Explaining the Concept of Palliative Care in Patients With Stroke, Development and Validation of a Questionnaire: A Mixed-Method Study Protocol by Zakiyeh Jafaryparvar, Fatemeh Bahramnezhad, Fatemeh Hajibabaee, Mahdi Shafiee Sabet, Nahid Dehghan Nayeri

“…As a result, there are few referrals of stroke patients to specialized palliative care services, typically happening only at the time of death. Methods and Analysis: This research is sequential mixed-method exploratory analysis. …”
Get full text

Study protocol for developing deprescribing clinical practice guidelines: evidence-based GRADE methodology and a Delphi consensus method by Hui Wen Quek, Amy Page, Kenneth Lee, Christopher Etherton-Beer

“…For areas with insufficient quality evidence, consensus-based recommendations will be developed using a modified Delphi method. Additional good practice statements will be developed where necessary to facilitate the practical application of these recommendations. …”
Get full text

Development and application of a highly sensitive quadruple droplet digital PCR method for simultaneous quantification of sulfonamide resistance genes by Xirong Yin, Jiayuan Nie, Huifang Tian, Huifang Tian, Lihong Duan, Lixia Wu, Xiangdong Xu, Yumei Guo, Yumei Guo, Ke Wang, Ke Wang

“…Therefore, there is an urgent need to develop more efficient detection methods to enhance the monitoring of sul genes. …”
Get full text

Development and Validation of a Versatile UPLC-PDA Method for Simultaneous Determination of Paracetamol, Tizanidine, Aceclofenac, and Nimesulide in Their New Combinations by Sami Bawazeer, Khalid M. Badr El-Din, Ahmed M. Abdel-Megied

“…A simple, rapid, and validated UPLC method was developed for the simultaneous quantitation of paracetamol (PAR), tizanidine (TIZ), aceclofenac (ACF), and nimesulide (NIM) either in pure forms or in their different tablet dosage forms. …”
Get full text

Development of a novel non-targeted analytical method on evaluating the thermal stability of pesticides, enabling the identification of degradation products by Florian Dubocq, Roua Bou Orm, Pierre L’Yvonnet, Xavier Sarda, Gaelle Vial, Arnaud Duboisset, Benjamin Carbonnier, Julien Parinet

Get full text

EXPERIMENTAL STUDIES OF THE INTERFACE DEVELOPED USING THE METHOD OF INFORMATION MODEL SYNTHESIS AT THE AUTOMATED WORKSTATION OF AIR TRAFFIC CONTROL MANAGER by O. A. Kaptsevich, D. I. Rabchenok, K. Y. Ponomarev

“…Using the method of synthesis of the information model at the automated workstation of the air traffic control dispatcher, a fragment of the user interface at the automated workstation of the radar control dispatcher of the Minsk district control center was synthesized, which allows to simulate the stages of the dispatcher's activity in the automated air traffic control system at the modern level of air traffic intensity. …”
Get full text

Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals by Alejandra Álvarez-Mínguez, Natalia del Río, Ana Belén-Blázquez, Elena Casanova, José-María Orduña, Patricia Camarero, Carolina Hurtado-Marcos, Carmen del Águila, María–Jesús Pérez-Pérez, Miguel A. Martín-Acebes, Rubén Agudo

“…This result supports the utility of this novel method for the screening of inhibitors against WNV MTase activity, which can be of special relevance to the discovery and development of therapeutics against WNV.…”
Get full text

Development of a green GC-FID method for residual solvent analysis in paliperidone nanocrystal formulations: Validation and greenness assessment by Manohar S K, Gowrav M P, Mounika P, Karthika Paul, Hemanth Vikram P R, Maged Mohammed Abdo Mohsen, Bannimath Gurupadayya

“…The developed gas chromatography method was validated as per ICH Q2 (R1) guidelines. …”
Get full text

Development and validation of a UPLC-MS/MS method for the quantification of parsaclisib and its application to pharmacokinetics and metabolic stability studies by Chenjian Zhou, Peiqi Wang, Jie Chen, Hualu Wu, Yige Yu

“…However, there is no accurate and rapid method for the determination of parsaclisib. The aim of this study was to establish a rapid, specific and reliable ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of parsaclisib, and to investigate in vitro metabolic stability using rat liver microsomes (RLMs) and in vivo pharmacokinetics in rats. …”
Get full text

Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni. by Valentin Buchter, Pierre H H Schneeberger, Jennifer Keiser

“…Aiming to reduce animal use, we validated an in vitro growth method for juvenile Schistosoma mansoni for the purpose of drug sensitivity assays.…”
Get full text

Development and Validation of a Sensitive LC-MS/MS Method for the Determination of N-Nitroso-Atenolol in Atenolol-Based Pharmaceuticals by Soonho Kwon, Sang-Hyun Ahn, Yongha Chang, Joon-Sang Park, Hwangeui Cho, Jung-Bok Kim

“…The recent detection of N-nitroso-atenolol, a mutagenic and potentially carcinogenic impurity in atenolol-based pharmaceuticals, has raised serious safety concerns and emphasized the need for stringent analytical control. This study developed and validated a highly sensitive LC-MS/MS method for quantifying N-nitroso-atenolol in both active pharmaceutical ingredients (APIs) and finished products. …”
Get full text

DEVELOPMENT OF A NOVEL REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF SODIUM DITHIONITE IN BREAD PRODUCTS by SHAHIN SHAHBAZI, FOROUGH SARAEE, NASER ABBASI, ELAHE KARIMI, HORI GHANEIALVAR, MAHMOUD BAHMANI, ALI AIDY, SAJAD MAZLOOMI, MASOUMEH TAHMASEBI, ASADOLLAH JALALI GHALOUSANGH

Get full text

A method development for improving the stability of vegetable polyphenol complexes for semi-finished minced meat products with antioxidant effect by A. V. Gerasimov, B. A. Bazhenova, S. D. Zhamsaranova, Yu. Yu. Zabalueva, N. D. Zambulaeva, A. D. Burkhanova

“…The aim of the work was to develop an immobilization method as a way for improving the stability of polyphenols in dried cowberry squeezing extract (DCSE) and to develop semi-finished minced meat products with antioxidant effect without changing their nutritional value. …”
Get full text

ASSESSMENT OF EFFICIENCY OF THE MODIFIED IFA METHOD AIMED TO DETECT ANTIBODIES AGAINST TUBERCULOSIS FOR DEVELOPMENT AND DIAGNOSTICS OF TUBERCULOSIS IN HIV PATIENTS by A. P. Tsibulkin, I. M. Khаertynovа, R. Sh. Vаliev, K. S. Khаertynov

Get full text

Development of a Comprehensive Evaluation Scale for LLM-Powered Counseling Chatbots (CES-LCC) Using the eDelphi Method by Marco Bolpagni, Silvia Gabrielli

Get full text

Development and application of a blocking ELISA method based on Cap protein for detecting antibodies against porcine circovirus 2 by Qingyan Liu, Shuolei Gao, Jiannan Li, Jingyi Yang, Yuxiang Zhu, Jun Zhu, YanJun Zhou, TongLing Shan, Wu Tong, Hao Zheng, Ning Kong, YiFeng Jiang, ChangLong Liu, GuangZhi Tong, Hai Yu

“…Consequently, there is a pressing need to develop a new blocking ELISA method that is more efficient to detect antibodies against PCV2.…”
Get full text

Development and application of a triplex real-time PCR method for the detection of Lawsonia intracellularis, Brachyspira hyodysenteriae, and Clostridium perfringens by Wenqing Wu, Lei Wang, Rui Xie, Changjiang Peng, Hao Yang, Hechao Zhu, Yajuan Luo, Lin Hua, Huanchun Chen, Bin Wu, Zhong Peng

“…In addition, mixed infections between some pathogens were also found.IMPORTANCEIn this study, we developed a triple real-time PCR method for the detection of Lawsonia intracellularis (LI), Brachyspira hyodysenteriae (Bhy), and Clostridium perfringens (Cp). …”
Get full text

Development of a fruit size estimation method using Mask RCNN for water stress estimation in Satsuma mandarin trees. by Ringo Komiya, Mitsunori Iwasaki, Harshana Habaragamuwa, Hiroshi Fukamachi

“…The developed method combined Mask RCNN and a regression model. …”
Get full text

Development and verification of a novel tiling PCR method for long-range HIV-1 sequencing in a diagnostic setting by Bethany A. Horsburgh, Arunasingam Abayasingam, Frances Jenkins, Hui Li, Charles S. P. Foster, Andrew Lloyd, Lachlan Coin, William Rawlinson, Anthony D. Kelleher, Sebastiaan van Hal, Rowena A. Bull, Francesca Di Giallonardo, The H2Seq Genome Sequencing Working Group

Get full text

Development of a method to evaluate strain in weld solidification using in-situ observations with high-brightness synchrotron X-rays by Houichi Kitano, Tomoya Nagira, Fumiyoshi Yoshinaka, Takahiro Sawaguchi, Takayuki Yamashita, Yasuhiro Aoki, Hidetoshi Fujii

“…The strain distribution obtained using the proposed method is compared with that calculated using the template matching method, and its effectiveness is verified. …”
Get full text