Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks. by Eva-Maria Schilling, Myriam Scherer, Franziska Rothemund, Thomas Stamminger

“…Furthermore, our results indicate that FEN1 is required for the formation of DSBs during HCMV infection suggesting that IE1 acts as viral activator of FEN1 in order to re-initiate stalled replication forks. In summary, we propose a novel mechanism of viral FEN1 activation to overcome replication fork barriers at difficult-to-replicate sites in viral genomes.…”
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Stall Margin Improvement in a Centrifugal Compressor through Inducer Casing Treatment by V. V. N. K. Satish Koyyalamudi, Quamber H. Nagpurwala

“…The casing treatment technique of stall control is found to be effective in axial compressors, but very limited research work is published on the application of this technique in centrifugal compressors. …”
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Sensitivity of Dynamic Stall Models to Dynamic Excitation on Large Flexible Wind Turbine Blades in Edgewise Vibrations by Galih Bangga

“…The beginning of the research work starts by evaluating different dynamic stall models on rigid blade section forces against known airfoil datasets. …”
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Evaluating model generalization for cow detection in free-stall barn settings: Insights from the COw LOcalization (COLO) dataset by Mautushi Das, Gonzalo Ferreira, C.P. James Chen

“…This study investigates the generalization capabilities of object detection models for cow detection in indoor free-stall barn settings, focusing on varying training data characteristics such as view angles and lighting, and model complexities. …”
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How artificial intelligence can enable data classification for market sizing - Insights from applications in practice by L. Stallings, P. Bhat, J. Jacobs, K. Lynch, Q. Risch

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Genome-wide analysis of DNA replication and DNA double-strand breaks using TrAEL-seq. by Neesha Kara, Felix Krueger, Peter Rugg-Gunn, Jonathan Houseley

“…Faithful replication of the entire genome requires replication forks to copy large contiguous tracts of DNA, and sites of persistent replication fork stalling present a major threat to genome stability. …”
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A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells by Mathew J. K. Jones, Subash Kumar Rai, Pauline L. Pfuderer, Alexis Bonfim-Melo, Julia K. Pagan, Paul R. Clarke, Francis Isidore Garcia Totañes, Catherine J. Merrick, Sarah E. McClelland, Michael A. Boemo

“…Our method can differentiate between fork slowing and fork stalling in cells treated with hydroxyurea, as well as inhibitors of ATR, WEE1, and PARP1. …”
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Condensin II interacts with BLM helicase in S phase to maintain genome stability by Brian Rodemoyer, Ganesha Kariyawasam, Veena Subramanian, Kristina Schmidt

“…Disrupting the BLM-condensin II interaction reduced replication speed, increased fork stalling and sister-chromatid exchanges, delayed repair of DNA double-strand breaks, and led to micronuclei. …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect by Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs

“…Abstract Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two independent pathways, controlled by the polymerase REV1 and ubiquitinated PCNA, respectively. …”
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MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants. by Jeffrey D Stumpf, William C Copeland

“…Increased mutagenesis could be explained by mutant variants stalling the replication fork, thereby predisposing the template DNA to irreparable damage that is bypassed with poor fidelity. …”
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Real-Time Energy Management Control for Hybrid Electric Powertrains by Mohamed Zaher, Sabri Cetinkunt

“…The real-time control challenge is to balance the system power demands from the engine and the hybrid storage device, without depleting the energy storage device or stalling the engine in any work cycle. In the worst-case scenario, only the engine is used and the hybrid system is completely disabled. …”
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Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms by Laura Ryder, Frederic Schrøder Arendrup, José Francisco Martínez, Goda Snieckute, Chiara Pecorari, Riyaz Ahmad Shah, Anders H. Lund, Melanie Blasius, Simon Bekker-Jensen

“…In addition, NO production is associated with ZNF598-mediated ubiquitination of the ribosomal protein RPS10 and GCN2-mediated activation of the integrated stress response, which are well-described responses to the collision of ribosomes. In sum, our work implicates a novel role of NO as an inducer of ribosome collision and activation of ribosomal surveillance mechanisms in human cells.…”
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Studying the UK job market during the COVID-19 crisis with online job ads. by Rudy Arthur

“…As well as the analysis, this work presents an open methodology that enables a rapid and detailed survey of the job market in unsettled conditions and describes a web application jobtrender.com that allows others to query this data set.…”
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CardioGenAI: a machine learning-based framework for re-engineering drugs for reduced hERG liability by Gregory W. Kyro, Matthew T. Martin, Eric D. Watt, Victor S. Batista

“…Scientific contribution This work introduces CardioGenAI, an open-source machine learning-based framework designed to re-engineer drugs for reduced hERG liability while preserving their pharmacological activity. …”
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Experimental Investigations of Self-adjusting Bionic Flaps on Low-aspect Ratio Wings by A. Verma, V. Kulkarni, S. Shinde

“…Therefore, in the present work, this flap is tested on a S5010 profiled wing of two different low ARs, 2.0 and 1.0, in the Re range of MAVs application. …”
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gammaH2AX foci form preferentially in euchromatin after ionising-radiation. by Ian G Cowell, Nicola J Sunter, Prim B Singh, Caroline A Austin, Barbara W Durkacz, Michael J Tilby

“…H2AX phosphorylation has also been demonstrated previously to occur at stalled replication forks induced by UV radiation or exposure to agents such as hydroxyurea. …”
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PRODUCTION PROSTHETIC NOSE FOR CAD / CAM TECHNOLOGY: ADVANTAGES AND DISADVANTAGES by L.B. Yerys

“…The purpose and goal of our work was to study computer technology and compared them to the production of classic maxillofacial prostheses and benefits of CAD / CAM technology in traditional prosthetic nose, for example. …”
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Lessons Learned for Developing an Effective High-Speed Research Compressor Facility by Nicholas J. Kormanik, Douglas R. Matthews, Nicole L. Key, Aaron J. King

“…The Purdue High-Speed Compressor Research Laboratory has a longstanding tradition of partnering with industry sponsors to perform high-TRL (technology readiness level) experiments on axial and radial compressors for aerospace applications. Early work in the laboratory with Professor Sanford Fleeter and Professor Patrick Lawless involved aeromechanics and the addition of a multistage axial compressor facility to support compressor performance studies. …”
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Impact of Additives on Poly(acrylonitrile-butadiene-styrene) Membrane Formation Process Using Non-Solvent-Induced Phase Separation by Sulaiman Dhameri, Jason Stallings, Endras Fadhilah, Emily Ingram, Mara Leach, Anastasiia Aronova, Malgorzata Chwatko

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Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells. by Rebeka Sultana, Tarek Abdel-Fatah, Christina Perry, Paul Moseley, Nada Albarakti, Vivek Mohan, Claire Seedhouse, Stephen Chan, Srinivasan Madhusudan

“…<h4>Introduction</h4>Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. …”
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