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17061
PRKDC regulates cGAMP to enhance immune response in lung cancer treatment
Published 2024-11-01“…This study aimed to investigate the antitumor effects of 2’,3’-cGAMP in LUAD.MethodHerein, patients with LUAD were screened for prognostic biomarkers, which were then assessed for sensitivity to immunotherapy and chemotherapy utilizing the “TIDE” algorithm and CellMiner database. The results were validated using a mouse xenograft model. …”
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17062
Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study
Published 2025-12-01“…In addition, we performed correlation analysis and Cmap algorithm for regulatory network establishment and candidate inhibitor prediction. …”
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17063
Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation inte...
Published 2025-06-01“…Objectives: This study investigated the role of low-frequency integrase strand transfer inhibitor (INSTI) resistance mutations, detectable by next-generation sequencing (NGS), at predicting virological rebound (VR) among people with HIV (PWH) starting second-generation INSTI-based first-line regimens. …”
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17064
Systematic elucidation of the effective constituents and potential mechanisms of Scrophulariae Radix against neoplasm based on LC-MS, network pharmacology, and molecular docking ap...
Published 2025-07-01“…As a result, the material–liquid ratio was significantly reduced from 100 g/mL to 32 g/mL, and the extraction efficiency was 1.332%, which was close to the predicted value of 1.346% in the response surface method, indicating that the algorithm model had a good fit. …”
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17065
Exploring the Shared Genetic Characteristics of Peri-Implantitis and Osteoporosis: A Transcriptomic Analysis Perspective
Published 2025-10-01“…Potential drugs related to the hub genes were predicted using the Genecards database. Finally, the CIBERSORT core algorithm was used to calculate immune cell infiltration levels. …”
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17066
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17067
Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma
Published 2025-07-01“…Notably, sex-based differences were identified: female mice showed greater bone loss near the hip joint at later stages, with significant HUmean reductions at days 25 (p = 0.008) and 32 (p = 0.002). …”
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17068
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17069
Elementary Growth Modes provide a molecular description of cellular self-fabrication.
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17070
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17071
Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy.
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17072
The association between ozone exposure and blood pressure in a general Chinese middle-aged and older population: a large-scale repeated-measurement study
Published 2024-11-01“…During the study period of up to 30 days, each 10 μg/m3 increase in maximum daily 8-h average O3 concentration was associated with reductions in SBP (β = − 1.176 mm Hg), DBP (− 0.237 mm Hg), PP (β = − 0.973 mm Hg), and MAP (β = − 0.544 mm Hg). …”
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17073
Spatio-temporal variability of San Francisco Bay Plume from space
Published 2025-08-01“…This paper provides the first observationally based investigation of the spatio-temporal variability of the SFBP, using a plume tracking algorithm applied to more than two decades (2002-2023) of ocean color data from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor onboard satellites Aqua and Terra. …”
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17074
Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning
Published 2025-08-01“…Immune cell infiltration was analysed using the CIBERSORT algorithm. CRSwNP samples were classified via consensus clustering. …”
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17075
Association between hemoglobin glycation index and the risk of cardiovascular disease in early-stage cardiovascular-kidney-metabolic syndrome: evidence from the China health and re...
Published 2025-05-01“…Extreme gradient boosting (XGBoost) algorithm was applied, with the Shapley additive explanation (SHAP) method used to determine feature importance. …”
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17076
Surface Soil Organic Carbon Estimation Based on Habitat Patches in Southwest China
Published 2025-01-01“…This study proposed a new method using the partitioning around medoids clustering algorithm to partition the study area into distinct habitat patch types. …”
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17077
Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease
Published 2025-12-01“…Finally, the predicted functional capability of a DKD-specific biomarker, Gemmiger spp. is enriched in carbohydrate metabolism and branched-chain amino acid (BCAA) biosynthesis. …”
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17078
Multiplicity dependence of charged-particle intra-jet properties in pp collisions at $$\sqrt{{{\varvec{s}}}}$$ s = 13 TeV
Published 2024-10-01“…The results are compared with predictions of QCD-inspired event generators, PYTHIA 8 with Monash 2013 tune and EPOS LHC. …”
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17079
High-Resolution Mapping of Litter and Duff Fuel Loads Using Multispectral Data and Random Forest Modeling
Published 2024-11-01“…A set of vegetation indices and texture metrics derived from the multispectral data, optimized by a “Variable Selection Using Random Forests” (VSURF) algorithm, were used to train random forest (RF) models, enabling the modeling of high-resolution maps of litter and duff fuel loads. …”
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17080
A Multi-Omics Prognostic Model Capturing Tumor Stemness and the Immune Microenvironment in Clear Cell Renal Cell Carcinoma
Published 2024-09-01“…Recognizing tumor stemness helps to predict treatment efficacy, recurrence, and drug resistance, informing treatment strategies and enhancing ccRCC patient outcomes.…”
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