Analytical screening of polymorphic variants of 20S proteasome genes when planning a study of pathogenetic effects of modification of NFKB1 post-translational processing by A. V. Meyer, M. V. Ulyanova, D. O. Imekina, A. D. Padyukova, T. A. Tolochko, E. A. Astafieva, M. B. Lavryashina

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Rapid adaptation to human protein kinase R by a unique genomic rearrangement in rhesus cytomegalovirus. by Stephanie J Child, Alexander L Greninger, Adam P Geballe

“…Cytomegaloviruses (CMVs) are generally unable to cross species barriers, in part because prolonged coevolution with one host species limits their ability to evade restriction factors in other species. …”
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Complete Genome and Characterization Analysis of a <i>Bifidobacterium animalis</i> Strain Isolated from Wild Pigs (<i>Sus scrofa ussuricus</i>) by Tenggang Di, Huan Zhang, Cheng Zhang, Liming Tian, Menghan Chang, Wei Han, Ruiming Qiao, Ming Li, Shuhong Zhang, Guangli Yang

“…This study indicated the genomic basis of <i>Bifidobacterium</i>–host crosstalk in intestinal protection, providing a framework for developing novel probiotic interventions.…”
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Identification and characterization of the powdery mildew resistance in cultivated emmer wheat accession Lxd-682 via bulked segregant RNA sequencing by Jiatong Li, Ningning Yu, Nina Sun, Lige Geng, Yanmin Qie, Dongfeng Zhai, Yuxiang Wang, Linzhi Li, Xueqing Liu, Xusheng Sun, Jiangchun Wang, Ruishan Liu, Guantong Pan, Shengmao Zou, Guohao Han, Yuli Jin, Pengtao Ma

“…To verify the potential regulatory genes, three key genes, TRITD2 Av1G294940, TRITD2 Av1G036490 and TRITD2 Av1G295220 all encoding disease resistance protein, were selected from six candidates via qRT-PCR following post-Bgt invasion. …”
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The Putative Virulence Plasmid pYR4 of the Fish Pathogen <i>Yersinia ruckeri</i> Is Conjugative and Stabilized by a HigBA Toxin–Antitoxin System by Fisentzos Floras, Chantell Mawere, Manvir Singh, Victoria Wootton, Luke Hamstead, Gareth McVicker, Jack C. Leo

“…The Norwegian <i>Y. ruckeri</i> outbreak isolate NVH_3758 carries a relatively uncharacterized plasmid, pYR4, which encodes both type 4 pili and a type 4 secretion system. …”
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Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. by Siyuan Ding, Nancie Mooney, Bin Li, Marcus R Kelly, Ningguo Feng, Alexander V Loktev, Adrish Sen, John T Patton, Peter K Jackson, Harry B Greenberg

“…Rotaviruses (RVs) are the leading cause of severe gastroenteritis in young children, accounting for half a million deaths annually worldwide. RV encodes non-structural protein 1 (NSP1), a well-characterized interferon (IFN) antagonist, which facilitates virus replication by mediating the degradation of host antiviral factors including IRF3 and β-TrCP. …”
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A self-supervised multimodal deep learning approach to differentiate post-radiotherapy progression from pseudoprogression in glioblastoma by Ahmed Gomaa, Yixing Huang, Pluvio Stephan, Katharina Breininger, Benjamin Frey, Arnd Dörfler, Oliver Schnell, Daniel Delev, Roland Coras, Anna-Jasmina Donaubauer, Charlotte Schmitter, Jenny Stritzelberger, Sabine Semrau, Andreas Maier, Siming Bayer, Stephan Schönecker, Dieter H Heiland, Peter Hau, Udo S. Gaipl, Christoph Bert, Rainer Fietkau, Manuel A. Schmidt, Florian Putz

“…The encoder is trained in a self-supervised upstream task on unlabeled glioma MRI datasets from the open BraTS2021, UPenn-GBM, and UCSF-PDGM datasets (n = 2317 MRI studies) to generate compact, clinically relevant representations from FLAIR and T1 post-contrast sequences. …”
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Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. by Bryna Erblich, Liyin Zhu, Anne M Etgen, Kostantin Dobrenis, Jeffrey W Pollard

“…In these mice microglia are >99% depleted at embryonic day 16 and day 1 post-partum brain. At three weeks of age this microglial depletion continues in most regions of the brain although some contain clusters of rounded microglia. …”
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Transcriptomic, phenotypic and physiological analyses identify candidate regulators of Dendrobium stigma maturation and pollen-stigma interaction by Qian Wu, Shuxian Ren, Yuehong Ruan, Jiaxue Hu, Yin Li, Zongyan Li

“…Among these unique DEGs, one was found to encode superoxide dismutase (SOD) enzymes, while seventeen encoded esterases. …”
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