Prognostic importance of an indicator related to systemic inflammation and insulin resistance in patients with gastrointestinal cancer: a prospective study by Guo-Tian Ruan, Guo-Tian Ruan, Guo-Tian Ruan, Guo-Tian Ruan, Guo-Tian Ruan, Jin-Yu Shi, Jin-Yu Shi, Jin-Yu Shi, Jin-Yu Shi, Jin-Yu Shi, Hai-Lun Xie, Hai-Lun Xie, Hai-Lun Xie, Hai-Lun Xie, Hai-Lun Xie, He-Yang Zhang, He-Yang Zhang, He-Yang Zhang, He-Yang Zhang, He-Yang Zhang, Hong Zhao, Hong Zhao, Hong Zhao, Hong Zhao, Hong Zhao, Xiao-Yue Liu, Xiao-Yue Liu, Xiao-Yue Liu, Xiao-Yue Liu, Xiao-Yue Liu, Yi-Zhong Ge, Yi-Zhong Ge, Yi-Zhong Ge, Yi-Zhong Ge, Yi-Zhong Ge, Xiao-Wei Zhang, Xiao-Wei Zhang, Xiao-Wei Zhang, Xiao-Wei Zhang, Xiao-Wei Zhang, Ming Yang, Ming Yang, Ming Yang, Ming Yang, Ming Yang, Li-Chen Zhu, Li-Chen Zhu, Li-Chen Zhu, Li-Chen Zhu, Li-Chen Zhu, Han-Ping Shi, Han-Ping Shi, Han-Ping Shi, Han-Ping Shi, Han-Ping Shi

“…BackgroundSystemic inflammation (SI) and insulin resistance (IR) are correlated to the progression of gastrointestinal (GI) cancer. Therefore, this study aimed to analyze the potential clinical value of the C-reactive protein-triglyceride-glucose index (CTI) in relation to SI and IR in patients with GI cancer.MethodsThis prospective cohort study included patients with GI cancer. …”
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Efficacy of PD-(L)1 inhibitors plus anlotinib in the second-line treatment of extensive-stage small cell lung cancer by Jian Zhang, Zijie Wu, Shuyun Wang, Yanxin Sun, Jiake Wu, Dahai Wang, Yihui Ge, Juan Li, Haifeng Sun, Qinglei Cheng, Aiqin Gao, Yuping Sun

“…The efficacy, including the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety were compared among the three groups. …”
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Relationship between self-management behavior and family care among Chinese older adults hospitalized for stroke: the mediating role of chronic disease resource utilization by Zhangyi Wang, Fen Zhu, Juan Zuo, Li Yang, Feng Lu, Li Chen, Liping Li, Xiaochun Tang, Tingrui Wang, Junbo Wu, Weimin Xie, Yating Zhan, Jiaofeng Peng, Yan Wang, Jie Yang, Yue Zhu, Zhenfa Li, Huilong Shen, Jun Yin

“…Healthcare professionals should focus on enhancing health education and providing psychological support for stroke patients to improve family care, alleviate fears regarding disease progression, and ultimately promote better self-management behavior.…”
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HS-10375, a selective EGFR C797S tyrosine kinase inhibitor, in advanced non–small cell lung cancer by Jianhua Zhan, Jinhui Xue, Lin Wu, Zhiye Zhang, Qiming Wang, Yuxiang Ma, Yan Huang, Yunpeng Yang, Yuanyuan Zhao, Wenfeng Fang, Yang Zhang, Qianwen Liu, Wen Xu, Yan Yang, Zhenming Chen, Baili Song, Danni Sun, Xia Sun, Peng Gao, Hongyun Zhao, Li Zhang

“…One patient with EGFR mutations showed tumor shrinkage after progression on five-line treatment including gefitinib, almonertinib, chemotherapy, immunotherapy, and EGFRxHER3 antibody–drug conjugate. …”
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Targeting YBX1‐m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma by Ouwen Li, Ke An, Han Wang, Xianbin Li, Yueqin Wang, Lan Huang, Yue Du, Nuo Qin, Jiasheng Dong, Jingyao Wei, Ranran Sun, Yong Shi, Yanjia Guo, Xiangyi Sun, Ying Yang, Yun‐Gui Yang, Quancheng Kan, Xin Tian

“…Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation of ferroptosis is closely associated with HCC. …”
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Implementation of guideline‐directed medical therapy in patients with heart failure with reduced ejection fraction (OpTIMa‐HF Registry) by Stefania Paolillo, Christian Basile, Federica Marzano, Dario Bruzzese, Piergiuseppe Agostoni, Irene Mattavelli, Angelo Aloisio, Pietro Ameri, Martina Solimano, Natale Daniele Brunetti, Paolo Calabrò, Arturo Cesaro, Matteo Cameli, Giulia Elena Mandoli, Erberto Carluccio, Chiara Belardinelli, Stefano Carugo, Laura Casalino, Emilia Chiuini, Deborah Cosmi, Frank Lloyd Dini, Mariafrancesca Di Santo, Gennaro Esposito, Ferdinando Ferrara, Maria Francesca Fierro, Gennaro Galasso, Luca Gallo, Antonella Rispoli, Paola Gargiulo, Francesco Grigioni, Andrea Segreti, Franco Guarnaccia, Natale Guarnaccia, Federico Guerra, Emanuele Cicchirillo, Ciro Indolfi, Mauro Larcher, Adele Lillo, Marco Metra, Roberta Montisci, Maria Francesca Marchetti, Savina Nodari, Francesco Fioretti, Ermanno Nardi, Ugo Oliviero, Alberto Palazzuoli, Giuseppe Patti, Marco Pepe, Filomena Pacelli, Fabrizio Perrone Filardi, Giuseppe Putortì, Giosuè Santoro, Michele Senni, Emilia D'Elia, Paolo Severino, Andrea D'Amato, Simona Soriano, Gianfranco Sinagra, Maddalena Rossi, Monica Franzese, Giovanni Smaldone, Giovanni Battista Zito, Pasquale Perrone Filardi

“…Abstract Aims The last released European guidelines on the management of heart failure (HF) recommend in patients with chronic HF with reduced ejection fraction (HFrEF) a pharmacological approach based on four fundamental drugs to be rapidly implemented and then uptitrated to modify disease progression. The aim of the Optimization of Therapy in the Italian Management of Heart Failure (OPTIMA‐HF) registry is to collect data on chronic HF outpatients in different settings of care. …”
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GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis by Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, Shuo Yu, Yao Xie, Cheng-Jiang Jin, Yi-Min Shen, Si-Yu Zhou, Xiao-Ce Dai, Sheng-An Su, Lan Xie, Zheng-Xing Huang, Hui Gong, Mei-Xiang Xiang, Hong Ma

“…Further investigation of molecular mechanisms indicated that GSTM1 may suppress the initiation and progression of fibrosis by modulating lipid metabolism and ferroptosis-related pathways. …”
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Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression by Lei Feng, Yan Chen, Liang Wang, Fei Huang, Yi-Yang Hu, Jun-Long Zhao, Shi-Qian Liang, Lei Dong, Heng-Chao Yu, Jian Bai, Jia-Meng Yang, Jie-Yi Fan, San-Zhong Li, Hua Han, Hong-Yan Qin

“…Background Accumulating evidence has shown that tumor-associated macrophages (TAMs) play a critical role in tumor progression. Targeting TAMs is a potential strategy for tumor immunotherapy. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Background and aimsPatients with Crohn’s disease (CD) exhibit excessive apoptosis of intestinal epithelial cells (IECs), which contributes to damage to the intestinal barrier structure and function, thereby playing a role in the progression of colitis. Preventing IEC apoptosis and protecting the intestinal barrier are critical to alleviating colitis. …”
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Clinical and hematological factors predicting the effectiveness of ruxolitinib in primary and secondary myelofibrosis. Results of a prospective single-center study by O. Yu. Vinogradova, M. M. Pankraskina, A. L. Neverova, D. I. Shikhbabaeva, M. A. Murzabekova, M. V. Chernikov, A. V. Popova, V. P. Kosenkova, L. B. Egoryan, V. V. Ptushkin

“…The median allele burden of JAK2 V617F during observation decreased more than twice from the initial value in half of the patients. The median of progression-free survival (PFS) from the start of ruxolitinib therapy was 28 months, the median of overall survival (OS) has not been achieved. …”
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Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

“…Summary: Background: The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine were repurposed for the treatment of early COVID-19 based on their antiviral activity in vitro, and observational and clinical trial evidence suggesting they prevented progression to severe disease. However, these SSRIs have not been recommended in therapeutic guidelines and their antiviral activity in vivo has not been characterised. …”
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Retrospective Analysis of Fungal Isolations in Patients on Veno-Venous Extracorporeal Membrane Oxygenation: The Multicenter RANGER STUDY 2.0 by Annalisa Boscolo, Andrea Bruni, Marco Giani, Eugenio Garofalo, Nicolò Sella, Tommaso Pettenuzzo, Arianna Peralta, Michela Bombino, Matteo Palcani, Emanuele Rezoagli, Matteo Pozzi, Elena Falcioni, Eugenio Biamonte, Francesco Murgolo, Leonardo Gottin, Federico Longhini, Salvatore Grasso, Paolo Navalesi, Giuseppe Foti

“…<b>Background:</b> Veno-venous extracorporeal membrane oxygenation (V-V ECMO) represents a progressively adopted life-sustaining intervention worldwide, particularly in the management of acute respiratory distress syndrome. …”
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Improved tumor-type informed compared to tumor-informed mutation tracking for ctDNA detection and microscopic residual disease assessment in epithelial ovarian cancer by Mehdi Ben Sassi, Henri Azais, Charles Marcaillou, Sylvain Guibert, Emmanuel Martin, Jérôme Alexandre, Louise Benoit, Aurélien de Reynies, Emilie Laude, Cam Duong, Jacques Medioni, Bruno Borghese, Anne-Sophie Bats, Valerie Taly, Pierre Laurent-Puig

“…Conclusion The tumor-type informed classifier demonstrated sensitivity and specificity for ctDNA detection, outperforming the tumor-informed approach in monitoring EOC progression. Requiring fewer sequencing data, it offers a practical, efficient solution for clinical management of EOC.…”
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Modified FOLFOX6 plus bevacizumab with and without nivolumab for first-line treatment of metastatic colorectal cancer: phase 2 results from the CheckMate 9X8 randomized clinical tr... by Takayuki Yoshino, Josep Tabernero, Jin Yao, Amit Mahipal, Eric Chen, Heinz-Josef Lenz, Aparna Parikh, Timothy Larson, Dustin Deming, David R Spigel, Allen L Cohn, Mark Kochenderfer, Elena Elez, Spencer H Shao, Regan Holdridge, Antonio Ucar, Dana Cullen, Edwina Baskin-Bey, Tong Kang, Amy B Hammell

“…The primary endpoint was progression-free survival (PFS) by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors V.1.1. …”
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Elevated platelet-to-lymphocyte ratio predicts poor clinical outcomes in non-muscle invasive bladder cancer: a systematic review and meta-analysis by Wenfeng Hu, Jinze Liang, Jin Luo, Jin Luo, Jin Luo, Jie Fan, Jie Fan, Jie Fan, Huaichun Hu, Xinwen Wang, Xinwen Wang, Xinwen Wang, Peng Zhou, Xiaoyi Zhang, Jie Zhou, Jie Zhou, Jie Zhou

“…Elevated PLR notably correlated with inferior progression-free survival (PFS) (HR=2.132, 95% CI: 1.146-3.967, p=0.017) and relapse-free survival (RFS) (HR=1.732, 95% CI: 1.174-2.554, p=0.006). …”
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BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double‐Blind Randomised Interventional Phase 2b Trial by Roger A. Fielding, Michael M. Dao, Kevin Cannon, Moise Desvarieux, Sam S. Miller, Michael Paul Gimness, Donald M. Brandon, Dennis T. Villareal, Olivier Bruyere, Ivan Bautmans, Kyle Rickner, Robert Perry, Stephen B. Kritchevsky, Nicolas Musi, Joe M. Chehade, Judith L. Kirstein, Evelien Gielen, Paul Pickrell, Pierre Dilda, Rene Lafont, Carole Margalef, Yves Rolland, Susanna Del Signore, Jean Mariani, Samuel Agus, Cendrine Tourette, Waly Dioh, Rob vanMaanen, Stanislas Veillet

“…ABSTRACT Background Sarcopenia is a progressive muscle disorder that may lead to mobility disability. …”
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Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver by Monika Gjorgjieva, Nicolas Calo, Cyril Sobolewski, Dorothea Portius, Jean-Luc Pitetti, Flavien Berthou, Anne-Sophie Ay, Marion Peyrou, Lucie Bourgoin, Christine Maeder, Margot Fournier, Marta Correia de Sousa, Etienne Delangre, Laurent Vinet, Xavier Montet, Christine Sempoux, Serge Nef, Michelangelo Foti

“…Impact and implications:: This study underscores the pivotal roles of phosphatase and tensin homolog (PTEN), insulin receptor (IR), and IGF-1 receptor (IGF1R) in controlling liver metabolism, systemic adiposity, and liver cancer progression. Our findings on the distinct and combined effects of these receptors in PTEN-deficient mice offer key insights into the mechanisms driving metabolic dysfunction-associated steatotic liver disease and related hepatocarcinogenesis. …”
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Right atrial strain in atrial fibrillation: the hidden side of the moon by Eleonora Ruscio, Francesca Augusta Gabrielli, Gaetano Pinnacchio, Francesco Raffaele Spera, Francesco Raffaele Spera, Federica Giordano, Federica Giordano, Roberto Scacciavillani, Maria Lucia Narducci, Maria Lucia Narducci, Gianluigi Bencardino, Francesco Perna, Filippo Crea, Filippo Crea, Gemma Pelargonio, Gemma Pelargonio

“…However, the CHA2DS2-VASc score remained the sole independent predictor of AF recurrence (HR 1.47, 95% CI 1.003–2.158, p = 0.048).ConclusionRA function, assessed through strain imaging, was progressively impaired in more severe AF subtypes, strongly correlating with bi-atrial mechanical and electroanatomical properties. …”
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Independent validation and outlier analysis of EuroPOND Alzheimer’s disease staging model using ADNI and real-world clinical data by Mandy M. J. Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs

“…Abstract Background Event-based modeling (EBM) traces sequential progression of events in complex processes like neurodegenerative diseases, adept at handling uncertainties. …”
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Phenotype and prognostic factors in geriatric and non‐geriatric patients with transthyretin cardiomyopathy by Eugenia Volpentesta, Mounira Kharoubi, Cristiano Donadio, Kahina Rebiai, Pascale Fanen, Benoit Funalot, Thierry Gendre, Vincent Audard, Florence Canoui‐Poitrine, Emmanuel Itti, Emmanuel Teiger, Violaine Planté‐Bordeneuve, Silvia Oghina, Denis Tixier, Sophie Mallet, Amaury Broussier, Thibaud Damy, Amira Zaroui

“…The population exhibited conduction abnormalities, atrial fibrillation and ischaemic heart disease that progressively deteriorated with age. Among ATTRwt patients, peripheral neuropathy, neurovegetative symptoms, and hearing loss were present across all age groups, but reports of carpal tunnel symptoms or surgery decreased with age. …”
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