Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model by Rongwan Sun, Leonie-Kim Zimbalski, Stefanie Schreyer, David Baidoe-Ansah, Aida Harutyunyan, Arnd Heuser, Rachel N. Lippert, Joachim Spranger, Knut Mai, Sebastian Brachs

“…Understanding these sex-specific metabolic differences could provide new insights into AD progression and highlight the need for targeted treatments.…”
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Body composition derangements in lung cancer patients treated with first‐line pembrolizumab: A multicentre observational study by Ilaria Trestini, Lorenzo Belluomini, Alessandra Dodi, Marco Sposito, Alberto Caldart, Dzenete Kadrija, Luca Pasqualin, Silvia Teresa Riva, Ilaria Mariangela Scaglione, Daniela Tregnago, Alice Avancini, Jessica Insolda, Linda Confortini, Miriam Casali, Jessica Menis, Emanuele Vita, Marco Cintoni, Marco Todesco, Gianluca Milanese, Isabella Sperduti, Mirko D'Onofrio, Marco Infante, Marcello Tiseo, Maria Cristina Mele, Giampaolo Tortora, Michele Milella, Emilio Bria, Sara Pilotto

“…Primary endpoint was objective response rate (ORR), secondary endpoints progression‐free survival and overall survival (PFS and OS), compared through the log‐rank test and the Cox proportional hazards model. …”
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The use of blastocysts developing from nonpronuclear and monopronuclear zygotes can be considered in PGT-SR: a retrospective cohort study by Jingzhen Wang, Hongqiang Xie, Yang Zou, Ming Gao, Lijuan Wang, Xiaowei Liu, Se-Xin Huang, Junhao Yan, Yuan Gao

“…In a subset of 54 cycles (12.8%), preimplantation genetic testing for structural rearrangements (PGT-SR) was implemented for blastocysts originating from 0PN and 1PN embryos that progressed to Day 5/6 development stage prior to vitrification. …”
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Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia by Seongjun Park, Min‐Kyoung Shin, Dong Seok Jeong, Xin Yi Yeo, Yeo Jin Kim, Junaid Muhammad, Minju Kim, Seongeun Gu, Jeoung Eun Lee, Yunjin Park, Su Bin Lim, Ji Young Mun, Sangyong Jung, Dong Ryul Lee, Junghyun Jo

“…Here, we aimed to develop a sarcopenia model using human pluripotent stem cells (hPSCs)‐derived skeletal muscle organoids (hSkMOs) and prevent the sarcopenia progression by testosterone treatment. Methods The 3D hSkMOs were generated from hPSC and exhibited structurally and functionally mature muscle fibres and spinal‐derived neurons including motor neurons and interneurons. …”
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Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort by Masahito Kubota, Shogyoku Bun, Keisuke Takahata, Shin Kurose, Yuki Momota, Yu Iwabuchi, Toshiki Tezuka, Hajime Tabuchi, Morinobu Seki, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Takayuki Hoshino, Sho Shimohama, Natsumi Suzuki, Ayaka Morimoto, Azusa Oosumi, Yuka Hoshino, Kenji Tai, Hirofumi Aoyagi, Yoshiaki Sato, Junro Kuromitsu, Jin Nakahara, Masaru Mimura, Daisuke Ito

“…P-tau217 exhibited a linear increase with disease progression. All biomarkers correlated strongly with logical memory scores. …”
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Serum extracellular vesicle microRNAs as potential biomarkers to predict pembrolizumab response and prognosis in metastatic non-small cell lung cancer patients by Daniela Lamorte, Luciana De Luca, Alfredo Tartarone, Stefania Trino, Irene Giulivo, Angelo De Stradis, Maddalena Maietti, Antonella Caivano, Ilaria Laurenzana

“…All data were associated with immunotherapy response, Progression Free Survival (PFS), Overall Survival (OS), Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and metastases.ResultsTwelve NSCLC-related microRNAs have been found, for the first time, in serum cEVs from a specific cohort of metastatic advanced stage NSCLC patients. …”
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Study protocol to assess clinical outcomes of breast cancer and its relationship with access to healthcare in Brazil—BREAST trial (BRaziLian outcomE for metAStatic breasT cancer):... by Leticia Kawano-Dourado, Alexandre Biasi Cavalcanti, Afonso Celso Pinto Nazário, Vanessa Monteiro Sanvido, Lucíola de Barros Pontes, Rachel HV Machado, Jackeline Oliveira Gomes, Leticia Galvão Barbante, Marina Lazzari Nicola, Samira Martins Tokunaga, Tamiris Abait Miranda, Ligia Nasi Laranjeira, Karina Leal Negrelli, Nanci Valeis, Maria Silvia Petty Moutinho, Henrique Alkalay Helber, Rafael da Silva Sá

“…The project aims to assess health inequities by evaluating the prognosis of patients treated in the public versus private healthcare systems. Outcomes include progression-free survival (PFS), overall survival (OS), quality of life and cost-effectiveness. …”
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The burden of a new coronavirus infection in a Children’s multidisciplinary hospital in St. Petersburg 2020–2021 by E. A. Dondurei, V. А. Kondratev, L. N. Isankina, N. Yu. Kaika, Yu. A. Gaist, V. V. Yesikov, I. M. Kosenko, V. A. Kaziakhmedov, K. V. Pshenisnov, O. V. Zabirova, S. I. Dvorak, L. V. Ivanova, O. O. Osipova, O. I. Afanasyeva, D. A. Lioznov

“…All severe cases of COVID-19 in children require a personalized approach, taking into account the existing background diseases and possible options for the progression of the process. MIS-C should be considered as a systemic inflammatory response syndrome within the framework of an infectious disease of various etiologies, differentiated with Kawasaki disease and the debut of systemic diseases. …”
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Comprehensive Evaluation of Growth Performance, Hematological Parameters, Antioxidant Capacity, Innate Immunity, and Disease Resistance in Crucian Carp (<i>Carassius auratus</i>) L... by Ran Zhao, Jianqiang Zhu, Shaowu Li, Zhipeng Sun, Tingting Zhang, Jing Wang, Xianhu Zheng, Youyi Kuang, Di Wang

“…Following an <i>Aeromonas hydrophila</i> challenge, WT demonstrated a rapid transcriptional induction of pro-inflammatory cytokines (<i>TNF-α</i>, <i>IL-1β</i>, <i>IL-6</i>) and immunoregulatory mediators (<i>IL-10</i>, <i>TGF-β</i>), with mRNA levels reaching maximal expression at 24 h post-infection (hpi) followed by progressive attenuation. In contrast, WUCI exhibited a delayed immune activation profile characterized by the peak expression of <i>TNF-α</i>, <i>IL-1β</i>, <i>IL-6</i>, and <i>IL-10</i> transcripts after 72 hpi, with the maximum transcript abundance remaining lower than corresponding peak values observed in WT at 24 hpi. …”
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Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic by Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit

“…Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure. Methods and results Our prospective cohort study was conducted at a multidisciplinary Cardiomyopathy Clinic with 421 patients enrolled (42.5% female, median age 58 years), including 224 patients with dilated cardiomyopathy (DCM, 42.9% female, median age 57 years), 72 with hypertrophic cardiomyopathy (HCM, 43.1% female, median age 60 years), 79 with infiltrative cardiomyopathy (65.8% female, median age 70 years) and 46 who were stage A/at risk for genetic cardiomyopathy (54.3% female, median age 36 years). …”
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Genetic variants in immune mediators as potential molecular biomarkers for oral cancer evaluation: Insights from a systematic revaluation by computational analyses and Bayesian app... by Juliana Campos Botelho, Samuel Arcebispo Brasileiro, André Victor Oliveira Monteiro, Alessandro Luiz Araújo Bentes Leal, Naum Neves da Costa dos Santos, Gabrielly Ribeiro Alves, Reyce Santos Koga, Haline Alves da Silva, José Rogério Souza Monteiro, Denis Vieira Gomes Ferreira, Adenilson Leão Pereira, Ana Carolina Alves de Oliveira, Márcia Socorro Silva Lima Duarte, Felipe Rodolfo Pereira da Silva

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An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten by Lisa Leinhos, Paul Robinson, Giulia Poloni, Sophie Broadway-Stringer, Julia Beglov, Adam B. Lokman, Gillian Douglas, Sajjad Nuthay, Oveena Fonseka, Manuel Schmid, Evie Singer, Charlotte Hooper, Kate Thomson, Richard D. Bagnall, Jodie Ingles, Christopher Semsarian, Elizabeth Ormondroyd, Christopher N. Toepfer, Benjamin Davies, Charles Redwood, Hugh Watkins, Katja Gehmlich

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Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

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Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height by A. Papadopoulou, E. M. Litkowski, M. Graff, Z. Wang, R. A. J. Smit, G. Chittoor, I. Dinsmore, N. S. Josyula, M. Lin, J. Shortt, W. Zhu, S. L. Vedantam, L. Yengo, A. R. Wood, S. I. Berndt, I. A. Holm, F. D. Mentch, H. Hakonarson, K. Kiryluk, C. Weng, G. P. Jarvik, D. Crosslin, D. Carrell, I. J. Kullo, O. Dikilitas, M. G. Hayes, W. -Q. Wei, D. R. V. Edwards, T. L. Assimes, J. N. Hirschhorn, J. E. Below, C. R. Gignoux, A. E. Justice, R. J. F. Loos, Y. V. Sun, S. Raghavan, P. Deloukas, K. E. North, E. Marouli

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Not evolved to save the planet, yet capable to promote pro-environmental action leveraging human nature by Marco Antonio Correa Varella, Marco Antonio Correa Varella, Marco Antonio Correa Varella, Felipe Carvalho Novaes, Felipe Carvalho Novaes, Ramon Felipe Bicudo da Silva, Renato de Mei Romero, Paulo Henrique Santos Gonçalves, Paulo Henrique Santos Gonçalves, Joelson Moreno Brito de Moura, Joelson Moreno Brito de Moura, Risoneide Henriques da Silva, Risoneide Henriques da Silva, Matheus Adriano Ferreira Coelho, Matheus Adriano Ferreira Coelho, João Vitor Rodrigues Costa, Mauro Dias Silva Júnior, Mauro Dias Silva Júnior, Markus J. Rantala, Katariina Elsa Maria Vuorinen

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Parasympathetic response in women with coronary vascular dysfunction during mental stress compared to those with non-cardiac chest pain and reference controls by Puja K. Mehta, Shafa-at A. Sheikh, Esha K. Dave, Rahim K. Shakoor, Tina Torbati, Amit Shah, Marc D. Thames, Liu Qiang, Yi-An Ko, Janet Wei, Chrisandra Shufelt, Michael D. Nelson, Bruce Samuels, Babak Azarbal, Jeanie Park, Michael R. Irwin, David S. Krantz, C. Noel Bairey Merz

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The Effect of Exercise on Spexin and Follistatin in Elderly Individuals by Elif Yıldırım Ayaz, Berna Dincer, Gülser Cinbaz, Esra Karacan, Reyhan Kaygusuz Benli, Emel Mete, Hilal Bilgiç, Banu Mesci

“…Conclusions It was found that spexin, which provides metabolic homeostasis, and follistatin, which expresses the increase in muscle mass, increased with the implementation of a 12‐week aerobic and resistance exercise program in elderly individuals, and these increases were found to be associated with each other. …”
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Utilization of agricultural waste to reduce enteric methane emissions on livestock in tropical environment by Sulistyo ., Pranoto ., E. Mahajoeno, S.H. Pranolo, A. Sofyan, H. Herdian, B. Haryanto, R.H. Praptana

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Further assessment of a ~2-million-year-old hominin pelvis (DNH 43) from Drimolen Main Quarry, South Africa by Ellie Berg, Ashley S. Hammond, Anna G. Warrener, Mary Shirley Mitchell, Matthew W. Tocheri, Stephanie E. Baker, Andy I.R. Herries, David S. Strait, Caley M. Orr

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Interleukin-4 and specific IgE to oranges levels study in persons with allergic anamnesis by A. S. Prilutskiy, N. B. Abylgazinova, K. Y. Tkachenko

“…Statistical analysis was performed using the licensed program “MedStat” (Donetsk, Ukraine). The median, the median error, the left and right limits of 95% confidence interval were calculated for all of three samples (IL-4, total IgE-Ab, sIgE-Ab). …”
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