Prevalence of dyslipidemia and its association with blood pressure control in Iranian hypertensive patients: insights from STEPS 2021 by Shervin Mossavarali, Yosra Azizpour, Ali Golestani, Nazila Rezaei, Sepehr Khosravi, Mina Mirzad, Pouria Khashayar, Ozra Tabatabaei-Malazy

“…Lipid markers, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), Non-HDL-C, and triglycerides (TG), were evaluated using the National Cholesterol Education Program Adult Treatment Panel III 2004 criteria. Associations between lipid markers and uncontrolled hypertension were assessed using a multivariable modified Poisson regression model, with results presented as adjusted prevalence ratio (APR) and 95% confidence interval (CI). …”
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Synergy of rehabilitation for stress-related disorders and ARIs in school-age children under the war condition in Ukraine by I.O. Mityuryayeva-Kornijko, Ie.A. Burlaka, T.D. Klets, O.A. Panchenko, A.V. Kabantseva, E.S. Sukhodolska

“…The study was carried out as part of the program of outpatient observation of children with various acute manifestations of ARIs against the background of stress damage to the nervous system due to the war in Ukraine, and taking naturopathic drugs with immunocorrective properties (scheme (1)): 1) affinity-purified antibodies to human interferon gamma (6 mg), histamine (6 mg) and CD4 (6 mg) — a mixture of homeopathic dilutions C12, C30 and C50; or in combination with a drug with a sedative effect (scheme (1+2)): 1) affinity-purified antibodies to human gamma interferon (6 mg), histamine (6 mg) and CD4 (6 mg) — a mixture of homeopathic dilutions C12, C30 and C50; 2) affinity-purified antibodies to brain-specific protein S100 (3 mg) — a mixture of homeopathic dilutions C12, C30 and C50. …”
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Characteristic of herd immunity among the population of Stavropol region amid the COVID-19 epidemic by A. Yu. Popova, E. B. Ezhlova, A. A. Melnikova, V. S. Smirnov, L. V. Lyalina, A. V. Ermakov, N. I. Solomashchenko, I. V. Kovalchuk, E. A. Vasilenko, E. N. Romanenko, A. V. Zvoliborskaya, A. V. Ryabykh, L. I. Dmitrienko, N. A. Mezhlumyan, A. A. Sharova, V. V. Vetrov, A. A. Totolian

“…The SARS-CoV-2 study was carried out according to a unified methodology within the framework of the program for assessing the population immunity of the population of the Russian Federation, developed by Rospotrebnadzor with the participation of the St. …”
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Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis by Wei Ren, Hanyu Zhang, Yixin Li, Wu Sun, Hexiang Peng, Huangda Guo, Tianjiao Hou, Mengying Wang, Mengying Wang, Zhendong Hu, Tao Wu, Tao Wu, Baorui Liu

“…Two researchers independently extracted trial data, including efficacy-related outcomes such as overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and duration of response (DoR), along with their subgroup data and safety-related indicators. …”
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Ixazomib or Lenalidomide combined with cyclophosphamide and dexamethasone in the treatment of elderly transplant-ineligible newly diagnosed multiple myeloma by Yan Wang, Yuan-Fang Liu, Shi-Wei Jin, Yi Tao, Wei-Ping Zhang, Jian-Lin Chen, Song-Fu Jiang, Jian-Qing Mi

“…The primary objective was to compare the two regimens by analyzing the overall response rate (ORR), safety profiles, progression-free survival (PFS) and overall survival (OS). …”
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ADULT T-CELL LEUKEMIA/LYMPHOMA RELAPSED AFTER AUTOLOGOUS TRANSPLANT AND TREATED WITH HAPLOIDENTICAL STEM CELL TRANSPLANT by TFN Araújo, LPDS Rocha, CF Oliveira, BA Souza, CFM Ferreira, LS Abreu, RAF Machado, ML Puls, PHA Moraes, EL Rosa, CD Liz, RS Szor, VC Molla, C Arrais

“…Six months after transplant, she progressively presented worsening of her skin lesions. …”
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CSRP2 promotes the glioblastoma mesenchymal phenotype via p130Cas-mediated NF-κB and MAPK pathways by Jiawei He, Liang Zhang, Hao Xu, Chengtian Gao, Wentao Zhao, Bingchang Zhang, Wanhong Han, Wenpeng Zhao, Guowei Tan, Sifang Chen, Ping Zhong, Zhe Shen, Jian Meng, Ziqian Tang, Hanwen Lu, Xin Gao, Zhangyu Li, Wenhua Li, Jianyao Mao, Bosen Liu, Yun-wu Zhang, Zhanxiang Wang

“…Mechanisms of CSRP2 involvement in GBM progression were analyzed with gene set enrichment analysis and KEGG enrichment analysis in available databases. …”
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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... by Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

“…By protocol, at median follow-up 11.3-years, progression-free survival (PFS) remained superior for IFRT+(R)CVP vs. …”
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MiR-221, miR-320a, miR133a, and miR-133b as potential biomarkers in leiomyosarcoma by Mst Nasrin Akhtar, Mst Nasrin Akhtar, Annabell Walter, Annabell Walter, Kathrin Katenkamp, Kathrin Katenkamp, Yuan Chen, Yuan Chen, Thomas Lehmann, Thomas Lehmann, Wolfram Weschenfelder, Wolfram Weschenfelder, Christian Spiegel, Christian Spiegel, Matthias Vogt, Gunther O. Hofmann, Gunther O. Hofmann, Andreas Hochhaus, Andreas Hochhaus, Nikolaus Gaßler, Nikolaus Gaßler, Joachim H. Clement, Joachim H. Clement, Karin G. Schrenk, Karin G. Schrenk

“…MicroRNAs (miRNAs) function in modulating a multitude of targets and are involved in tumorigenesis, cancer progression, and metastasis. This study was designed to evaluate miR-221, miR-320a, miR-133a, and miR-133b as potential biomarkers in leiomyosarcoma.Materials and methodsThe expression levels of miR-221, miR-320a, miR-133a, and miR-133b as well as their target mRNAs CDKN1B, TGFBR1, and IGF1R were assessed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) in tissue samples from 33 patients with leiomyosarcoma. …”
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Mechanisms underlying delayed loss of HBeAg and HBV DNA following HBsAg seroclearance in PEG-IFNα treated patients of chronic hepatitis B by Bei Jiang, Guiwen Guan, Kaitao Zhao, Zhiqiang Gu, Lin Wang, Weilin Gu, Minghui Li, Yuchen Xia, Xiangmei Chen, Yifei Guo, Jiming Zhang, Zhenhuan Cao, Man-fung Yuen, Fengmin Lu

“…Transcriptional suppression of SP1/SP2 promoters through mutations and/or epigenetic changes supports the maintenance of chronic HBV infection by enhancing the transcriptional activity of the BCP, which in turn promotes cccDNA replenishment.HighlightsApproximately 20% of patients with CHB who have just achieved HBsAg loss under IFNα treatment show positive serum HBV DNA and/or HBeAg.During disease progression, in frame indel mutations accumulate in the HBV genome’s SP1 and SP2 promoters, with epigenetic modifications contributing to their suppression.In frame indel mutations in the HBV genome’s SP1 and SP2 promoters inhibit the transcription of HBV S mRNA and promote the transcription of 3.5 kb HBV RNA.The loss of L-HBs and envelop proteins leads to an increase in intracellular cccDNA, promoting the maintenance of chronic infection.…”
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Remote, smart telemonitoring of COVID-19 survivors for early detection of deterioration in cardiac health (the PARTMO study) by Josephine Sau Fan Chow, Josephine Sau Fan Chow, Josephine Sau Fan Chow, Josephine Sau Fan Chow, Josephine Sau Fan Chow, Nutan Maurya, Nutan Maurya, Susan San Miguel, Rumbidzai Teramayi, Ahilan Parameswaran, Annamarie D’Souza, Gregory Melbourne, Joseph Descallar, Young Juhn, Enoch Chan, Jerome Pong

“…Two patients developed long COVID symptoms (progressive dyspnoea) 2–5 months post-COVID-19 infection.ConclusionsConsidering the risk of developing cardiovascular complications post-COVID-19 infection, regular monitoring, reassessment, and evaluation are recommended as a part of post-COVID-19 management for all patients, including young, healthy, and asymptomatic populations. …”
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Activation of AMP-activated Protein Kinase by Metformin Inhibits Dedifferentiation of Platelet-derived Growth Factor-BB-induced Vascular Smooth Muscle Cells to Improve Arterial Rem... by Guangbo Wu, Qiang Fan, Min Chen, Guqing Luo, Zhenghao Wu, Jinbo Zhao, Jiayun Lin, Chihao Zhang, Hongjie Li, Xiaoliang Qi, Haizhong Huo, Lei Zheng, Meng Luo

“…These findings suggest that AMPK can ameliorate the progression of arterial remodeling during PHT via suppressing the PDGF-BB/PDGFRβ signaling pathway, thereby offering novel insights into seek PHT treatment approaches. …”
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Outcomes with bridging radiation therapy prior to chimeric antigen receptor T-cell therapy in patients with aggressive large B-cell lymphomas by Gohar S. Manzar, Chelsea C. Pinnix, Stephanie O. Dudzinski, Kathryn E. Marqueen, Elaine E. Cha, Lewis F. Nasr, Alison K. Yoder, Michael K. Rooney, Paolo Strati, Sairah Ahmed, Chijioke Nze, Ranjit Nair, Luis E. Fayad, Michael Wang, Loretta J. Nastoupil, Jason R. Westin, Christopher R. Flowers, Sattva S. Neelapu, Jillian R. Gunther, Bouthaina S. Dabaja, Susan Y. Wu, Penny Q. Fang

“…Median overall survival (OS) was 22.1 months (6.6-not reached) and the median progression-free survival (PFS) was 7.4 months (5.5-30). …”
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Load-bearing characteristics of clamped coal and ground inclined-borehole hydraulic fracturing method for rockburst control in steeply inclined coal seams by Bin YU, Yong LI, Mingxian PENG, Rui GAO, Wenlian YANG, Ming LI, Yang TAI, Ziyu SHANG, Jun DING, Weidong MIAO, Hongjie ZHAO

“…Additionally, the dynamic impact load induced by roof failure shifts from sudden impact to progressive release, effectively mitigating rockburst risks. …”
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Multicenter Study of Resistant Arterial Hypertension Course After Classic and Eversion Carotid Endarterectomy by A. N. Kazantsev, R. A. Vinogradov, M. A. Chernyavsky, V. N. Kravchuk, D. V. Shmatov, A. A. Sorokin, A. A. Erofeyev, V. A. Lutsenko, R. V. Sultanov, A. R. Shabayev, I. M. Radjabov, G. Sh. Bagdavadze, N. E. Zarkua, V. V. Matusevich, E. F. Vaiman, A. I. Solobuyev, R. Yu. Lider, V. A. Porkhanov, G. G. Khubulava

“…The intersection of the latter with eversion CEE provokes labile hypertension, progression of RAH and a statistically significant increase in the number of all unfavorable cardiovascular events. …”
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DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids by Gen Yamamoto, Raquel Carvalho-Gontijo Weber, Wonseok Lee, Vivian Zhang, Haeum Jang, Sadatsugu Sakane, Xiao Liu, Hyun Young Kim, David A. Brenner, Na Li, Tatiana Kisseleva

“…Impact and implications: This study demonstrates the critical role of de novo lipogenesis and cholesterol synthesis in the pathogenesis of metabolic dysfunction and alcohol-associated liver disease (MetALD) and its progression to hepatocellular carcinoma (HCC). Our findings identified that the upregulation of DHCR7 contributes to the pathogenesis of MetALD and its inhibition suppresses hepatic steatosis, inflammation, fibrosis, and tumor proliferation. …”
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A novel prognostic model utilizing TMTV and SUVmax from 18F-FDG PET/CT for predicting overall survival in patients with extranodal NK/T- cell lymphoma by Hua Wang, Demei Feng, Yiwen Mo, Huangming Hong, Yingying Hu, Li Huang, Xiaolei Wei, Yajun Li, Haibin Huang, Runhui Zheng, Yonghua Li, Hui Zeng, Robert Peter Gale, Tian Ying, Jing Guo, Zhenshu Xu, Wei Fan, Tongyu Lin

“…Metabolic tumor volume (MTV) was calculated using a 41% SUVmax threshold, and TLG was computed as MTV multiplied by the average SUV. Progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan–Meier curves and compared with log-rank tests. …”
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Efficacy and safety of bevacizumab biosimilar SIBP04 compared with bevacizumab (Avastin®) as first-line treatment for locally advanced or metastatic non-squamous non-small-cell lun... by Yuankai Shi, Minghong Bi, Qingshan Li, Guolei Wang, Jianhua Chen, Mingjun Li, Jianhua Shi, Jiazhuan Mei, Yinghua Ji, Qingdi Xia, Yuanqing Feng, Shufeng Xu, Tongmei Zhang, Xiaohui Gao, Shubin Tang, Jie Weng, Zhuo Cao, Hongbo Wu, Xiubao Ren, Hua Xie, Hua Liu, Qiang Liu, Xing Yin, Xiaoyong Luo, Jun Chen, Haiming Zhang, Zhiyuan Guo, Cuimin Ding, Xin Jin, Rongli Sun, Sheng Yang

“…Secondary endpoints included progression-free survival, overall survival, duration of response, disease control rate, safety, immunogenicity, and pharmacological bioequivalence of steady-state trough concentrations. …”
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Three-dimensional characterization of ascending aortic strain, motion and growth in patients undergoing thoracic endovascular aortic repair by Nicasius Tjahjadi, MD, Carlos Campello Jorge, MD, Prabhvir S. Marway, MD, Taeouk Kim, MSc, Timothy Baker, PhD, Constantijn Hazenberg, MD, PhD, Joost A. van Herwaarden, MD, PhD, C. Alberto Figueroa, PhD, Himanshu J. Patel, MD, Nicholas S. Burris, MD

“…Patients with lower post-TEVAR strain, suggesting higher aortic stiffness, may be at highest risk of progressive growth. Imaging-based assessment of aortic biomechanics may help improve risk stratification for long-term outcomes post-TEVAR. : Clinical Relevance: Although thoracic endovascular aortic repair (TEVAR) is popular as a minimally invasive treatment for aortic aneurysm and dissection, concerns remain about unfavorable long-term cardiovascular outcomes due to stiffening and geometric changes in the native aorta. …”
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The VDAC3/DHODH Axis Ameliorates Sepsis-induced Myocardial Injury by Regulating Ferroptosis by Jiali Wang, Fan Zhang, Chaoqing Tan, Nana Wang, Xuexia Xia, Yun Ye, Yue Cao, Xin Huang, Zhenjiang Bai, He Zhao, Ling Sun, Qiuqin Xu, Huiting Zhou, Jie Huang

“…Overexpression of VDAC3 reduced mitochondrial oxidative stress, increased the expression of DHODH, and altered the progression of ferroptosis. …”
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