yi Zhao, John J. Farrell, Michelle A. Grunin, Yuk Yee Leung, Pavel P. Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B. Mez, Ellen L. Palmer, Jagan Pillai, Richard M. Sherva, Yeunjoo E. Song, Xiaoling Zhang, Takeshi Ikeuchi, Taha Iqbal, Omkar Pathak, Otto Valladares, Dolly Reyes-Dumeyer, Amanda B. Kuzma, Erin Abner, Larry D. Adams, Perrie M. Adams, Alyssa Aguirre, Marilyn S. Albert, Roger L. Albin, Mariet Allen, Lisa Alvarez, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig S. Atwood, Sanford Auerbach, Gayle Ayres, Clinton T. Baldwin, Robert C. Barber, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, Bruno A. Benitez, David Bennett, John Bertelson, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James Brewer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Christopher S. Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A. Chin, Helena C. Chui, Jaeyoon Chung, Suzanne Craft, Paul K. Crane, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Michael L. Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L. De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W. Dickson, Beth A. Dombroski, Rachelle S. Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A. Evans, Kelley M. Faber, Thomas J. Fairchild, Kenneth B. Fallon, David W. Fardo, Martin R. Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Robert P. Friedland, Tatiana M. Foroud, Matthew P. Frosch, Brian Fulton-Howard, Douglas R. Galasko, Adriana Gamboa, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Rodney C.P. Go, Alison M. Goate, Thomas J. Grabowski, Neill R. Graff-Radford, Robert C. Green, John H. Growdon, Hakon Hakonarson, James Hall, Ronald L. Hamilton, Oscar Harari, John Hardy, Lindy E. Harrell, Elizabeth Head, Victor W. Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S. Honig, Ryan M. Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Linda S. Hynan, Laura Ibanez, Gail P. Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M. Ilyas Kamboh, Anna M. Karydas, Mindy J. Katz, John S. Kauwe, Jeffrey A. Kaye, C. Dirk Keene, Aisha Khaleeq, Masataka Kikuchi, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H. Kramer, Walter A. Kukull, Frank M. LaFerla, James J. Lah, Eric B. Larson, Alan Lerner, James B. Leverenz, Allan I. Levey, Andrew P. Lieberman, Richard B. Lipton, Mark Logue, Oscar L. Lopez, Kathryn L. Lunetta, Constantine G. Lyketsos, Douglas Mains, Flanagan E. Margaret, Daniel C. Marson, Eden RR. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Stefan McDonough, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, Edwin S. Monuki, John C. Morris, Shubhabrata Mukherjee, Amanda J. Myers, Trung Nguyen, Thomas Obisesan, Sid O’Bryant, John M. Olichney, Marcia Ory, Raymond Palmer, Joseph E. Parisi, Henry L. Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C. Petersen, Helen Petrovitch, Aimee Pierce, Marsha Polk, Wayne W. Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Joan S. Reisch, John M. Ringman, Erik D. Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Marwan Sabbagh, A. Dessa Sadovnick, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Susan H. Slifer, Scott Small, Amanda G. Smith, Janet P. Smith, Joshua A. Sonnen, Salvatore Spina, Peter St George-Hyslop, Takiyah D. Starks, Robert A. Stern, Alan B. Stevens, Stephen M. Strittmatter, David Sultzer, Russell H. Swerdlow, Rudolph E. Tanzi, Jeffrey L. Tilson, John Q. Trojanowski, Juan C. Troncoso, Magda Tsolaki, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. van Eldik, Jeffery M. Vance, Badri N. Vardarajan, Robert Vassar, Harry V. Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Patrice L. Whitehead, Ellen M. Wijsman, Kirk C. Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S. Wingo, Thomas Wisniewski, Randall L. Woltjer, Martin Woon, Clinton B. Wright, Chuang-Kuo Wu, Steven G. Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W. Kunkle, William S. Bush, Akinori Miyashita, Goldie S. Byrd, Li-San Wang, Lindsay A. Farrer, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Gyungah R. Jun, Christiane Reitz, Adam C. Naj, on behalf of Alzheimer’s Disease Genetics Consortium (ADGC)

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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Here, we present Non-lethal Sonodynamic Therapy (NL-SDT), in which ultrasound is used to activate locally sonosensitizers, thereby stimulating the production of reactive oxygen species for the purpose of modulating cell function or fate, as a novel methodology to inhibit progression of hypertensive renal fibrosis. To confirm whether NL-SDT can reduce hypertensive renal fibrosis and its mechanism. …”
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Sõjakäsitlus tavateadvuses: Esimene maailmasõda tänapäeva noorte silme läbi / Lay Representations of War: The First World War through the Eyes of Today’s Youth by Maaris Raudsepp, Triin Roosalu

“…Generalising the answers, we can conclude that most young people took a progressive, linear view of history, according to which war is an anomaly, a disease of society that can and should be prevented. …”
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Phenomenological Analysis of Lived Experience of Cancer: A Case Study of Patients at Ayatollah Kashani Hospital in Shahrekord by Hedari Arman, Sayedeh Sapideh Hashemi

“…In terms of the spatial dimension, as cancer progressed, patients often perceived themselves as weak, helpless, unstable, and at risk of sudden death. …”
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Genetic diversity of Lecanicillium lecanii and its pathogenicity against Diaphorina citri by Lu Lianming, Cheng Baoping, Du Danchao, Hu Xiurong, Pu Zhanxu, Chen Guoqing

“…After 60 h post-inoculation, the internal organs of host such as fat body, muscle tissue, digestive tract and ovary were invaded and progressively degraded. Finally, a large number of newly-developed conidia could be observed on the hyphae which covered the body surface of host.In conclusion, genetic diversities and pathogenicity differences exist in populations of L. lecanii. …”
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Ambulatory Oxygen for Pulmonary Fibrosis (OxyPuF): a randomised controlled trial and acceptability study by Rachel L Adams, Alisha Maher, Nicola Gale, Anjali Crawshaw, David Thickett, Alice M Turner

“…Introduction Idiopathic pulmonary fibrosis is a devastating condition of unknown cause that results in progressive, irreversible scarring of the lung, manifesting as breathlessness and dry cough. …”
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Antropometria e Aptidão Física de Adolescentes Latino-Americanos (Antropometría y Aptitud Física de Adolescentes Latino-Americanos) (Anthropometry and Physical Fitness of Latin Ame... by Dartagnan Pinto Guedes, Paulo César Franzini, Raymundo Pires Júnior, José Maria Moya Morales

“…As for physical fitness, tests for sit-and-reach, squat jump, conter-moviment jump, handgrip strength, sit-up, 10 X 5 meter races and progressive endurance walk/run were applied. The results showed that anthropometric measurements only begin to present important gender-based differences after 14 years of age, while for physical fitness differences were found favoring boys in almost all motor tests from 12 years on, with an increasing sexual dimorphism index as the adolescents grew. …”
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Spatiotemporal variations in surface marine carbonate system properties across the western Mediterranean Sea using volunteer observing ship data by D. Curbelo-Hernández, D. González-Santana, A. G. González, J. M. Santana-Casiano, M. González-Dávila

“…The seasonal amplitude of SST, which is becoming larger due to progressively warmer summers, was the primary driver of the observed slope of interannual trends. …”
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N4BP3 Activates TLR4-NF-&amp;kappa;B Pathway in Inflammatory Bowel Disease by Promoting K48-Linked I&amp;kappa;B&amp;alpha; Ubiquitination by Jiang W, Yin J, Han M, He W, Zhao Y, Hu J, Wang M, Wang S, Xu J, Deng C, Li J, Gong X, Shen Y

“…Furthermore, we observed interaction between N4BP3 and IκBα, with N4BP3-overexpressing THP-1 cells demonstrating significantly elevated K48-linked ubiquitination levels versus controls.Conclusion: LPS upregulates N4BP3 expression, which subsequently enhances K48-linked ubiquitination of IκBα, leading to NF-κB pathway activation, and exacerbating IBD progression. These findings suggest N4BP3 as a potential therapeutic target for developing novel IBD treatments.Keywords: N4BP3, ubiquitination, TLR4, NF-κB, IκBα, inflammatory bowel disease…”
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Integrating Gut Microbiome and Metabolomics with Magnetic Resonance Enterography to Advance Bowel Damage Prediction in Crohn&amp;rsquo;s Disease by Huang L, Meng J, Lin S, Peng Z, Zhang R, Shen X, Zheng W, Zheng Q, Wu L, Wang X, Wang Y, Mao R, Sun C, Li X, Feng ST

“…Lili Huang,1,&amp;ast; Jixin Meng,1,2,&amp;ast; Shaochun Lin,1,&amp;ast; Zhenpeng Peng,1,&amp;ast; Ruonan Zhang,1 Xiaodi Shen,1 Weikai Zheng,1 Qingzhu Zheng,1 Luyao Wu,1 Xinyue Wang,1 Yangdi Wang,1 Ren Mao,3 Canhui Sun,1 Xuehua Li,1 Shi-Ting Feng1 1Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Radiology, Henan Provincial People’s Hospital &amp; Zhengzhou University People’s Hospital, Zhengzhou, People’s Republic of China; 3Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xuehua Li, Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China, Tel +86-20-87755766-8471, Email lxueh@mail.sysu.edu.cn Shi-Ting Feng, Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China, Fax +86-20-87615805, Email fengsht@mail.sysu.edu.cnPurpose: Cumulative bowel damage (BD) critically influences the progression and prognosis of Crohn’s disease (CD). Although the Lémann Index (LI) remains the standard for BD assessment, its clinical utility is limited by heavy reliance on extensive clinical data. …”
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MODULATION AS A MULTIMODAL TRANSLATION STRATEGY OF GRAPHIC NOVEL PERSEPOLIS BY M. SATRAPI by Anna V. Khodorenko

“…The connection between temporal progression and spatial representation is examined in both the original and translated texts, highlighting the narrative strategies employed to convey historical contexts and cultural frameworks. …”
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The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…None of the included studies reported whether renal or cardiovascular disease progression events occurred. Compared with angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) alone, the combination with GBE was more beneficial in improving urinary albumin excretion rate (UAER) [mean difference (MD) = -22.99 μg/min, 95% confidence interval (CI): −27.66 to −18.31, p &lt; 0.01], serum creatinine (SCr) [MD = −8.30 μmol/L, 95% CI: −11.55 to −5.05, p &lt; 0.01], blood urea nitrogen (BUN) [MD = −0.77 mmol/L, 95% CI: −1.04 to −0.49, p &lt; 0.01], 24-hour urinary total protein (24hUTP) [MD = −0.28 g/d, 95% CI: −0.35 to −0.22, p &lt; 0.01], cystatin C (Cys-C) [MD = −0.30 mg/L, 95% CI: −0.43 to −0.17, p &lt; 0.01], total cholesterol (TC) [MD = −0.69 mmol/L, 95% CI: −1.01 to −0.38, p &lt; 0.01], triglyceride (TG) [MD = −0.40 mmol/L, 95% CI: −0.56 to −0.23, p &lt; 0.01], low-density lipoprotein cholesterol (LDL-C) [MD = −0.97 mmol/L, 95% CI: −1.28 to −0.65, p &lt; 0.01], fasting blood glucose (FBG) [MD = −0.30 mmol/L, 95% CI: −0.54 to −0.05, p = 0.02], hematocrit [MD = −4.58%, 95% CI: −5.25 to −3.90, p &lt; 0.01] and fibrinogen [MD = −0.80 g/L, 95% CI: −1.12 to −0.47, p &lt; 0.01]. …”
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Tumores neuroendocrinos gastroenteropancreáticos: un estudio retrospectivo en el suroccidente colombiano by J.C. Bravo-Ocaña, N. López-Moreno, E.D. Salazar-Cardona, A.F. Mejía-Hurtado, V. Gutiérrez-Aragón, M. Gonzáles-Hurtado, L.A. Satizabal-Mayor, J.F. Lbasseauny-Morales, N. Rojas-Rojas, C.A. Rojas-Rodríguez

“…At the last evaluation, 40.9% of the patients were disease-free, disease was stable in 24.7% and progressive in 11.8%, and 18.3% of the patients died. …”
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The influence of the opponent's quality on team offensive efficacy in youth football: an observational study with sequential analysis (La influencia de la calidad del oponente en... by Matheus de Oliveira Jaime, Leandro Rechenchosky, Vanessa Menezes Menegassi, Paulo Henrique Borges, João Cláudio Braga Pereira Machado, Wilson Rinaldi

“…Offensive patterns with efficacy occurred mainly from directly ball recoveries (lag -5: z=3.13; lag -3: z=2.93), with progression through ball conduction (lag -4: z=2.85; lag -3: z=2.40; lag -2: z=2.64) and dribble (lag -5: 2.62; lag -2: z=2.51; lag -1: z=2.13; 1.97), playing between the lines against the opponent's last defenders’ line (lag -1: z=3.42; 2.72; 2.05; lag 0: z=4.65; 5.06; 3.15; 3.02) or performing rupture unmarks for the empty space between the goalkeeper and the last defensive line (lag -4: z=3.11; lag -1: z=3.48; lag 0: z=4.13; 7.80). …”
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Elevated thyroid autoantibodies as risk factors for metabolic dysfunction-associated fatty liver disease in type 2 diabetes mellitus by Wenchang Wu, Wenchang Wu, Ziyi Yang, Ziyi Yang, Owen Li, Lulu Gan, Lulu Gan, Yue Gao, Yue Gao, Cheng Xiang, Ling Li, Yimin Yan, Yimin Yan

“…TgAb and TPOAb levels vary among liver fibrosis risk groups, showing an inverted “V” pattern, suggesting a role in MAFLD progression to liver fibrosis.…”
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State of local immunity in patients with furunculosis by M.M. Popov, D.S. Samusenko, O.V. Ohnivenko

“…In patients with nasal furunculosis and general furunculosis complicated by a furuncle of the nose, local immunity is significantly suppressed, which creates conditions for the development and progression of inflammation of the nose and the occurrence of rhinogenic complications.Indicators of local immunity can serve as prognostic criteria for the course of the inflammatory process in the nose and correction of the therapy.…”
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Identification Method of Dynamic Propagation Process of Rock Fracture Based on Ground Penetrating Radar by CHEN Jun, ZHANG Bo, ZHUANG Xingyue, SONG Zhishu, ZHENG Jun

“…These fractures, acting as weak planes and seepage channels, can lead to catastrophic events like landslides and collapses when they evolve progressively. While the existing monitoring techniques such as borehole imaging, CT scanning, and acoustic emission offer valuable insights, they fall short in dynamic tracking, spatial resolution, and engineering applicability, especially for complex fracture networks. …”
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