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Identifying the risk of Kawasaki disease based solely on routine blood test features through novel construction of machine learning models
Published 2025-01-01“…Additional explainable AI analyses revealed that several top predictive features in KDpredictor are consistent with prior clinical findings. …”
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12662
Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation
Published 2025-05-01“…A protein-protein interaction (PPI) network of mitoDEGs was constructed, and hub mitoDEGs associated with MI were identified using CytoHubba and molecular complex detection (MCODE) algorithms. Transcription factor (TF) and microRNA (miRNA) targets of hub mitoDEGs were predicted using iRegulon and miRWalk plug-ins, respectively, and a regulatory network involving TFs, hub mitoDEGs, and miRNA was established. …”
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12663
Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling
Published 2025-02-01“…The target gene of miR-17-5p were predicted with different algorithms from five databases and further confirmed with dual-luciferase reporter assay. …”
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12664
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12665
Assessing reading fluency in elementary grades: A machine learning approach
Published 2025-06-01“…The research objective was to determine which algorithm best predicts fluency, considering diverse evaluation setups including binary classification (fluent versus non-fluent), multiclass classification (differentiated fluency levels), and regression analysis to estimate continuous fluency scores. …”
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12666
Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics
Published 2025-06-01“…Conclusion Overall, the full-cycle dynamic changes in skin thickness and depth-resolved vascular alterations during the progression of dermatitis can be effectively predicted using OCT/OCTA, which can inform more targeted AD diagnosis and treatment strategies. …”
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12667
Proximity-based solutions for optimizing autism spectrum disorder treatment: integrating clinical and process data for personalized care
Published 2025-01-01“…A central data hub, the Master Data Plan (MDP), will aggregate and analyze information from diverse sources, feeding AI algorithms that can identify risk factors for ASD, personalize treatment plans based on individual needs, and even predict potential relapses. …”
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12668
Habitat analysis of iron deposition in the basal ganglia for diagnosing cognitive impairment in chronic kidney disease: evidence from a case-control study
Published 2025-04-01“…The two habitats-based model achieved an area under the curve of 0.926 (95% CI 0.842-1.000) on the test set, the highest among all prediction models. The two-habitat maps indicated that chronic kidney disease had two distinct patterns of impact on iron deposition in the basal ganglia region. …”
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12669
Randomised controlled trial to evaluate the effectiveness of using the RD-1-based C-Tb skin test as a replacement for blood-based interferon-γ release assay for detection of, and i...
Published 2021-12-01“…Introduction The predictive utility for incident tuberculosis (TB) of the purified protein derivative tuberculin skin test and region of difference 1 (RD1)-based interferon-gamma release assays (IGRA) is comparable; and either is recommended to test for latent TB infection (LTBI). …”
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12671
Surface Soil Organic Carbon Estimation Based on Habitat Patches in Southwest China
Published 2025-01-01“…Results showed higher SOC content (0–15 cm) in the southwestern mountains and the northwestern plateaus of Sichuan, while lower in the Sichuan Basin. The prediction uncertainty exhibited a similar pattern. …”
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12672
A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma
Published 2023-02-01“…Conclusions For the elderly NDMM, the CEMM2021 algorithm in our center might provide a valuable reference for the guidance of therapeutic strategies, with the combination of Bregs resulting in an effective and clinically meaningful prediction in contemporary treatment.…”
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12673
Heat transfer with magnetic force and slip velocity on non-Newtonian fluid flow through a porous medium
Published 2025-03-01“…This model advances previous studies by demonstrating that fractional derivatives significantly enhance the prediction of fluid behavior in porous media, underscoring the effectiveness of fractional modeling for complex convection processes. …”
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12674
The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality
Published 2025-08-01“…After multivariable adjustment, symptom status strongly predicted risk. Patients with symptomatic moderate AS had a similar risk to those with severe AS without symptoms (adjusted HR: 1.77 [95% CI: 1.65-1.91] vs 1.81 [95% CI: 1.51-2.17] for death, P = 0.81; aHR: 2.27 [95% CI: 2.13-2.41] vs 2.40 [95% CI: 2.08-2.77] for AS-related hospitalization, P = 0.42). …”
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12675
Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions
Published 2025-03-01“…However, the field of computational biology has faced substantial challenges due to the lack of methods for precise protein structural comparisons and accurate prediction of molecular interactions. In our previous studies, we introduced the Triangular Spatial Relationship (TSR)-based algorithm, which represents a protein’s 3D structure using a vector of integers (keys). …”
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Static stress triggering of Morocco M 6.9 earthquake on 9 September 2023
Published 2025-02-01“…It contributes to enhancing earthquake monitoring, prediction, and risk mitigation capabilities, promotes the formulation of relevant policies, and safeguards people's lives and property. …”
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12677
Exploring the role of neutrophil extracellular traps in neuroblastoma: identification of molecular subtypes and prognostic implications
Published 2024-11-01“…This stratification might provide insight into the prediction of prognosis and ideal immunotherapy strategies for patients with NB. …”
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Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies
Published 2025-02-01“…As a subset of artificial intelligence, machine learning algorithms create a mathematical model based on sample data or "training data" in order to predict or make decisions without overt planning (Du et al., 2019). …”
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Estimation of the water content of needles under stress by Erannis jacobsoni Djak. via Sentinel-2 satellite remote sensing
Published 2025-04-01“…Multiple vegetation indices are screened via recursive feature elimination cross validation (RFECV), and then support vector regression (SVR) and back-propagation neural network (BP) models are used to predict the leaf weight content fresh (LWCF) and leaf weight content dry (LWCD) of needles over a large area. …”
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Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics
Published 2025-02-01“…The relationship of key genes with immune cells and other cells was evaluated by immune infiltration algorithm and single-cell transcription analysis. Drug prediction was performed by cMAP and the obtained drugs were molecularly docked with the key genes. …”
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