SPARTA: Interpretable functional classification of microbiomes and detection of hidden cumulative effects. by Baptiste Ruiz, Arnaud Belcour, Samuel Blanquart, Sylvie Buffet-Bataillon, Isabelle Le Huërou-Luron, Anne Siegel, Yann Le Cunff

“…Both profiles, microbial and functional, are used to train Random Forest classifiers to discern unhealthy from control samples. …”
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Prognosis of Functional Results of Arising or Immature Cataract Phacoemulsification High Myopia by A. A. Pilyagina, O. A. Fabrikantov, S. V. Shutova

“…The true prognosis of visual functions in these patients will allow solving the problem of cataract phacoemulsification expediency, decreasing the risks of complications.Purpose. …”
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Calcium nanoparticles target and activate T cells to enhance anti-tumor function by Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang, Yong Teng, Wendy T. Watford, Gang Zhou, Jin Xie

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Stabilization of Oil-in-Water Pickering Emulsions by Surface-Functionalized Cellulose Hydrogel by Inimfon A. Udoetok, Mohamed H. Mohamed, Lee D. Wilson

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Improvement of Functional and Technological Properties of Chickpea Aquafaba Through Lactic Fermentation by Rosa Colucci Cante, Federica Nigro, Giulia Lentini, Francesca Passannanti, Marianna Gallo, Francesca Mauriello, Andrea Luigi Budelli, Roberto Nigro

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On Sharp Coefficients and Hankel Determinants for a Novel Class of Analytic Functions by Dong Liu, Adeel Ahmad, Huma Ikhlas, Saqib Hussain, Saima Noor, Huo Tang

“…In this article, a new subclass of starlike functions is defined by using the technique of subordination and introducing a novel generalized domain. …”
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γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct by Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde

“…Abstract γ‐Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader panel of substrates, we demonstrate that clinical GSIs are pharmacologically distinct. …”
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Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies by Shizuka Hirai, Nobuyuki Takahashi, Tsuyoshi Goto, Shan Lin, Taku Uemura, Rina Yu, Teruo Kawada

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Hexokinase2-engineered T cells display increased anti-tumor function by Raphaëlle Toledano Zur, Shiran Didi Zurinam, Maria Radman, Elia Funaro Balouka, Tatiana Borodianskiy-Shteinberg, Dieter Saur, Cyrille J. Cohen

“…These engineered T cells were tested in vitro and in vivo to evaluate their metabolic and therapeutic efficacy.ResultsHK2-engineered T cells exhibited increased glycolytic capacity, leading to enhanced cytokine secretion, activation marker expression, and metabolic activity compared to controls. In vivo studies using a human tumor xenograft model demonstrated the superior therapeutic efficacy of HK2-engineered T cells, including delayed tumor growth and improved survival.ConclusionHK2 overexpression improves T-cell metabolic fitness and functionality in hostile TMEs, offering a promising foundation for the development of next-generation immunotherapies targeting T-cell metabolism.…”
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From sensation to regulation: the diverse functions of peripheral sensory nervous system by Yixiao Mei, Yixiao Mei, Yixiao Mei, Bing-Lin Zhou, Da Zhong, Xuan-Jie Zheng, Yu-Tao Deng, Lina Yu, Lina Yu, Bao-Chun Jiang, Bao-Chun Jiang, Bao-Chun Jiang

“…The PNS exerts regulatory functions within the organs it innervates through direct interactions with local cells or through microbe-nerve-cell interactions that differ from the traditional feedback regulatory modes used by the hormonal and sensory brain-sympathetic/parasympathetic systems. …”
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Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation by Agnes Lau, Alex McDonald, Nathalie Daude, Charles E Mays, Eric D Walter, Robin Aglietti, Robert CC Mercer, Serene Wohlgemuth, Jacques van der Merwe, Jing Yang, Hristina Gapeshina, Chae Kim, Jennifer Grams, Beipei Shi, Holger Wille, Aru Balachandran, Gerold Schmitt‐Ulms, Jiri G Safar, Glenn L Millhauser, David Westaway

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Enhancer RNA transcription pinpoints functional genetic variants linked to asthma by Sarah K. Sasse, Amber Dahlin, Lynn Sanford, Margaret A. Gruca, Arnav Gupta, Fabienne Gally, Ann Chen Wu, Carlos Iribarren, Robin D. Dowell, Scott T. Weiss, Anthony N. Gerber

“…The role of rs258760 as a protective variant for asthma was independently validated using UK Biobank data. Our findings establish eRNA signatures as a tool for discovery of functional genetic variants and define a novel association between air pollution, glucocorticoid signaling and asthma.…”
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Microbial Biomass as a Bioresource of Functional Food Ingredients: A Review by Elena M. Serba, Tatyana V. Yuraskina, Liubov V. Rimareva, Polina Yu. Tadzibova, Elena N. Sokolova, Galina S. Volkova

“…Microbial biomass is a promising source of essential macro- and micronutrients to be used in the food industry, e.g., protein, vitamins, essential amino acids, polysaccharide, etc. …”
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Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies by Yuhan Du, Yujie Liu, Yuanchi Zhang, Yangyi Nie, Zili Xu, Ling Qin, Wei Zhang, Yuxiao Lai

“…Finally, it summarizes the construction strategies of BP used for treating bone defects from various perspectives including structural and functional biomimicry, and discusses the latest advances in current research.…”
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Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions by Antonio R. Cerullo, Maxwell B. McDermott, Lauren E. Pepi, Zhi-Lun Liu, Diariou Barry, Sheng Zhang, Xu Yang, Xi Chen, Parastoo Azadi, Mande Holford, Adam B. Braunschweig

“…Here, we characterize mucus proteins, glycosylation, ion content, and mechanical properties that could be used to provide insight into structure-function relationships through an integrative “mucomics” approach. …”
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Wearable photonic smart wristband for cardiorespiratory function assessment and biometric identification by Wenbo Li, Yukun Long, Yingyin Yan, Kun Xiao, Zhuo Wang, Di Zheng, Arnaldo Leal-Junior, Santosh Kumar, Beatriz Ortega, Carlos Marques, Xiaoli Li, Rui Min

“…The assessment of cardiorespiratory function and biometric identification (ID) is crucial for the effectiveness of such personalized health services. …”
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Integrated Functional Analysis of the Nuclear Proteome of Classically and Alternatively Activated Macrophages by John E. Wiktorowicz, Imran H. Chowdhury, Susan Stafford, Subhadip Choudhuri, Nilay Dey, Nisha J. Garg

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Thyroidectomy, especially total thyroidectomy, adversely affects erectile function in men by Yushu Huang, Dan Guo, Daixing Hu, Yaru Yang, Qin Deng

“…Abstract Objectives To evaluate the frequency of erectile dysfunction in male patients who undergo thyroidectomy using the International Index of Erectile Function (IIEF-5), and explore possible risk factors. …”
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The Formation of a Stable Political Governance: Structural-Functional and Morphological Analysis by A. D. Tumanov

“…Political stability implies that the distribution of resources in society involves not only the institutional subsystem of the political system, but also the functional, regulatory and ideological subsystems. Morphological analysis demonstrates that a stable political system is characterized by a balanced interaction of subsystems, in which at least the institutional, regulatory and functional subsystems jointly determine the process of functioning and development of the political system. …”
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Physiological and Hormonal Effects of Titanium Dioxide Nanoparticles on Thyroid and Kidney Functions by Noori Mohammed Luaibi, Raghda Ali Mohammed

“…            Titanium dioxide nanoparticles (TiO2 NPs) are generally used in different types of applications such as the industry of plastics, paper industry, paints, toothpaste, cosmetics, sunscreens, and in various lifestyles, because of the vast range of applications and our daily exposure to these nanoparticles and a lack of information on animal and human health this study was designed to reveal dose and time-dependent effects of TiO2-NPs on the thyroid gland and kidney functions in male rats. …”
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