Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis by Boli Qin, Xiaopeng Qin, Jie Ma, Chenxing Zhou, Tianyou Chen, Jichong Zhu, Chengqian Huang, Shaofeng Wu, Rongqing He, Songze Wu, Sitan Feng, Jiarui Chen, Jiang Xue, Wendi Wei, Tengxiang Long, Quan Pan, Kechang He, Zhendong Qin, Tiejun Zhou, Jiayan Jiang, Xinli Zhan, Chong Liu

“…The CBC data of 23,289 patients were collected, and six machine learning algorithms were applied to develop disease prediction models for AS and RA. …”
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Local adaptation and validation of a transdiagnostic risk calculator for first episode psychosis using mental health patient records by Elizabeth Ford, James Stone, James Stone, James Stone, Dominic Oliver, Dominic Oliver, Dominic Oliver, Benjamin Fell, Gloria Roque, Sam Robertson, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Kathryn Greenwood, Kathryn Greenwood

“…We developed new machine-learning NLP algorithms for diagnosis, symptom and substance use concepts by fine-tuning existing open-source transformer models. …”
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In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design by Rayhan Chowdhury, Samia Akter Saima, Md. Al Amin, Md. Kawsar Habib, Ramisa Binti Mohiuddin, Ali Mohamod Wasaf Hasan, Roksana Khanam, Shahin Mahmud

“…This research aims to predict new compounds using ligand-based pharmacophore models while optimizing existing drugs. …”
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Application and prospect of artificial intelligence in empowering the operation and managment of oil and gas pipelines by Qi LIAO, Chunying LIU, Jian DU, Hao LAN, Yongtu LIANG, Haoran ZHANG

“…AI methodologies have found extensive application across various research domains, largely focusing on leak detection, corrosion analysis, risk evaluation, identification, prediction, and optimization. The evolution of AI-driven research has transitioned from conventional approaches like neural networks, expert systems, fuzzy logic, and wavelet analysis towards new-generation algorithms, including deep learning, transfer learning, and reinforcement learning. …”
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DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure by Wenwu Tang, Wenwu Tang, Zhixin Wang, Xinzhu Yuan, Liping Chen, Haiyang Guo, Zhirui Qi, Ying Zhang, Xisheng Xie

“…In addition, we further explored potential mechanism and function of hub genes in HF of patients with MHD through GSEA, immune cell infiltration analysis, drug analysis and establishment of molecular regulatory network.ResultsTotally 23 candidate genes were screened out by overlapping 673 differentially expressed genes (DEGs) and 147 key module genes, of which four hub genes (DEPDC1B, CDCA2, APOBEC3B and TYMS) were obtained by two machine learning algorithms. Through GSEA analysis, it was found that the four genes were closely related to ribosome, cell cycle, ubiquitin-mediated proteolysis. …”
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Optimal vaccination model of airborne infection under variable humidity and demographic heterogeneity for hybrid fractional operator technique by Saima Rashid, Ilyas Ali, Nida Fatima, Tehreem Fatima, Fekadu Tesgera Agam, Sayed K. Elagan

“…Our system’s best-fit parameter settings were detected using the Markov Chain Monte Carlo (M-C-M-C) technique with influenza information collected in Spain. We predict a basic reproduction number of 1.3645 (96% C.I: (1.3644, 1.3646)). …”
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At-Home Evaluation of Both Wearable and Touchless Digital Health Technologies for Measuring Nocturnal Scratching in Atopic Dermatitis: Analytical Validation Study by Stefan Avey, Mark Morris, Davit Sargsyan, Molly V Lucas, Andrea O'Brisky, Kenneth Mosca, Andrew Elias, Nicholas Fountoulakis, Mehdi Boukhechba, Xuen Hoong Kok, Saiyam Jain, Mehrnoosh Oghbaie, Nikolay V Manyakov, Miao Wang, Zuleima Aguilar, Lynn Yieh

“…ObjectiveIn this study, we present the analytical validation of 2 DHTs: the GENEActiv wristband with Philips sleep and scratch algorithms (“Philips”) and the Emerald radio frequency touchless sensor (“Emerald”) to measure nocturnal scratching in adults with AD. …”
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Diagnosis methods for pancreatic cancer with the technique of deep learning: a review and a meta-analysis by Yuanbo Bi, Dongrui Li, Ruochen Pang, Chengxv Du, Da Li, Xiaoyv Zhao, Haitao Lv

“…Inclusion criteria were studies involving PDAC patients, using deep learning algorithms for diagnosis evaluation, using histopathological results as the reference standard, and having sufficient data. …”
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Bioinformatics‑Based Analysis Reveals Diagnostic Biomarkers and Immune Landscape in Atopic Dermatitis by Yang M, Zhang X, Zhou C, Du Y, Zhou M, Zhang W

“…Potential microRNA (miRNA)-messenger RNA (mRNA) and miRNA-long non-coding RNA (lncRNA) interactions were predicted using miRanda and TargetScan tools.Results: We identified 381 DEGs (217 upregulated, 164 downregulated). …”
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Differential chemoproteomic analysis of RRS-1 candidate molecule and molecules of several nonsteroidal anti-inflammatory drugs by P. A. Galenko-Yaroshevsky, I. Yu. Torshin, A. N. Gromov, O. A. Gromova, K. F. Suzdalev, R. A. Murashko, A. V. Zelenskaya, A. V. Zadorozhniy, T. R. Glechyan, G. V. Simavonyan, E.M. I. Muhammad

“…Chemoproteomic modeling of pharmacological effects of RRS-1 molecule and a number of well-known NSAIDs (diclofenac, nimesulide, ketorolac) on human proteome was carried out on the basis of numerical prediction algorithms over the space of heterogeneous feature descriptions, developed in the topological approach to recognition by Yu.I. …”
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Relationship between stress hyperglycemia ratio and the incidence of atrial fibrillation in patients after coronary artery bypass grafting: a retrospective study based on the MIMIC... by Runjia Liu, Jiatong Li, Jing Zeng, Yuxuan Tao, Dong Chen, Haixia Li

“…We employed logistic regression models, restricted cubic splines (RCS), threshold effect analysis, ubgroup analysis, Boruta algorithm, lasso algorithm, and receiver operating characteristics (ROC) to analyze the relationship between SHR and POAF incidence comprehensively. …”
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The underlying molecular mechanisms and biomarkers of Hip fracture combined with deep vein thrombosis based on self sequencing bioinformatics analysis by Guanghua Shi, Xiaocui Shi, Meng Zhang, Rui Cheng, Mengqing Hu, Yu Zhao, Shimei Li, Xiuxiu Li, Haiyun Ma, Pengcui Li

“…Feature genes were further refined by intersecting results from three machine learning algorithms and constructing an artificial neural network (ANN). …”
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Single cell transcriptomic analysis reveals tumor immune infiltration by macrophage cells gene signature in lung adenocarcinoma by Xiaotong Guo, Youjun Deng, Wenjun Jiang, Heng Li, Yisheng Luo, Huachuan Zhang, Hao Wu

“…High TGS tumors exhibited enrichment in TGF-β signaling and hypoxia pathways, suggesting their potential utility in predicting prognosis and immune responses in patients with LUAD. …”
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Integrated Bioinformatics and Experimental Validation Reveal Macrophage Polarization-Related Biomarkers for Osteoarthritis Diagnosis by He Q, Liu L, Hu X, Lin L, Song Z, Xia Y, Lin Q, Wei J, Li S

“…Least absolute shrinkage and selection operator (LASSO), random forest (RF), and support vector machine recursive feature elimination (SVM-RFE) algorithms were used to identify hub genes and construct a diagnostic model validated through internal datasets and multiple external bulk RNA-seq and single-cell RNA-seq data. …”
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Development of a Diagnostic Model for Focal Segmental Glomerulosclerosis: Integrating Machine Learning on Activated Pathways and Clinical Validation by Ge Y, Liu X, Shu J, Jiang X, Wu Y

“…We then developed a highly accurate diagnostic model by integrating nine machine learning algorithms into 101 combinations, achieving near-perfect AUC values across training, validation, and external cohorts. …”
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ATP6V0A4 as a novel prognostic biomarker and potential therapeutic target in oral squamous cell carcinoma by Xiaopu Gao, Jiamin Zhou, Yu Qiao, Chuyin Lin, Guanxiong Zhang, Qiuyu Wu, Zhikang Su, Qianji Zhang, Songkai Huang

“…Further, immunotherapy response prediction models and drug sensitivity analysis were utilized to define therapeutic potential. …”
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Identifying mating events of group-housed broiler breeders via bio-inspired deep learning models by Venkat U.C. Bodempudi, Guoming Li, J. Hunter Mason, Jeanna L. Wilson, Tianming Liu, Khaled M. Rasheed

“…The DLM framework included a bird detection model, data filtering algorithms based on mating duration, and logic frameworks for mating identification based on bird count changes. …”
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Genetic variants of the DLK1, KISS1R, MKRN3 genes in girls with precocious puberty by E. A. Sazhenova, O. Yu. Vasilyeva, E. A. Fonova, M. B. Kankanam Pathiranage, A. Yu. Sambyalova, E. E. Khramova, L. V. Rychkova, S. A. Vasilyev, I. N. Lebedev

“…The pathogenicity of identified genetic variants and the functional significance of the protein synthesized by them were analyzed according to recommendations for interpretation of NGS analysis results using online algorithms for pathogenicity prediction (Variant Effect Predictor, Franklin, Varsome, and PolyPhen2). …”
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TELEPROM Psoriasis: Enhancing patient-centered care and health-related quality of life (HRQoL) in moderate-to-severe plaque psoriasis by Gabriel Mercadal-Orfila, Gabriel Mercadal-Orfila, Piedad López Sánchez, Aranzazu Pou Alonso, Olatz Ibarra-Barrueta, Emilio Monte-Boquet, Joaquin Borrás Blasco, Nuria Padullés Zamora, Patricia Sanmartin-Fenollera, Cristina Capilla Montes, M. Ángeles Bernabéu Martínez, Salvador Herrera-Pérez

“…Similarly, the PSSD - 7 Days questionnaire showed major reductions, with scores dropping from 55.43 ± 29.94 to 30.73 ± 30.66 at 6 months, and 53% of patients reaching a score of 20 or less. …”
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Multi-scenario analysis of green water resource efficiency under carbon emission constraints in the Chengdu-Chongqing urban agglomeration, China: A system dynamics approach by Keyao Yu, Zhigang Li

“…Five scenarios are then set up: baseline development, economic priority, green innovation, water-saving and emission reduction, and comprehensive development. These scenarios are used to simulate and predict different development paths and evaluate the impact of various key indicators on GWRE. …”
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