Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trialResearch in... by Sean W.X. Ong, Ruxandra Pinto, Asgar Rishu, Steven Y.C. Tong, Robert J. Commons, John M. Conly, Gerald A. Evans, Michael Fralick, Christopher Kandel, Philippe R.S. Lagacé-Wiens, Todd C. Lee, Sylvain A. Lother, Derek R. MacFadden, John C. Marshall, Valérie Martel-Laferrière, Michael Mayette, Emily G. McDonald, John D. Neary, Josef Prazak, Edward Raby, Adrian Regli, Benjamin A. Rogers, Stephanie Smith, Linda R. Taggart, Han Ting Wang, Terence Wuerz, Dafna Yahav, Paul J. Young, Robert A. Fowler, Nick Daneman, Nick Daneman, Asgar Rishu, Ruxandra Pinto, Benjamin Rogers, Yahya Shehabi, Rachael Parke, Deborah J. Cook, Yaseen Arabi, John Muscedere, Steven Reynolds, Richard Hall, Dhiraj Bhatia Dwivedi, Colin McArthur, Shay McGuinness, Dafna Yahav, Bryan Coburn, Anna Geagea, Pavani Das, Phillip Shin, Michael Detsky, Andrew Morris, Michael Fralick, Jeff E. Powis, Christopher Kandel, Wendy Sligl, Sean M. Bagshaw, Nishma Singhal, Emilie Belley-Cote, Richard Whitlock, Kosar Khwaja, Susan Morpeth, Alex Kazemi, Tony Williams, Derek R. MacFadden, Lauralyn McIntyre, Jennifer L.Y. Tsang, Francois Lamontagne, Alex Carignan, John Marshall, Jan O. Friedrich, Robert Cirone, Mark Downing, Christopher Graham, Joshua Davis, Erick Duan, John Neary, Gerald Evans, Basem Alraddadi, Sameera Al Johani, Claudio Martin, Sameer Elsayed, Ian Ball, François Lauzier, Alexis F. Turgeon, Henry Thomas Stelfox, John Conly, Todd C. Lee, Emily G. McDonald, Richard Sullivan, Jennifer Grant, Ilya Kagan, Paul Young, Cassie Lawrence, Kevin O'Callaghan, Matthew Eustace, Keat Choong, Pierre Aslanian, Ulrike Buehner, Tom Havey, Alexandra Binnie, Josef Prazak, Brenda Reeve, Edward Litton, Sylvain Lother, Anand Kumar, Ryan Zarychanski, Tomer Hoffman, David L. Paterson, Peter Daley, Robert J. Commons, Emmanuel Charbonney, Jean-Francois Naud, Sally Roberts, Ravindranath Tiruvoipati, Sachin Gupta, Gordon Wood, Omar Shum, Spiros Miyakis, Peter Dodek, Clement Kwok, Linda R. Taggart, Stephanie Smith, Karen Doucette, Robert A. Fowler

“…VML is supported by Clinical Research Scholar—Junior 2 program (FRQ-S).…”
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Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v by Ulrich Moebius, Radek Špíšek, David Béchard, Zuzana Antosova, Nada Podzimkova, Irena Adkins, Klara Danova, Ekaterina Simonova, Katerina Behalova, Petr Danek, Matej Fabisik, Kamila Hladikova, Lucie Kosinova, Pavel Marasek, Vladyslav Mazhara, Katerina Sajnerova, Milada Sirova, Marek Kovar, Martin Steegmaier, Hana Matuskova, Iva Malatova, Klara Hrabankova, Denise Greco, Ondrej Martinec, Romana Mikyskova, Milan Reinis, Lenka Palova Jelinkova

“…Background SOT201 and its murine surrogate mSOT201 are novel cis-acting immunocytokines consisting of a humanized/murinized/, Fc-silenced anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb) fused to an attenuated human interleukin (IL)-15 and the IL-15Rα sushi+ domain. …”
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Echocardiographic evaluation of myocardial structural and functional changes in patients with stage 5 chronic kidney disease before and after kidney transplantation by M. Sh. Khubutiya, E. V. Shuvalova, O. N. Rzhevskaya, L. T. Khamidova, A. A. Ivannikov, Kh. G. Alidzhanova, A. G. Balkarov, I. V. Dmitriev

“…A retrospective cross-sectional study included 111 individuals of whom 36 patients underwent evaluation for kidney transplant waiting list placement program (Group I), and 51 patients received kidney transplants from deceased donors (Group II). …”
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Possibilities of rehabilitation of the psychological state of children over 10 years old, suffering from acute respiratory diseases, in conditions of war in Ukraine by I.O. Mityuryayeva-Kornijko, Ie.A. Burlaka, T.D. Klets, O.A. Panchenko, A.V. Kabantseva, R.V. Terletskiy

“…The study was carried out as part of the program of outpatient observation of children with various acute manifestations of acute respiratory infections against the background of stress damage to the nervous system due to the war in Ukraine. …”
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Evaluation of Immunogenicity of Inactivated Whole-Virion Booster Vaccine against SARS-CoV-2 in a phase I, II Clinical Trial by I. O. Stoma, E. V. Voropaev, E. I. Mikhailova, K. S. Korsak, O. V. Osipkina, A. V. Molchanova, A. A. Kovalev, D. M. Los, A. A. Ziatskov, A. S. Shaforost, M. N. Yatsuk, A. Yu. Braga, N. V. Trofimova, A. M. Dronina, E. L. Gasich, V. A. Gorbunov, A. Ev. Hancharou

“…Statistical processing of the data was performed using the R programming language.Results. The values of fold change in IgG concentration to SARS-CoV-2 on day 42 and 90 in subjects who received «BelCovidVac» vaccine were significantly higher than those of subjects who received placebo (p=0,05, p=0,02, respectively). …”
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Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation by Pengyu Wang, Weihua Guo, Shuyue Liu, Shouyi Li, Jiaqi Li, Bowen Ding, Fengyi Yin, Yang Yang, Xingjiang Li, Pei Cao, Chaozhe Ma, Wanying Zhang, Yidan Song, Yating Geng, Lantao Liu, Jing Hu, Jihui Hao, Yukuan Feng

“…Recent studies have highlighted the critical role of intratumoral copper levels in regulating the expression of programmed cell death ligand-1 (PD-L1), suggesting that copper-induced cuproptosis not only enhances cancer cell death but may also amplify the effects of anti-PD-L1 antibodies (αPD-L1). …”
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Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy by Ke Xu, Qingfeng Zhu, Suzanne L Topalian, Robert A Anders, Janis M Taube, Mark Yarchoan, Keziban Ünsal-Kaçmaz, Logan L Engle, Tracee L McMiller, Sepideh Besharati, Junghwa Lee, Feriyl Bhaijee, Alan E Berger

“…Background Gastric carcinomas (GC) are aggressive malignancies, and only ~15% of patients respond to anti-programmed cell death (ligand) 1 (PD-(L)1) monotherapy. …”
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Development, validation, and clinical application of a machine learning model for risk stratification and management of cervical cancer screening based on full-genotyping hrHPV tes... by Binhua Dong, Zhen Lu, Tianjie Yang, Junfeng Wang, Yan Zhang, Xunyuan Tuo, Juntao Wang, Shaomei Lin, Hongning Cai, Huan Cheng, Xiaoli Cao, Xinxin Huang, Zheng Zheng, Chong Miao, Yue Wang, Huifeng Xue, Shuxia Xu, Xianhua Liu, Huachun Zou, Pengming Sun

“…Funding: National Natural Science Foundation of China; Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province, China; Fujian Province Central Government-Guided Local Science and Technology Development Project; Fujian Province's Third Batch of Flexible Introduction of High-Level Medical Talent Teams; Fujian Provincial Natural Science Foundation of China; Fujian Provincial Science and Technology Innovation Joint Fund.…”
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First-line treatment options for PD-L1-negative lung adenocarcinoma: a real-world analysis by Lijuan Chen, Lijuan Chen, Jie Liu, Jie Liu, Junfeng Lu, Junfeng Lu, Xiufeng Hu, Xiufeng Hu, Erjing An, Erjing An, Yanqiu Zhao, Yanqiu Zhao

“…ObjectiveTo evaluate the optimal first-line treatment options for programmed death-ligand 1 (PD-L1) negative lung adenocarcinoma (LUAD) patients without common gene-alterations.MethodsA total of 159 PD-L1-negative LUAD patients without common gene-alterations were included. …”
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AI-based pelvic floor surface electromyography reference ranges and high-precision pelvic floor dysfunction diagnosisResearch in context by Juan Chen, Jiahui Yao, Wei Chen, Feng Zhang, Heyuan Wang, Xiaoying Xu, Huan Ge, Hongmei Zhou, Jin Cen, Dan Li, Bengui Jiang, Li He, Tingting Fu, Zhengxian Xu, Lei Chu, Shuxia Zhang, Dongmei Yao, Linyi Wei, Liu Huang, Anjing Ge, Cuiping Jin, Zimu Fu, Qin Liu, Xuefeng Yu, Chengmao Zhao, Tengjiao Wang, Lan Zhu

“…Funding: This study was supported by grants from the National Key R&D Program of China: The Establishment of a Comprehensive Network for PFD Prevention, Rehabilitation, Pelvic Floor Surgery and Related Complications (2021YFC2701300), Perception and Analysis of the Situation of Major Infectious Disease Outbreaks Based on Internet Big Data (2021ZD0111202), Research on New Models for Forecasting Major Infectious Diseases and Policy Evaluation (2021ZD0111205); Beijing Natural Science Foundation (7212073), National High-Level Hospital Clinical Research Funding (2022-PUMCH-B-087) and the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2021-I2M- C&T-B- 021).…”
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Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancerResearch in context by Ying-Tzu Yen, Chen Zhao, Tian Gao, Jacqueline Ziqian Yang, Ning Kang, Jiahui Pu, Lei Qiu, Qixin Hu, Hyoyong Kim, Anmin Wang, Junseok Lee, Ryan Y. Zhang, Na Liu, Yue Ma, You-Ren Ji, Yong Ju, Lynn L. Zheng, James Lee-South, Vivian X. Zuo, Audrey Qian, Aaron Kwan, Yating Zhang, Shenghua Zhang, Zhili Wang, Jing Ren, Huaichao Liu, Zihan Wang, Yang Yue, Jina Kim, Jennifer Sun, Gabriella A. DiBernardo, Laura B. James-Allan, Ying Chen, Weipei Zhu, Guoyun Wang, Renjun Pei, Sanaz Memarzadeh, Sungyong You, Bobbie J. Rimel, Kate Lawrenson, Beth Y. Karlan, Myung Shin Sim, Shaohua Lu, Jipeng Wan, Na Sun, Hsian-Rong Tseng, Yazhen Zhu

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Intratumoral microbiota composition in women’s cancers: a systematic review and meta-analysis by Qin Wen, Qin Wen, Shubin Wang, Shubin Wang, Shunlian Fu, Xinxiang Zhou, Xinxiang Zhou, Yalan Min, Yalan Min, Jinyi Lang, Jinyi Lang, Meihua Chen

“…BackgroundThe intratumoral microbiota has attracted considerable interest in carcinogenesis, progression, and treatment owing to advancements in sequencing technology. …”
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Journals Operating Predatory Practices Are Systematically Eroding the Science Ethos: A Gate and Code Strategy to Minimise Their Operating Space and Restore Research Best Practice by Kenneth Timmis, Paul Williams, Zeynep Ceren Karahan, Purificación López‐García, Paul Rainey, Max Chavarria, Chris Greening, Karen Steward, John E. Hallsworth, Cristina Silva Pereira, Rafael Giraldo, Willy Verstraete, Stipan Jonjić, Juan Luis Ramos, Olga Nunes, Antonio Ventosa, Rachel Armstrong, Angela Sessitsch, Eliora Ron, Hui Wang

“…These trends will inevitably progressively erode public trust in scientists and the research ecosystem. …”
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How to Apply the Sequential Correction Technique to Treatment of Congenital Cervicothoracic Scoliosis: A Technical Note and Case Series by Saihu Mao, Kai Sun, Song Li, Jie Zhou, Hongda Bao, Benlong Shi, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu

“…Additionally, 3 patients suffered severe distal curve progression with trunk tilt and were surgically revised with instrumentation extending to the stable zone. …”
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Temporal dichotomy of neutrophil function in acute liver injury and repair by Jennifer A. Cartwright, Philippe M.D. Potey, Eilidh Livingstone, Lara Campana, Philip J. Starkey Lewis, Magdalena E.M. Oremek, Naomi N. Gachanja, Giulia Rinaldi, Rhona E. Aird, Tak Yung Man, Anuruddika J. Fernando, Joanna P. Simpson, Natalie Z.M. Homer, Nicole Barth, Melisande Addison, Candice Ashmore-Harris, Maria Elena Candela, Alastair M. Kilpatrick, Matthieu Vermeren, Calum T. Robb, David A. Dorward, Christopher D. Lucas, Stuart J. Forbes, Adriano G. Rossi

“…Neutrophil products and functions are potential targets for future therapies, but current literature controversy and a lack of time-dependent studies hinder progression. This study resolves the literature controversy, showing that neutrophils have time-dependent dichotomous roles in APAP-ALI. …”
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LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study by Zarnie Lwin, Eng-Siew Koh, Mustafa Khasraw, Elizabeth H Barnes, Hui K Gan, Anna K Nowak, Cleo Robinson, Benhur Amanuel, Michael E Buckland, Sonia Yip, Benjamin Y Kong, Hao-Wen Sim, Bryan W Day, Roel Verhaak, Terrance Johns, Marc A Thomas, Tindaro Giardina, Andrew M Scott, Jonathon Parkinson, Rosalind Jeffree, Richard de Abreu Lourenco, Elizabeth J Hovey, Lawrence M Cher, Ganessan Kichendasse, Merryn Hall, Emily Tu

“…The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. …”
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Current Genetic Models for Prediction of Primary Myelofibrosis by LB Polushkina, VA Shuvaev, MS Fominykh, YuA Krivolapov, EA Belyakova, ZP Asaulenko, V Motyko, LS Martynenko, MP Bakai, NYu Tsybakova, SV Voloshin, SS Bessmeltsev, AV Chechetkin, IS Martynkevich

“…To study the relationship of karyotype, JAK2, CALR, and MPL driver mutations and ASXL1 mutation status with the progression and prediction of primary myelofibrosis (PMF). …”
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Evaluating a 12-week aerobic exercise intervention in adults with persisting post-concussive symptoms by Leah J. Mercier, Leah J. Mercier, Samantha J. McIntosh, Samantha J. McIntosh, Chloe Boucher, Chloe Boucher, Julie M. Joyce, Julie M. Joyce, Julia Batycky, Julia Batycky, Jean-Michel Galarneau, Joel S. Burma, Joel S. Burma, Joel S. Burma, Joel S. Burma, Joel S. Burma, Jonathan D. Smirl, Jonathan D. Smirl, Jonathan D. Smirl, Jonathan D. Smirl, Jonathan D. Smirl, Michael J. Esser, Michael J. Esser, Michael J. Esser, Kathryn J. Schneider, Kathryn J. Schneider, Kathryn J. Schneider, Sean P. Dukelow, Sean P. Dukelow, Ashley D. Harris, Ashley D. Harris, Ashley D. Harris, Chantel T. Debert, Chantel T. Debert, Chantel T. Debert

“…Clinicians should consider prescription of progressive, individualized, sub-symptom threshold aerobic exercise for adults with PPCS even if presenting with exercise intolerance and months-to-years of symptoms.…”
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Sex differences in the peripheral levels of cytokines during 12-month antipsychotic treatment in a drug-naïve schizophrenia spectrum cohort by I. Ratke, A. Torsvik, C.A. Bartz-Johannessen, F. Fathian, I. Joa, S.M. Klæbo Reitan, E.M. Løberg, M. Rettenbacher, S. Skrede, V.M. Steen, E. Johnsen, R.A. Kroken

“…There were significant sex differences in progression of cytokine levels at weeks 3 (IL-6: p = 0.046), 6 (IL-4: p = 0.022, IL-6: p = 0.015), 12 (IL-6: p = 0.01), 26 (IL-4: p < 0.001, IL-6: p = 0.015, TNF-α: p = 0.026), 39 (IL-4: p = 0.003, TNF-α: p = 0.023) and 52 (IL-4: p < 0.001, TNF-α: p = 0.009). …”
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Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer by Lin-Ting Zhang, Yuejia Zhou, Tiantian Wang, Boran Chen, Zhigao Cai, Shubin Wang, Gangling Tong

“…Circular RNAs (circRNAs) have emerged as crucial players in the onset and progression of CRC. This research aims to investigate the expression levels of a novel circRNA, hsa_circ_0002238, in CRC and to explore its association with alterations in CRC functional phenotypes.MethodsHigh-throughput RNA sequencing identified abnormal circRNA expressions, and qRT-PCR validated hsa_circ_0002238 expression. …”
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