Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models by Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jin Ju Lim, Yeong Hoon Kang, Ji Wook Moon, Jeong Min Nam, Jeong Hyeon Kim, Donghun Kim, Jae Ho Shim, Hyeon Soo Kim

“…ABSTRACT Background Cancer‐associated cachexia (CAC) is a multifactorial syndrome characterised by progressive loss of muscle mass with limited Food and Drug Administration treatments. …”
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A Comparison and Evaluation of Landslide Stabilization Methods (Case Study: The Landslide Occurred in the 194 km of Malayer - Kermanshah Railway) by Jahangir Khazaei, Mehdi Ghaem

“…Furthermore, the behavior of the progressive landslide was monitored using five stable monitoring points in different locations. …”
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SIAE-Mediated Loss of Sialic Acid Acetylation Contributes to Ulcerative Colitis by Bo S, Wang X, Qian J, Ma G, Ying Z, Hu D, Hou C, Ma J, Xu L, Yang S

“…This study investigates the role of glycosylation changes, specifically sialic acid de-acetylation, in UC progression.Methods: Tissue samples were obtained from patients with ulcerative colitis (UC) and colorectal cancer at the Second Affiliated Hospital of Soochow University. …”
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Biomarker, efficacy and safety analysis of transcatheter arterial chemoembolization combined with atezolizumab and bevacizumab for unresectable hepatocellular carcinoma by Shaobo Zhang, Zebin Zhu, Lianxin Liu, Björn Nashan, Shugeng Zhang

“…The primary endpoint of the study was the correlation between baseline NLR and PLR with overall survival (OS) and progression-free survival (PFS). The secondary endpoints were the efficacy and safety of the Atezo-Bev-TACE regimen. …”
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Efectividad clínica y microbiológica del tratamiento erradicador de Helicobacter pylori con terapia triple by Yasmin Ghandour Fawaz, Nagore Rojo Ruiz, Javier Díaz Núñez, Alba Sariola Molins, Saúl Barreales Soto, Jordi Vilaseca Canals

“…The majority of patients experienced a progressive improvement in their symptoms.…”
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Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…Summary: Background: Prior studies suggest prevalence of heart failure (HF) has remained steady or progressively decreased over past 30 years in the general population. …”
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Implementing Positive Youth Development in Primary Physical Education: The Learning Trajectories of a Physical Education Department Head (Fomentar el Desarrollo Positivo de los Jóv... by Fernando Santos, Cláudio Farias, Ivo van Hilvoorde, Daniel Gould, Paulo Pereira

“…Findings showed the PE department head progressed from a perspective of PYD as an inherent and naturally emerging outcome to an understanding of PYD as more structured programmes of activities that include a deliberate approach. …”
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Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39 by Xing Yu, Xiaojun Chen, Weibin Wu, Huibin Tang, Yunyun Su, Guili Lian, Yujie Zhang, Liangdi Xie

“…ABSTRACT Background Muscle atrophy is a severe complication of diabetes, with autophagy playing a critical role in its progression. Zinc has been shown to alleviate hyperglycaemia and several diabetes‐related complications, but its direct role in mediating diabetic muscle atrophy remains unclear. …”
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Features of expression of immunohistochemical markers in local and generalized clear cell kidney cancer by E. M. Frantsiyants, A. N. Shevchenko, E. A. Dzhenkova, N. S. Karnaukhov, T. A. Gudtskova, A. A. Breus, E. V. Filatova, D. A. Shvyrev

“…One of the main markers of extracellular matrix degradation MMP‑9 was approximately at the same level at both stages: at local‑50±6% and 49.6±7.2% at generalized, the difference in indicators is not reliable (P<0.05).Conclusion. Progression of clear cell kidney cancer from local to generalized forms is accompanied by hyperexpression of cyclin D1, a decreased e‑cadherin expression while increasing vimentin expression (increasing signs of epithelial-mesenchymal transformation), an increase in CD44 and VEGF expression.…”
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Current opportunities to improve outcomes of COVID-19 infection prevention and course in patients with lymphoproliferative diseases (regional analysis) by Ch. Kh. Valiakhmetova, E. I. Siraeva

“…No mortality from COVID-19 infection has been reported with the combination of tixagevimab 150 mg + cilgavimab 150 mg.The only lethal outcome in the 1st group was due to the progression of oncohematological disease. Among the 30 patients who died in 2nd group, almost half (46 %) died due to COVID-19 infection. …”
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The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective by Jian-Di Li, Li-Li Deng, Jia-Yuan Luo, Chao-Hua Mo, Bang-Teng Chi, Wan-Ying Huang, Rong-Quan He, Di-Yuan Qin, Chang Song, Wen Zou, Gang Chen

“…This study aimed to elucidate COL6A6 expression patterns, assess its impact on the tumor immune microenvironment, and uncover underlying molecular mechanisms in breast cancer progression. Methods Immunohistochemical staining of COL6A6 was conducted on 136 breast cancer tissues and 50 non-breast-cancer controls in-house. …”
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Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study by Ana Checa-Ros, Antonella Locascio, Owahabanun-Joshua Okojie, Pablo Abellán-Galiana, Luis D’Marco

“…BMD originates from reduced 1,25-dihydroxy vitamin D and hypocalcemia, which lead to secondary hyperparathyroidism, with increased parathyroid hormone (PTH) levels and hyperphosphatemia as the progression of renal damage. Due to their pleiotropic effects, vitamin D and its analogs, such as cholecalciferol, calcitriol, or paricalcitol, have proven effective in controlling BMD and CVD. …”
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Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma by Cheng-Hui Lu, Xue-Lai Yin, Zhuo-Deng Huang, Si-Ang Lv, Jun Wu, Jie Wei

“…The present study aimed to evaluate the effects and mechanisms of RRGs on OSCC development progression. Methods RNA-seq transcriptome data, along with clinical and prognostic information, were extracted for 328 patients with OSCC from the TCGA database. …”
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A Novel Hypoxia-Related Gene Signature with Strong Predicting Ability in Non-Small-Cell Lung Cancer Identified by Comprehensive Profiling by Huajun Yang, Zhongan Wang, Ling Gong, Guichuan Huang, Daigang Chen, Xiaoping Li, Fei Du, Jiang Lin, Xueyi Yang

“…Circular RNAs (circRNAs) have been reported to sponge miRNAs to regulate target gene expression and play an essential role in tumorigenesis and progression. This study is aimed at identifying whether circRNAs could be used as the diagnostic biomarkers for NSCLC. …”
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Formulating a Comprehensive System of Contractual Excuses in the Iranian Legal Order by Seyyed Mohammad Hasan Momeni, Amir Mahdi Ghorban Poor

“…The research structure is divided into three progressive stages: (1) a conceptual analysis of contractual excuses, emphasizing Shi’a jurisprudential principles; (2) the establishment of classification criteria for different types of excuses, tailored to Iranian law; and (3) an explication of these excuses based on practical and doctrinal applications. …”
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Role and Therapeutic Potential of miR-301b-3p in Regulating the PI3K-AKT Pathway via PIK3CB in Eosinophilic Chronic Rhinosinusitis by Shu F, Wang Y, Jiang Y, Li L, Mu Z, Shi L, Gong X, Zhang B, Zhang F, Mao D

“…Given the limited sample size of this study, we plan to expand our cohort and implement a longitudinal follow-up design to monitor dynamic changes in miR-301b-3p expression and their relationship to disease progression.Keywords: miR-301b-3p, PIK3CB, eosinophilic chronic rhinosinusitis, PI3K-AKT pathway, epithelial-mesenchymal transition…”
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Effect of Zinc Nano Oxide on the Quality of Turkey Sperm in Liquid State by Vahid Lotfi vafa, Khalil Mirzadeh, Saleh Tabatabaei Vakili, Amin Kazemizadeh

“…Different concentrations of zinc oxide nanoparticles (0, 50, 100, and 200 µg/mL) were added to the semen extender, and sperm quality parameters (total motility, progressive motility, viability, membrane integrity, and abnormality) were evaluated at 0, 12, 24, and 48 hours of storage at 4°C. …”
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Role of NLRP3 Inflammasome in Heart Failure Patients Undergoing Cardiac Surgery as a Potential Determinant of Postoperative Atrial Fibrillation and Remodeling: Is SGLT2 Cotransport... by Rodrigo L. Castillo, Jorge Farías, Cristian Sandoval, Alejandro González-Candia, Esteban Figueroa, Mauricio Quezada, Gonzalo Cruz, Paola Llanos, Gonzalo Jorquera, Sawa Kostin, Rodrigo Carrasco

“…The anti-inflammatory, antioxidant, and anti-remodeling effects of SGLT-2 i have progressively expanded from HFrEF and HFpEF to other forms of cardiac remodeling. …”
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Numerical Simulation of Hybrid Electric–Structural Control for Microdroplet Formation in Ribbed T-Junction Microchannels by Ruyi Fu

“…Furthermore, an increase in rib height <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>a</mi><mo>/</mo><msub><mi>w</mi><mi>c</mi></msub></mrow></semantics></math></inline-formula> enhances the shear stress of the continuous phase above the rib, causing a progressive shift from a fully pinning to an unpinning regime, which results in a linear decrease in droplet size. …”
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Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction by Nousjka P. A. Vranken, Xinyu Li, Heleen Bouman, Sanne G. J. Mourmans, Anouk Achten, Arantxa Barandiarán Aizpurua, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P. M. van Empel, Jerremy Weerts

“…Diabetes mellitus is an important cardiovascular risk factor in patients with HFpEF, contributing to disease progression and worse outcomes. Albuminuria is a prognostic marker in heart failure patients and more prevalent in patients with diabetes What is the key research question? …”
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