Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma by Can Xu, Jin Yang, Huan Xiong, Xiaoteng Cui, Yuhao Zhang, Mingjun Gao, Lei He, Qiuyue Fang, Changxi Han, Wei Liu, Yangyang Wang, Jin Zhang, Ying Yuan, Zhaomu Zeng, Ruxiang Xu

“…The TIDE algorithm was used to examine immunotherapy scores. …”
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Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study by Bernard A Fox, Chichung Wang, Kristin Roman, Carla Coltharp, Carmen Ballesteros-Merino, Shawn M Jensen, Janis M Taube, David L Rimm, Cliff Hoyt, Mei Jiang, Edwin R Parra, Ignacio Wistuba, Elizabeth L Engle, John McGuire, Bethany Remeniuk, Darren Locke

“…Background Emerging data suggest predictive biomarkers based on the spatial arrangement of cells or coexpression patterns in tissue sections will play an important role in precision immuno-oncology. …”
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FEATURES OF LOCAL IMMUNITY IN PATIENTS WITH OROPHARYNGEAL CANCER by O. I. Keith, M. N. Tilliashaihov, P. V. Svetitsky, E. Yu. Zlatnik, G. I. Zakora, A. A. Ganiev, G. P. Nistratov

“…Modern laboratory techniques allow predicting patient’s condition before and during the course of treatment; they were implemented into clinical practice for successful treatment correction. …”
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Pulmonary Hemodynamic Correlates and Prognostic Value of the Cardiopulmonary Exercise Score in Patients With Left Heart Failure by Qianqian Chen, Wande Yu, Peipei Cheng, Mengyu Zhang, Wei Li, Dandan Wei, Hang Zhang, Hanjia Gao, Xiaoxia Fu

“…The objective of this study is to develop an algorithm by using data from cardiopulmonary exercise testing (CPET) to assess the severity of pulmonary hemodynamics and predict clinical worsening and mortality in patients with heart failure. …”
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Research on Model Reconstruction Methods for Partial Point Cloud Information Loss by Zhengping CHANG, Guoshuai YUAN, Jiuhua LI, Yang ZHAO, Zhongqi WANG

“…Finally, the scanned point cloud carried on region partition, and the Interactive Closest Point (ICP) algorithm was utilized to match the scanned area with the theoretical model. …”
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Forecasting Spatiotemporal Dynamics of Daytime Surface Urban Cool Islands in Response to Urbanization in Drylands: Case Study of Kerman and Zahedan Cities, Iran by Mohammad Karimi Firozjaei, Naeim Mijani, Solmaz Fathololoumi, Jamal Jokar Arsanjani

“…Various methods, including a random forest algorithm, spectral indices, Cellular Automata-Markov (CA-Markov) model, the cross-tabulation model, and spatial overlay and zonal statistics, were employed to assess and model the spatiotemporal changes in SUCII. …”
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Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. by Scott C Schuyler, Yueh-Fu Olivia Wu, Hsin-Yu Chen, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao, Jia-Hua Jhuo, Vivien Cheng

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Can vegetation breakpoints in Eastern Mongolia rangeland be detected using Sentinel-1 coherence time series data? by Shuxin Ji, Ganzorig Gonchigsumlaa, Sugar Damdindorj, Tserendavaa Tseren, Densmaa Sharavjamts, Amartuvshin Otgondemberel, Enkh-Amgalan Gurjav, Munguntsetseg Puntsagsuren, Batnaran Tsabatshir, Tumendemberel Gungaa, Narantsetseg Batbold, Lukas Drees, Bayarchimeg Ganbayar, Dulamragchaa Orosoo, Bayartsetseg Lkhamsuren, Badamtsetseg Ganbat, Myagmarsuren Damdinsuren, Gantogoo Gombosuren, Batnyambuu Dashpurev, Thanh Noi Phan, Nandintsetseg Dejid, Thomas Müller, Lukas Lehnert

“…In drier and less intensively used areas, the predicted pattern agrees less with the known movements. …”
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Cellular interactions and Ion channel signatures in atrial fibrillation remodeling: insights from single-cell analysis and machine learning by Bin He, Yan Cheng, Juan Wang, Ya Zhan, YanQun Liu

“…In the electrical remodeling investigation, ion channel gene sets and gene expression data were utilized alongside LASSO and SVM machine-learning algorithms combined with ROC curve analysis. This approach ultimately identified ANO1 and GRIK2 as the characteristic ion channel genes for AF. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…The system includes a combination of real-time continuous glucose monitoring from a continuous glucose monitoring device and a control algorithm to direct insulin delivery through an insulin pump. …”
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The effect of lipid accumulation product and its interaction with other factors on hypertension risk in Chinese Han population: A cross-sectional study. by Jian Song, Yingying Zhao, Sumei Nie, Xue Chen, Xuesen Wu, Jing Mi

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Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile by Yan Ma, Xingdong Chen, Jie Wei, Li Guo, Jian Huang, Li Xie, Lei Chen, Ping Lu, Wei Sun, Wei Shi, Feng Ding, Liping Zhang, Yue Zhang, Linlin Zhang, Rui Song, Yi Huang, Jun Shen, Hong Xu, Zhigang Chen, Qian Shen, Ying Ma, Yiwen Zhang, Hongxia Li, Yihui Zhai, Biao Xu, Xian Zhou, Jun Sun, Bing Wu, Rui Su, Xiaoyan Yu, Jianhong Zhu, Yihong Huang, Ling Gong, Nana Wu, Jingjing Sun, Tianyi Liu, He Yuan, Yiwen Shen, Jiaojiao Liu, Xia Han, Juanjuan Wu, Yinghua Sun, Suxiang Xu, Qinyi Zhang, Na Xie, Jianfeng Ji, Weizhi Mo, Yuanxin Liu, Xinghua Shi, Wanshan Qiu, Jiapeng Mi, Juhua Yan, Minghui Zhu, Pei Feng, Wenqian Sheng, Mingqin Tai, Chunqin Zhou, Qian Jin, Chengyu Gu, Xiujuan Huang, Qinfang Qian, Yixin Cao, Haochen Shen, Ziwen Xue, Yucui Ma, Juan Tian, Yingdan Zhang, Weiyuan Zhuang, Kaiqun Yang, Xiaohui Shen, Yanwei Gu, Beibei Shi, Chenhong Pan, Hongmei Zhou, Xiuchen Zhang, Meihua Tang, Kaixuan Gu, Hongping Liu, Yuanxian Li

“…We aim to develop multimodal risk prediction models by integrating genomics and artificial intelligence algorithms. …”
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LcProt: Proteomics‐based identification of plasma biomarkers for lung cancer multievent, a multicentre study by Hengrui Liang, Runchen Wang, Ran Cheng, Zhiming Ye, Na Zhao, Xiaohong Zhao, Ying Huang, Zhanpeng Jiang, Wangzhong Li, Jianqi Zheng, Hongsheng Deng, Yu Jiang, Yuechun Lin, Yun Yan, Lei Song, Jie Li, Xin Xu, Wenhua Liang, Jun Liu, Jianxing He

“…ABSTRACT Background Plasma protein has gained prominence in the non‐invasive predicting of lung cancer. We utilised Zeolite Zotero NaY‐based plasma proteomics to investigate its potential for multiple event predicting, including lung cancer diagnosis (task #1), lymph node metastasis detection (task #2) and tumour‒node‒metastasis (TNM) staging (task #3). …”
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Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBR... by Nasim Mavaddat, Debra Frost, Emily Zhao, Daniel R. Barnes, Munaza Ahmed, Julian Barwell, Angela F. Brady, Paul Brennan, Hector Conti, Jackie Cook, Harriet Copeland, Rosemarie Davidson, Alan Donaldson, Emma Douglas, David Gallagher, Rachel Hart, Louise Izatt, Zoe Kemp, Fiona Lalloo, Zosia Miedzybrodzka, Patrick J. Morrison, Jennie E. Murray, Alex Murray, Hannah Musgrave, Claire Searle, Lucy Side, Katie Snape, Vishakha Tripathi, Lisa Walker, Stephanie Archer, D. Gareth Evans, Marc Tischkowitz, Antonis C. Antoniou, Douglas F. Easton

“…Conclusion Information on the distribution of cancer risk factors in PV carriers is needed for incorporating these factors into multifactorial cancer risk prediction algorithms. Contrary to previous reports, we found no evidence that BRCA1 or BRCA2 PV are associated with hormonal or anthropometric factors, except for a weak association with height. …”
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The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT by Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo

“…A previous clinical trial showed that a logistic regression algorithm including the transcript levels of a set of five genes in a liver biopsy could predict the success of immunosuppression withdrawal with high sensitivity and specificity. …”
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In Vivo Noncontact Imaging of Conjunctival Goblet Cells with Customized Widefield Fluorescence Microscopy by Yushuang Liu, MS, Zhengyu Duan, PhD, Zhongzhou Luo, BEng, Runze Zhang, MS, Jiaxiong Li, MS, Jinze Zhang, PhD, Zeyu Meng, MS, Bowen Wang, MD, PhD, Jin Yuan, MD, PhD, Peng Xiao, PhD

“…Methods: Based on the intrinsic fluorescence properties of moxifloxacin, a high-resolution noncontact widefield fluorescence microscopy (WFFM) was customized with an all-in-focus algorithm to optimize in vivo CGC imaging over the curved conjunctival surface. …”
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Study on the factors influencing the impaired abilities of daily living in middle-aged and older adult arthritis patients based on binary logistic regression and categorical decisi... by Bao-xuan Zhang, Bao-xuan Zhang, Bao-xuan Zhang, Jin-ping Luo, Jin-ping Luo, Jin-ping Luo, Jia-ying Sun, Jia-ying Sun, Jia-ying Sun, Ming-hui Geng, Ming-hui Geng, Ming-hui Geng, Yi-fan Mou, Yi-fan Mou, Yi-fan Mou, Nan-nan Cheng, Nan-nan Cheng, Nan-nan Cheng, Zhao-xuan Wang, Zhao-xuan Wang, Zhao-xuan Wang, Wen-qiang Yin, Wen-qiang Yin, Wen-qiang Yin, Zhong-ming Chen, Zhong-ming Chen, Zhong-ming Chen, Dong-ping Ma, Dong-ping Ma, Dong-ping Ma

“…The decision tree results showed that pain was the most important variable predicting impaired ADL in middle-aged and older adult arthritis patients. …”
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Artificial intelligence and anti-cancer drugs' response by Xinrui Long, Kai Sun, Sicen Lai, Yuancheng Liu, Juan Su, Wangqing Chen, Ruhan Liu, Xiaoyu He, Shuang Zhao, Kai Huang

“…This review aims to comprehensively summarize the research progress in utilizing AI algorithms to analyze multi-omics data including genomics, transcriptomics, epigenomics, proteomics, metabolomics, radiomics, and histopathology, for predicting cancer drug resistance. …”
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Results of a non-interventional multicenter observational study on the diagnosis and treatment of patients with axial psoriatic arthritis in rea-world clinical practice in the Russ... by T. V. Korotaeva, E. E. Gubar, E. Yu. Loginova, Yu. L. Korsakova, E. A. Vasilenko, I.-D. Yu. Ilyevsky, L. V. Ivanova, E. Yu. Akulinushkina, P. А. Shesternya, O. V. Matveychuk, Yu. Yu. Grabovetskaya, A. A. Barakat, M. A. Korolev, E. V. Zonova, O. A. Georginova, I. V. Kolotilina, I. M. Marusenko, I. B. Vinogradova, O. B. Nesmeyanova, N. E. Grigoriadi, A. V. Petrov, D. G. Krechikova, T. V. Kropotina, S. P. Yakupova, V. I. Mazurov

“…Switching therapy to bDMARDs led to a significant reduction in disease activity.In order to improve the quality of medical care, the Russian clinical guidelines for the treatment of patients with PsA and the algorithms for the diagnosis of axial involvement need to be comprehensively implemented.…”
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Clinical diagnosis of partial or complete anterior cruciate ligament tears using patients' history elements and physical examination tests. by Simon Décary, Michel Fallaha, Sylvain Belzile, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Debbie Feldman, Marie-Pierre Sylvestre, Pascal-André Vendittoli, François Desmeules

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