Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer by Jeffrey S Miller, Martin Felices, Peter Hinderlie, James Lim, Naomi Fujioka, Shee Kwan Phung, Yvette Soignier, Joshua T Walker, Melissa A Geller, Madison Shackelford, Carly Selleck, Philippa R Kennedy, Mihir Shetty, Melissa J Khaw, Paolo P Provenzano, Nicholas A Zorko, Laura E Bendzick, Riley C Lyons, Elise L Femino, Terran Stenger, Tumpa Dasgupta, Laura E Kotz, Eng Hock Lee, Quynhanh Lu, Zachary B Davis, John E Wagner, Margaret L MacMillan

“…Models of acute and prolonged hypoxia (1% oxygen) were carried out to assess tumor killing. Tumor progression, NK cell persistence, and survival differences between IL-15-treated and TriKE-treated mice were studied using NOD-scidIL2Rgnull (NSG) mice engrafted with human HNSCC.Results High B7-H3 expression was found in HPV− HNSCC cell lines, even when the FA gene was knocked out, and The Cancer Genome Atlas patient data showed that high B7-H3 expression predicted poor survival in patients with HPV− HNSCC. …”
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IFN-treated macrophage-derived exosomes prevents HBV-HCC migration and invasion via regulating miR-106b-3p/PCGF3/PI3K/AKT signaling axis by Jing Chen, Jing Chen, Jing Chen, Qi Yin, Qi Yin, Shiheng Xu, Xiaoqing Tan, Yu Liang, Chaohui Chen, Li Li, Li Li, Tao Zhang, Tao Shen, Tao Shen, Tao Shen, Tao Shen

“…MiR-106b-3p has been shown to play a paradoxical role in disease progressing from different studies. However, its specific role in HBV-related hepatocellular carcinoma (HBV-HCC) and the underlying mechanism remains unclear.MethodHuh7 cells transient transfected with plasmids of HBV-C2 and B3 were co-cultured with IFN-exo. …”
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Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trialResearch in context by Giacomo Koch, Martina Assogna, Yasmine Gadola, Antonella Alberici, Francesco Di Lorenzo, Sonia Bonnì, Ilaria Borghi, Emanuele Cerulli Irelli, Lucia Mencarelli, Michele Maiella, Romina Esposito, Elias Paolo Casula, Valentina Pezzopane, Alessia D'Acunto, Francesca Candeo, Matteo Ferraresi, Gisella Guerrera, Luca Battistini, Enrico Premi, Valeria Bracca, Silvia Lucchini, Francesco Bertagna, Pasquale Romano, Andrea Ludovici, Antonio Daniele, Caterina Motta, Clarissa Ferrari, Alessandro Martorana, Barbara Borroni

“…Interpretation: Rotigotine administration may not be a viable therapeutic option for enhancing frontal function, slowing disease progression, mitigating functional decline or ameliorating behavioral disturbances in bvFTD patients. …”
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Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes by Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries

“…Five percent of the cases progressed to acute liver failure, necessitating transplantation. …”
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Combined use of 3D-printed customized prostheses and denosumab for the treatment of giant cell tumor of the distal radius: clinical outcomes and efficacy by Ye Li, Longqing Li, Longqing Li, Xuanhong He, Xuanhong He, Taojun Gong, Taojun Gong, Zhuangzhuang Li, Zhuangzhuang Li, Xiaoyan Liu, Yi Luo, Yi Luo, Yong Zhou, Yong Zhou, Li Min, Li Min, Chongqi Tu, Chongqi Tu

“…Regarding complications, one patient experienced wrist subluxation postoperatively, and two patients experienced distal radioulnar joint separation.ConclusionDenosumab treatment during the prosthesis production period improved wrist function and inhibited tumor progression. Patients undergoing 3D-printed biological prosthesis replacement of the distal radius showed good short- and mid-term functional outcomes, with good integration of the prosthesis with the host bone and low prosthesis-related complications. …”
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Targeting EIF4A1 is effective against human intrahepatic cholangiocarcinoma by Wunan Mi, Antonio Cigliano, Grazia Galleri, Isabella Gigante, Sara Martina Steinmann, Ezgi Cibali, Marina Serra, Giovanni Mario Pes, Denise Schloesser, Elena Pizzuto, Heiko Siegmund, Claudia Fischer, Anna Saborowski, Gianluigi Giannelli, Matthias Evert, Luc Johannes Wilhelmus van der Laan, Monique Maria Andrea Verstegen, Diego Francesco Calvisi

“…Impact and implications: Dysregulation of the translational machinery is a hallmark of cancer, often linked to tumor progression and poor prognosis. This study underscores the potential of zotatifin, a specific inhibitor of EIF4A1 (an essential component of translation initiation) to inhibit the growth of iCCA cells. …”
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Efficacy of PARPi re-maintenance therapy for recurrent ovarian cancer by Yulin Wang, Yunjie Yang, Binghong Guo, Binghong Guo, Xiaoyan Li, Renakezi Tuersun, Ye Cao, Jundong Li, Jihong Liu, Su Li, Tao Liu, Yongwen Huang

“…The efficacy was evaluated via progression-free survival (PFS) and prognostic factors were also analyzed.ResultsIn the PSM subgroup, the median PFS (mPFS) of Re-PARPi-P group (44 cases) and Chem-A-P (44 cases) group were 10.0 months and 6.5 months (HR 1.64, P=0.041) respectively, confirming that re-maintenance therapy was superior to relapse chemotherapy alone. …”
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HLX07 alone or combined with serplulimab, cisplatin and 5‐fluorouracil for advanced esophageal squamous cell carcinoma: A phase 2 study by Yun Liu, Yanfeng Wang, Yanrong Zhu, Tao Wu, Zhenyang Liu, Jin Zhou, Yuan Yuan, Mudan Yang, Bo Liu, Zhenbo Tan, Wu Zhuang, Jiayan Chen, Ning Li, Ying Wang, Xuhui Hu, Lin Wang, Haoyu Yu, Qingyu Wang, Jun Zhu, Jing Huang

“…The primary endpoints were progression‐free survival (PFS) and objective response rate (ORR). …”
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Longitudinal profiling of hormone receptor positive, HER2 negative metastatic breast cancer through droplet digital PCR-based circulating tumor DNA fragmentomics by Lorenzo Foffano, Alessandra Franzoni, Elisabetta Molteni, Fabiola Giudici, Arianna Dri, Debora Basile, Linda Cucciniello, Silvia Buriolla, Claudia Noto, Stefania Russo, Elena Nascimbeni, Silvia Bolzonello, Brenno Pastò, Serena Della Rossa, Lorenzo Allegri, Marta Bonotto, Alessandro Marco Minisini, Barbara Belletti, Giuseppe Damante, Lorenzo Gerratana, Fabio Puglisi

“…Background: In the context of hormone receptor positive, HER2 negative Metastatic breast cancer (MBC), CDK 4/6 inhibitors (CDK4/6i) combined with endocrine therapy represent the standard first-line treatment, improving Progression-Free Survival (PFS) and Overall Survival (OS). …”
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Severe alpha-1 antitrypsin deficiency is associated with a higher risk of complications after first decompensation than other aetiologies of cirrhosis by Lorenz Balcar, Malin Fromme, Naomi Kappe, Benedikt Schaefer, Soňa Fraňková, Lukas van Melkebeke, Jan Stolk, Mathias Jachs, Georg Semmler, Benedikt S. Hofer, Tammo L. Tergast, Hannah Rieland, Anna Sophie Karl, Jan Sperl, Martin Wagner, Mònica Pons, Harald Hofer, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger, Benjamin Maasoumy, Heinz Zoller, Bart van Hoek, Jef Verbeek, Pavel Strnad, Mattias Mandorfer

“…Conclusion: Our study defines the course of decompensated cirrhosis in patients with severe AATD (Pi∗ZZ), who are particularly prone to complications of cirrhosis and exhibit a more progressive disease course than those with cirrhosis of other aetiologies. …”
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Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress by Zhuhui Huang, William Adiwignya Winata, Kui Zhang, Yang Zhao, Yang Li, Ning Zhou, Shaoyou Zhou, Wei Fu, Bokang Qiao, Guoqi Li, Yihui Shao, Jubing Zheng, Ran Dong

“…LncRNA-associated ceRNA networks play a vital role in the initiation and progression of several pathological mechanisms. However, the lncRNA-miRNA-mRNA ceRNA network in endothelial cells under cyclic stretch is seldom studied. …”
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Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1 by Francisco Xavier Guerra-Castillo, Francisco Xavier Guerra-Castillo, Sandra Pinto-Cardoso, Santiago Ávila-Ríos, Monserrat Chávez-Torres, Amy Peralta-Prado, Carolina González-Torres, Javier Gaytán-Cervantes, Brenda Requena-Benitez, Dafne Díaz-Rivera, Carmen Alaez-Verson, María Concepción Hernández-García, Vilma Carolina Bekker-Méndez

“…Coreceptor switching from R5 to X4 and elevated immune activation have been associated with disease progression. X4-tropic HIV-1 is predominantly observed in the late stage of infection, when the immune environment characterized by chronic activation is optimal for their replication. …”
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Ibrutinib in the Treatment of Refractory Chronic Lymphocytic Leukemia by EA Nikitin, EA Dmitrieva, MA Panteleev, EI Emelina, VL Ivanova, YuB Kochkareva, EG Arshanskaya, IE Lazarev, EE Markova, LA Mukha, NG Novitskaya, MM Pankrashkina, VV Glazunova, AV Shubina, SA Chernysh, NK Khuazheva, EV Naumova, SA Lugovskaya, ME Pochtar’, TN Obukhova, OYu Vinogradova, GE Gendlin, VV Ptushkin

“…Ibrutinib was administered at a dosage of 420 mg per day daily until progression or intolerable toxicity. The median duration of ibrutinib therapy was 10.3 months. …”
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Abstract 082: Angiographic Features and Treatment Results of Dural Arteriovenous Fistulas Cognitive Impairment by Sebastian A. Sanchez, Linder Wendt, Chen Ching‐Jen, Minako Hayakawa, Edgar Samaniego, Jason Sheehan, Louis Kim, Issac Abecassis, Michael Levitt, Michael Meyer, Ridhima Guniganti, Akash Pabaney, Giuseppe Lanzino, Enrico Giordan, Waleed Brinjikji, Diederik Bulters, Santiago Ortega, Andrew Durnford, Gregory Zipfel, W Fox, Colin Derdeyn, Jessica Smith, Bradley Gross, Sepideh Amin‐Hanjani, Ali Alaraj

“…Introduction Dural arteriovenous fistulas (dAVFs) have been associated with rapidly progressive dementia in relatively young patients. However, the specific angioarchitecture and characteristics of these dAVFs remain to be fully described. …”
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Peripheral cellular immune alterations during excessive alcohol consumption by Karla Z. Medina-Avila, Abigail Hernandez-Barragan, Marisela Hernández-Santillan, Isabel Villagómez-López, Adrián Flores-Sanchez, Melanie Acosta-Gutiérrez, Viridiana Bautista-Nava, Isaac B Flores-Islas, Jesús A Dorantes-Álvarez, Moisés Martinez-Castillo, Fátima Higuera-de la Tijera, José L Pérez-Hernández, Gabriela Gutiérrez-Reyes

“…Conclusions: The immune abnormalities presented during risky consumption, abuse, dependence and cirrhosis due to alcohol are differential, the most significant changes are observed in the cytotoxic NK, NKT and CD8+ and regulatory CD4+ populations generating a cellular imbalance that could be related to development and progression of liver damage.…”
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Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling by Rui-Qiang Qi, Yu-Fei Chen, Jing Cheng, Jia-Wei Song, Yi-Hang Chen, Si-Yuan Wang, Ying Liu, Kai-Xin Yan, Xiao-Yan Liu, Jing Li, Jiu-Chang Zhong

“…Alizarin red and von-Kossa staining indicated that the administration of Elabela effectively hindered the progression of vascular cuproptosis and arterial calcification in VitD3-overloaded mice and rat arterial rings models. …”
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A colloidal gold immunochromatographic test strip based on mAbs anti-N protein to detect feline coronavirus by Zhe Liu, Yupeng Yang, Ruibin Qi, Haorong Gu, Mengru Chen, Kexin Feng, Qian Jiang, Honglin Jia, Hongtao Kang, Jiasen Liu

“…In contrast, FIPV infection leads to severe immune-mediated disease with rapid progression and a very high mortality rate. The occurrence of feline infectious peritonitis (FIP) is associated with mutations in the viral genome during FECV infection, which makes diagnosing FECV an effective measure for preventing FIP. …”
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High-risk neuroblastoma in Mexico: from multimodal treatment to immunotherapy. Regarding the first case treated with naxitamab by Alberto Olaya Vargas, Haydee Salazar-Rosales, Marcela Caballero-Palacios, Nideshda Ramírez-Uribe, Gerardo López-Hernández, Erika Morales-Martinez, María Cervantes-Delgado, Liliana Velasco Hidalgo, Araceli Castellanos-Toledo, Rocío Cárdenas-Cardos, Rocío Cárdenas-Cardos, Ana Niembro-Zúñiga, Roberto Rivera-Luna, Alberto Olaya-Nieto, Jesús Ponce-Cruz, Jaime Shalkow-Klincovstein, Yadira Melchor-Vidal, Rodrigo Díaz-Machorro

“…Despite intensive care, he progressed to brain death, with neurotoxicity suspected as the cause.DiscussionThe primary objective of implementing novel immunotherapeutic strategies, in addition to improving event-free survival (EFS) and overall survival (OS) in patients diagnosed with high-risk neuroblastoma, is to reduce adverse effects and lower both short- and long-term mortality. …”
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An integrative model with HLA‐DR, CD64, and PD‐1 for the diagnostic and prognostic evaluation of sepsis by Guosheng Chen, Huimin Chong, Peng Zhang, Dalin Wen, Juan Du, Chu Gao, Shi Zeng, Ling Zeng, Jin Deng, Kejun Zhang, Anqiang Zhang

“…Abstract Background Sepsis is a life‐threatening organ dysfunction caused by a dysregulated host response to infection and progressive immunosuppression with high mortality. HLA‐DR, CD64, and PD‐1 were assumed to be useful biomarkers for sepsis prediction. …”
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Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile by Chao Zhang, Dong Li, Yu Chen, Fang Liu, Fang Wang, Xiaolong Li, Kang Li, Shuang Li, Haiyan Yang, Guangcai Duan, Guowei Li, Ling Tao, Zhi Li, Chenyu Wang, Wenyi Liu, Yaodong Zhang, Wangquan Ji, Huifen Feng, Shouhang Chen, Yuanfang Shen, Jiaying Zheng, Demin Feng, Meili Sui, Shuaiyin Chen, Jinzhao Long, Zhuangzhuang Wang, Qingmei Wang, Shujuan Han, Bowen Dai, Dejian Dang, Peiyu Zhu, Zijie Li, Yuefei Jin

“…This dataset will be updated and expanded on an annual basis to support the continuous monitoring of patient health and disease progression. From HNHFMDCS, the study will provide a comprehensive overview of the potential harm caused by this common infectious disease, assess the social burden caused by this disease and make recommendations for the rehabilitation of survivors and prevention of further disability.…”
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