Identifying Lactylation-related biomarkers and therapeutic drugs in ulcerative colitis: insights from machine learning and molecular docking by Yao Yang, Xu Sun, Bin Liu, Yunshu Zhang, Tong Xie, Junchen Li, Jifeng Liu, Qingkai Zhang

“…Through machine learning algorithms, the diagnostic model was established. Further elucidating the mechanisms and regulatory network of the model gene in UC were GSVA, immunological correlation analysis, transcription factor prediction, immunofluorescence, and single-cell analysis. …”
Get full text

Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer by Yifei Zhu, Huixia Huang, Jiayu Chen, Keji Chen, Yanxi Yao, Yaxian Wang, Yuxue Li, Zhibing Qiu, Dawei Li, Ping Wei

“…Conclusions The FDRG score is a robust tool for predicting CRC prognosis, tumor microenvironment dynamics, and response to immunotherapy. …”
Get full text

OMAL: A Multi-Label Active Learning Approach from Data Streams by Qiao Fang, Chen Xiang, Jicong Duan, Benallal Soufiyan, Changbin Shao, Xibei Yang, Sen Xu, Hualong Yu

“…To solve these two issues, we propose a novel online multi-label active learning (OMAL) algorithm that considers simultaneously adopting uncertainty (using the average entropy of prediction probabilities) and diversity (using the average cosine distance between feature vectors) as an active query strategy. …”
Get full text

Simulation of energy consumption processes at the metallurgical enterprises in the energy-saving projects implementation by Kiyko S. G., Druzhinin E. A., Prokhorov O. V., Haidabrus B. V.

“…The model likewise includes algorithms for transport equipment management that minimize disruptions in continuous casting machines’ operation and simulate emergencies. …”
Get full text

Assessing cyber risks in construction projects: A machine learning-centric approach by Dongchi Yao, Borja García de Soto

“…A two-phase model development strategy is proposed to select the optimal model for each risk. (2) For risk factor analysis, ML feature analysis methods are adapted to identify risk factors that contribute significantly to risks of specific projects. (3) For the risk reduction strategy, a greedy optimization algorithm is proposed to efficiently address high-contributing risk factors. …”
Get full text

Genetic and bioinformatics analysis of an individual with Am phenotype due to variant of A-glycosyltransferase enzyme gene by ZHANG Xu, ZHOU Zhuren, HUANG Xuying, LI Lichun, LI Xiaofeng, LI Jianping

“…The c.912C>A mutation was predicted to be “probably damaging” and “deleterious” by PolyPhen2 and PROVEAN algorithms, respectively. …”
Get full text

Screening biomarkers related to cholesterol metabolism in osteoarthritis based on transcriptomics by ChenDeng Lao, Wei Wei, JianWen Cheng, ShiJie Liao, XiaoLin Luo, Qian Huang, HengZhen Huang, JinMin Zhao

“…Three machine learning algorithms identified ATF3, CHKA, CLU, CTNNB1, and FASN as potential biomarkers. …”
Get full text

Optimization of Flight Scheduling in Urban Air Mobility Considering Spatiotemporal Uncertainties by Lingzhong Meng, Minggong Wu, Xiangxi Wen, Zhichong Zhou, Qingguo Tian

“…Additionally, the proposed phased artificial lemming algorithm (ALA) outperforms traditional optimization algorithms in terms of solution quality. …”
Get full text

Downscaling Satellite Night-Time Light Imagery While Addressing the Blooming Effect by Nikolaos Tziokas, Ce Zhang, Alexandros Tziokas, Qunming Wang, Peter M. Atkinson

“…We compared several image fusion algorithms for downscaling while reducing the blooming effect. …”
Get full text

A Novel Approach for Maize Straw Type Recognition Based on UAV Imagery Integrating Height, Shape, and Spectral Information by Xin Liu, Huili Gong, Lin Guo, Xiaohe Gu, Jingping Zhou

“…An object-oriented classification method, utilizing a “two-step segmentation with multiple algorithms” strategy, was employed to integrate height, shape, and spectral features, enabling rapid and accurate mapping of maize straw types. …”
Get full text

Mammographic Screening as a Tool for Cardiovascular Risk Assessing. Part 2. Association of Breast Arterial Calcification and Cardiovascular Diseases by E. V. Bochkareva, I. V. Kim, E. K. Butina, I. D. Stulin, S. A. Trukhanov, B. A. Rudenko, S. A. Boytsov, O. M. Drapkina

“…It is shown that the addition of BAC to the generally accepted (standard) vascular risk assessment algorithms Framingham Risk Score and Pooled Cohort Equation significantly increases the accuracy of prediction of CHD (p=0.02 and p=0.010, respectively). …”
Get full text

RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients by Xiliang Zhang, Hanjie Guo, Xiaolong Li, Wei Tao, Xiaoqing Ma, Yuxing Zhang, Weidong Xiao

“…These genes were analyzed using univariate COX and machine learning algorithms to develop a prognostic scoring algorithm. …”
Get full text

Thrombotic Lesion of the Pulmonary Vessels in Patients with Pulmonary Embolism by A. A. Klimenko, N. A. Demidova, N. A. Shostak, M. O. Anischenko

“…Pathogenetic aspects of this condition are not fully investigated. It is important to predict the development of postembolic syndrome and to develop algorithms for the diagnosis, treatment and rehabilitation of patients with symptoms and residual pulmonary thrombosis. …”
Get full text

Engineered feature embeddings meet deep learning: A novel strategy to improve bone marrow cell classification and model transparency by Jonathan Tarquino, Jhonathan Rodríguez, David Becerra, Lucia Roa-Peña, Eduardo Romero

“…This assessment is still manually performed by trained specialists, who may be a bottleneck within the clinical process. Deep learning algorithms are a promising approach to automate this bone marrow cell evaluation. …”
Get full text

A Task Offloading and Resource Allocation Strategy Based on Multi-Agent Reinforcement Learning in Mobile Edge Computing by Guiwen Jiang, Rongxi Huang, Zhiming Bao, Gaocai Wang

“…Finally, an offloading decision algorithm TOMAC-PPO is proposed. The algorithm applies the proximal policy optimization to the multi-agent system and combines the Transformer neural network model to realize the memory and prediction of network state information. …”
Get full text

Feasibility and case studies on converting small hydropower stations to pumped storage by Yangqing Dan, Qingyue Chen, Daren Li, Wenhuan Bai, Weiming Zhou, Anyu Yang, Jia Yang

“…The proposed conversion scheme has been assessed, and predictions regarding annual operating hours, power generation, and energy consumption have been formulated. …”
Get full text

Investigation of granuloma-targeted host-pathogen interactions identify vaccine correlates of immune protection associated with control of M. tuberculosis replication by David Forrest Ackart, Dr. Faye Lanni, Victoria Mitcham, Dr. G. Brooke Anderson, Dr. Michael Lyons, Dr. Marcela Henao-Tamayo, Dr Brendan Podell

“…While a number of blood transcriptomic signatures have been shown to predict clinical states of TB in human subjects, no correlates exist to indicate immune signatures that control bacterial growth, which would inform improved vaccine design. …”
Get full text

Trends in Russia’s GDP Growth under Environmental Constraints by Z. V. Bragina, A. R. Denisov, N. N. Masyuk, N. V. Steblyanskii

“…Methods used: empirical and statistical analysis, building regression models, algorithmic and predictions, building time trends, etc. …”
Get full text

Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis by Hua Lai, Siming Xin, Jinliang Zhang, Yang Hu, Wenjuan Fan, Hong Wan, Bowen Chen, Yang Zou, Xiaoming Zeng, Xianxian Liu

“…These variants exhibited the following characteristics: (1) complete absence in 1,237 controls and all public genomic databases (1000 Genomes, ExAC, and dbSNP); (2) evolutionary conservation of the affected residues, with unanimous pathogenic predictions from all algorithms (PolyPhen-2: damaging; SIFT: deleterious; MutationTaster: disease-causing); (3) molecular modeling demonstrating structural perturbations in critical functional domains, including steroid-binding and redox partner interaction sites. …”
Get full text

Federated Learning Based on an Internet of Medical Things Framework for a Secure Brain Tumor Diagnostic System: A Capsule Networks Application by Roman Rodriguez-Aguilar, Jose-Antonio Marmolejo-Saucedo, Utku Köse

“…It enables machine learning or deep learning algorithms to establish a client–server relationship, whereby specific parameters are securely shared between models while maintaining the integrity of the learning tasks being executed. …”
Get full text