Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…The primary endpoints were safety, tolerability and efficacy including objective response rate (ORR), disease control rate (DCR), duration of response (DoR), progression-free survival (PFS) assessed by RECIST v1.1 and overall survival (OS). …”
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Relationship Between Social Support, Symptom Burden, Dyspnea, Perceived Stress, Perceived Stigma, Coping Styles, and Psychological Distress in Patients with Stable COPD: A Structur... by Tian X, Yi L, Liu X, Zuo F, Shang H, Zhang J, Ren Y

“…Xu Tian,1,* Lijuan Yi,2,* Xiaoling Liu,3 Fengli Zuo,4 Hongcai Shang,5 Jianping Zhang,6 Yi Ren7 1Division of Science & Technology and Foreign Affairs, Chongqing Center for Evidence-Based Traditional Chinese Medicine, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400020, People’s Republic of China; 2Department of Nursing, Hunan Traditional Chinese Medical College, Zhuzhou, 412012, People’s Republic of China; 3Department of Nuclear Medicine, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 4Department of Lung Diseases, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400020, People’s Republic of China; 5Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People’s Republic of China; 6Department of Nursing, Shapingba District Hospital of Traditional Chinese Medicine, Chongqing, 400030, People’s Republic of China; 7Department of Classic Traditional Chinese Medicine, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400020, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianping Zhang, Department of Nursing, Shapingba District Hospital of Traditional Chinese Medicine, No. 167, Xiaoyanggongqiao, Shapingba District, Chongqing, 400030, People’s Republic of China, Email 339009454@qq.com Yi Ren, Department of Classic Traditional Chinese Medicine, Chongqing Traditional Chinese Medicine Hospital, No. 6 of 7th Brach of Panxi Road, Jiangbei District, Chongqing, 400020, People’s Republic of China, Email cqszyyrenyi@163.comBackground: Psychological distress is prevalent in patients with stable chronic obstructive pulmonary disease (COPD) and may contribute to disease progression. However, the interplay among its influencing factors remains unclear. …”
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A Novel Retinal Nerve Fiber Layer Biomarker of Amyotrophic Lateral Sclerosis (ALS) Identified Using Longitudinal in vivo Ocular Imaging by Khorrami F, Gupta N, Zhou X, Liang Y, Yucel YH

“…We aim to assess the presence of inner retinal pathology in a mouse model of ALS and its possible progression with age.Methods: Transgenic SOD1G93A mice (n=8, 4M/4F) and age-matched controls (n=8, 4M/4F) underwent in vivo retinal imaging with confocal scanning laser ophthalmoscopy (cSLO) coupled with optical coherence tomography (OCT) at 20 weeks of age. …”
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Effect of Gender on Patients with Non-Small-Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Real-World Study by Teresa Calleja-Chucla, Patricia Cordeiro González, Alejandro Martínez Pradeda, Sonia Pértega-Díaz, Luis Margusino-Framiñán, Silvia Antolín Novoa

“…<b>Objective:</b> To evaluate the differences in overall survival (OS) and progression-free survival (PFS) between men and women with non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) in second-line and later treatments. …”
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Characteristics of clinical, laboratory, and immunological manifestations in patients with anticentromere antibody-associated Sjögren's disease by B. D. Chaltsev, V. I. Vasilyev, S. G. Palshina, A. V. Torgashina, E. V. Sokol, Yu. I. Khvan, E. B. Rodionova, T. N. Safonova, S. V. Lapin, O. Yu. Tkachenko, A. V. Mazing

“…Regardless of the detected type of antibodies and the presence or absence of extraglandular manifestations, damage to the salivary and lacrimal glands progresses in SD, which often leads to lymphomas; therefore, the therapy that may prevent this complication should be initiated as soon as possible after SD diagnosis. …”
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Early diagnosis of mineral and bone disorders in patients with diabetic kidney disease on the background of type 2 diabetes by V.M. Yerokhovych, O.V. Karpenko, I.A. Paliienko, N.M. Kobyliak, M.I. Bobryk, L.V. Shuliarenko, O.A. Rudenko, D.V. Kyriienko, M. Bolanowski, Y.I. Komisarenko

“…Today, diabetes mellitus is an actual problem, characterized by a progressive increase in the number of patients with a high frequency of complications that require early diagnosis and timely treatment. …”
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Evaluation of the state of small intestinal microbiota, pro- and anti-inflammatory cytokines, short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease in... by Yu.M. Stepanov, V.I. Didenko, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko, R.M. Kyslova

“…One of the unresolved problems associated with MASLD is the identification of pathogenetic links that affect the risk of rapid progression of the disease and the development of irreversible changes in the liver. …”
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Preliminary study on early warning value and mechanism of interleukin-1β in extremely severe oral and maxillofacial space infections by ZHU Hanyi, SHI Huan, YU Chuangqi, ZHENG Lingyan

“…Macrophage migration inhibitory factor (MIF) signaling between T cells and monocytes also increased notably. With infection progression, the mRNA levels of NLRP3 and IL1B in peripheral blood rose steadily, and the protein levels of NLRP3, caspase-1 p20, apoptosis-associated speck-like protein containing a CARD (ASC) and IL-1β were persistently elevated.Conclusion·The combined levels of IL-1β and PCT at admission can effectively predict extremely severe OMSI. …”
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Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular Carcinoma by Zhang J, Xu Y, Ni X, Mao Z, Xiao H, Chen M, Lin Y, Pan J, Zhang B, Zhang L, Zheng X, Song G, Ge N

“…Functional validation confirmed that PBK knockdown significantly inhibited Huh7 cell migration capacity (P &lt; 0.05). scRNA-seq analysis showed PBK-enriched tumors contained elevated proportions of immunosuppressive SPP1(+) macrophages (22.33% vs 6.6%, FDR corrected P &lt; 0.001) and CD8(+) SLC4A10(+) MAIT cells (9.82% vs 4.7%, FDR corrected P &lt; 0.001).Conclusion: PBK synergistically drives HCC progression through three synergistic mechanisms: (1) promoting oncogenic mutation accumulation (eg, TP53), (2) increasing metastatic potential, and (3) reprogramming an immune-suppressive microenvironment enriched for SPP1(+) macrophages and CD8(+)SLC4A10(+) MAIT cells. …”
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Integrated Early CRP Kinetics and Plasma EBV DNA Clearance as Prognostic Biomarkers in De Novo Metastatic Nasopharyngeal Carcinoma Treated with First-Line Chemoimmunotherapy by Fang M, Hu Y, Wang T, Su Y, Lu T, Zhang H, Li J, Xie C, Gong X

“…Associations with objective response rate (ORR), and progression-free survival (PFS) were evaluated.Results: The multicenter study included 149 patients with dmNPC (median follow-up: 22 months). …”
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Lung cancer-associated fibroblasts-mediated collagen deposition drives mediastinal lymph node metastasis in non-small cell lung cancer by Caoyang Chen, Caoyang Chen, Yuqian Feng, Yuqian Feng, Frankie Chi Fat Ko, Sze Kwan Lam, Sheng Yan, James Chung Man Ho

“…Cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) play a crucial role in tumor progression by promoting growth and invasion. However, the specific contributions of lung CAFs to mediastinal lymph node metastasis in NSCLC remain poorly understood. …”
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Pre-treatment loss to follow-up and associated factors among drug-resistant tuberculosis patients diagnosed in Wakiso district, central Uganda by James Arinaitwe, James Muleme, Perez N. Ochanda, Rebecca Nuwematsiko, Samson Omongot, Barnabas Bakamutumaho, Esther Buregyeya

“…Pre-treatment loss to follow-up (LTFU) among diagnosed DR-TB patients also signifies a setback in the timely prevention of disease progression and transmission, especially in low-resource settings. …”
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Multi-omics analysis unveils the predictive value of IGF2BP3/SPHK1 signaling in cancer stem cells for prognosis and immunotherapeutic response in muscle-invasive bladder cancer by Yaobang Wang, Wuyue Song, Chao Feng, Shulin Wu, Zezu Qin, Tao Liu, Yu Ye, Rong Huang, Yuanliang Xie, Zhong Tang, Qiuyan Wang, Tianyu Li

“…Conclusions Our study highlighted the critical involvement of the IGF2BP3/SPHK1 signaling in maintaining the stemness of CSCs and promoting MIBC progression. Additionally, these findings suggested that the IGF2BP3/SPHK1 signaling might serve as a biomarker for prognosis and immunotherapy response in MIBC.…”
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Gut microbiota modulation through Traditional Chinese Medicine (TCM) - improving outcomes in Gastrointestinal (GI) cancer prevention and management by Yuying Wang, Yu Zeng, Xiaoli Chen, Aiping Lu, Wei Jia, Kenneth CP Cheung

“…Results: This review highlights the functions of gut microbiota and the implications of microbial dysbiosis in GI carcinogenesis, specifically focusing on the mechanisms that link disruptions in gut microbial communities to cancer progression. Additionally, it highlights the potential integration of Traditional Chinese Medicine into conventional cancer treatment and management by both pharmacological and non-pharmacological approaches. …”
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Treatment of febrile seizures with intermittent clobazam Tratamento de convuslsões febris com clobazam intermitente by Maria Luiza G. Manreza, José Luiz D. Gherpelli, Lúcia R. Machado-Haertel, Cristiane C. Costas Pedreira, Carlos O. Heise, Aron Diament

“…Cases with severe neurological abnormalities, progressive neurological disease, afebrile seizures, symptomatic seizures of other nature, or seizures during a central nervous system infection were excluded. …”
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ASSOCIATION OF BLOOD GENE EXPRESSIONS IN RHEUMATOID ARTHRITIS PATIENTS WITH CLINICAL AND LABORATORY PARAMETERS BEFORE AND AFTER METHOTREXATE THERAPY by E. V. Chetina, N. V. Demidova, D. E. Karateev, G. A. Markova, M. A. Makarov, V. V. Kolomatsky, A. L. Logunov, E. A. Naryshkin, M. M. Lipina, S. A. Makarov, A. N. Kuzin

“…The high initial blood expression of the other examined genes is associated with the more effective action of MTX on stiffness (TNF-α, Runx2, cathepsin K, and TGFβ1), TJC and SJC (mTOR, p21, and TNF-α), and the progression of joint destruction (mTOR) and may play a protective role. …”
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Formació, llenguatge i experiència. Sobre diàlegs poeticofilosòfics de Plató i Borges by Liliana J. Guzmán

“…Par rapport à ces deux textes, nous abordons une interprétation de l’éducation par l’art comme formation et comme inquiétude, selon une structure discursive qui commence avec la question de soi-même, progresse par des moments divers de rencontre avec la vérité, et s’achève sans conclure par un pari sur le choix pour la formation comme oeuvre d’art et le choix de soimême comme autre manière d’éduquer.…”
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Nivel de adaptación al contexto táctico en futbolistas juveniles (Level of adaptation to the tactical context in youth football players) by Santiago Gaviria Echavarría, Mateo Sepulveda Arango, Santiago Sepúlveda Arango, Wilder Geovanny Valencia Sánchez, Jose Albeiro Echeverri Ramos

“…On the other hand, the principle of progressing it had a greater performance in the second time (37.33%) finding significant differences between both times (p< .01); in the principle of finishing there is a 33.33% difference between the times. …”
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Best evidence topic: implante valvular aórtico transcatéter en pacientes con estenosis aórtica grave asintomática by Elio Martín Gutiérrez, Pasquale Maiorano, Laura Castillo Pardo, Blanca Meana Fernández, Belén Ramos Barragán, Javier Gualis Cardona, Mario Castaño Ruiz, José Manuel Martínez Comendador, José Manuel Garrido Jiménez

“…Patients with severe aortic stenosis may present an increased risk of mortality in the asymptomatic phase. Furthermore, the progression of their heart disease may have prognostic implications. …”
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Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model by Wang X, Li M, Liu X, Sun G, Zhang D, Sun L, Yin Y, Zhang W, Hao J

“…In the caerulein-treated group, mPSC activation was significantly greater than in the saline-treated control group. RT-PCR revealed progressive upregulation of acta2 (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2, &amp;num;&amp;num;p&lt; 0.01,d7 compared to d4,&amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2), col1a (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2,&amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2), and actg2 (&amp;ast;&amp;ast;p&lt; 0.01, d4 compared to d2, &amp;num;&amp;num;p&lt; 0.01,d7 compared to d4, &amp;ast;&amp;ast;p&lt; 0.01,d7 compared to d2) mRNA levels at 2, 4, and 7 days post-adhesion. …”
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