Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins by Emelie Foord, Charlotte Klynning, Esther Schoutrop, Judith M. Förster, Jennifer Krieg, Anette Mörtberg, Mischa R. Müller, Christel Herzog, Dieter Schiegg, Denis Villemagne, Ulrike Fiedler, Dan Snell, Benjamin Kebble, Jonas Mattsson, Victor Levitsky, Michael Uhlin

“…Our aim was to explore the enhancement of T-cell function by using novel PD-1-blocking proteins and compare with clinically approved monoclonal antibodies (mAbs). …”
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Using a user–defined function in Ansys Fluent to implement the energy release profile in model fuel elements taking into account radiation heating by Н.А. Сулейменов, Н.Е. Мухамедов, О.М. Жанболатов

“…After that, the obtained data are used as initial conditions for development of user-defined functions and conducting thermophysical calculations to determine the distribution of the temperature field in the tested device, the ANSYS Fluent software package. …”
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A Comparison Study of Numerical Techniques for Solving Ordinary Differential Equations Defined on a Semi-Infinite Domain Using Rational Chebyshev Functions by Mohamed A. Ramadan, Taha Radwan, Mahmoud A. Nassar, Mohamed A. Abd El Salam

“…Two definitions of the derivative of the RC functions are introduced as operational matrices. Also, a theoretical study carried on the RC functions shows that the RC approximation has an exponential convergence. …”
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Using the Functional Object Detection—Advanced Driving Simulator Scenario to Examine Task Combinations and Age-Based Performance Differences: A Case Study by Johnell O. Brooks, Rakesh Gangadharaiah, Elenah B. Rosopa, Rebecca Pool, Casey Jenkins, Patrick J. Rosopa, Lauren Mims, Breno Schwambach, Ken Melnrick

“…Driving, a common goal for clients after an injury or illness, is a complex task that relies on visual, cognitive, and motor skills. The Functional Object Detection and Functional Object Detection (FOD)—Advanced driving simulator scenarios were developed to provide objective and repeatable driving experiences allowing clinicians to assess their clients’ forward (focal) and peripheral vision, lane keeping, and speed maintenance, as well as provide interventions. …”
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NETWORK OPTIMIZATION FOR EFFICIENT DATA TRANSMISSION IN AN IOT NETWORK USING ITERATIVE HYBRID GREY WOLF COOT OPTIMIZATION AND DYNAMIC PHYSICALLY UNCLONABLE FUNCTIONS by Varalakshmi Kalluru, Azad S.M.A.K

“…The main purpose of this model is to utilize Dynamic Physically Unclonable Functions (DPuFs) embedded in network nodes to facilitate swift dynamic encryption, substantially diminishing the i) packet delivery ratio; ii) energy consumption; iii) jitter; v) throughput; and vi) delay typically associated with secure data transmission. …”
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Characteristics of Wheat Noodle “Kitanokaori” Using Weakly Acidic Hard Water in Terms of Functional Qualities, Such as Inhibiting Postprandial Abrupt Increase in Blood Glucose by Sumiko Nakamura, Ken’ichi Ohtsubo

“…The KIT using weakly acidic hard water would be acceptable in terms of palatability and bio-functionality in terms of delaying digestion.…”
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Evaluation of the effectiveness of conservative treatment of patients with stage III osteoarthritis of the knee joint using functional unloading orthoses with the possibility of varus-valgus correction by M. A. Makarov, V. A. Nesterenko, V. E. Bialik, E. G. Zotkin, E. I. Bialik, S. A. Makarov, A. E. Karateev, A. A. Bialik

“…The aim of the study – Is to evaluate the effectiveness and safety of the use of a functional unloading orthosis with the possibility of varus–valgus correction (FUOVVC) in patients with stage III osteoarthritis of the knee joint.Materials and methods. …”
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Bone reconstruction using CAD/CAM technology in head and neck surgical oncology. A narrative review of state of the art and aesthetic-functional outcomes by Chiara Copelli, Federica Cacciatore, Stefan Cocis, Fabio Maglitto, Francesco Barbara, Oreste Iocca, Alfonso Manfuso

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OPTIMAL CUT-OFF POINTS OF INSTANTANEOUS WAVE-FREE RATIO IN THE ASSESSMENT OF THE FUNCTIONAL SIGNIFICANCE OF CORONARY ARTERY STENOSES USING NONINVASIVE METHODS AS REFERENCE by D. I. Darenskiy, V. V. Gramovich, E. A. Zharova, M. G. Mitroshkin, R. V. Atanesyan, G. N. Bakashvili, Y. G. Matchin

“…ABSTRACT Objective: the aim of our study was to determine the optimal instantaneous wave-free ratio (iFR) cut-off points in assessing the functional significance of intermediate coronary artery stenoses in patients with chronic coronary artery diseases (CAD) using non-invasive methods of myocardial ischemia verification as reference. …”
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Modelling dynamic transitions in neurological functional disability in patients with intracerebral haemorrhage: a prospective cohort study using a multistate Markov model by Ke Ma, Yang Song, Zheng Yan, Dezhi Kang, Shuna Huang, Shaowei Lin, Siying Wu, Minghuan Liu, Shiying Lin, Jialiang Xu, Xiaowan Zhou, Hang Zeng, Huangyuang Li, Xiao-Xu Xie

“…Objectives This study aims to explore the dynamics of neurological functional disability in patients with intracerebral haemorrhage (ICH) using a multistate Markov model and to investigate the factors influencing the shift in neurological functional disability.Design A prospective cohort study.Setting Electronic medical record data for adults, from July 2019 and October 2023 in neurosurgery at 27 national centres in China.Participants Patients with ICH with cerebral haemorrhage in the supratentorial parenchyma confirmed by CT of the brain within 48 hours of onset of symptoms. …”
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Continuous measurement of derailment quotient and wheel-rail contact position in railway vehicle using axially-asymmetric bridge circuits and orthogonal weighting functions by Takatoshi HONDO, Takayuki TANAKA

“…Instrumented wheelsets are widely used in the railway industry for the purpose of measurement of the wheel-rail interaction forces, which are crucial factors in a running safety assessment. …”
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Longitudinal analysis of coal workers’ pneumoconiosis using enhanced resolution-computed tomography images: unveiling patterns in lung structure, function, and clinical correlations by Ngan-Khanh Chau, Ngan-Khanh Chau, Eun-Kee Park, Sanghun Choi

“…Inspiratory qCT images were enhanced using a deep learning-based super-resolution model and then processed to extract lung functional and airway structural metrics. …”
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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…Our research provides updated risk estimates for stroke and dementia using the new estimation for kidney function in a large multiethnic cohort.…”
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Functional group, transversal optic and longitudinal optic analysis using kramer-kronig method of mycellium and oyster mushroom in 35, 40, and 45 days by Irzaman, Nurmaniah Irlian, Har Nazopatul Patonah, Jenie Renan Prasta, Siskandar Ridwan, Negara Teguh Puja, Pratama Erdiansyah, Syafutra Heriyanto, Alatas Husin, Irmansyah

“…Based on FTIR result, function groups of molecules are C-O, C=O, C-H, and O-H in the mycelium and oyster mushrooms. …”
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The Effect of Increasing the Body’s Core Temperature and Improving Blood Flow by Using Far-Infrared Rays Emitted from Functional Loess Bio-Balls by Yong-Il Shin, Min-Seok Kim, Yeong-Ae Yang, Gye-Rok Jeon, Jae-Ho Kim, Yeon-Jin Choi, Woo-Cheol Choi, Jae-Hyung Kim

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In Korea, Developing a Predictive System for Safety Assessment of Combined and Concurrent Intake of Functional Ingredients in Health Foods and Pharmaceuticals Using Big Data by Hyemi Kim, Kwang Suk Ko, Soohan Jung, Hyeonju Yu, Yejin Lee, Minju Kim, Seungyoun Jung, Seok-Hee Lee, Ga-Hee Shin, SangMin Lee

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Effects of Dietary Supplementation Using Phytobiotics with Different Functional Properties on Expression of Immunity Genes, Intestinal Histology, Growth, and Meat Productivity of Broiler Chickens by Marina I. Selionova, Vladimir I. Trukhachev, Artem Yu. Zagarin, Egor I. Kulikov, Nina P. Belyaeva

“…The aim of this study was to investigate the expression of immunity-related genes and morpho-histological features of the intestines, and the growth and meat production of broiler chickens when fed plant extracts with different functional components. Chickens in the control group received a basic diet. …”
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Identification and characterization of endogenous biomarkers for hepatic vectorial transport (OATP1B3-P-gp) function using metabolomics with serum pharmacology by Yong-wen Jin, Yan-rong Ma, Ming-kang Zhang, Wen-bin Xia, Pei Yuan, Bo-xia Li, Yu-hui Wei, Xin-an Wu

“…The present study was designed to identify a suitable endogenous biomarker for the assessment of OATP1B3-P-gp function in the liver. We established stably transfected HEK293T-OATP1B3 and HEK293T-P-gp cell lines. …”
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Systems approaches to predict the functions of glycoside hydrolases during the life cycle of Aspergillus niger using developmental mutants ∆brlA and ∆flbA. by Jolanda M van Munster, Benjamin M Nitsche, Michiel Akeroyd, Lubbert Dijkhuizen, Marc J E C van der Maarel, Arthur F J Ram

“…By comparing the transcriptomes, proteomes, enzyme activities and the fungal cell wall compositions of a wild type A. niger strain and these developmental mutants during carbon starvation, a global overview of the function of carbohydrate-active enzymes is provided. …”
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Demographic, socioeconomic and functional health-related factors in the selection of vaginal pessaries used for the conservative treatment of pelvic organ prolapse: a retrospective study by Orsolya Oláh, Miklós Romics, Nándor Ács, Richárd Cseh, Péter Nyirády, Attila Majoros

“…Methods 115 female patients using vaginal pessaries for POP were included in our study (group I:73 pts used a daily control “cube” pessary (DCP), group II.:42 pts used a long-term wear ring pessary (LTP). …”
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